Souvenaid in the management of mild cognitive impairment: an expert consensus opinion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-08-17

AUTHORS

Jeffrey Cummings, Peter Passmore, Bernadette McGuinness, Vincent Mok, Christopher Chen, Sebastiaan Engelborghs, Michael Woodward, Sagrario Manzano, Guillermo Garcia-Ribas, Stefano Cappa, Paulo Bertolucci, Leung-Wing Chu

ABSTRACT

BACKGROUND: Mild cognitive impairment (MCI) among an aging global population is a growing challenge for healthcare providers and payers. In many cases, MCI is an ominous portent for dementia. Early and accurate diagnosis of MCI provides a window of opportunity to improve the outcomes using a personalized care plan including lifestyle modifications to reduce the impact of modifiable risk factors (for example, blood pressure control and increased physical activity), cognitive training, dietary advice, and nutritional support. Souvenaid is a once-daily drink containing a mixture of precursors and cofactors (long-chain omega-3 fatty acids, uridine, choline, B vitamins, vitamin C, vitamin E, and selenium), which was developed to support the formation and function of neuronal membranes and synapses. Healthcare providers, patients, and carers require expert advice about the use of Souvenaid. METHODS: An international panel of experts was convened to review the evidence and to make recommendations about the diagnosis and management of MCI, identification of candidates for Souvenaid, and use of Souvenaid in real-world practice. This article provides a summary of the expert opinions and makes recommendations for clinical practice and future research. Early diagnosis of MCI requires the use of suitable neuropsychological tests combined with a careful clinical history. A multimodal approach is recommended; dietary and nutritional interventions should be considered alongside individualized lifestyle modifications. Although single-agent nutritional supplements have failed to produce cognitive benefits for patients with MCI, a broader nutritional approach warrants consideration. Evidence from randomized controlled trials suggests that Souvenaid should be considered as an option for some patients with early Alzheimer's disease (AD), including those with MCI due to AD (prodromal AD). CONCLUSION: Early and accurate diagnosis of MCI provides a window of opportunity to improve the outcomes using a multimodal management approach including lifestyle risk factor modification and consideration of the multinutrient Souvenaid. More... »

PAGES

73

Journal

TITLE

Alzheimer's Research & Therapy

ISSUE

1

VOLUME

11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13195-019-0528-6

DOI

http://dx.doi.org/10.1186/s13195-019-0528-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120389690

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31421681


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21 schema:description BACKGROUND: Mild cognitive impairment (MCI) among an aging global population is a growing challenge for healthcare providers and payers. In many cases, MCI is an ominous portent for dementia. Early and accurate diagnosis of MCI provides a window of opportunity to improve the outcomes using a personalized care plan including lifestyle modifications to reduce the impact of modifiable risk factors (for example, blood pressure control and increased physical activity), cognitive training, dietary advice, and nutritional support. Souvenaid is a once-daily drink containing a mixture of precursors and cofactors (long-chain omega-3 fatty acids, uridine, choline, B vitamins, vitamin C, vitamin E, and selenium), which was developed to support the formation and function of neuronal membranes and synapses. Healthcare providers, patients, and carers require expert advice about the use of Souvenaid. METHODS: An international panel of experts was convened to review the evidence and to make recommendations about the diagnosis and management of MCI, identification of candidates for Souvenaid, and use of Souvenaid in real-world practice. This article provides a summary of the expert opinions and makes recommendations for clinical practice and future research. Early diagnosis of MCI requires the use of suitable neuropsychological tests combined with a careful clinical history. A multimodal approach is recommended; dietary and nutritional interventions should be considered alongside individualized lifestyle modifications. Although single-agent nutritional supplements have failed to produce cognitive benefits for patients with MCI, a broader nutritional approach warrants consideration. Evidence from randomized controlled trials suggests that Souvenaid should be considered as an option for some patients with early Alzheimer's disease (AD), including those with MCI due to AD (prodromal AD). CONCLUSION: Early and accurate diagnosis of MCI provides a window of opportunity to improve the outcomes using a multimodal management approach including lifestyle risk factor modification and consideration of the multinutrient Souvenaid.
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29 Souvenaid
30 accurate diagnosis
31 advice
32 approach
33 approach warrants consideration
34 article
35 benefits
36 broader nutritional approach warrants consideration
37 candidates
38 care plans
39 careful clinical history
40 carers
41 cases
42 challenges
43 clinical history
44 clinical practice
45 cofactor
46 cognitive benefits
47 cognitive impairment
48 cognitive training
49 consensus opinion
50 consideration
51 daily drinks
52 dementia
53 diagnosis
54 dietary advice
55 disease
56 drinks
57 early Alzheimer's disease
58 early diagnosis
59 evidence
60 expert advice
61 expert consensus opinion
62 expert opinion
63 experts
64 factor modification
65 factors
66 formation
67 function
68 future research
69 global population
70 healthcare providers
71 history
72 identification
73 identification of candidates
74 impact
75 impairment
76 individualized lifestyle modifications
77 international panel
78 intervention
79 lifestyle modification
80 lifestyle risk factor modification
81 management
82 management approach
83 management of MCI
84 membrane
85 mild cognitive impairment
86 mixture
87 mixture of precursors
88 modifiable risk factors
89 modification
90 multimodal approach
91 multimodal management approach
92 multinutrient Souvenaid
93 neuronal membranes
94 neuropsychological tests
95 nutritional approach warrants consideration
96 nutritional intervention
97 nutritional supplements
98 nutritional support
99 ominous portent
100 opinion
101 opportunities
102 options
103 outcomes
104 panel
105 patients
106 payers
107 personalized care plan
108 plan
109 population
110 portent
111 practice
112 precursors
113 providers
114 real-world practice
115 recommendations
116 research
117 risk factor modification
118 risk factors
119 single-agent nutritional supplements
120 suitable neuropsychological tests
121 summary
122 supplements
123 support
124 synapses
125 test
126 training
127 trials
128 use
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131 window
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