Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-14

AUTHORS

Toyonobu Tsuda, Hayato Tada, Yoshihiro Tanaka, Naoto Nishida, Taiji Yoshida, Takeshi Sawada, Kenji Sakata, Kenshi Hayashi, Masa-aki Kawashiri, Takeru Oyama, Motoko Sasaki, Nozomu Kurose, Masakazu Yamagishi

ABSTRACT

BackgroundAmiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury.Case presentationWe report the clinical and histological features of two contrasting Japanese patients with amiodarone-induced reversible and irreversible hepatotoxicity. One patient with amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, showed a reversible course of liver function and imaging after discontinuation of amiodarone.ConclusionsWe emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. More... »

PAGES

95

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13256-018-1629-8

DOI

http://dx.doi.org/10.1186/s13256-018-1629-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103251419

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29653592


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