Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody panitumumab: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Hitomi Kamo, Eiji Shinozaki, Takanobu Sugase, Nobuyuki Mizunuma, Shoji Taniguchi, Takashi Gotoh, Keisyo Chin, Tomoaki Tanaka, Kazumi Koga, Kensei Yamaguchi

ABSTRACT

BACKGROUND: Panitumumab is the first human combinatorial antibody for the treatment of metastatic colorectal carcinoma. Dermatologic toxicity of all grades occurs in more than 90% of patients. However, there are few reports of purpura induced by anti-epidermal growth factor receptor antibody. Renal failure is also uncommon as an adverse event of anti-epidermal growth factor receptor antibody. CASE PRESENTATION: A 67-year-old Japanese man with advanced colon cancer received monotherapy with panitumumab. General malaise, bilateral edema of his legs, and bilateral purpura of his forearms developed 2 days after the second cycle of panitumumab. A skin biopsy was performed to evaluate the purpuric lesions on his left leg and leukocytoclastic vasculitis was diagnosed. Blood tests showed grade III acute renal failure with a blood urea nitrogen level of 33.8 mg/dL and a creatinine level of 3.10 mg/dL. CONCLUSIONS: This is the first reported case of leukocytoclastic vasculitis followed by purpura and acute renal failure associated with panitumumab. More... »

PAGES

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13256-018-1877-7

DOI

http://dx.doi.org/10.1186/s13256-018-1877-7

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https://app.dimensions.ai/details/publication/pub.1111415859

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30646927


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