The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Eleftheria Pervolaraki, Adam L. Tyson, Francesca Pibiri, Steven L. Poulter, Amy C. Reichelt, R. John Rodgers, Steven J. Clapcote, Colin Lever, Laura C. Andreae, James Dachtler

ABSTRACT

Background: Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of presynaptic proteins are the neurexins (NRXN), and recent genetic and mouse evidence has suggested a causative role for NRXN2 in generating altered social behaviours. Autism has been conceptualised as a disorder of atypical connectivity, yet how single-gene mutations affect such connectivity remains under-explored. To attempt to address this, we have developed a quantitative analysis of microstructure and structural connectivity leveraging diffusion tensor MRI (DTI) with high-resolution 3D imaging in optically cleared (CLARITY) brain tissue in the same mouse, applied here to the Nrxn2α knockout (KO) model. Methods: Fixed brains of Nrxn2α KO mice underwent DTI using 9.4 T MRI, and diffusion properties of socially relevant brain regions were quantified. The same tissue was then subjected to CLARITY to immunolabel axons and cell bodies, which were also quantified. Results: DTI revealed increases in fractional anisotropy in the amygdala (including the basolateral nuclei), the anterior cingulate cortex, the orbitofrontal cortex and the hippocampus. Axial diffusivity of the anterior cingulate cortex and orbitofrontal cortex was significantly increased in Nrxn2α KO mice, as were tracts between the amygdala and the orbitofrontal cortex. Using CLARITY, we find significantly altered axonal orientation in the amygdala, orbitofrontal cortex and the anterior cingulate cortex, which was unrelated to cell density. Conclusions: Our findings demonstrate that deleting a single neurexin gene (Nrxn2α) induces atypical structural connectivity within socially relevant brain regions. More generally, our combined within-subject DTI and CLARITY approach presents a new, more sensitive method of revealing hitherto undetectable differences in the autistic brain. More... »

PAGES

8

References to SciGraph publications

  • 2018-12. Brain-specific functional relationship networks inform autism spectrum disorder gene prediction in TRANSLATIONAL PSYCHIATRY
  • 2017-12. Ventricular myocardium development and the role of connexins in the human fetal heart in SCIENTIFIC REPORTS
  • 2006-08. The neuroligin and neurexin families: from structure to function at the synapse in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2014-11. Deletion of α-neurexin II results in autism-related behaviors in mice in TRANSLATIONAL PSYCHIATRY
  • 2018-04-27. An integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorder in MOLECULAR PSYCHIATRY
  • 2011-10. Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia in HUMAN GENETICS
  • 2014-04. Impaired Hippocampal Neuroligin-2 Function by Chronic Stress or Synthetic Peptide Treatment is Linked to Social Deficits and Increased Aggression in NEUROPSYCHOPHARMACOLOGY
  • 2015-12. Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation in MOLECULAR AUTISM
  • 2014-02. The role of de novo mutations in the genetics of autism spectrum disorders in NATURE REVIEWS GENETICS
  • 2017-09. Targeted sequencing and functional analysis reveal brain-size-related genes and their networks in autism spectrum disorders in MOLECULAR PSYCHIATRY
  • 1998-06. The human amygdala in social judgment in NATURE
  • 2014-03. Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior in NATURE NEUROSCIENCE
  • 2007-07. Diffusion tensor imaging of the brain in NEUROTHERAPEUTICS
  • 2003-06. α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis in NATURE
  • 2013-05. Structural and molecular interrogation of intact biological systems in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13229-019-0261-9

    DOI

    http://dx.doi.org/10.1186/s13229-019-0261-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112462495

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30858964


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