Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-07-26

AUTHORS

Pinyan Liu, Yongcui Mao, Ye Xie, Jiayun Wei, Jia Yao

ABSTRACT

Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fibrosis/cirrhosis and provide the latest overview of various cell sources, cell doses, and delivery methods. We also describe the limitations and strengths of various stem cells in clinical applications. Furthermore, to clarify how stem cells play a therapeutic role in liver fibrosis, we discuss the molecular mechanisms of stem cells for treatment of liver fibrosis, including liver regeneration, immunoregulation, resistance to injury, myofibroblast repression, and extracellular matrix degradation. We provide a perspective for the prospects of future clinical implementation of stem cells. More... »

PAGES

356

References to SciGraph publications

  • 2014-10-28. Amniotic Membrane Mesenchymal Cells-Derived Factors Skew T Cell Polarization Toward Treg and Downregulate Th1 and Th17 Cells Subsets in STEM CELL REVIEWS AND REPORTS
  • 2016-01-11. Detection of hepatic maturation by Raman spectroscopy in mesenchymal stromal cells undergoing hepatic differentiation in STEM CELL RESEARCH & THERAPY
  • 2020-04-20. MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation in CELL DEATH & DISEASE
  • 2016-12-05. Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF in SCIENTIFIC REPORTS
  • 2020-09-03. Infusion of Human Mesenchymal Stem Cells Improves Regenerative Niche in Thioacetamide-Injured Mouse Liver in TISSUE ENGINEERING AND REGENERATIVE MEDICINE
  • 2022-04-04. Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects in STEM CELL RESEARCH & THERAPY
  • 2020-09-03. Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury in STEM CELL RESEARCH & THERAPY
  • 2019-05-27. Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice in STEM CELL RESEARCH & THERAPY
  • 2021-03-30. Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis in NPJ REGENERATIVE MEDICINE
  • 2011-02-11. Hepatic Differentiation of Mesenchymal Stem Cells: In Vitro Strategies in MESENCHYMAL STEM CELL ASSAYS AND APPLICATIONS
  • 2021-01-13. Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells in STEM CELL RESEARCH & THERAPY
  • 2020-09-25. Therapeutic effect and safety of stem cell therapy for chronic liver disease: a systematic review and meta-analysis of randomized controlled trials in STEM CELL RESEARCH & THERAPY
  • 2007-05-31. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells in LEUKEMIA
  • 2021-07-13. Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling in STEM CELL RESEARCH & THERAPY
  • 2009-06-17. Contribution of human hematopoietic stem cells to liver repair in SEMINARS IN IMMUNOPATHOLOGY
  • 2013-11-20. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis in NATURE
  • 2016-04-05. Tissue-specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal Tissues in SCIENTIFIC REPORTS
  • 2020-06-29. Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway in STEM CELL RESEARCH & THERAPY
  • 2016-11-10. Report on Liver Cell Transplantation Using Human Fetal Liver Cells in HEPATOCYTE TRANSPLANTATION
  • 2019-03-18. Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway in STEM CELL RESEARCH & THERAPY
  • 2021-10-24. Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium in STEM CELL RESEARCH & THERAPY
  • 2015-06-19. In vitro culture of isolated primary hepatocytes and stem cell-derived hepatocyte-like cells for liver regeneration in PROTEIN & CELL
  • 2010-04-06. Human hepatocyte transplantation: current experience and future challenges in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2022-01-05. hUC-MSCs: evaluation of acute and long-term routine toxicity testing in mice and rats in CYTOTECHNOLOGY
  • 2019-05-02. Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets in SCIENTIFIC REPORTS
  • 2016-11-24. Adipose Stem Cells Display Higher Regenerative Capacities and More Adaptable Electro-Kinetic Properties Compared to Bone Marrow-Derived Mesenchymal Stromal Cells in SCIENTIFIC REPORTS
  • 2017-11-17. Liver fibrosis alleviation after co-transplantation of hematopoietic stem cells with mesenchymal stem cells in patients with thalassemia major in ANNALS OF HEMATOLOGY
  • 2018-08-09. Primate stem cells: bridge the translation from basic research to clinic application in SCIENCE CHINA LIFE SCIENCES
  • 2007-03-05. Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice in WORLD JOURNAL OF SURGERY
  • 2018-03-09. Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis in STEM CELL RESEARCH & THERAPY
  • 2016-05-12. Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases in STEM CELL RESEARCH & THERAPY
  • 2018-01-09. RETRACTED ARTICLE: Chemokine receptor 7 overexpression promotes mesenchymal stem cell migration and proliferation via secreting Chemokine ligand 12 in SCIENTIFIC REPORTS
  • 2015-09-10. In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice in STEM CELL RESEARCH & THERAPY
  • 2021-05-20. Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells in STEM CELL RESEARCH & THERAPY
  • 2015-01-16. Mesenchymal Stem Cells: A Friend or Foe in Immune-Mediated Diseases in STEM CELL REVIEWS AND REPORTS
  • 2018-03-21. A pooled analysis of mesenchymal stem cell-based therapy for liver disease in STEM CELL RESEARCH & THERAPY
  • 2021-11-29. Mesenchymal stem cell therapy in decompensated liver cirrhosis: a long-term follow-up analysis of the randomized controlled clinical trial in HEPATOLOGY INTERNATIONAL
  • 2021-06-22. Individual heterogeneity screened umbilical cord-derived mesenchymal stromal cells with high Treg promotion demonstrate improved recovery of mouse liver fibrosis in STEM CELL RESEARCH & THERAPY
  • 2021-03-29. The effect of bone marrow-derived mesenchymal stem cell co-transplantation with hematopoietic stem cells on liver fibrosis alleviation and survival in patients with class III β-thalassemia major in STEM CELL RESEARCH & THERAPY
  • 2018-09-17. Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9 in STEM CELL RESEARCH & THERAPY
  • 2020-09-14. Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis in STEM CELL RESEARCH & THERAPY
  • 2020-08-06. Liver regeneration: biological and pathological mechanisms and implications in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2021-09-13. Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways in CELL DEATH DISCOVERY
  • 2019-01-03. The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine in STEM CELL RESEARCH & THERAPY
  • 2021-11-12. Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells in STEM CELL RESEARCH & THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13287-022-03041-5

    DOI

    http://dx.doi.org/10.1186/s13287-022-03041-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149784447

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35883127


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