A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-09-30

AUTHORS

J. Fastman, J. Foss-Feig, Y. Frank, D. Halpern, H. Harony-Nicolas, C. Layton, S. Sandin, P. Siper, L. Tang, P. Trelles, J. Zweifach, J. D. Buxbaum, A. Kolevzon

ABSTRACT

BackgroundPhelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused by haploinsufficiency of the SHANK3 gene and characterized by global developmental delays, deficits in speech and motor function, and autism spectrum disorder (ASD). Monogenic causes of ASD such as PMS are well suited to investigations with novel therapeutics, as interventions can be targeted based on established genetic etiology. While preclinical studies have demonstrated that the neuropeptide oxytocin can reverse electrophysiological, attentional, and social recognition memory deficits in Shank3-deficient rats, there have been no trials in individuals with PMS. The purpose of this study is to assess the efficacy and safety of intranasal oxytocin as a treatment for the core symptoms of ASD in a cohort of children with PMS.MethodsEighteen children aged 5–17 with PMS were enrolled. Participants were randomized to receive intranasal oxytocin or placebo (intranasal saline) and underwent treatment during a 12-week double-blind, parallel group phase, followed by a 12-week open-label extension phase during which all participants received oxytocin. Efficacy was assessed using the primary outcome of the Aberrant Behavior Checklist-Social Withdrawal (ABC-SW) subscale as well as a number of secondary outcome measures related to the core symptoms of ASD. Safety was monitored throughout the study period.ResultsThere was no statistically significant improvement with oxytocin as compared to placebo on the ABC-SW (Mann–Whitney U = 50, p = 0.055), or on any secondary outcome measures, during either the double-blind or open-label phases. Oxytocin was generally well tolerated, and there were no serious adverse events. LimitationsThe small sample size, potential challenges with drug administration, and expectancy bias due to relying on parent reported outcome measures may all contribute to limitations in interpreting results.ConclusionOur results suggest that intranasal oxytocin is not efficacious in improving the core symptoms of ASD in children with PMS.Trial registration NCT02710084. More... »

PAGES

62

References to SciGraph publications

  • 2015-10-27. The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial in MOLECULAR PSYCHIATRY
  • 2005-06. Oxytocin increases trust in humans in NATURE
  • 1994-10. Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 2000-06. Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 2020-11-17. Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats in MOLECULAR AUTISM
  • 2020-12-02. The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2012-12-05. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial in MOLECULAR AUTISM
  • 2017-02-09. SHANK proteins: roles at the synapse and in autism spectrum disorder in NATURE REVIEWS NEUROSCIENCE
  • 2019-07-22. Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice in NATURE NEUROSCIENCE
  • 2013-06-11. Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency in MOLECULAR AUTISM
  • 2017-06-05. Autism spectrum disorder: neuropathology and animal models in ACTA NEUROPATHOLOGICA
  • 1992-04. Structure and expression of a human oxytocin receptor in NATURE
  • 2018-09-27. Neurochemical evidence for differential effects of acute and repeated oxytocin administration in MOLECULAR PSYCHIATRY
  • 2009-09. Oxytocin enhances the perception of biological motion in humans in COGNITIVE, AFFECTIVE, & BEHAVIORAL NEUROSCIENCE
  • 2010-12-17. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication in MOLECULAR AUTISM
  • 2013-09-26. Oxytocin Promotes Facial Emotion Recognition and Amygdala Reactivity in Adults with Asperger Syndrome in NEUROPSYCHOPHARMACOLOGY
  • 2006-12-17. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders in NATURE GENETICS
  • 2006-07-25. The postsynaptic density in CELL AND TISSUE RESEARCH
  • 2011-09-29. Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish in PSYCHOPHARMACOLOGY
  • 2017-05-10. Neurite Outgrowth Stimulated by Oxytocin Is Modulated by Inhibition of the Calcium Voltage-Gated Channels in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2014-07-29. Oxytocin’s neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial in MOLECULAR PSYCHIATRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13229-021-00459-1

    DOI

    http://dx.doi.org/10.1186/s13229-021-00459-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141527567

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34593045


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autism Spectrum Disorder", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Deletion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, Pair 22", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxytocin", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fastman", 
            "givenName": "J.", 
            "id": "sg:person.011665633455.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011665633455.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Foss-Feig", 
            "givenName": "J.", 
            "id": "sg:person.0607036155.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607036155.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Frank", 
            "givenName": "Y.", 
            "id": "sg:person.01304370720.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304370720.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Halpern", 
            "givenName": "D.", 
            "id": "sg:person.01211447274.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211447274.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
                "Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harony-Nicolas", 
            "givenName": "H.", 
            "id": "sg:person.01012605405.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012605405.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Layton", 
            "givenName": "C.", 
            "id": "sg:person.013252102003.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013252102003.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
                "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sandin", 
            "givenName": "S.", 
            "id": "sg:person.0641615405.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641615405.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siper", 
            "givenName": "P.", 
            "id": "sg:person.0773140046.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773140046.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "L.", 
            "id": "sg:person.013566254567.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013566254567.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trelles", 
            "givenName": "P.", 
            "id": "sg:person.014723440753.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014723440753.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zweifach", 
            "givenName": "J.", 
            "id": "sg:person.01367644534.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367644534.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
                "Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buxbaum", 
            "givenName": "J. D.", 
            "id": "sg:person.01160234271.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160234271.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA", 
                "Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
                "Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kolevzon", 
            "givenName": "A.", 
            "id": "sg:person.01121635722.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121635722.10"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10571-017-0503-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085381392", 
              "https://doi.org/10.1007/s10571-017-0503-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41380-018-0249-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107235057", 
              "https://doi.org/10.1038/s41380-018-0249-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn.2016.183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083735506", 
              "https://doi.org/10.1038/nrn.2016.183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2040-2392-1-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026591820", 
              "https://doi.org/10.1186/2040-2392-1-15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-020-03714-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1133093679", 
              "https://doi.org/10.1007/s00018-020-03714-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-011-2482-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008062785", 
              "https://doi.org/10.1007/s00213-011-2482-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2013.254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001573883", 
              "https://doi.org/10.1038/npp.2013.254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024392128", 
              "https://doi.org/10.1038/nature03701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006673623", 
              "https://doi.org/10.1038/ng1933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13229-020-00393-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1132678322", 
              "https://doi.org/10.1186/s13229-020-00393-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2040-2392-4-18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024783548", 
              "https://doi.org/10.1186/2040-2392-4-18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2014.74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043541369", 
              "https://doi.org/10.1038/mp.2014.74"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2040-2392-3-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031702654", 
              "https://doi.org/10.1186/2040-2392-3-16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1005596502855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036844286", 
              "https://doi.org/10.1023/a:1005596502855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/356526a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027340373", 
              "https://doi.org/10.1038/356526a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-006-0274-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051210789", 
              "https://doi.org/10.1007/s00441-006-0274-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02172145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017747169", 
              "https://doi.org/10.1007/bf02172145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1736-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085861661", 
              "https://doi.org/10.1007/s00401-017-1736-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41593-019-0445-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1118143447", 
              "https://doi.org/10.1038/s41593-019-0445-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.3758/cabn.9.3.237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025305497", 
              "https://doi.org/10.3758/cabn.9.3.237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2015.162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000586147", 
              "https://doi.org/10.1038/mp.2015.162"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-09-30", 
        "datePublishedReg": "2021-09-30", 
        "description": "BackgroundPhelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused by haploinsufficiency of the SHANK3 gene and characterized by global developmental delays, deficits in speech and motor function, and autism spectrum disorder (ASD). Monogenic causes of ASD such as PMS are well suited to investigations with novel therapeutics, as interventions can be targeted based on established genetic etiology. While preclinical studies have demonstrated that the neuropeptide oxytocin can reverse electrophysiological, attentional, and social recognition memory deficits in Shank3-deficient rats, there have been no trials in individuals with PMS. The purpose of this study is to assess the efficacy and safety of intranasal oxytocin as a treatment for the core symptoms of ASD in a cohort of children with PMS.MethodsEighteen children aged 5\u201317 with PMS were enrolled. Participants were randomized to receive intranasal oxytocin or placebo (intranasal saline) and underwent treatment during a 12-week double-blind, parallel group phase, followed by a 12-week open-label extension phase during which all participants received oxytocin. Efficacy was assessed using the primary outcome of the Aberrant Behavior Checklist-Social Withdrawal (ABC-SW) subscale as well as a number of secondary outcome measures related to the core symptoms of ASD. Safety was monitored throughout the study period.ResultsThere was no statistically significant improvement with oxytocin as compared to placebo on the ABC-SW (Mann\u2013Whitney U\u2009=\u200950, p\u2009=\u20090.055), or on any secondary outcome measures, during either the double-blind or open-label phases. Oxytocin was generally well tolerated, and there were no serious adverse events.\nLimitationsThe small sample size, potential challenges with drug administration, and expectancy bias due to relying on parent reported outcome measures may all contribute to limitations in interpreting results.ConclusionOur results suggest that intranasal oxytocin is not efficacious in improving the core symptoms of ASD in children with PMS.Trial registration NCT02710084.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13229-021-00459-1", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1043709", 
            "issn": [
              "2040-2392"
            ], 
            "name": "Molecular Autism", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "keywords": [
          "autism spectrum disorder", 
          "core symptoms", 
          "intranasal oxytocin", 
          "social recognition memory deficits", 
          "recognition memory deficits", 
          "expectancy bias", 
          "Secondary outcome measures", 
          "neuropeptide oxytocin", 
          "spectrum disorder", 
          "memory deficits", 
          "Phelan-McDermid syndrome", 
          "withdrawal subscale", 
          "outcome measures", 
          "safety of intranasal", 
          "neurodevelopmental disorders", 
          "parallel-group phase", 
          "open-label extension phase", 
          "open-label phase", 
          "serious adverse events", 
          "SHANK3 gene", 
          "developmental delay", 
          "oxytocin", 
          "cohort of children", 
          "children", 
          "deficits", 
          "rare neurodevelopmental disorder", 
          "global developmental delay", 
          "participants", 
          "MethodsEighteen children", 
          "primary outcome", 
          "adverse events", 
          "small sample size", 
          "measures", 
          "motor function", 
          "preclinical studies", 
          "Drug Administration", 
          "disorders", 
          "ConclusionOur results", 
          "monogenic causes", 
          "novel therapeutics", 
          "extension phase", 
          "study period", 
          "speech", 
          "symptoms", 
          "subscales", 
          "group phase", 
          "genetic etiology", 
          "placebo", 
          "intranasal", 
          "syndrome", 
          "parents", 
          "trials", 
          "significant improvement", 
          "efficacy", 
          "potential challenges", 
          "treatment", 
          "individuals", 
          "intervention", 
          "sample size", 
          "bias", 
          "safety", 
          "ResultsThere", 
          "etiology", 
          "cohort", 
          "rats", 
          "administration", 
          "outcomes", 
          "therapeutics", 
          "cause", 
          "haploinsufficiency", 
          "study", 
          "results", 
          "purpose", 
          "PMS", 
          "period", 
          "limitations", 
          "delay", 
          "genes", 
          "events", 
          "improvement", 
          "challenges", 
          "function", 
          "investigation", 
          "number", 
          "phase", 
          "size"
        ], 
        "name": "A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome", 
        "pagination": "62", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1141527567"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13229-021-00459-1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34593045"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13229-021-00459-1", 
          "https://app.dimensions.ai/details/publication/pub.1141527567"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_892.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13229-021-00459-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00459-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00459-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00459-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13229-021-00459-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    369 TRIPLES      22 PREDICATES      143 URIs      113 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13229-021-00459-1 schema:about N0b8be2efc22844028b88cd37c22b6c7e
    2 N16258a487eec45419357985dcf235168
    3 N206ccd90a08c421f9d4229a00ca16960
    4 N3c1a3f44255f40d9a668c397c8fe2ab7
    5 N5c8cfddb9870446ca92c0ed946675aea
    6 Nc4a4fea290a9440bb51321cf572fda8e
    7 Nd162e18491a94e1e869b48707019241f
    8 Nea1f3c4457c24aa1a8fa36fa40bcf575
    9 Nfef0b00fe8a14a7ebca8df891f568749
    10 anzsrc-for:11
    11 anzsrc-for:1103
    12 anzsrc-for:1109
    13 schema:author Nc1b8fcddfd974d5fbbebb94f64b4ac6c
    14 schema:citation sg:pub.10.1007/bf02172145
    15 sg:pub.10.1007/s00018-020-03714-5
    16 sg:pub.10.1007/s00213-011-2482-2
    17 sg:pub.10.1007/s00401-017-1736-4
    18 sg:pub.10.1007/s00441-006-0274-5
    19 sg:pub.10.1007/s10571-017-0503-3
    20 sg:pub.10.1023/a:1005596502855
    21 sg:pub.10.1038/356526a0
    22 sg:pub.10.1038/mp.2014.74
    23 sg:pub.10.1038/mp.2015.162
    24 sg:pub.10.1038/nature03701
    25 sg:pub.10.1038/ng1933
    26 sg:pub.10.1038/npp.2013.254
    27 sg:pub.10.1038/nrn.2016.183
    28 sg:pub.10.1038/s41380-018-0249-4
    29 sg:pub.10.1038/s41593-019-0445-9
    30 sg:pub.10.1186/2040-2392-1-15
    31 sg:pub.10.1186/2040-2392-3-16
    32 sg:pub.10.1186/2040-2392-4-18
    33 sg:pub.10.1186/s13229-020-00393-8
    34 sg:pub.10.3758/cabn.9.3.237
    35 schema:datePublished 2021-09-30
    36 schema:datePublishedReg 2021-09-30
    37 schema:description BackgroundPhelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused by haploinsufficiency of the SHANK3 gene and characterized by global developmental delays, deficits in speech and motor function, and autism spectrum disorder (ASD). Monogenic causes of ASD such as PMS are well suited to investigations with novel therapeutics, as interventions can be targeted based on established genetic etiology. While preclinical studies have demonstrated that the neuropeptide oxytocin can reverse electrophysiological, attentional, and social recognition memory deficits in Shank3-deficient rats, there have been no trials in individuals with PMS. The purpose of this study is to assess the efficacy and safety of intranasal oxytocin as a treatment for the core symptoms of ASD in a cohort of children with PMS.MethodsEighteen children aged 5–17 with PMS were enrolled. Participants were randomized to receive intranasal oxytocin or placebo (intranasal saline) and underwent treatment during a 12-week double-blind, parallel group phase, followed by a 12-week open-label extension phase during which all participants received oxytocin. Efficacy was assessed using the primary outcome of the Aberrant Behavior Checklist-Social Withdrawal (ABC-SW) subscale as well as a number of secondary outcome measures related to the core symptoms of ASD. Safety was monitored throughout the study period.ResultsThere was no statistically significant improvement with oxytocin as compared to placebo on the ABC-SW (Mann–Whitney U = 50, p = 0.055), or on any secondary outcome measures, during either the double-blind or open-label phases. Oxytocin was generally well tolerated, and there were no serious adverse events. LimitationsThe small sample size, potential challenges with drug administration, and expectancy bias due to relying on parent reported outcome measures may all contribute to limitations in interpreting results.ConclusionOur results suggest that intranasal oxytocin is not efficacious in improving the core symptoms of ASD in children with PMS.Trial registration NCT02710084.
    38 schema:genre article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N5f7ab9d395af41e3b22dfeac6f667a0a
    42 Nd63ac4ebb2c94451896048fafc9cb6e4
    43 sg:journal.1043709
    44 schema:keywords ConclusionOur results
    45 Drug Administration
    46 MethodsEighteen children
    47 PMS
    48 Phelan-McDermid syndrome
    49 ResultsThere
    50 SHANK3 gene
    51 Secondary outcome measures
    52 administration
    53 adverse events
    54 autism spectrum disorder
    55 bias
    56 cause
    57 challenges
    58 children
    59 cohort
    60 cohort of children
    61 core symptoms
    62 deficits
    63 delay
    64 developmental delay
    65 disorders
    66 efficacy
    67 etiology
    68 events
    69 expectancy bias
    70 extension phase
    71 function
    72 genes
    73 genetic etiology
    74 global developmental delay
    75 group phase
    76 haploinsufficiency
    77 improvement
    78 individuals
    79 intervention
    80 intranasal
    81 intranasal oxytocin
    82 investigation
    83 limitations
    84 measures
    85 memory deficits
    86 monogenic causes
    87 motor function
    88 neurodevelopmental disorders
    89 neuropeptide oxytocin
    90 novel therapeutics
    91 number
    92 open-label extension phase
    93 open-label phase
    94 outcome measures
    95 outcomes
    96 oxytocin
    97 parallel-group phase
    98 parents
    99 participants
    100 period
    101 phase
    102 placebo
    103 potential challenges
    104 preclinical studies
    105 primary outcome
    106 purpose
    107 rare neurodevelopmental disorder
    108 rats
    109 recognition memory deficits
    110 results
    111 safety
    112 safety of intranasal
    113 sample size
    114 serious adverse events
    115 significant improvement
    116 size
    117 small sample size
    118 social recognition memory deficits
    119 spectrum disorder
    120 speech
    121 study
    122 study period
    123 subscales
    124 symptoms
    125 syndrome
    126 therapeutics
    127 treatment
    128 trials
    129 withdrawal subscale
    130 schema:name A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome
    131 schema:pagination 62
    132 schema:productId N97930f4b1c25457a8912bebf3b1affb8
    133 Nb11f761db2134ca09fe07eba892f9a4d
    134 Nd2e159d986914a5eb4ada02903c1ad73
    135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141527567
    136 https://doi.org/10.1186/s13229-021-00459-1
    137 schema:sdDatePublished 2022-05-20T07:38
    138 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    139 schema:sdPublisher Nae4081f77250458fbf2dabd63db0a980
    140 schema:url https://doi.org/10.1186/s13229-021-00459-1
    141 sgo:license sg:explorer/license/
    142 sgo:sdDataset articles
    143 rdf:type schema:ScholarlyArticle
    144 N01e8f758fe0c4afc8b8b333103fd038f rdf:first sg:person.0773140046.14
    145 rdf:rest Ne0e3971beee04780b2a7dc1d1994cc49
    146 N0b8be2efc22844028b88cd37c22b6c7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Adolescent
    148 rdf:type schema:DefinedTerm
    149 N16258a487eec45419357985dcf235168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Humans
    151 rdf:type schema:DefinedTerm
    152 N206ccd90a08c421f9d4229a00ca16960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Chromosome Deletion
    154 rdf:type schema:DefinedTerm
    155 N26afbf1b4f864bcebd97bc873d8df704 rdf:first sg:person.01304370720.83
    156 rdf:rest Nd335a40a894d4f579fbef33f7172bddb
    157 N3c1a3f44255f40d9a668c397c8fe2ab7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Autism Spectrum Disorder
    159 rdf:type schema:DefinedTerm
    160 N4aac8017ff8143588acc72edaecfab66 rdf:first sg:person.013252102003.43
    161 rdf:rest Nc877b772c8234cf6b095b038ba38c4dd
    162 N5c2f52dbe1834f689ef42d1a927c5dd8 rdf:first sg:person.0607036155.37
    163 rdf:rest N26afbf1b4f864bcebd97bc873d8df704
    164 N5c8cfddb9870446ca92c0ed946675aea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Child
    166 rdf:type schema:DefinedTerm
    167 N5f7ab9d395af41e3b22dfeac6f667a0a schema:volumeNumber 12
    168 rdf:type schema:PublicationVolume
    169 N5ffc87b6ac444923ad1adf42e805e316 rdf:first sg:person.01012605405.46
    170 rdf:rest N4aac8017ff8143588acc72edaecfab66
    171 N78a4bc1801ac48939cead0aa2bb7faf1 rdf:first sg:person.01367644534.38
    172 rdf:rest Naa66217111874397ba76f5b1f43dff88
    173 N806fc57d02fa4efe947c5829db3a824a rdf:first sg:person.014723440753.91
    174 rdf:rest N78a4bc1801ac48939cead0aa2bb7faf1
    175 N97930f4b1c25457a8912bebf3b1affb8 schema:name dimensions_id
    176 schema:value pub.1141527567
    177 rdf:type schema:PropertyValue
    178 Naa66217111874397ba76f5b1f43dff88 rdf:first sg:person.01160234271.56
    179 rdf:rest Nff94b36c133b42719bc11fe278ae6359
    180 Nae4081f77250458fbf2dabd63db0a980 schema:name Springer Nature - SN SciGraph project
    181 rdf:type schema:Organization
    182 Nb11f761db2134ca09fe07eba892f9a4d schema:name doi
    183 schema:value 10.1186/s13229-021-00459-1
    184 rdf:type schema:PropertyValue
    185 Nc1b8fcddfd974d5fbbebb94f64b4ac6c rdf:first sg:person.011665633455.77
    186 rdf:rest N5c2f52dbe1834f689ef42d1a927c5dd8
    187 Nc4a4fea290a9440bb51321cf572fda8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Chromosome Disorders
    189 rdf:type schema:DefinedTerm
    190 Nc877b772c8234cf6b095b038ba38c4dd rdf:first sg:person.0641615405.18
    191 rdf:rest N01e8f758fe0c4afc8b8b333103fd038f
    192 Nd162e18491a94e1e869b48707019241f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Chromosomes, Human, Pair 22
    194 rdf:type schema:DefinedTerm
    195 Nd2e159d986914a5eb4ada02903c1ad73 schema:name pubmed_id
    196 schema:value 34593045
    197 rdf:type schema:PropertyValue
    198 Nd335a40a894d4f579fbef33f7172bddb rdf:first sg:person.01211447274.35
    199 rdf:rest N5ffc87b6ac444923ad1adf42e805e316
    200 Nd63ac4ebb2c94451896048fafc9cb6e4 schema:issueNumber 1
    201 rdf:type schema:PublicationIssue
    202 Ne0e3971beee04780b2a7dc1d1994cc49 rdf:first sg:person.013566254567.29
    203 rdf:rest N806fc57d02fa4efe947c5829db3a824a
    204 Nea1f3c4457c24aa1a8fa36fa40bcf575 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Oxytocin
    206 rdf:type schema:DefinedTerm
    207 Nfef0b00fe8a14a7ebca8df891f568749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Child, Preschool
    209 rdf:type schema:DefinedTerm
    210 Nff94b36c133b42719bc11fe278ae6359 rdf:first sg:person.01121635722.10
    211 rdf:rest rdf:nil
    212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Medical and Health Sciences
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Clinical Sciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Neurosciences
    220 rdf:type schema:DefinedTerm
    221 sg:journal.1043709 schema:issn 2040-2392
    222 schema:name Molecular Autism
    223 schema:publisher Springer Nature
    224 rdf:type schema:Periodical
    225 sg:person.01012605405.46 schema:affiliation grid-institutes:grid.59734.3c
    226 schema:familyName Harony-Nicolas
    227 schema:givenName H.
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012605405.46
    229 rdf:type schema:Person
    230 sg:person.01121635722.10 schema:affiliation grid-institutes:grid.59734.3c
    231 schema:familyName Kolevzon
    232 schema:givenName A.
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121635722.10
    234 rdf:type schema:Person
    235 sg:person.01160234271.56 schema:affiliation grid-institutes:grid.59734.3c
    236 schema:familyName Buxbaum
    237 schema:givenName J. D.
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160234271.56
    239 rdf:type schema:Person
    240 sg:person.011665633455.77 schema:affiliation grid-institutes:grid.59734.3c
    241 schema:familyName Fastman
    242 schema:givenName J.
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011665633455.77
    244 rdf:type schema:Person
    245 sg:person.01211447274.35 schema:affiliation grid-institutes:grid.59734.3c
    246 schema:familyName Halpern
    247 schema:givenName D.
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211447274.35
    249 rdf:type schema:Person
    250 sg:person.01304370720.83 schema:affiliation grid-institutes:grid.59734.3c
    251 schema:familyName Frank
    252 schema:givenName Y.
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304370720.83
    254 rdf:type schema:Person
    255 sg:person.013252102003.43 schema:affiliation grid-institutes:grid.59734.3c
    256 schema:familyName Layton
    257 schema:givenName C.
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013252102003.43
    259 rdf:type schema:Person
    260 sg:person.013566254567.29 schema:affiliation grid-institutes:grid.59734.3c
    261 schema:familyName Tang
    262 schema:givenName L.
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013566254567.29
    264 rdf:type schema:Person
    265 sg:person.01367644534.38 schema:affiliation grid-institutes:grid.59734.3c
    266 schema:familyName Zweifach
    267 schema:givenName J.
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367644534.38
    269 rdf:type schema:Person
    270 sg:person.014723440753.91 schema:affiliation grid-institutes:grid.59734.3c
    271 schema:familyName Trelles
    272 schema:givenName P.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014723440753.91
    274 rdf:type schema:Person
    275 sg:person.0607036155.37 schema:affiliation grid-institutes:grid.59734.3c
    276 schema:familyName Foss-Feig
    277 schema:givenName J.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607036155.37
    279 rdf:type schema:Person
    280 sg:person.0641615405.18 schema:affiliation grid-institutes:grid.4714.6
    281 schema:familyName Sandin
    282 schema:givenName S.
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641615405.18
    284 rdf:type schema:Person
    285 sg:person.0773140046.14 schema:affiliation grid-institutes:grid.59734.3c
    286 schema:familyName Siper
    287 schema:givenName P.
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773140046.14
    289 rdf:type schema:Person
    290 sg:pub.10.1007/bf02172145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017747169
    291 https://doi.org/10.1007/bf02172145
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s00018-020-03714-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1133093679
    294 https://doi.org/10.1007/s00018-020-03714-5
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s00213-011-2482-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008062785
    297 https://doi.org/10.1007/s00213-011-2482-2
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1007/s00401-017-1736-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085861661
    300 https://doi.org/10.1007/s00401-017-1736-4
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1007/s00441-006-0274-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051210789
    303 https://doi.org/10.1007/s00441-006-0274-5
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s10571-017-0503-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085381392
    306 https://doi.org/10.1007/s10571-017-0503-3
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1023/a:1005596502855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036844286
    309 https://doi.org/10.1023/a:1005596502855
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/356526a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027340373
    312 https://doi.org/10.1038/356526a0
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/mp.2014.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043541369
    315 https://doi.org/10.1038/mp.2014.74
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/mp.2015.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000586147
    318 https://doi.org/10.1038/mp.2015.162
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nature03701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024392128
    321 https://doi.org/10.1038/nature03701
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/ng1933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006673623
    324 https://doi.org/10.1038/ng1933
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/npp.2013.254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001573883
    327 https://doi.org/10.1038/npp.2013.254
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/nrn.2016.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083735506
    330 https://doi.org/10.1038/nrn.2016.183
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/s41380-018-0249-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107235057
    333 https://doi.org/10.1038/s41380-018-0249-4
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/s41593-019-0445-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1118143447
    336 https://doi.org/10.1038/s41593-019-0445-9
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1186/2040-2392-1-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026591820
    339 https://doi.org/10.1186/2040-2392-1-15
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1186/2040-2392-3-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031702654
    342 https://doi.org/10.1186/2040-2392-3-16
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1186/2040-2392-4-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024783548
    345 https://doi.org/10.1186/2040-2392-4-18
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1186/s13229-020-00393-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132678322
    348 https://doi.org/10.1186/s13229-020-00393-8
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.3758/cabn.9.3.237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025305497
    351 https://doi.org/10.3758/cabn.9.3.237
    352 rdf:type schema:CreativeWork
    353 grid-institutes:grid.4714.6 schema:alternateName Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    354 schema:name Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    355 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    356 Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA
    357 rdf:type schema:Organization
    358 grid-institutes:grid.59734.3c schema:alternateName Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    359 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    360 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    361 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    362 Icahn School of Medicine at Mount Sinai, New York, NY, USA
    363 schema:name Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    364 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    365 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    366 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    367 Icahn School of Medicine at Mount Sinai, New York, NY, USA
    368 Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA
    369 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...