Ontology type: schema:ScholarlyArticle Open Access: True
2021-10-12
AUTHORSPierre Ellul, Michelle Rosenzwajg, Hugo Peyre, Gwladys Fourcade, Encarnita Mariotti-Ferrandiz, Vincent Trebossen, David Klatzmann, Richard Delorme
ABSTRACTBackgroundImmune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients with ASD. To better define lymphocytes abnormalities in ASD, we performed a meta-analysis of the lymphocyte profiles from subjects with ASD.MethodsWe used the PRISMA recommendations to query PubMed, Embase, PsychoINFO, BIOSIS, Science Direct, Cochrane CENTRAL, and Clinicaltrials.gov for terms related to clinical diagnosis of ASD and to lymphocytes’ populations. We selected studies exploring lymphocyte subpopulations in children with ASD. The search protocol has been registered in the international Prospective Register of Systematic Reviews (CRD42019121473).ResultsWe selected 13 studies gathering 388 ASD patients and 326 healthy controls. A significant decrease in the CD4+ lymphocyte was found in ASD patients compared to controls [− 1.51 (95% CI − 2.99; − 0.04) p = 0.04] (I2 = 96% [95% CI 94.6, 97.7], p < 0.01). No significant difference was found for the CD8+ T, B and natural killer lymphocytes. Considering the CD4+ subpopulation, there was a significant decrease in regulatory T lymphocytes (Tregs) in ASD patients (n = 114) compared to controls (n = 107) [− 3.09 (95% CI − 4.41; − 1.76) p = 0.0001]; (I2 = 90.9%, [95% CI 76.2, 96.5], p < 0.0001) associated with an increase oin the Th17 lymphocytes (ASD; n = 147 controls; n = 128) [2.23 (95% CI 0.79; 3.66) p = 0,002] (I2 = 95.1% [95% CI 90.4, 97.5], p < 0.0001).LimitationsSeveral factors inducing heterogeneity should be considered. First, differences in the staining method may be responsible for a part in the heterogeneity of results. Second, ASD population is also by itself heterogeneous, underlying the need of studying sub-groups that are more homogeneous.ConclusionOur meta-analysis indicates defects in CD4+ lymphocytes, specifically decrease oin Tregs and increase in Th17 in ASD patients and supports the development of targeted immunotherapies in the field of ASD. More... »
PAGES68
http://scigraph.springernature.com/pub.10.1186/s13229-021-00472-4
DOIhttp://dx.doi.org/10.1186/s13229-021-00472-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1141826104
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34641964
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Autism Spectrum Disorder",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "T-Lymphocytes, Regulatory",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"AP-HP (Assistance Publique-H\u00f4pitaux de Paris), Robert Debr\u00e9 Hospital, Child and Adolescent Psychiatry Department, Paris University, 48 Boulevard S\u00e9rurier, 75019, Paris, France",
"INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France"
],
"type": "Organization"
},
"familyName": "Ellul",
"givenName": "Pierre",
"id": "sg:person.016532146554.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016532146554.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Biotherapy (CIC-BTi), Paris, France",
"id": "http://www.grid.ac/institutes/grid.411439.a",
"name": [
"INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France",
"AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Biotherapy (CIC-BTi), Paris, France"
],
"type": "Organization"
},
"familyName": "Rosenzwajg",
"givenName": "Michelle",
"id": "sg:person.01320711167.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320711167.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Robert Debr\u00e9 Hospital, UMR 1141, NeuroDiderot Inserm \u2013 Paris University, Paris, France",
"id": "http://www.grid.ac/institutes/grid.413235.2",
"name": [
"AP-HP (Assistance Publique-H\u00f4pitaux de Paris), Robert Debr\u00e9 Hospital, Child and Adolescent Psychiatry Department, Paris University, 48 Boulevard S\u00e9rurier, 75019, Paris, France",
"Robert Debr\u00e9 Hospital, UMR 1141, NeuroDiderot Inserm \u2013 Paris University, Paris, France"
],
"type": "Organization"
},
"familyName": "Peyre",
"givenName": "Hugo",
"id": "sg:person.0640526764.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640526764.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France"
],
"type": "Organization"
},
"familyName": "Fourcade",
"givenName": "Gwladys",
"id": "sg:person.0611002511.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611002511.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France"
],
"type": "Organization"
},
"familyName": "Mariotti-Ferrandiz",
"givenName": "Encarnita",
"id": "sg:person.0624226677.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624226677.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "AP-HP (Assistance Publique-H\u00f4pitaux de Paris), Robert Debr\u00e9 Hospital, Child and Adolescent Psychiatry Department, Paris University, 48 Boulevard S\u00e9rurier, 75019, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"AP-HP (Assistance Publique-H\u00f4pitaux de Paris), Robert Debr\u00e9 Hospital, Child and Adolescent Psychiatry Department, Paris University, 48 Boulevard S\u00e9rurier, 75019, Paris, France"
],
"type": "Organization"
},
"familyName": "Trebossen",
"givenName": "Vincent",
"id": "sg:person.012065005133.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012065005133.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Biotherapy (CIC-BTi), Paris, France",
"id": "http://www.grid.ac/institutes/grid.411439.a",
"name": [
"INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Universit\u00e9, Paris, France",
"AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Biotherapy (CIC-BTi), Paris, France"
],
"type": "Organization"
},
"familyName": "Klatzmann",
"givenName": "David",
"id": "sg:person.0774460013.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774460013.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"AP-HP (Assistance Publique-H\u00f4pitaux de Paris), Robert Debr\u00e9 Hospital, Child and Adolescent Psychiatry Department, Paris University, 48 Boulevard S\u00e9rurier, 75019, Paris, France",
"Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France"
],
"type": "Organization"
},
"familyName": "Delorme",
"givenName": "Richard",
"id": "sg:person.0667140354.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667140354.02"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature10110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030400360",
"https://doi.org/10.1038/nature10110"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.3193",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050493821",
"https://doi.org/10.1038/nm.3193"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10803-019-04184-w",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1120481934",
"https://doi.org/10.1007/s10803-019-04184-w"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01531729",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051312814",
"https://doi.org/10.1007/bf01531729"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-019-38730-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1112396018",
"https://doi.org/10.1038/s41598-019-38730-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri.2016.125",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016145811",
"https://doi.org/10.1038/nri.2016.125"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.4528",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084129399",
"https://doi.org/10.1038/nn.4528"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02276236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046381402",
"https://doi.org/10.1007/bf02276236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.3656",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011609039",
"https://doi.org/10.1038/ni.3656"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn3978",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022644745",
"https://doi.org/10.1038/nrn3978"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.4276",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100454612",
"https://doi.org/10.1038/nn.4276"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-018-04392-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104192178",
"https://doi.org/10.1038/s41467-018-04392-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms6748",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036271603",
"https://doi.org/10.1038/ncomms6748"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-016-9977-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000726522",
"https://doi.org/10.1007/s12035-016-9977-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41586-019-1843-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1123476068",
"https://doi.org/10.1038/s41586-019-1843-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri.2017.75",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090928740",
"https://doi.org/10.1038/nri.2017.75"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrneurol.2016.81",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007914063",
"https://doi.org/10.1038/nrneurol.2016.81"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri.2015.18",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042142647",
"https://doi.org/10.1038/nri.2015.18"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41577-021-00508-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1135823274",
"https://doi.org/10.1038/s41577-021-00508-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/mp.2013.101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050894156",
"https://doi.org/10.1038/mp.2013.101"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41577-020-00487-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1134730815",
"https://doi.org/10.1038/s41577-020-00487-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri.2017.118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092439722",
"https://doi.org/10.1038/nri.2017.118"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41398-018-0335-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1111780031",
"https://doi.org/10.1038/s41398-018-0335-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-018-04908-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104915612",
"https://doi.org/10.1038/s41467-018-04908-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-017-0822-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100232436",
"https://doi.org/10.1007/s12035-017-0822-x"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-10-12",
"datePublishedReg": "2021-10-12",
"description": "BackgroundImmune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients with ASD. To better define lymphocytes abnormalities in ASD, we performed a meta-analysis of the lymphocyte profiles from subjects with ASD.MethodsWe used the PRISMA recommendations to query PubMed, Embase, PsychoINFO, BIOSIS, Science Direct, Cochrane CENTRAL, and Clinicaltrials.gov for terms related to clinical diagnosis of ASD and to lymphocytes\u2019 populations. We selected studies exploring lymphocyte subpopulations in children with ASD. The search protocol has been registered in the international Prospective Register of Systematic Reviews (CRD42019121473).ResultsWe selected 13 studies gathering 388 ASD patients and 326 healthy controls. A significant decrease in the CD4+\u2009lymphocyte was found in ASD patients compared to controls [\u2212\u20091.51 (95% CI\u2009\u2212\u20092.99;\u2009\u2212\u20090.04) p\u2009=\u20090.04] (I2\u2009=\u200996% [95% CI 94.6, 97.7], p\u2009<\u20090.01). No significant difference was found for the CD8+\u2009T, B and natural killer lymphocytes. Considering the CD4+\u2009subpopulation, there was a significant decrease in regulatory T lymphocytes (Tregs) in ASD patients (n\u2009=\u2009114) compared to controls (n\u2009=\u2009107) [\u2212\u20093.09 (95% CI\u2009\u2212\u20094.41;\u2009\u2212\u20091.76) p\u2009=\u20090.0001]; (I2\u2009=\u200990.9%, [95% CI 76.2, 96.5], p\u2009<\u20090.0001) associated with an increase oin the Th17 lymphocytes (ASD; n\u2009=\u2009147 controls; n\u2009=\u2009128) [2.23 (95% CI 0.79; 3.66) p\u2009=\u20090,002] (I2\u2009=\u200995.1% [95% CI 90.4, 97.5], p\u2009<\u20090.0001).LimitationsSeveral factors inducing heterogeneity should be considered. First, differences in the staining method may be responsible for a part in the heterogeneity of results. Second, ASD population is also by itself heterogeneous, underlying the need of studying sub-groups that are more homogeneous.ConclusionOur meta-analysis indicates defects in CD4+\u2009lymphocytes, specifically decrease oin Tregs and increase in Th17 in ASD patients and supports the development of targeted immunotherapies in the field of ASD.",
"genre": "article",
"id": "sg:pub.10.1186/s13229-021-00472-4",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1043709",
"issn": [
"2040-2392"
],
"name": "Molecular Autism",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "12"
}
],
"keywords": [
"ASD patients",
"T lymphocytes/",
"autism spectrum disorder",
"natural killer lymphocytes",
"regulatory T lymphocytes",
"significant decrease",
"International Prospective Register",
"lymphocyte abnormalities",
"Th17 lymphocytes",
"lymphocyte profiles",
"lymphocyte subpopulations",
"Cochrane CENTRAL",
"heterogeneity of results",
"lymphocytes/",
"system dysfunction",
"Prospective Register",
"healthy controls",
"killer lymphocytes",
"T lymphocytes",
"spectrum disorder",
"PRISMA recommendations",
"patients",
"lymphocytes",
"systematic review",
"clinical diagnosis",
"CD4",
"Science Direct",
"significant differences",
"conflicting reports",
"abnormalities",
"disorders",
"ASD population",
"staining method",
"subpopulations",
"numerous studies",
"critical role",
"Tregs",
"CD8",
"Th17",
"immunotherapy",
"EMBASE",
"dysfunction",
"pathophysiology",
"BIOSIS",
"population",
"PubMed",
"MethodsWe",
"diagnosis",
"control",
"ResultsWe",
"study",
"ConclusionOur",
"PsychoInfo",
"differences",
"children",
"decrease",
"Register",
"subjects",
"report",
"review",
"heterogeneity",
"search protocol",
"Direct",
"evidence",
"imbalance",
"factors",
"recommendations",
"protocol",
"role",
"Central",
"increase",
"defects",
"field of ASD",
"profile",
"need",
"development",
"query PubMed",
"results",
"part",
"method",
"terms",
"field"
],
"name": "Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis",
"pagination": "68",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1141826104"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13229-021-00472-4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"34641964"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13229-021-00472-4",
"https://app.dimensions.ai/details/publication/pub.1141826104"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:30",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_909.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s13229-021-00472-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00472-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00472-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00472-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00472-4'
This table displays all metadata directly associated to this object as RDF triples.
322 TRIPLES
22 PREDICATES
137 URIs
104 LITERALS
11 BLANK NODES