Mesenchymal stem cells for critical limb ischemia: their function, mechanism, and therapeutic potential View Full Text


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Article Info

DATE

2022-07-26

AUTHORS

Laura V. Lozano Navarro, Xueyi Chen, Lady Tatiana Giratá Viviescas, Andrea K. Ardila-Roa, Maria L. Luna-Gonzalez, Claudia L. Sossa, Martha L. Arango-Rodríguez

ABSTRACT

Peripheral arterial disease is atherosclerotic occlusive disease of the lower extremity arteries and afflicts hundreds of millions of individuals worldwide. Its most severe manifestation is chronic limb-threatening ischemia (Petersen et al. (Science 300(5622):1140–2, 2003)), which is associated with severe pain at rest in the limbs, which progresses to necrosis, limb amputation, and/or death of the patient. Consequently, the care of these patients is considered a financial burden for both patients and health systems. Multidisciplinary endeavors are required to address this refractory disease and to find definitive solutions that lead to improved living conditions. Revascularization is the cornerstone of therapy for preventing limb amputation, and both open vascular surgery and endovascular therapy play a key role in the treatment of patients with CLI. Around one-third of these patients are not candidates for conventional surgical treatment, however, leading to higher amputation rates (approaching 20–25% at one year) with high morbidity and lower quality of life. Advances in regenerative medicine have enabled the development of cell-based therapies that promote the formation of new blood vessels. Particularly, mesenchymal stem cells (MSCs) have emerged as an attractive therapeutic agent in various diseases, including CLI, due to their role in tissue regeneration and immunomodulation. This review discusses the characteristics of MSCs, as well as their regenerative properties and their action mechanisms on CLI. More... »

PAGES

345

References to SciGraph publications

  • 2010-11-21. Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms in ANGIOGENESIS
  • 2021-04-21. Mesenchymal Stem Cell Transplantation for Ischemic Diseases: Mechanisms and Challenges in TISSUE ENGINEERING AND REGENERATIVE MEDICINE
  • 2018-10-25. LincRNA-p21 promotes mesenchymal stem cell migration capacity and survival through hypoxic preconditioning in STEM CELL RESEARCH & THERAPY
  • 2022-03-21. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases in SIGNAL TRANSDUCTION AND TARGETED THERAPY
  • 2010-04-28. A Direct Comparison of Anti-microRNA Oligonucleotide Potency in PHARMACEUTICAL RESEARCH
  • 2016-08-31. Mechanisms of mesenchymal stem/stromal cell function in STEM CELL RESEARCH & THERAPY
  • 2019-08-06. The progression rate of peripheral arterial disease in patients with intermittent claudication: a systematic review in JOURNAL OF FOOT AND ANKLE RESEARCH
  • 2015-03-24. Interaction between mesenchymal stem cells and endothelial cells restores endothelial permeability via paracrine hepatocyte growth factor in vitro in STEM CELL RESEARCH & THERAPY
  • 2017-05-19. Adipose-derived mesenchymal stem cells from liposuction and resected fat are feasible sources for regenerative medicine in EUROPEAN JOURNAL OF MEDICAL RESEARCH
  • 2018-12-27. Tissue engineering strategies for the induction of angiogenesis using biomaterials in JOURNAL OF BIOLOGICAL ENGINEERING
  • 2013-06-10. A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2019-05-04. Biological functions of mesenchymal stem cells and clinical implications in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2011-05-14. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC in CELL COMMUNICATION AND SIGNALING
  • 2015-09-18. Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns in BURNS & TRAUMA
  • 2016-07-13. Platelet lysate as a substitute for animal serum for the ex-vivo expansion of mesenchymal stem/stromal cells: present and future in STEM CELL RESEARCH & THERAPY
  • 2012-07-30. Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia in STEM CELL RESEARCH & THERAPY
  • 2016-05-29. Paracrine Mechanisms of Mesenchymal Stem Cells in Tissue Repair in MESENCHYMAL STEM CELLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13287-022-03043-3

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    33 schema:description Peripheral arterial disease is atherosclerotic occlusive disease of the lower extremity arteries and afflicts hundreds of millions of individuals worldwide. Its most severe manifestation is chronic limb-threatening ischemia (Petersen et al. (Science 300(5622):1140–2, 2003)), which is associated with severe pain at rest in the limbs, which progresses to necrosis, limb amputation, and/or death of the patient. Consequently, the care of these patients is considered a financial burden for both patients and health systems. Multidisciplinary endeavors are required to address this refractory disease and to find definitive solutions that lead to improved living conditions. Revascularization is the cornerstone of therapy for preventing limb amputation, and both open vascular surgery and endovascular therapy play a key role in the treatment of patients with CLI. Around one-third of these patients are not candidates for conventional surgical treatment, however, leading to higher amputation rates (approaching 20–25% at one year) with high morbidity and lower quality of life. Advances in regenerative medicine have enabled the development of cell-based therapies that promote the formation of new blood vessels. Particularly, mesenchymal stem cells (MSCs) have emerged as an attractive therapeutic agent in various diseases, including CLI, due to their role in tissue regeneration and immunomodulation. This review discusses the characteristics of MSCs, as well as their regenerative properties and their action mechanisms on CLI.
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