Tumor lysis syndrome following trastuzumab and pertuzumab for metastatic breast cancer: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

C. Baudon, F. P. Duhoux, I. Sinapi, J. L. Canon

ABSTRACT

BACKGROUND: Tumor lysis syndrome is a rare and potentially fatal complication of oncologic treatments, especially in solid tumors. To the best of our knowledge, tumor lysis syndrome has never been reported after trastuzumab and pertuzumab combination therapy. Knowledge of risk factors and active prevention proceedings is of utmost importance to avoid fatal outcomes. CASE PRESENTATION: We present the case of a chemo-naive 58-year-old Belgian woman developing hypovolemic shock and multiple organ failure due to tumor lysis syndrome after a single dose of trastuzumab and pertuzumab in the context of the treatment of a metastatic breast cancer and resulting in fatal outcome despite optimal management. CONCLUSIONS: Considering that targeted cancer therapies become increasingly effective, oncologists should be extremely cautious when treating patients at high risk of tumor lysis syndrome, even if they are not treated with cytotoxic chemotherapy, and determine appropriate prophylaxis. More... »

PAGES

178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13256-016-0969-5

DOI

http://dx.doi.org/10.1186/s13256-016-0969-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053632202

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27312594


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