In vitro MSC function is related to clinical reaction in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Aileen L. Rowland, Jiajie Jessica Xu, Amanda Jo Joswig, Carl A. Gregory, Douglas F. Antczak, Kevin J. Cummings, Ashlee E. Watts

ABSTRACT

BACKGROUND: We recently demonstrated that intracellular xenogen-contaminated autologous MSCs (FBS) and non-xenogen-contaminated allogeneic (ALLO) MSCs caused an adverse clinical response after repeated intra-articular injection in horses, whereas autologous (AUTO) MSCs did not. Our current objective was to use clinical data from the previous study to compare MSC stemness against adverse response indicated by synovial total nucleated cell count (TNCC) following intra-articular MSC injection. METHODS: Stemness, quantified by a trilineage differentiation (TLD) score; immunomodulation, quantified by mixed lymphocyte reactions (MLRs); and degree of MHCI expression, quantified by mean fluorescent intensity (MFI); were correlated to the synovial TNCC 24 h after naïve and primed injection. RESULTS: There was a trend of a negative correlation (p = 0.21, r = - 0.44) between TLD score and TNCC after primed injection in the ALLO group. Within the ALLO group only, there was a significant positive correlation (p = 0.05, r = 0.77) between MHCI MFI and TNCC after naïve injection and a trend (p = 0.16, r = 0.49) of a positive association of MHCI MFI to TNCC after primed injection. Within the FBS group only, there was a positive correlation (p = 0.04, r = 1) between TNCC and lymphocyte proliferation after both injections. CONCLUSIONS: The trend of a negative correlation of TLD score and TNCC in the ALLO, but not the FBS group, together with the association of MHCI expression and TNCC in the ALLO group, indicates that improved stemness is associated with reduced MSC immunogenicity. When inflammation was incited by xenogen, there was a strong correlation of lymphocyte activation in vitro to adverse response in vivo, confirming that MLRs in vitro reflect MSC immunomodulatory activity in vivo. The relationship of stemness in vitro, suppression of lymphocyte activation in vitro, MHCI expression in vitro, and clinical response in vivo should be further investigated. More... »

PAGES

295

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13287-018-1037-4

DOI

http://dx.doi.org/10.1186/s13287-018-1037-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109780344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30409211


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Texas A&M University", 
          "id": "https://www.grid.ac/institutes/grid.264756.4", 
          "name": [
            "Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rowland", 
        "givenName": "Aileen L.", 
        "id": "sg:person.015415310266.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015415310266.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas A&M University", 
          "id": "https://www.grid.ac/institutes/grid.264756.4", 
          "name": [
            "Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Jiajie Jessica", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas A&M University", 
          "id": "https://www.grid.ac/institutes/grid.264756.4", 
          "name": [
            "Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joswig", 
        "givenName": "Amanda Jo", 
        "id": "sg:person.01311034776.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311034776.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas A&M Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.412408.b", 
          "name": [
            "Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center, College Station, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gregory", 
        "givenName": "Carl A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antczak", 
        "givenName": "Douglas F.", 
        "id": "sg:person.01341537770.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341537770.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cummings", 
        "givenName": "Kevin J.", 
        "id": "sg:person.01354374617.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354374617.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas A&M University", 
          "id": "https://www.grid.ac/institutes/grid.264756.4", 
          "name": [
            "Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watts", 
        "givenName": "Ashlee E.", 
        "id": "sg:person.01034271324.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034271324.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s13287-015-0146-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000058001", 
          "https://doi.org/10.1186/s13287-015-0146-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/scrt479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001975433", 
          "https://doi.org/10.1186/scrt479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/evj.12647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013046917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2052.2010.02125.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015711334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2052.2010.02125.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015711334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015828112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015828112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-11-011650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018597944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-950x.2006.00197.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021945052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/scrt402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024431950", 
          "https://doi.org/10.1186/scrt402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2006.12.447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024935823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14653240600855905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025538709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2014.01.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030558798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-9255-2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039719946", 
          "https://doi.org/10.1186/1476-9255-2-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/sccaa.s3824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041804406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2015.00400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043167101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2011.01509.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044055288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13287-015-0053-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049131624", 
          "https://doi.org/10.1186/s13287-015-0053-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13287-015-0053-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049131624", 
          "https://doi.org/10.1186/s13287-015-0053-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-2427(00)00149-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051408696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.2006.12.2141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059313797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2012-0099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073577348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2014-0156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073577525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079314126", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13287-017-0503-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084252423", 
          "https://doi.org/10.1186/s13287-017-0503-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13287-017-0503-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084252423", 
          "https://doi.org/10.1186/s13287-017-0503-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2017/9824698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085134069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/acel.12567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085153522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fvets.2017.00084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085985692"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: We recently demonstrated that intracellular\u00a0xenogen-contaminated autologous MSCs (FBS) and non-xenogen-contaminated allogeneic (ALLO) MSCs caused an adverse clinical response after repeated intra-articular injection in horses, whereas autologous (AUTO) MSCs did not. Our current objective was to use clinical data from the previous study to compare MSC stemness against adverse response indicated by synovial total nucleated cell count (TNCC) following intra-articular MSC injection.\nMETHODS: Stemness, quantified by a trilineage differentiation (TLD) score; immunomodulation, quantified by mixed lymphocyte reactions (MLRs); and degree of MHCI expression, quantified by mean fluorescent intensity (MFI); were correlated to the synovial TNCC 24\u00a0h after na\u00efve and primed injection.\nRESULTS: There was a trend of a negative correlation (p = 0.21,\u00a0r\u2009=\u2009-\u20090.44) between TLD score and TNCC after primed injection in the ALLO group. Within the ALLO group only, there was a significant positive correlation (p\u2009=\u20090.05, r\u2009=\u20090.77) between MHCI MFI and TNCC after na\u00efve injection and a trend (p\u2009=\u20090.16, r\u2009=\u20090.49) of a positive association of MHCI MFI to TNCC after primed injection. Within the FBS group only, there was a positive correlation\u00a0(p = 0.04, r = 1) between TNCC and lymphocyte proliferation after both injections.\nCONCLUSIONS: The trend of a negative correlation of TLD score and TNCC in the ALLO, but not the FBS group, together with the association of MHCI expression and TNCC in the ALLO group, indicates that improved stemness is associated with reduced MSC immunogenicity. When inflammation was incited by xenogen, there was a strong correlation of lymphocyte activation in vitro to adverse response in vivo, confirming that MLRs in vitro reflect MSC immunomodulatory activity in vivo. The relationship of stemness in vitro, suppression of lymphocyte activation in vitro, MHCI expression in vitro, and clinical response in vivo should be further investigated.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13287-018-1037-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043222", 
        "issn": [
          "1757-6512"
        ], 
        "name": "Stem Cell Research & Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "In vitro MSC function is related to clinical reaction in vivo", 
    "pagination": "295", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "38385bc92c580a2061f2f47468c3743bc90e7bdc85cfdd22ddfbecf3d0c348ba"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30409211"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101527581"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13287-018-1037-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1109780344"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13287-018-1037-4", 
      "https://app.dimensions.ai/details/publication/pub.1109780344"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87104_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13287-018-1037-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13287-018-1037-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13287-018-1037-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13287-018-1037-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13287-018-1037-4'


 

This table displays all metadata directly associated to this object as RDF triples.

195 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13287-018-1037-4 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nfc119654b4b644fb847eda0f3756ee37
4 schema:citation sg:pub.10.1186/1476-9255-2-8
5 sg:pub.10.1186/s13287-015-0053-x
6 sg:pub.10.1186/s13287-015-0146-6
7 sg:pub.10.1186/s13287-017-0503-8
8 sg:pub.10.1186/scrt402
9 sg:pub.10.1186/scrt479
10 https://app.dimensions.ai/details/publication/pub.1079314126
11 https://doi.org/10.1002/stem.312
12 https://doi.org/10.1016/j.bbmt.2006.12.447
13 https://doi.org/10.1016/j.ydbio.2014.01.024
14 https://doi.org/10.1016/s0165-2427(00)00149-5
15 https://doi.org/10.1080/14653240600855905
16 https://doi.org/10.1089/ten.2006.12.2141
17 https://doi.org/10.1111/acel.12567
18 https://doi.org/10.1111/evj.12647
19 https://doi.org/10.1111/j.1365-2052.2010.02125.x
20 https://doi.org/10.1111/j.1532-950x.2006.00197.x
21 https://doi.org/10.1111/j.1582-4934.2011.01509.x
22 https://doi.org/10.1155/2017/9824698
23 https://doi.org/10.1182/blood-2005-11-011650
24 https://doi.org/10.2147/sccaa.s3824
25 https://doi.org/10.3389/fimmu.2015.00400
26 https://doi.org/10.3389/fvets.2017.00084
27 https://doi.org/10.5966/sctm.2012-0099
28 https://doi.org/10.5966/sctm.2014-0156
29 schema:datePublished 2018-12
30 schema:datePublishedReg 2018-12-01
31 schema:description BACKGROUND: We recently demonstrated that intracellular xenogen-contaminated autologous MSCs (FBS) and non-xenogen-contaminated allogeneic (ALLO) MSCs caused an adverse clinical response after repeated intra-articular injection in horses, whereas autologous (AUTO) MSCs did not. Our current objective was to use clinical data from the previous study to compare MSC stemness against adverse response indicated by synovial total nucleated cell count (TNCC) following intra-articular MSC injection. METHODS: Stemness, quantified by a trilineage differentiation (TLD) score; immunomodulation, quantified by mixed lymphocyte reactions (MLRs); and degree of MHCI expression, quantified by mean fluorescent intensity (MFI); were correlated to the synovial TNCC 24 h after naïve and primed injection. RESULTS: There was a trend of a negative correlation (p = 0.21, r = - 0.44) between TLD score and TNCC after primed injection in the ALLO group. Within the ALLO group only, there was a significant positive correlation (p = 0.05, r = 0.77) between MHCI MFI and TNCC after naïve injection and a trend (p = 0.16, r = 0.49) of a positive association of MHCI MFI to TNCC after primed injection. Within the FBS group only, there was a positive correlation (p = 0.04, r = 1) between TNCC and lymphocyte proliferation after both injections. CONCLUSIONS: The trend of a negative correlation of TLD score and TNCC in the ALLO, but not the FBS group, together with the association of MHCI expression and TNCC in the ALLO group, indicates that improved stemness is associated with reduced MSC immunogenicity. When inflammation was incited by xenogen, there was a strong correlation of lymphocyte activation in vitro to adverse response in vivo, confirming that MLRs in vitro reflect MSC immunomodulatory activity in vivo. The relationship of stemness in vitro, suppression of lymphocyte activation in vitro, MHCI expression in vitro, and clinical response in vivo should be further investigated.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N13756d11f4684e2bb96048a39887ba6a
36 N5e588504cf43455db89de1eae0832e98
37 sg:journal.1043222
38 schema:name In vitro MSC function is related to clinical reaction in vivo
39 schema:pagination 295
40 schema:productId N0afae13df9bd4018b9245bc99e51f5e3
41 N4897b1ef15694d1faeb110df2c650920
42 N972307f017ba49398ba3dcbf8bad0f59
43 Nb332b3cdf2fa4866b9397ae966ab7119
44 Nd2cc591078294266bb7614449f40a590
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109780344
46 https://doi.org/10.1186/s13287-018-1037-4
47 schema:sdDatePublished 2019-04-11T12:25
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N9eb6521598c341cdae6ebca2551b1908
50 schema:url https://link.springer.com/10.1186%2Fs13287-018-1037-4
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N0afae13df9bd4018b9245bc99e51f5e3 schema:name readcube_id
55 schema:value 38385bc92c580a2061f2f47468c3743bc90e7bdc85cfdd22ddfbecf3d0c348ba
56 rdf:type schema:PropertyValue
57 N13756d11f4684e2bb96048a39887ba6a schema:volumeNumber 9
58 rdf:type schema:PublicationVolume
59 N1c8e7adccc05454f8df9cde5c1e6c893 rdf:first sg:person.01311034776.88
60 rdf:rest Nd29ae3058ac045d2922201a8684cfb24
61 N2b61aad70be24593b8aac0c4d4690bfd rdf:first sg:person.01341537770.97
62 rdf:rest N76f6f19848754da3962699dd14ae69ec
63 N4897b1ef15694d1faeb110df2c650920 schema:name doi
64 schema:value 10.1186/s13287-018-1037-4
65 rdf:type schema:PropertyValue
66 N514467ef637047d5a0cebe2fbdf28e3a schema:affiliation https://www.grid.ac/institutes/grid.412408.b
67 schema:familyName Gregory
68 schema:givenName Carl A.
69 rdf:type schema:Person
70 N5e588504cf43455db89de1eae0832e98 schema:issueNumber 1
71 rdf:type schema:PublicationIssue
72 N76f6f19848754da3962699dd14ae69ec rdf:first sg:person.01354374617.90
73 rdf:rest Ne7208aaea0214c9eba06c94bd544728f
74 N84e28090a38a403588e2f2e423238c07 rdf:first Na69c230a95d844bea0a1ffed3a6f9bbf
75 rdf:rest N1c8e7adccc05454f8df9cde5c1e6c893
76 N972307f017ba49398ba3dcbf8bad0f59 schema:name dimensions_id
77 schema:value pub.1109780344
78 rdf:type schema:PropertyValue
79 N9eb6521598c341cdae6ebca2551b1908 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 Na69c230a95d844bea0a1ffed3a6f9bbf schema:affiliation https://www.grid.ac/institutes/grid.264756.4
82 schema:familyName Xu
83 schema:givenName Jiajie Jessica
84 rdf:type schema:Person
85 Nb332b3cdf2fa4866b9397ae966ab7119 schema:name pubmed_id
86 schema:value 30409211
87 rdf:type schema:PropertyValue
88 Nd29ae3058ac045d2922201a8684cfb24 rdf:first N514467ef637047d5a0cebe2fbdf28e3a
89 rdf:rest N2b61aad70be24593b8aac0c4d4690bfd
90 Nd2cc591078294266bb7614449f40a590 schema:name nlm_unique_id
91 schema:value 101527581
92 rdf:type schema:PropertyValue
93 Ne7208aaea0214c9eba06c94bd544728f rdf:first sg:person.01034271324.46
94 rdf:rest rdf:nil
95 Nfc119654b4b644fb847eda0f3756ee37 rdf:first sg:person.015415310266.20
96 rdf:rest N84e28090a38a403588e2f2e423238c07
97 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
98 schema:name Medical and Health Sciences
99 rdf:type schema:DefinedTerm
100 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
101 schema:name Immunology
102 rdf:type schema:DefinedTerm
103 sg:journal.1043222 schema:issn 1757-6512
104 schema:name Stem Cell Research & Therapy
105 rdf:type schema:Periodical
106 sg:person.01034271324.46 schema:affiliation https://www.grid.ac/institutes/grid.264756.4
107 schema:familyName Watts
108 schema:givenName Ashlee E.
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034271324.46
110 rdf:type schema:Person
111 sg:person.01311034776.88 schema:affiliation https://www.grid.ac/institutes/grid.264756.4
112 schema:familyName Joswig
113 schema:givenName Amanda Jo
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311034776.88
115 rdf:type schema:Person
116 sg:person.01341537770.97 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
117 schema:familyName Antczak
118 schema:givenName Douglas F.
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341537770.97
120 rdf:type schema:Person
121 sg:person.01354374617.90 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
122 schema:familyName Cummings
123 schema:givenName Kevin J.
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354374617.90
125 rdf:type schema:Person
126 sg:person.015415310266.20 schema:affiliation https://www.grid.ac/institutes/grid.264756.4
127 schema:familyName Rowland
128 schema:givenName Aileen L.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015415310266.20
130 rdf:type schema:Person
131 sg:pub.10.1186/1476-9255-2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039719946
132 https://doi.org/10.1186/1476-9255-2-8
133 rdf:type schema:CreativeWork
134 sg:pub.10.1186/s13287-015-0053-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049131624
135 https://doi.org/10.1186/s13287-015-0053-x
136 rdf:type schema:CreativeWork
137 sg:pub.10.1186/s13287-015-0146-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000058001
138 https://doi.org/10.1186/s13287-015-0146-6
139 rdf:type schema:CreativeWork
140 sg:pub.10.1186/s13287-017-0503-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252423
141 https://doi.org/10.1186/s13287-017-0503-8
142 rdf:type schema:CreativeWork
143 sg:pub.10.1186/scrt402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024431950
144 https://doi.org/10.1186/scrt402
145 rdf:type schema:CreativeWork
146 sg:pub.10.1186/scrt479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001975433
147 https://doi.org/10.1186/scrt479
148 rdf:type schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1079314126 schema:CreativeWork
150 https://doi.org/10.1002/stem.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015828112
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/j.bbmt.2006.12.447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024935823
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/j.ydbio.2014.01.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030558798
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/s0165-2427(00)00149-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051408696
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1080/14653240600855905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025538709
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1089/ten.2006.12.2141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059313797
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1111/acel.12567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085153522
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1111/evj.12647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013046917
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1111/j.1365-2052.2010.02125.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015711334
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1111/j.1532-950x.2006.00197.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021945052
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1111/j.1582-4934.2011.01509.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044055288
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1155/2017/9824698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085134069
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1182/blood-2005-11-011650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018597944
175 rdf:type schema:CreativeWork
176 https://doi.org/10.2147/sccaa.s3824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041804406
177 rdf:type schema:CreativeWork
178 https://doi.org/10.3389/fimmu.2015.00400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043167101
179 rdf:type schema:CreativeWork
180 https://doi.org/10.3389/fvets.2017.00084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085985692
181 rdf:type schema:CreativeWork
182 https://doi.org/10.5966/sctm.2012-0099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073577348
183 rdf:type schema:CreativeWork
184 https://doi.org/10.5966/sctm.2014-0156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073577525
185 rdf:type schema:CreativeWork
186 https://www.grid.ac/institutes/grid.264756.4 schema:alternateName Texas A&M University
187 schema:name Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA
188 rdf:type schema:Organization
189 https://www.grid.ac/institutes/grid.412408.b schema:alternateName Texas A&M Health Science Center
190 schema:name Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center, College Station, TX, USA
191 rdf:type schema:Organization
192 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
193 schema:name Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA
194 Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, USA
195 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...