Ontology type: schema:ScholarlyArticle Open Access: True
2021-03-06
AUTHORSAnna Sandebring-Matton, Julen Goikolea, Ingemar Björkhem, Laura Paternain, Nina Kemppainen, Tiina Laatikainen, Tiia Ngandu, Juha Rinne, Hilkka Soininen, Angel Cedazo-Minguez, Alina Solomon, Miia Kivipelto
ABSTRACTBackground27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer’s disease (AD), has not been investigated previously in relation to cognition and neuroimaging markers in the context of preventive interventions.MethodsThe 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) included older individuals (60–77 years) at increased risk for dementia but without dementia or substantial cognitive impairment from the general population. Participants were randomized to a multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice) in a 1:1 ratio. Outcome assessors were masked to group allocation. This FINGER exploratory sub-study included 47 participants with measures of 27-OH, cognition, brain MRI, brain FDG-PET, and PiB-PET. Linear regression models were used to assess the cross-sectional and longitudinal associations between 27-OH, cognition, and neuroimaging markers, considering several potential confounders/intervention effect modifiers.Results27-OH reduction during the intervention was associated with improvement in cognition (especially memory). This was not observed in the control group. The intervention reduced 27-OH particularly in individuals with the highest 27-OH levels and younger age. No associations were found between changes in 27-OH levels and neuroimaging markers. However, at baseline, a higher 27-OH was associated with lower total gray matter and hippocampal volume, and lower cognitive scores. These associations were unaffected by total cholesterol levels. While sex seemed to influence associations at baseline, it did not affect longitudinal associations.Conclusion27-OH appears to be a marker not only for dementia/AD risk, but also for monitoring the effects of preventive interventions on cholesterol metabolism.Trial registrationClinicalTrials.gov, NCT01041989. Registered on 4 January 2010 More... »
PAGES56
http://scigraph.springernature.com/pub.10.1186/s13195-021-00790-y
DOIhttp://dx.doi.org/10.1186/s13195-021-00790-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1136164781
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33676572
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cognition",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cognitive Dysfunction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cross-Sectional Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Finland",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydroxycholesterols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Magnetic Resonance Imaging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neuroimaging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neuropsychological Tests",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"id": "http://www.grid.ac/institutes/grid.4714.6",
"name": [
"Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Sandebring-Matton",
"givenName": "Anna",
"id": "sg:person.010717265661.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010717265661.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"id": "http://www.grid.ac/institutes/grid.4714.6",
"name": [
"Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Goikolea",
"givenName": "Julen",
"id": "sg:person.01337042702.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337042702.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska University Hospital, Stockholm, Sweden",
"id": "http://www.grid.ac/institutes/grid.24381.3c",
"name": [
"Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska University Hospital, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Bj\u00f6rkhem",
"givenName": "Ingemar",
"id": "sg:person.010302215024.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010302215024.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"id": "http://www.grid.ac/institutes/grid.4714.6",
"name": [
"Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Paternain",
"givenName": "Laura",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland",
"id": "http://www.grid.ac/institutes/grid.470895.7",
"name": [
"Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland",
"Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland"
],
"type": "Organization"
},
"familyName": "Kemppainen",
"givenName": "Nina",
"id": "sg:person.01122137640.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122137640.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Public Health Promotion Unit, Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland",
"id": "http://www.grid.ac/institutes/grid.14758.3f",
"name": [
"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland",
"Joint Municipal Authority for North Karelia Social and Health Services, Joensuu, Finland",
"Public Health Promotion Unit, Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland"
],
"type": "Organization"
},
"familyName": "Laatikainen",
"givenName": "Tiina",
"id": "sg:person.01223364111.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223364111.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Public Health Promotion Unit, Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland",
"id": "http://www.grid.ac/institutes/grid.14758.3f",
"name": [
"Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"Public Health Promotion Unit, Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland"
],
"type": "Organization"
},
"familyName": "Ngandu",
"givenName": "Tiia",
"id": "sg:person.01172636643.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172636643.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland",
"id": "http://www.grid.ac/institutes/grid.470895.7",
"name": [
"Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland"
],
"type": "Organization"
},
"familyName": "Rinne",
"givenName": "Juha",
"id": "sg:person.012653127617.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012653127617.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Neurocenter, Neurology Kuopio University Hospital, Kuopio, Finland",
"id": "http://www.grid.ac/institutes/grid.410705.7",
"name": [
"Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland",
"Neurocenter, Neurology Kuopio University Hospital, Kuopio, Finland"
],
"type": "Organization"
},
"familyName": "Soininen",
"givenName": "Hilkka",
"id": "sg:person.0604436333.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604436333.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"id": "http://www.grid.ac/institutes/grid.4714.6",
"name": [
"Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Cedazo-Minguez",
"givenName": "Angel",
"id": "sg:person.0601232770.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601232770.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland",
"Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK"
],
"type": "Organization"
},
"familyName": "Solomon",
"givenName": "Alina",
"id": "sg:person.01205237735.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205237735.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Theme Aging, Karolinska University Hospital, Stockholm, Sweden",
"id": "http://www.grid.ac/institutes/grid.24381.3c",
"name": [
"Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden",
"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland",
"Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK",
"Theme Aging, Karolinska University Hospital, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Kivipelto",
"givenName": "Miia",
"id": "sg:person.01041126327.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041126327.22"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s12944-016-0344-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046237387",
"https://doi.org/10.1186/s12944-016-0344-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10571-015-0285-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040712679",
"https://doi.org/10.1007/s10571-015-0285-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13195-019-0506-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1116652825",
"https://doi.org/10.1186/s13195-019-0506-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-981-13-3540-2_5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1113951934",
"https://doi.org/10.1007/978-981-13-3540-2_5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-014-8749-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032569968",
"https://doi.org/10.1007/s12035-014-8749-y"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-03-06",
"datePublishedReg": "2021-03-06",
"description": "Background27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer\u2019s disease (AD), has not been investigated previously in relation to cognition and neuroimaging markers in the context of preventive interventions.MethodsThe 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) included older individuals (60\u201377\u2009years) at increased risk for dementia but without dementia or substantial cognitive impairment from the general population. Participants were randomized to a multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice) in a 1:1 ratio. Outcome assessors were masked to group allocation. This FINGER exploratory sub-study included 47 participants with measures of 27-OH, cognition, brain MRI, brain FDG-PET, and PiB-PET. Linear regression models were used to assess the cross-sectional and longitudinal associations between 27-OH, cognition, and neuroimaging markers, considering several potential confounders/intervention effect modifiers.Results27-OH reduction during the intervention was associated with improvement in cognition (especially memory). This was not observed in the control group. The intervention reduced 27-OH particularly in individuals with the highest 27-OH levels and younger age. No associations were found between changes in 27-OH levels and neuroimaging markers. However, at baseline, a higher 27-OH was associated with lower total gray matter and hippocampal volume, and lower cognitive scores. These associations were unaffected by total cholesterol levels. While sex seemed to influence associations at baseline, it did not affect longitudinal associations.Conclusion27-OH appears to be a marker not only for dementia/AD risk, but also for monitoring the effects of preventive interventions on cholesterol metabolism.Trial registrationClinicalTrials.gov, NCT01041989. Registered on 4 January 2010",
"genre": "article",
"id": "sg:pub.10.1186/s13195-021-00790-y",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.7926886",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1041797",
"issn": [
"1758-9193"
],
"name": "Alzheimer's Research & Therapy",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"keywords": [
"control group",
"preventive interventions",
"cognitive impairment",
"Alzheimer's disease",
"Finnish Geriatric Intervention Study",
"lower total gray matter",
"dementia/AD risk",
"longitudinal associations",
"total cholesterol levels",
"brain FDG-PET",
"Prevent Cognitive Impairment",
"total gray matter",
"substantial cognitive impairment",
"lower cognitive scores",
"multidomain intervention",
"outcome assessors",
"FDG-PET",
"cholesterol levels",
"PiB-PET",
"hippocampal volume",
"group allocation",
"brain MRI",
"effect modifiers",
"general population",
"AD risk",
"cholesterol metabolism",
"intervention studies",
"younger age",
"gray matter",
"older individuals",
"potential missing link",
"cognitive scores",
"intervention",
"linear regression models",
"dementia",
"markers",
"association",
"disease",
"impairment",
"baseline",
"regression models",
"risk",
"participants",
"hypercholesterolemia",
"group",
"finger",
"levels",
"individuals",
"cognition",
"MRI",
"brain",
"trials",
"age",
"disability",
"sex",
"scores",
"oxysterols",
"MethodsThe",
"metabolism",
"humans",
"assessors",
"population",
"study",
"missing link",
"measures",
"reduction",
"effect",
"volume",
"improvement",
"changes",
"modifiers",
"ratio",
"link",
"relation",
"model",
"matter",
"context",
"allocation",
"OH reduction"
],
"name": "27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial",
"pagination": "56",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1136164781"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13195-021-00790-y"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"33676572"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13195-021-00790-y",
"https://app.dimensions.ai/details/publication/pub.1136164781"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:39",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_904.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s13195-021-00790-y"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13195-021-00790-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13195-021-00790-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13195-021-00790-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13195-021-00790-y'
This table displays all metadata directly associated to this object as RDF triples.
315 TRIPLES
22 PREDICATES
122 URIs
108 LITERALS
18 BLANK NODES