Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Xiaowei Wei, Baoyi Liu, Ge Liu, Fan Yang, Fang Cao, Xiaojie Dou, Weiting Yu, Benjie Wang, Guoshuang Zheng, Liangliang Cheng, Zhijie Ma, Yu Zhang, Jiahui Yang, Zihua Wang, Junlei Li, Daping Cui, Wei Wang, Hui Xie, Lu Li, Feng Zhang, William C. Lineaweaver, Dewei Zhao

ABSTRACT

BACKGROUND: The body is unable to repair and regenerate large area bone defects. Moreover, the repair capacity of articular cartilage is very limited. There has long been a lack of effective treatments for osteochondral lesions. The engineered tissue with biphase synthetic for osteochondral repair has become one of the hot research fields over the past few years. In this study, an integrated biomanufacturing platform was constructed with bone marrow mesenchymal stem cells (BMSCs)/porous tantalum (pTa) associated with chondrocytes/collagen membranes (CM) to repair large osteochondral defects in load-bearing areas of goats. METHODS: Twenty-four goats with a large osteochondral defect in the femoral heads of the left hind legs were randomly divided into three groups: eight were treated with chondrocytes/CM-BMSCs/pTa, eight were treated with pure CM-pTa composite, and the other eight goats were untreated. The repair effect was assessed by X-ray, gross observation, and histomorphology for 16 weeks after the operation. In addition, the biocompatibility of chondrocytes/CM-BMSCs/pTa was observed by flow cytometry, CCK8, immunocytochemistry, and Q-PCR. The characteristics of the chondrocytes/CM-BMSCs/pTa were evaluated using both scanning electron microscopy and mechanical testing machine. RESULTS: The integrated repair material consists of pTa, injectable fibrin sealant, and CM promoted adhesion and growth of BMSCs and chondrocytes. pTa played an important role in promoting the differentiation of BMSCs into osteoblasts. Three-dimensional CM maintained the phenotype of chondrocytes successfully and expressed chondrogenic genes highly. The in vivo study showed that after 16 weeks from implantation, osteochondral defects in almost half of the femoral heads had been successfully repaired by BMSC-loaded pTa associated with biomimetic 3D collagen-based scaffold. CONCLUSIONS: The chondrocytes/CM-BMSCs/pTa demonstrated significant therapeutic efficacy in goat models of large osteochondral defect. This provides a novel therapeutic strategy for large osteochondral lesions in load-bearing areas caused by severe injury, necrosis, infection, degeneration, and tumor resection with a high profile of safety, effectiveness, and simplicity. More... »

PAGES

72

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13287-019-1176-2

DOI

http://dx.doi.org/10.1186/s13287-019-1176-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112548075

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30837004


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Xiaowei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Baoyi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Ge", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dalian University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.30055.33", 
          "name": [
            "Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Fan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dalian University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.30055.33", 
          "name": [
            "Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Fang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dou", 
        "givenName": "Xiaojie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Weiting", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Benjie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Guoshuang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Liangliang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dalian University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.30055.33", 
          "name": [
            "Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Zhijie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Jiahui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Zihua", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Junlei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "Daping", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Hui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Lu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "JMS Burn and Reconstructive Center, Jackson, MS, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Feng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "JMS Burn and Reconstructive Center, Jackson, MS, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lineaweaver", 
        "givenName": "William C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Zhongshan Hospital of Dalian University", 
          "id": "https://www.grid.ac/institutes/grid.459353.d", 
          "name": [
            "Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Dewei", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1177/1535370216629578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000684168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1535370216629578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000684168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ahe.12018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005862740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2010.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006434738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/79449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007162451", 
          "https://doi.org/10.1038/79449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/79449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007162451", 
          "https://doi.org/10.1038/79449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rb/rbv015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009216546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2003.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009583039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000080341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012378650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2015.05.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013371615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013706792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1166/jnn.2013.6733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014276545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biotechadv.2012.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015536301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.matlet.2016.05.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019795107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041430304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020047111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.04.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024726556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.1069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026422301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0757.1999.tb00148.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027009497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2011.0544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027787677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.20983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032561419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.20983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032561419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.31602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033396783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0066263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034175320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2013.12.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035416738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2013.05.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037847672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.05.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041170454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947603512444597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042280972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947603512444597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042280972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1987.tb01309.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043555012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibtech.2012.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044429006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.knee.2011.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044525111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001665-199807000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046613221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001665-199807000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046613221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(99)00061-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046869701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1290/1071-2690(2002)038<0457:cdohms>2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050639850", 
          "https://doi.org/10.1290/1071-2690(2002)038<0457:cdohms>2.0.co;2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar3142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053049416", 
          "https://doi.org/10.1186/ar3142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0042-118458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057382893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/10763270260424187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059206046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107632704322791871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059206368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2010.0691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.teb.2008.0388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059316920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.teb.2011.0141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059317010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-197860020-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068886754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.j.02010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.j.02010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.j.02010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.22203/ecm.v020a23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069338894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077428582", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079251827", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083254379", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.csm.2017.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101368873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1748-605x/aac91f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104305771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13287-018-0916-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105153734", 
          "https://doi.org/10.1186/s13287-018-0916-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13287-018-0916-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105153734", 
          "https://doi.org/10.1186/s13287-018-0916-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/7651_2018_197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110225091", 
          "https://doi.org/10.1007/7651_2018_197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/7651_2018_197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110225091", 
          "https://doi.org/10.1007/7651_2018_197"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: The body is unable to repair and regenerate large area bone defects. Moreover, the repair capacity of articular cartilage is very limited. There has long been a lack of effective treatments for osteochondral lesions. The engineered tissue with biphase synthetic for osteochondral repair has become one of the hot research fields over the past few years. In this study, an integrated biomanufacturing platform was constructed with bone marrow mesenchymal stem cells (BMSCs)/porous tantalum (pTa) associated with chondrocytes/collagen membranes (CM) to repair large osteochondral defects in load-bearing areas of goats.\nMETHODS: Twenty-four goats with a large osteochondral defect in the femoral heads of the left hind legs were randomly divided into three groups: eight were treated with chondrocytes/CM-BMSCs/pTa, eight were treated with pure CM-pTa composite, and the other eight goats were untreated. The repair effect was assessed by X-ray, gross observation, and histomorphology for 16\u2009weeks after the operation. In addition, the biocompatibility of chondrocytes/CM-BMSCs/pTa was observed by flow cytometry, CCK8, immunocytochemistry, and Q-PCR. The characteristics of the chondrocytes/CM-BMSCs/pTa were evaluated using both scanning electron microscopy and mechanical testing machine.\nRESULTS: The integrated repair material consists of pTa, injectable fibrin sealant, and CM promoted adhesion and growth of BMSCs and chondrocytes. pTa played an important role in promoting the differentiation of BMSCs into osteoblasts. Three-dimensional CM maintained the phenotype of chondrocytes successfully and expressed chondrogenic genes highly. The in vivo study showed that after 16\u2009weeks from implantation, osteochondral defects in almost half of the femoral heads had been successfully repaired by BMSC-loaded pTa associated with biomimetic 3D collagen-based scaffold.\nCONCLUSIONS: The chondrocytes/CM-BMSCs/pTa demonstrated significant therapeutic efficacy in goat models of large osteochondral defect. This provides a novel therapeutic strategy for large osteochondral lesions in load-bearing areas caused by severe injury, necrosis, infection, degeneration, and tumor resection with a high profile of safety, effectiveness, and simplicity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13287-019-1176-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043222", 
        "issn": [
          "1757-6512"
        ], 
        "name": "Stem Cell Research & Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats", 
    "pagination": "72", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "08ea33dc678317dc79f9b4058497ed6f2696f842be995f3b79b3d8e9e69ba5d3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30837004"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101527581"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13287-019-1176-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112548075"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13287-019-1176-2", 
      "https://app.dimensions.ai/details/publication/pub.1112548075"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78972_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13287-019-1176-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13287-019-1176-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13287-019-1176-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13287-019-1176-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13287-019-1176-2'


 

This table displays all metadata directly associated to this object as RDF triples.

347 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13287-019-1176-2 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N258845b0fb0a4b85a7136e865b2e177a
4 schema:citation sg:pub.10.1007/7651_2018_197
5 sg:pub.10.1038/79449
6 sg:pub.10.1186/ar3142
7 sg:pub.10.1186/s13287-018-0916-z
8 sg:pub.10.1290/1071-2690(2002)038<0457:cdohms>2.0.co;2
9 https://app.dimensions.ai/details/publication/pub.1077428582
10 https://app.dimensions.ai/details/publication/pub.1079251827
11 https://app.dimensions.ai/details/publication/pub.1083254379
12 https://doi.org/10.1002/art.10493
13 https://doi.org/10.1002/jbm.1069
14 https://doi.org/10.1002/jbm.a.31602
15 https://doi.org/10.1002/jcp.1041430304
16 https://doi.org/10.1002/jor.20983
17 https://doi.org/10.1016/j.actbio.2013.12.042
18 https://doi.org/10.1016/j.actbio.2015.05.023
19 https://doi.org/10.1016/j.biomaterials.2003.09.005
20 https://doi.org/10.1016/j.biomaterials.2006.04.041
21 https://doi.org/10.1016/j.biomaterials.2006.05.053
22 https://doi.org/10.1016/j.biomaterials.2010.04.017
23 https://doi.org/10.1016/j.biomaterials.2013.05.038
24 https://doi.org/10.1016/j.biotechadv.2012.11.004
25 https://doi.org/10.1016/j.csm.2017.12.008
26 https://doi.org/10.1016/j.knee.2011.03.011
27 https://doi.org/10.1016/j.matlet.2016.05.065
28 https://doi.org/10.1016/j.tibtech.2012.12.004
29 https://doi.org/10.1016/s0142-9612(99)00061-7
30 https://doi.org/10.1055/s-0042-118458
31 https://doi.org/10.1088/1748-605x/aac91f
32 https://doi.org/10.1089/10763270260424187
33 https://doi.org/10.1089/107632704322791871
34 https://doi.org/10.1089/ten.tea.2010.0691
35 https://doi.org/10.1089/ten.tea.2011.0544
36 https://doi.org/10.1089/ten.teb.2008.0388
37 https://doi.org/10.1089/ten.teb.2011.0141
38 https://doi.org/10.1093/rb/rbv015
39 https://doi.org/10.1097/00001665-199807000-00004
40 https://doi.org/10.1111/ahe.12018
41 https://doi.org/10.1111/j.1365-2184.1987.tb01309.x
42 https://doi.org/10.1111/j.1600-0757.1999.tb00148.x
43 https://doi.org/10.1159/000080341
44 https://doi.org/10.1166/jnn.2013.6733
45 https://doi.org/10.1177/1535370216629578
46 https://doi.org/10.1177/1947603512444597
47 https://doi.org/10.1371/journal.pone.0066263
48 https://doi.org/10.2106/00004623-197860020-00007
49 https://doi.org/10.2106/jbjs.d.02104
50 https://doi.org/10.2106/jbjs.j.02010
51 https://doi.org/10.22203/ecm.v020a23
52 schema:datePublished 2019-12
53 schema:datePublishedReg 2019-12-01
54 schema:description BACKGROUND: The body is unable to repair and regenerate large area bone defects. Moreover, the repair capacity of articular cartilage is very limited. There has long been a lack of effective treatments for osteochondral lesions. The engineered tissue with biphase synthetic for osteochondral repair has become one of the hot research fields over the past few years. In this study, an integrated biomanufacturing platform was constructed with bone marrow mesenchymal stem cells (BMSCs)/porous tantalum (pTa) associated with chondrocytes/collagen membranes (CM) to repair large osteochondral defects in load-bearing areas of goats. METHODS: Twenty-four goats with a large osteochondral defect in the femoral heads of the left hind legs were randomly divided into three groups: eight were treated with chondrocytes/CM-BMSCs/pTa, eight were treated with pure CM-pTa composite, and the other eight goats were untreated. The repair effect was assessed by X-ray, gross observation, and histomorphology for 16 weeks after the operation. In addition, the biocompatibility of chondrocytes/CM-BMSCs/pTa was observed by flow cytometry, CCK8, immunocytochemistry, and Q-PCR. The characteristics of the chondrocytes/CM-BMSCs/pTa were evaluated using both scanning electron microscopy and mechanical testing machine. RESULTS: The integrated repair material consists of pTa, injectable fibrin sealant, and CM promoted adhesion and growth of BMSCs and chondrocytes. pTa played an important role in promoting the differentiation of BMSCs into osteoblasts. Three-dimensional CM maintained the phenotype of chondrocytes successfully and expressed chondrogenic genes highly. The in vivo study showed that after 16 weeks from implantation, osteochondral defects in almost half of the femoral heads had been successfully repaired by BMSC-loaded pTa associated with biomimetic 3D collagen-based scaffold. CONCLUSIONS: The chondrocytes/CM-BMSCs/pTa demonstrated significant therapeutic efficacy in goat models of large osteochondral defect. This provides a novel therapeutic strategy for large osteochondral lesions in load-bearing areas caused by severe injury, necrosis, infection, degeneration, and tumor resection with a high profile of safety, effectiveness, and simplicity.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N3ad032f30cc941c69064558f6d3974e2
59 N6de39a1a6a3c4637b24c63c742367dd5
60 sg:journal.1043222
61 schema:name Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats
62 schema:pagination 72
63 schema:productId N55bd448c4d564804947c2c3333f3d0e5
64 N696efa2adf7f470fa6fb5739603e30ba
65 N794e9b4f38a744c2a341c8e11cf403d8
66 N7eeed5b5e16e416a8893549e831c4be2
67 N91532d2e79b44f62a04bd2cc50264751
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112548075
69 https://doi.org/10.1186/s13287-019-1176-2
70 schema:sdDatePublished 2019-04-11T13:21
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N1b075b11c52542739facba348176c535
73 schema:url https://link.springer.com/10.1186%2Fs13287-019-1176-2
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N04cd139edb514709b285adc310deb69d schema:affiliation N86a1e95e620547ab896327aefe959d1d
78 schema:familyName Zhang
79 schema:givenName Feng
80 rdf:type schema:Person
81 N06364ab52c8448648fb1449838811b7b schema:affiliation N0ac442dc682b43e48c68989ca18f29aa
82 schema:familyName Lineaweaver
83 schema:givenName William C.
84 rdf:type schema:Person
85 N0ac442dc682b43e48c68989ca18f29aa schema:name JMS Burn and Reconstructive Center, Jackson, MS, USA
86 rdf:type schema:Organization
87 N1690c73fb0a647cdac699c29c1ecd800 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
88 schema:familyName Cheng
89 schema:givenName Liangliang
90 rdf:type schema:Person
91 N18be3f495363418d966f4072a16cc232 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
92 schema:familyName Cui
93 schema:givenName Daping
94 rdf:type schema:Person
95 N1b075b11c52542739facba348176c535 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N1b955bd84b314a8ab59d0cec1057c4e1 rdf:first Na77b5426701e4f12a734cfbebcf62bec
98 rdf:rest N81299a5cf19c4fe09538f262d74d7127
99 N23af0bbe944c466397b1a3e6610f6619 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
100 schema:familyName Zhang
101 schema:givenName Yu
102 rdf:type schema:Person
103 N258845b0fb0a4b85a7136e865b2e177a rdf:first N5e0b8abe239c47489b44bd2242c2e127
104 rdf:rest N1b955bd84b314a8ab59d0cec1057c4e1
105 N30d45b6bcc804abc85201a51cca86eed rdf:first Nb93c75a504de4941a0260f74ea87a1a0
106 rdf:rest N5e42195beadc4d968674f618d472fbc6
107 N3717107431154c0b9f28d9df8081438f rdf:first Nb40f38cb988c42c5939e793ecadf6cf7
108 rdf:rest Nd69c0b698e154c6db0bfe778bb60e88e
109 N3770a0544dae4d86bff0a48b54458db2 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
110 schema:familyName Dou
111 schema:givenName Xiaojie
112 rdf:type schema:Person
113 N3a3e4349201a4602b864b6671cf05b99 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
114 schema:familyName Wang
115 schema:givenName Wei
116 rdf:type schema:Person
117 N3ad032f30cc941c69064558f6d3974e2 schema:volumeNumber 10
118 rdf:type schema:PublicationVolume
119 N43f5a2109b0a4034b383e03982c0bae8 rdf:first Nb91ab250df854159b5d0d47792e6aafe
120 rdf:rest Ne8a8d4b7b4ea45a5adbd1aabe196c712
121 N55bd448c4d564804947c2c3333f3d0e5 schema:name readcube_id
122 schema:value 08ea33dc678317dc79f9b4058497ed6f2696f842be995f3b79b3d8e9e69ba5d3
123 rdf:type schema:PropertyValue
124 N58331906996f4eadb0f6ab519e460c81 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
125 schema:familyName Li
126 schema:givenName Junlei
127 rdf:type schema:Person
128 N58655f81d14c4981b340f056eb36d332 rdf:first N58331906996f4eadb0f6ab519e460c81
129 rdf:rest Nc3ada5a155854bfeb32d92fb5b46b901
130 N5dc5d3ee5a2c4c1b9d0ee50f6cd000c0 rdf:first N23af0bbe944c466397b1a3e6610f6619
131 rdf:rest N43f5a2109b0a4034b383e03982c0bae8
132 N5e0b8abe239c47489b44bd2242c2e127 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
133 schema:familyName Wei
134 schema:givenName Xiaowei
135 rdf:type schema:Person
136 N5e42195beadc4d968674f618d472fbc6 rdf:first N04cd139edb514709b285adc310deb69d
137 rdf:rest Ndb2b99dd3a77411998f1f6f53da7596c
138 N5f62a52bf69e45c4bf5095d705d59d05 rdf:first N1690c73fb0a647cdac699c29c1ecd800
139 rdf:rest Nd7ee14303c404830a255bfca3cfde8f0
140 N61d5d814db8b4b9e8364708b17d16db0 schema:affiliation https://www.grid.ac/institutes/grid.30055.33
141 schema:familyName Ma
142 schema:givenName Zhijie
143 rdf:type schema:Person
144 N696efa2adf7f470fa6fb5739603e30ba schema:name nlm_unique_id
145 schema:value 101527581
146 rdf:type schema:PropertyValue
147 N6de39a1a6a3c4637b24c63c742367dd5 schema:issueNumber 1
148 rdf:type schema:PublicationIssue
149 N7227172c50ed42768e3e989bd487c21c schema:affiliation https://www.grid.ac/institutes/grid.459353.d
150 schema:familyName Wang
151 schema:givenName Zihua
152 rdf:type schema:Person
153 N794e9b4f38a744c2a341c8e11cf403d8 schema:name dimensions_id
154 schema:value pub.1112548075
155 rdf:type schema:PropertyValue
156 N7eeed5b5e16e416a8893549e831c4be2 schema:name pubmed_id
157 schema:value 30837004
158 rdf:type schema:PropertyValue
159 N81299a5cf19c4fe09538f262d74d7127 rdf:first Nbb9fc88bf10d45f8a934f2011bdfe7b1
160 rdf:rest Nae8315baef664e3bac2edc4c2a481377
161 N86a1e95e620547ab896327aefe959d1d schema:name JMS Burn and Reconstructive Center, Jackson, MS, USA
162 rdf:type schema:Organization
163 N8cff74685de746ff8c9b53d76f121e8d schema:affiliation https://www.grid.ac/institutes/grid.459353.d
164 schema:familyName Zhao
165 schema:givenName Dewei
166 rdf:type schema:Person
167 N91532d2e79b44f62a04bd2cc50264751 schema:name doi
168 schema:value 10.1186/s13287-019-1176-2
169 rdf:type schema:PropertyValue
170 Na77b5426701e4f12a734cfbebcf62bec schema:affiliation https://www.grid.ac/institutes/grid.459353.d
171 schema:familyName Liu
172 schema:givenName Baoyi
173 rdf:type schema:Person
174 Nae8315baef664e3bac2edc4c2a481377 rdf:first Nc4aebe2f24e347509dd451e49ec200f2
175 rdf:rest Nd23a1af947024cbba67181402a8709c7
176 Nb13dc773983e4621b0e88d9ca7c42d4b rdf:first Nee20b6ee5d6f4884b1274be9a26b6988
177 rdf:rest N5f62a52bf69e45c4bf5095d705d59d05
178 Nb40f38cb988c42c5939e793ecadf6cf7 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
179 schema:familyName Yu
180 schema:givenName Weiting
181 rdf:type schema:Person
182 Nb6cb3139e7244f589416045cc11b3d06 rdf:first N8cff74685de746ff8c9b53d76f121e8d
183 rdf:rest rdf:nil
184 Nb7103deab9a54347812a792e032a0074 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
185 schema:familyName Xie
186 schema:givenName Hui
187 rdf:type schema:Person
188 Nb91ab250df854159b5d0d47792e6aafe schema:affiliation https://www.grid.ac/institutes/grid.459353.d
189 schema:familyName Yang
190 schema:givenName Jiahui
191 rdf:type schema:Person
192 Nb93c75a504de4941a0260f74ea87a1a0 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
193 schema:familyName Li
194 schema:givenName Lu
195 rdf:type schema:Person
196 Nbb9fc88bf10d45f8a934f2011bdfe7b1 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
197 schema:familyName Liu
198 schema:givenName Ge
199 rdf:type schema:Person
200 Nc3ada5a155854bfeb32d92fb5b46b901 rdf:first N18be3f495363418d966f4072a16cc232
201 rdf:rest Ndcc56479ed2a42b5a448708a61708cd5
202 Nc4aebe2f24e347509dd451e49ec200f2 schema:affiliation https://www.grid.ac/institutes/grid.30055.33
203 schema:familyName Yang
204 schema:givenName Fan
205 rdf:type schema:Person
206 Nca0cabcba2134b67abb4f288e1409f79 rdf:first N3770a0544dae4d86bff0a48b54458db2
207 rdf:rest N3717107431154c0b9f28d9df8081438f
208 Nd23a1af947024cbba67181402a8709c7 rdf:first Nf4afbf50af2642a19ecf45b0c7260c4d
209 rdf:rest Nca0cabcba2134b67abb4f288e1409f79
210 Nd69c0b698e154c6db0bfe778bb60e88e rdf:first Ne1fb6056db6c493fb9aad94103709d12
211 rdf:rest Nb13dc773983e4621b0e88d9ca7c42d4b
212 Nd7ee14303c404830a255bfca3cfde8f0 rdf:first N61d5d814db8b4b9e8364708b17d16db0
213 rdf:rest N5dc5d3ee5a2c4c1b9d0ee50f6cd000c0
214 Ndb2b99dd3a77411998f1f6f53da7596c rdf:first N06364ab52c8448648fb1449838811b7b
215 rdf:rest Nb6cb3139e7244f589416045cc11b3d06
216 Ndcc56479ed2a42b5a448708a61708cd5 rdf:first N3a3e4349201a4602b864b6671cf05b99
217 rdf:rest Neb97725670e5491b9914fbabdf4d5675
218 Ne1fb6056db6c493fb9aad94103709d12 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
219 schema:familyName Wang
220 schema:givenName Benjie
221 rdf:type schema:Person
222 Ne8a8d4b7b4ea45a5adbd1aabe196c712 rdf:first N7227172c50ed42768e3e989bd487c21c
223 rdf:rest N58655f81d14c4981b340f056eb36d332
224 Neb97725670e5491b9914fbabdf4d5675 rdf:first Nb7103deab9a54347812a792e032a0074
225 rdf:rest N30d45b6bcc804abc85201a51cca86eed
226 Nee20b6ee5d6f4884b1274be9a26b6988 schema:affiliation https://www.grid.ac/institutes/grid.459353.d
227 schema:familyName Zheng
228 schema:givenName Guoshuang
229 rdf:type schema:Person
230 Nf4afbf50af2642a19ecf45b0c7260c4d schema:affiliation https://www.grid.ac/institutes/grid.30055.33
231 schema:familyName Cao
232 schema:givenName Fang
233 rdf:type schema:Person
234 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
235 schema:name Medical and Health Sciences
236 rdf:type schema:DefinedTerm
237 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
238 schema:name Clinical Sciences
239 rdf:type schema:DefinedTerm
240 sg:journal.1043222 schema:issn 1757-6512
241 schema:name Stem Cell Research & Therapy
242 rdf:type schema:Periodical
243 sg:pub.10.1007/7651_2018_197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110225091
244 https://doi.org/10.1007/7651_2018_197
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/79449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007162451
247 https://doi.org/10.1038/79449
248 rdf:type schema:CreativeWork
249 sg:pub.10.1186/ar3142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053049416
250 https://doi.org/10.1186/ar3142
251 rdf:type schema:CreativeWork
252 sg:pub.10.1186/s13287-018-0916-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1105153734
253 https://doi.org/10.1186/s13287-018-0916-z
254 rdf:type schema:CreativeWork
255 sg:pub.10.1290/1071-2690(2002)038<0457:cdohms>2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050639850
256 https://doi.org/10.1290/1071-2690(2002)038<0457:cdohms>2.0.co;2
257 rdf:type schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1077428582 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1079251827 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1083254379 schema:CreativeWork
261 https://doi.org/10.1002/art.10493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013706792
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/jbm.1069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026422301
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/jbm.a.31602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033396783
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/jcp.1041430304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020047111
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/jor.20983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032561419
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.actbio.2013.12.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035416738
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.actbio.2015.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013371615
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.biomaterials.2003.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009583039
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.biomaterials.2006.04.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024726556
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.biomaterials.2006.05.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041170454
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.biomaterials.2010.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006434738
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.biomaterials.2013.05.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037847672
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.biotechadv.2012.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015536301
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.csm.2017.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101368873
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.knee.2011.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044525111
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.matlet.2016.05.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019795107
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.tibtech.2012.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044429006
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0142-9612(99)00061-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046869701
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1055/s-0042-118458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057382893
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1088/1748-605x/aac91f schema:sameAs https://app.dimensions.ai/details/publication/pub.1104305771
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1089/10763270260424187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059206046
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1089/107632704322791871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059206368
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1089/ten.tea.2010.0691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315800
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1089/ten.tea.2011.0544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027787677
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1089/ten.teb.2008.0388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059316920
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1089/ten.teb.2011.0141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059317010
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/rb/rbv015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009216546
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/00001665-199807000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046613221
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1111/ahe.12018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005862740
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1111/j.1365-2184.1987.tb01309.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043555012
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/j.1600-0757.1999.tb00148.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027009497
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1159/000080341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012378650
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1166/jnn.2013.6733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014276545
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1177/1535370216629578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000684168
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1177/1947603512444597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042280972
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1371/journal.pone.0066263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034175320
332 rdf:type schema:CreativeWork
333 https://doi.org/10.2106/00004623-197860020-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068886754
334 rdf:type schema:CreativeWork
335 https://doi.org/10.2106/jbjs.d.02104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068899367
336 rdf:type schema:CreativeWork
337 https://doi.org/10.2106/jbjs.j.02010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068902419
338 rdf:type schema:CreativeWork
339 https://doi.org/10.22203/ecm.v020a23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069338894
340 rdf:type schema:CreativeWork
341 https://www.grid.ac/institutes/grid.30055.33 schema:alternateName Dalian University of Technology
342 schema:name Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China
343 rdf:type schema:Organization
344 https://www.grid.ac/institutes/grid.459353.d schema:alternateName Affiliated Zhongshan Hospital of Dalian University
345 schema:name Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, NO. 6 Jiefang Street, Zhongshan District, 116001, Dalian, Liaoning, China
346 Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China
347 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...