Plant callus-derived shikimic acid regenerates human skin through converting human dermal fibroblasts into multipotent skin-derived precursor cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-06-11

AUTHORS

Yoo-Wook Kwon, Shin-Hyae Lee, Ah-Reum Kim, Beom Joon Kim, Won-Seok Park, Jin Hur, Hyunduk Jang, Han-Mo Yang, Hyun-Jai Cho, Hyo-Soo Kim

ABSTRACT

BackgroundThe human skin-derived precursors (SKPs) are a good cell source for regeneration. However, the isolation of SKP from human skin is limited. To overcome this drawback, we hypothesized that the component of plant stem cells could convert human fibroblasts to SKPs.MethodsHuman dermal fibroblasts were treated with shikimic acid, a major component of Sequoiadendron giganteum callus extract. The characteristics of these reprogrammed cells were analyzed by qPCR, western blot, colony-forming assay, and immunofluorescence staining. Artificial human skin was used for CO2 laser-induced wound experiments. Human tissues were analyzed by immunohistochemistry.ResultsThe reprogrammed cells expressed nestin (a neural precursor-specific protein), fibronectin, and vimentin and could differentiate into the ectodermal and mesodermal lineage. Nestin expression was induced by shikimic acid through the mannose receptor and subsequent MYD88 activation, leading to P38 phosphorylation and then CREB binding to the nestin gene promoter. Finally, we confirmed that shikimic acid facilitated the healing of cut injury and enhanced dermal reconstruction in a human artificial skin model. Moreover, in a clinical study with healthy volunteers, plant callus extracts increased the expression of stem cell markers in the basal layer of the epidermis and collagen deposit in the dermis.ConclusionsThese results indicate that shikimic acid is an effective agent for tissue regeneration. More... »

PAGES

346

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13287-021-02409-3

DOI

http://dx.doi.org/10.1186/s13287-021-02409-3

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https://app.dimensions.ai/details/publication/pub.1138789582

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34116724


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