The diagnostic quandary of magnetic resonance imaging-negative Hirayama disease: a case report View Full Text


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Article Info

DATE

2020-08-21

AUTHORS

Rajeev Ojha, Sumit Shahi, Gaurav Nepal, Arjana Shakya, Bikram Prasad Gajurel, Ragesh Karn, Reema Rajbhandari, Niraj Gautam

ABSTRACT

BackgroundMagnetic resonance imaging (MRI) features are typical findings in Hirayama disease (HD) and are useful diagnostic entities but may not be present in all patients.Case presentationWe present the case of a 22-year-old Nepalese man who presented with insidious onset of weakness of his right upper limb of more than 5 years duration. His weakness was progressive for the first 3 years, and then remained static. On examination, weakness of the interossei, thenar, hypothenar, flexor, and extensor muscles were present in his right upper limb, power was normal in his left upper and bilateral lower limbs. Minipolymyoclonus was present in both upper limbs, less prominent on the left side. Electrophysiological findings showed motor axonal neuropathy in his right upper limb, neurogenic discharges and fibrillations, and fasciculations in both upper limbs. Contrast magnetic resonance imaging (MRI) of his cervical spine in flexion was normal. Our patient was diagnosed with HD based on clinical and electrophysiological findings. Our patient was advised to use a cervical collar and regular physiotherapy and was found to have subjective benefit.ConclusionA normal cervical MRI does not rule out HD and the diagnosis can also be made based on clinical and electrophysiological studies. Progressive distal upper limb weakness or tremor in young patients should be evaluated for HD, because early diagnosis and intervention might halt the progression. More... »

PAGES

133

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URI

http://scigraph.springernature.com/pub.10.1186/s13256-020-02453-2

DOI

http://dx.doi.org/10.1186/s13256-020-02453-2

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https://app.dimensions.ai/details/publication/pub.1130230724

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32819426


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