Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Johannes Leibacher, Reinhard Henschler

ABSTRACT

Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. They were found to be potent in situations such as tissue repair or severe inflammation. Still, data are lacking with regard to the biodistribution of MSCs, their cellular or molecular target structures, and the mechanisms by which MSCs reach these targets. This review discusses current hypotheses for how MSCs can reach tissue sites. Both preclinical and clinical studies using MSCs applied intravenously or intra-arterially are discussed in the context of our current understanding of how MSCs might work in physiological and pathological situations. More... »

PAGES

7

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13287-015-0271-2

    DOI

    http://dx.doi.org/10.1186/s13287-015-0271-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040091557

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26753925


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