Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Hiroyuki Yamamoto, Toru Hashimoto, Shunji Kawamura, Michiaki Hiroe, Taro Yamashita, Yukio Ando, Tomoki Yokochi

ABSTRACT

BACKGROUND: Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic heterogeneity and geographic diversity. Among them, a sporadic case of hereditary transthyretin amyloidosis with cardiac-predominant phenotype is very rare, progressive, and potentially fatal if left undiagnosed. However, a clinical diagnosis of cardiac amyloidosis still remains challenging due to non-specific symptoms, and less sensitivity and specificity of medical examinations. CASE PRESENTATION: A 60-year-old Japanese man with a history of embolic stroke and hypertrophic cardiomyopathy visited our department for heart failure. The present case exhibited only cardiomyopathy without any clinical signs of systemic amyloidosis manifested as carpal tunnel syndrome, polyneuropathy, or autonomic dysfunction. An echocardiogram revealed severe asymmetric left ventricular hypertrophy, biatrial dilatation, pericardial effusion, and preserved left ventricular ejection fraction of 50% with severe diastolic dysfunction. Technetium pyrophosphate scintigraphy indicated marked diffuse myocardial uptake of technetium pyrophosphate, strongly suggesting transthyretin cardiac amyloidosis, which was firmly confirmed by a left ventricular endomyocardial biopsy. Genetic analysis demonstrated a transthyretin C70T (Pro24Ser) heterozygous mutation. Tafamidis, a transthyretin stabilizer, was started. His cardiac symptoms remained unchanged for 12 months. CONCLUSIONS: Here we report the case of a patient with hereditary cardiac amyloidosis associated with a Pro24Ser mutation in transthyretin, which is the first case reported in Japan. Technetium pyrophosphate scintigraphy was extremely useful for definitive diagnosis. Thus, we propose that the nuclear imaging technique should be taken into account even for an exploratory diagnosis of transthyretin cardiac amyloidosis. More... »

PAGES

370

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13256-018-1931-5

DOI

http://dx.doi.org/10.1186/s13256-018-1931-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110565580

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30553273


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Showa General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415825.f", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, Showa General Hospital, 8-1-1 Hanakoganei, 187-8510, Kodaira City, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.01346031427.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346031427.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiovascular Medicine, Narita-Tomisato Tokushukai Hospital, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hashimoto", 
        "givenName": "Toru", 
        "id": "sg:person.014041300323.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014041300323.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Pathology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawamura", 
        "givenName": "Shunji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Global Health and Medicine", 
          "id": "https://www.grid.ac/institutes/grid.45203.30", 
          "name": [
            "Department of Cardiology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiroe", 
        "givenName": "Michiaki", 
        "id": "sg:person.0714645765.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714645765.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kumamoto University", 
          "id": "https://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamashita", 
        "givenName": "Taro", 
        "id": "sg:person.01207436552.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207436552.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kumamoto University", 
          "id": "https://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ando", 
        "givenName": "Yukio", 
        "id": "sg:person.015366431502.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015366431502.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Research, Chiba Tokushukai Hospital, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokochi", 
        "givenName": "Tomoki", 
        "id": "sg:person.010324131123.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010324131123.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1474-4422(11)70246-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007354889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13506129.2014.994597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009137089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1750-1172-8-31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012414979", 
          "https://doi.org/10.1186/1750-1172-8-31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehs123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016149847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.112.000132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022535230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.112.000132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022535230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.697763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022689142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13506129.2013.844689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023377105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.32.4.279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028271081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13506129.2012.673185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032632154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/hrt.74.5.541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041060387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.116.021612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063344418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.116.021612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063344418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehx047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083931584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13506129.2017.1322573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085346652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2017.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086111995", 
          "https://doi.org/10.1038/ejhg.2017.95"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic heterogeneity and geographic diversity. Among them, a sporadic case of hereditary transthyretin amyloidosis with cardiac-predominant phenotype is very rare, progressive, and potentially fatal if left undiagnosed. However, a clinical diagnosis of cardiac amyloidosis still remains challenging due to non-specific symptoms, and less sensitivity and specificity of medical examinations.\nCASE PRESENTATION: A 60-year-old Japanese man with a history of embolic stroke and hypertrophic cardiomyopathy visited our department for heart failure. The present case exhibited only cardiomyopathy without any clinical signs of systemic amyloidosis manifested as carpal tunnel syndrome, polyneuropathy, or autonomic dysfunction. An echocardiogram revealed severe asymmetric left ventricular hypertrophy, biatrial dilatation, pericardial effusion, and preserved left ventricular ejection fraction of 50% with severe diastolic dysfunction. Technetium pyrophosphate scintigraphy indicated marked diffuse myocardial uptake of technetium pyrophosphate, strongly suggesting transthyretin cardiac amyloidosis, which was firmly confirmed by a left ventricular endomyocardial biopsy. Genetic analysis demonstrated a transthyretin C70T (Pro24Ser) heterozygous mutation. Tafamidis, a transthyretin stabilizer, was started. His cardiac symptoms remained unchanged for 12\u2009months.\nCONCLUSIONS: Here we report the case of a patient with hereditary cardiac amyloidosis associated with a Pro24Ser mutation in transthyretin, which is the first case reported in Japan. Technetium pyrophosphate scintigraphy was extremely useful for definitive diagnosis. Thus, we propose that the nuclear imaging technique should be taken into account even for an exploratory diagnosis of transthyretin cardiac amyloidosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13256-018-1931-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1038062", 
        "issn": [
          "1752-1947"
        ], 
        "name": "Journal of Medical Case Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report", 
    "pagination": "370", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0179de8901843a9a8b2d24e5df37e5becd8e2baac2e304f6a58969f43b3b0d0b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30553273"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101293382"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13256-018-1931-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110565580"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13256-018-1931-5", 
      "https://app.dimensions.ai/details/publication/pub.1110565580"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000309_0000000309/records_106291_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13256-018-1931-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13256-018-1931-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13256-018-1931-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13256-018-1931-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13256-018-1931-5'


 

This table displays all metadata directly associated to this object as RDF triples.

166 TRIPLES      21 PREDICATES      43 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13256-018-1931-5 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Nc89fca317ec444338f812b3c8b5a6908
4 schema:citation sg:pub.10.1038/ejhg.2017.95
5 sg:pub.10.1186/1750-1172-8-31
6 https://doi.org/10.1016/s1474-4422(11)70246-0
7 https://doi.org/10.1080/13506129.2017.1322573
8 https://doi.org/10.1093/eurheartj/ehs123
9 https://doi.org/10.1093/eurheartj/ehx047
10 https://doi.org/10.1136/hrt.74.5.541
11 https://doi.org/10.1136/jmg.32.4.279
12 https://doi.org/10.1161/circimaging.112.000132
13 https://doi.org/10.1161/circulationaha.107.697763
14 https://doi.org/10.1161/circulationaha.116.021612
15 https://doi.org/10.3109/13506129.2012.673185
16 https://doi.org/10.3109/13506129.2013.844689
17 https://doi.org/10.3109/13506129.2014.994597
18 schema:datePublished 2018-12
19 schema:datePublishedReg 2018-12-01
20 schema:description BACKGROUND: Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic heterogeneity and geographic diversity. Among them, a sporadic case of hereditary transthyretin amyloidosis with cardiac-predominant phenotype is very rare, progressive, and potentially fatal if left undiagnosed. However, a clinical diagnosis of cardiac amyloidosis still remains challenging due to non-specific symptoms, and less sensitivity and specificity of medical examinations. CASE PRESENTATION: A 60-year-old Japanese man with a history of embolic stroke and hypertrophic cardiomyopathy visited our department for heart failure. The present case exhibited only cardiomyopathy without any clinical signs of systemic amyloidosis manifested as carpal tunnel syndrome, polyneuropathy, or autonomic dysfunction. An echocardiogram revealed severe asymmetric left ventricular hypertrophy, biatrial dilatation, pericardial effusion, and preserved left ventricular ejection fraction of 50% with severe diastolic dysfunction. Technetium pyrophosphate scintigraphy indicated marked diffuse myocardial uptake of technetium pyrophosphate, strongly suggesting transthyretin cardiac amyloidosis, which was firmly confirmed by a left ventricular endomyocardial biopsy. Genetic analysis demonstrated a transthyretin C70T (Pro24Ser) heterozygous mutation. Tafamidis, a transthyretin stabilizer, was started. His cardiac symptoms remained unchanged for 12 months. CONCLUSIONS: Here we report the case of a patient with hereditary cardiac amyloidosis associated with a Pro24Ser mutation in transthyretin, which is the first case reported in Japan. Technetium pyrophosphate scintigraphy was extremely useful for definitive diagnosis. Thus, we propose that the nuclear imaging technique should be taken into account even for an exploratory diagnosis of transthyretin cardiac amyloidosis.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N12c75e9ed110424db9a6167b63f8eab8
25 N4e25bad566994bcc8b4241aa0333e4ba
26 sg:journal.1038062
27 schema:name Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report
28 schema:pagination 370
29 schema:productId N0f0a09b79381483b88f825a0adc6f9ce
30 N117c3ea2d3fe44139ced77ce932aefc1
31 N1b7350191fb940149da80ce7bd41a430
32 N2fd1fa9df0724432bf25c9e956da6a21
33 N382b0a3b00b644a88aab9c60b45f1650
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110565580
35 https://doi.org/10.1186/s13256-018-1931-5
36 schema:sdDatePublished 2019-04-11T08:32
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher Nb23b04c143bd48fabee12acdb432a3d1
39 schema:url https://link.springer.com/10.1186%2Fs13256-018-1931-5
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N0f0a09b79381483b88f825a0adc6f9ce schema:name pubmed_id
44 schema:value 30553273
45 rdf:type schema:PropertyValue
46 N117c3ea2d3fe44139ced77ce932aefc1 schema:name nlm_unique_id
47 schema:value 101293382
48 rdf:type schema:PropertyValue
49 N12c75e9ed110424db9a6167b63f8eab8 schema:issueNumber 1
50 rdf:type schema:PublicationIssue
51 N1b7350191fb940149da80ce7bd41a430 schema:name doi
52 schema:value 10.1186/s13256-018-1931-5
53 rdf:type schema:PropertyValue
54 N2cec41da355a4ea9a3224c15fc239196 rdf:first sg:person.0714645765.11
55 rdf:rest N87bd0cde9b614573b40b7ffed47c8925
56 N2fd1fa9df0724432bf25c9e956da6a21 schema:name readcube_id
57 schema:value 0179de8901843a9a8b2d24e5df37e5becd8e2baac2e304f6a58969f43b3b0d0b
58 rdf:type schema:PropertyValue
59 N382b0a3b00b644a88aab9c60b45f1650 schema:name dimensions_id
60 schema:value pub.1110565580
61 rdf:type schema:PropertyValue
62 N3deb3494ebb04e1c9842b3f5b0285d1c rdf:first sg:person.010324131123.03
63 rdf:rest rdf:nil
64 N4e25bad566994bcc8b4241aa0333e4ba schema:volumeNumber 12
65 rdf:type schema:PublicationVolume
66 N584155c6e0a74acfa08273d1e2e240fe schema:name Department of Cardiovascular Medicine, Narita-Tomisato Tokushukai Hospital, Chiba, Japan
67 rdf:type schema:Organization
68 N5da3f6dba3554cea832ebd4a3a462f25 rdf:first sg:person.015366431502.53
69 rdf:rest N3deb3494ebb04e1c9842b3f5b0285d1c
70 N87bd0cde9b614573b40b7ffed47c8925 rdf:first sg:person.01207436552.60
71 rdf:rest N5da3f6dba3554cea832ebd4a3a462f25
72 N96e40e31b5bf4c13be23cd368a9795bf schema:affiliation https://www.grid.ac/institutes/grid.410818.4
73 schema:familyName Kawamura
74 schema:givenName Shunji
75 rdf:type schema:Person
76 Na2b744419c6640d4852bb16dce74213f rdf:first sg:person.014041300323.30
77 rdf:rest Neb2b811a90f8471d9c89655a5fb1a0f1
78 Nb23b04c143bd48fabee12acdb432a3d1 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 Nb9dbeb412171449b9c233fede8234fb7 schema:name Department of Clinical Research, Chiba Tokushukai Hospital, Chiba, Japan
81 rdf:type schema:Organization
82 Nc89fca317ec444338f812b3c8b5a6908 rdf:first sg:person.01346031427.47
83 rdf:rest Na2b744419c6640d4852bb16dce74213f
84 Neb2b811a90f8471d9c89655a5fb1a0f1 rdf:first N96e40e31b5bf4c13be23cd368a9795bf
85 rdf:rest N2cec41da355a4ea9a3224c15fc239196
86 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
87 schema:name Medical and Health Sciences
88 rdf:type schema:DefinedTerm
89 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
90 schema:name Cardiorespiratory Medicine and Haematology
91 rdf:type schema:DefinedTerm
92 sg:journal.1038062 schema:issn 1752-1947
93 schema:name Journal of Medical Case Reports
94 rdf:type schema:Periodical
95 sg:person.010324131123.03 schema:affiliation Nb9dbeb412171449b9c233fede8234fb7
96 schema:familyName Yokochi
97 schema:givenName Tomoki
98 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010324131123.03
99 rdf:type schema:Person
100 sg:person.01207436552.60 schema:affiliation https://www.grid.ac/institutes/grid.274841.c
101 schema:familyName Yamashita
102 schema:givenName Taro
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207436552.60
104 rdf:type schema:Person
105 sg:person.01346031427.47 schema:affiliation https://www.grid.ac/institutes/grid.415825.f
106 schema:familyName Yamamoto
107 schema:givenName Hiroyuki
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346031427.47
109 rdf:type schema:Person
110 sg:person.014041300323.30 schema:affiliation N584155c6e0a74acfa08273d1e2e240fe
111 schema:familyName Hashimoto
112 schema:givenName Toru
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014041300323.30
114 rdf:type schema:Person
115 sg:person.015366431502.53 schema:affiliation https://www.grid.ac/institutes/grid.274841.c
116 schema:familyName Ando
117 schema:givenName Yukio
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015366431502.53
119 rdf:type schema:Person
120 sg:person.0714645765.11 schema:affiliation https://www.grid.ac/institutes/grid.45203.30
121 schema:familyName Hiroe
122 schema:givenName Michiaki
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714645765.11
124 rdf:type schema:Person
125 sg:pub.10.1038/ejhg.2017.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086111995
126 https://doi.org/10.1038/ejhg.2017.95
127 rdf:type schema:CreativeWork
128 sg:pub.10.1186/1750-1172-8-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012414979
129 https://doi.org/10.1186/1750-1172-8-31
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1016/s1474-4422(11)70246-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007354889
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1080/13506129.2017.1322573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085346652
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1093/eurheartj/ehs123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016149847
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1093/eurheartj/ehx047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083931584
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1136/hrt.74.5.541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041060387
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1136/jmg.32.4.279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028271081
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1161/circimaging.112.000132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022535230
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1161/circulationaha.107.697763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022689142
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1161/circulationaha.116.021612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063344418
148 rdf:type schema:CreativeWork
149 https://doi.org/10.3109/13506129.2012.673185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032632154
150 rdf:type schema:CreativeWork
151 https://doi.org/10.3109/13506129.2013.844689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023377105
152 rdf:type schema:CreativeWork
153 https://doi.org/10.3109/13506129.2014.994597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009137089
154 rdf:type schema:CreativeWork
155 https://www.grid.ac/institutes/grid.274841.c schema:alternateName Kumamoto University
156 schema:name Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
157 rdf:type schema:Organization
158 https://www.grid.ac/institutes/grid.410818.4 schema:alternateName Tokyo Women's Medical University
159 schema:name Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan
160 rdf:type schema:Organization
161 https://www.grid.ac/institutes/grid.415825.f schema:alternateName Showa General Hospital
162 schema:name Department of Cardiology, Cardiovascular Center, Showa General Hospital, 8-1-1 Hanakoganei, 187-8510, Kodaira City, Tokyo, Japan
163 rdf:type schema:Organization
164 https://www.grid.ac/institutes/grid.45203.30 schema:alternateName National Center For Global Health and Medicine
165 schema:name Department of Cardiology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan
166 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...