Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-09

AUTHORS

Raphael Hesse, Ludwig Lausser, Pauline Gummert, Florian Schmid, Anke Wahler, Cathrin Schnack, Katja S. Kroker, Markus Otto, Hayrettin Tumani, Hans A. Kestler, Holger Rosenbrock, Christine A. F. von Arnim

ABSTRACT

BackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder, primarily affecting memory. That disorder is thought to be a consequence of neuronal network disturbances and synapse loss. Decline in cognitive function is associated with a high burden of neuropsychiatric symptoms (NPSs) such as depression. The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are essential second messengers that play a crucial role in memory processing as well as synaptic plasticity and are potential therapeutic targets. Biomarkers that are able to monitor potential treatment effects and that reflect the underlying pathology are of crucial interest.MethodsIn this study, we measured cGMP and cAMP in cerebrospinal fluid (CSF) in a cohort of 133 subjects including 68 AD patients and 65 control subjects. To address the association with disease progression we correlated cognitive status with cyclic nucleotide levels. Because a high burden of NPSs is associated with decrease in cognitive function, we performed an exhaustive evaluation of AD-relevant marker combinations in a depressive subgroup.ResultsWe show that cGMP, but not cAMP, levels in the CSF of AD patients are significantly reduced compared with the control group. Reduced cGMP levels in AD patients correlate with memory impairment based on Mini-Mental State Examination score (r = 0.17, p = 0.048) and tau as a marker of neurodegeneration (r = –0.28, p = 0.001). Moreover, we were able to show that AD patients suffering from current depression show reduced cGMP levels (p = 0.07) and exhibit a higher degree of cognitive impairment than non-depressed AD patients.ConclusionThese results provide further evidence for an involvement of cGMP in AD pathogenesis and accompanying co-morbidities, and may contribute to elucidating synaptic plasticity alterations during disease progression. More... »

PAGES

17

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13195-017-0245-y

DOI

http://dx.doi.org/10.1186/s13195-017-0245-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084252355

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28274265


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic GMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Depression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mental Status Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "tau Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hesse", 
        "givenName": "Raphael", 
        "id": "sg:person.012111666541.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012111666541.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Medical Systems Biology, Ulm University, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Institute of Medical Systems Biology, Ulm University, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lausser", 
        "givenName": "Ludwig", 
        "id": "sg:person.01216600201.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216600201.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gummert", 
        "givenName": "Pauline", 
        "id": "sg:person.013504627541.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013504627541.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Medical Systems Biology, Ulm University, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Institute of Medical Systems Biology, Ulm University, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmid", 
        "givenName": "Florian", 
        "id": "sg:person.01276714621.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276714621.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wahler", 
        "givenName": "Anke", 
        "id": "sg:person.0744507042.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744507042.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schnack", 
        "givenName": "Cathrin", 
        "id": "sg:person.0633152201.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633152201.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany", 
          "id": "http://www.grid.ac/institutes/grid.420061.1", 
          "name": [
            "Department of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kroker", 
        "givenName": "Katja S.", 
        "id": "sg:person.0645302612.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645302612.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Otto", 
        "givenName": "Markus", 
        "id": "sg:person.0710516633.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710516633.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tumani", 
        "givenName": "Hayrettin", 
        "id": "sg:person.01216652756.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216652756.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Medical Systems Biology, Ulm University, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Institute of Medical Systems Biology, Ulm University, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kestler", 
        "givenName": "Hans A.", 
        "id": "sg:person.013315234657.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013315234657.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany", 
          "id": "http://www.grid.ac/institutes/grid.420061.1", 
          "name": [
            "Department of CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenbrock", 
        "givenName": "Holger", 
        "id": "sg:person.0761531212.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761531212.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Arnim", 
        "givenName": "Christine A. F.", 
        "id": "sg:person.010304274057.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010304274057.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-3-540-68964-5_24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008438462", 
          "https://doi.org/10.1007/978-3-540-68964-5_24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-010-8104-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004478522", 
          "https://doi.org/10.1007/s12035-010-8104-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/361031a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042608618", 
          "https://doi.org/10.1038/361031a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031073156", 
          "https://doi.org/10.1038/nrn2867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.nurt.2010.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033194220", 
          "https://doi.org/10.1016/j.nurt.2010.03.006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00427396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044844455", 
          "https://doi.org/10.1007/bf00427396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01276464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042509970", 
          "https://doi.org/10.1007/bf01276464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00308809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000355620", 
          "https://doi.org/10.1007/bf00308809"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03-09", 
    "datePublishedReg": "2017-03-09", 
    "description": "BackgroundAlzheimer\u2019s disease (AD) is a neurodegenerative disorder, primarily affecting memory. That disorder is thought to be a consequence of neuronal network disturbances and synapse loss. Decline in cognitive function is associated with a high burden of neuropsychiatric symptoms (NPSs) such as depression. The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are essential second messengers that play a crucial role in memory processing as well as synaptic plasticity and are potential therapeutic targets. Biomarkers that are able to monitor potential treatment effects and that reflect the underlying pathology are of crucial interest.MethodsIn this study, we measured cGMP and cAMP in cerebrospinal fluid (CSF) in a cohort of 133 subjects including 68\u00a0AD patients and 65 control subjects. To address the association with disease progression we correlated cognitive status with cyclic nucleotide levels. Because a high burden of NPSs is associated with decrease in cognitive function, we performed an exhaustive evaluation of AD-relevant marker combinations in a depressive subgroup.ResultsWe show that cGMP, but not cAMP, levels in the CSF of AD patients are significantly reduced compared with the control group. Reduced cGMP levels in AD patients correlate with memory impairment based on Mini-Mental State Examination score (r\u2009=\u20090.17, p\u2009=\u20090.048) and tau as a marker of neurodegeneration (r\u2009=\u2009\u20130.28, p\u2009=\u20090.001). Moreover, we were able to show that AD patients suffering from current depression show reduced cGMP levels (p\u2009=\u20090.07) and exhibit a higher degree of cognitive impairment than non-depressed AD patients.ConclusionThese results provide further evidence for an involvement of cGMP in AD pathogenesis and accompanying co-morbidities, and may contribute to elucidating synaptic plasticity alterations during disease progression.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13195-017-0245-y", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1041797", 
        "issn": [
          "1758-9193"
        ], 
        "name": "Alzheimer's Research & Therapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "AD patients", 
      "neuropsychiatric symptoms", 
      "cerebrospinal fluid", 
      "cGMP levels", 
      "disease progression", 
      "high burden", 
      "non-depressed AD patients", 
      "cognitive function", 
      "Mini-Mental State Examination score", 
      "neuronal network disturbances", 
      "synaptic plasticity alterations", 
      "State Examination score", 
      "markers of neurodegeneration", 
      "severity of dementia", 
      "potential therapeutic target", 
      "involvement of cGMP", 
      "potential treatment effects", 
      "cyclic nucleotide levels", 
      "synapse loss", 
      "BackgroundAlzheimer\u2019s disease", 
      "control subjects", 
      "AD pathogenesis", 
      "depressive subgroups", 
      "therapeutic target", 
      "patients", 
      "current depression", 
      "control group", 
      "depression show", 
      "synaptic plasticity", 
      "memory impairment", 
      "cognitive impairment", 
      "cognitive status", 
      "ConclusionThese results", 
      "neurodegenerative disorders", 
      "cyclic guanosine", 
      "treatment effects", 
      "marker combinations", 
      "cGMP", 
      "examination scores", 
      "disease", 
      "impairment", 
      "progression", 
      "disorders", 
      "depression", 
      "memory processing", 
      "cyclic adenosine", 
      "burden", 
      "further evidence", 
      "essential second messenger", 
      "second messenger", 
      "subjects", 
      "nucleotide level", 
      "monophosphate", 
      "levels", 
      "pathogenesis", 
      "symptoms", 
      "cohort", 
      "dementia", 
      "MethodsIn", 
      "pathology", 
      "neurodegeneration", 
      "biomarkers", 
      "severity", 
      "ResultsWe", 
      "cAMP", 
      "subgroups", 
      "crucial role", 
      "scores", 
      "markers", 
      "adenosine", 
      "association", 
      "alterations", 
      "involvement", 
      "status", 
      "group", 
      "evidence", 
      "function", 
      "target", 
      "guanosine", 
      "messenger", 
      "plasticity", 
      "decrease", 
      "evaluation", 
      "study", 
      "role", 
      "high degree", 
      "loss", 
      "effect", 
      "disturbances", 
      "network disturbances", 
      "fluid", 
      "exhaustive evaluation", 
      "combination", 
      "consequences", 
      "degree", 
      "memory", 
      "results", 
      "crucial interest", 
      "interest", 
      "processing", 
      "show"
    ], 
    "name": "Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression", 
    "pagination": "17", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084252355"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13195-017-0245-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28274265"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13195-017-0245-y", 
      "https://app.dimensions.ai/details/publication/pub.1084252355"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_724.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13195-017-0245-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13195-017-0245-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13195-017-0245-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13195-017-0245-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13195-017-0245-y'


 

This table displays all metadata directly associated to this object as RDF triples.

349 TRIPLES      21 PREDICATES      152 URIs      135 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13195-017-0245-y schema:about N156dbbfb5e1e4fbab2dbc1e558465b50
2 N1e76ba7ac8004f2398d2b3ab58a1f836
3 N30ed390eae5a43f2a926e77e07fb8cd7
4 N455d76c1ae16475ba2d12fe5b8d4ba9d
5 N5d89b75a4a2f41c9843c4edc0ef16a93
6 N622dd5e4b5cb4949bff69aa6627590df
7 N69e4eaf5f5ff4ccd801fa4c6c1870ef0
8 N82ce07336d424b81a3c66fcf159d369e
9 N8d1c2a9b3a804ef4b9f9bf1a35b9d5eb
10 N97a28137db39427198bc2440e47085b1
11 Na8ce67de73fb4385b17e7071eaa3567f
12 Nb67c5b16139548df959a0d1088d36876
13 Nc30cf16b0db5406db5825474b6531f6b
14 Ne0031e76ce6a4ee3bfe844067cc0defb
15 Ne9cd729c69b645258c047987a88b8ef0
16 Nf77ec70dde8145978ec9f65b1abac39c
17 Nfface74045bb4a95b6ae2b846c2d5bb0
18 anzsrc-for:11
19 anzsrc-for:1103
20 anzsrc-for:1109
21 schema:author Nf4d1e72f29c24068a56bbfccf15a6fc1
22 schema:citation sg:pub.10.1007/978-3-540-68964-5_24
23 sg:pub.10.1007/bf00308809
24 sg:pub.10.1007/bf00427396
25 sg:pub.10.1007/bf01276464
26 sg:pub.10.1007/s12035-010-8104-x
27 sg:pub.10.1016/j.nurt.2010.03.006
28 sg:pub.10.1038/361031a0
29 sg:pub.10.1038/nrn2867
30 schema:datePublished 2017-03-09
31 schema:datePublishedReg 2017-03-09
32 schema:description BackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder, primarily affecting memory. That disorder is thought to be a consequence of neuronal network disturbances and synapse loss. Decline in cognitive function is associated with a high burden of neuropsychiatric symptoms (NPSs) such as depression. The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are essential second messengers that play a crucial role in memory processing as well as synaptic plasticity and are potential therapeutic targets. Biomarkers that are able to monitor potential treatment effects and that reflect the underlying pathology are of crucial interest.MethodsIn this study, we measured cGMP and cAMP in cerebrospinal fluid (CSF) in a cohort of 133 subjects including 68 AD patients and 65 control subjects. To address the association with disease progression we correlated cognitive status with cyclic nucleotide levels. Because a high burden of NPSs is associated with decrease in cognitive function, we performed an exhaustive evaluation of AD-relevant marker combinations in a depressive subgroup.ResultsWe show that cGMP, but not cAMP, levels in the CSF of AD patients are significantly reduced compared with the control group. Reduced cGMP levels in AD patients correlate with memory impairment based on Mini-Mental State Examination score (r = 0.17, p = 0.048) and tau as a marker of neurodegeneration (r = –0.28, p = 0.001). Moreover, we were able to show that AD patients suffering from current depression show reduced cGMP levels (p = 0.07) and exhibit a higher degree of cognitive impairment than non-depressed AD patients.ConclusionThese results provide further evidence for an involvement of cGMP in AD pathogenesis and accompanying co-morbidities, and may contribute to elucidating synaptic plasticity alterations during disease progression.
33 schema:genre article
34 schema:isAccessibleForFree true
35 schema:isPartOf N20a7e22c89db49bda3e788af2cd85980
36 N6d5b994f63e74f5ea695f4de0011b29b
37 sg:journal.1041797
38 schema:keywords AD pathogenesis
39 AD patients
40 BackgroundAlzheimer’s disease
41 ConclusionThese results
42 MethodsIn
43 Mini-Mental State Examination score
44 ResultsWe
45 State Examination score
46 adenosine
47 alterations
48 association
49 biomarkers
50 burden
51 cAMP
52 cGMP
53 cGMP levels
54 cerebrospinal fluid
55 cognitive function
56 cognitive impairment
57 cognitive status
58 cohort
59 combination
60 consequences
61 control group
62 control subjects
63 crucial interest
64 crucial role
65 current depression
66 cyclic adenosine
67 cyclic guanosine
68 cyclic nucleotide levels
69 decrease
70 degree
71 dementia
72 depression
73 depression show
74 depressive subgroups
75 disease
76 disease progression
77 disorders
78 disturbances
79 effect
80 essential second messenger
81 evaluation
82 evidence
83 examination scores
84 exhaustive evaluation
85 fluid
86 function
87 further evidence
88 group
89 guanosine
90 high burden
91 high degree
92 impairment
93 interest
94 involvement
95 involvement of cGMP
96 levels
97 loss
98 marker combinations
99 markers
100 markers of neurodegeneration
101 memory
102 memory impairment
103 memory processing
104 messenger
105 monophosphate
106 network disturbances
107 neurodegeneration
108 neurodegenerative disorders
109 neuronal network disturbances
110 neuropsychiatric symptoms
111 non-depressed AD patients
112 nucleotide level
113 pathogenesis
114 pathology
115 patients
116 plasticity
117 potential therapeutic target
118 potential treatment effects
119 processing
120 progression
121 results
122 role
123 scores
124 second messenger
125 severity
126 severity of dementia
127 show
128 status
129 study
130 subgroups
131 subjects
132 symptoms
133 synapse loss
134 synaptic plasticity
135 synaptic plasticity alterations
136 target
137 therapeutic target
138 treatment effects
139 schema:name Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression
140 schema:pagination 17
141 schema:productId Na37e2004d1ac478e9510fa5d25b6cf40
142 Na70b4a42faa0492d80de0d4f8596b3f9
143 Nb0e22f9e9ceb4087a5016f6deb273a2e
144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252355
145 https://doi.org/10.1186/s13195-017-0245-y
146 schema:sdDatePublished 2022-12-01T06:35
147 schema:sdLicense https://scigraph.springernature.com/explorer/license/
148 schema:sdPublisher N157af72aef3b4495b159cbb19de5ce1b
149 schema:url https://doi.org/10.1186/s13195-017-0245-y
150 sgo:license sg:explorer/license/
151 sgo:sdDataset articles
152 rdf:type schema:ScholarlyArticle
153 N156dbbfb5e1e4fbab2dbc1e558465b50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cohort Studies
155 rdf:type schema:DefinedTerm
156 N157af72aef3b4495b159cbb19de5ce1b schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 N1e76ba7ac8004f2398d2b3ab58a1f836 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Male
160 rdf:type schema:DefinedTerm
161 N20a7e22c89db49bda3e788af2cd85980 schema:issueNumber 1
162 rdf:type schema:PublicationIssue
163 N29b2682ca9874b098815edabee6fd06e rdf:first sg:person.0761531212.31
164 rdf:rest Nedb7c497363e46aea27976c29f5a3ebe
165 N30ed390eae5a43f2a926e77e07fb8cd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Depression
167 rdf:type schema:DefinedTerm
168 N455d76c1ae16475ba2d12fe5b8d4ba9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Alzheimer Disease
170 rdf:type schema:DefinedTerm
171 N4db61e510ac245b381da554d817142b4 rdf:first sg:person.0633152201.28
172 rdf:rest N9666f3d7dac04428a7d7ceb0cc5637c2
173 N5d89b75a4a2f41c9843c4edc0ef16a93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Peptide Fragments
175 rdf:type schema:DefinedTerm
176 N622dd5e4b5cb4949bff69aa6627590df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Female
178 rdf:type schema:DefinedTerm
179 N66f5c85977c143b8b5027ee50447fcfc rdf:first sg:person.013315234657.89
180 rdf:rest N29b2682ca9874b098815edabee6fd06e
181 N69e4eaf5f5ff4ccd801fa4c6c1870ef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Aged
183 rdf:type schema:DefinedTerm
184 N6d5b994f63e74f5ea695f4de0011b29b schema:volumeNumber 9
185 rdf:type schema:PublicationVolume
186 N82ce07336d424b81a3c66fcf159d369e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Middle Aged
188 rdf:type schema:DefinedTerm
189 N8d1c2a9b3a804ef4b9f9bf1a35b9d5eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Mental Status Schedule
191 rdf:type schema:DefinedTerm
192 N9666f3d7dac04428a7d7ceb0cc5637c2 rdf:first sg:person.0645302612.27
193 rdf:rest Nabd02a2a78b740908987c70aa213cbaf
194 N97a28137db39427198bc2440e47085b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Disease Progression
196 rdf:type schema:DefinedTerm
197 N9b273cf7d47d4ab888529dc59e838f34 rdf:first sg:person.013504627541.69
198 rdf:rest Nf13df27981164844a6d70b1000f284cc
199 Na37e2004d1ac478e9510fa5d25b6cf40 schema:name pubmed_id
200 schema:value 28274265
201 rdf:type schema:PropertyValue
202 Na70b4a42faa0492d80de0d4f8596b3f9 schema:name dimensions_id
203 schema:value pub.1084252355
204 rdf:type schema:PropertyValue
205 Na8ce67de73fb4385b17e7071eaa3567f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Biomarkers
207 rdf:type schema:DefinedTerm
208 Nabd02a2a78b740908987c70aa213cbaf rdf:first sg:person.0710516633.27
209 rdf:rest Ndcb998eb63c640cdba5d1bd33a23b7a6
210 Nb0e22f9e9ceb4087a5016f6deb273a2e schema:name doi
211 schema:value 10.1186/s13195-017-0245-y
212 rdf:type schema:PropertyValue
213 Nb67c5b16139548df959a0d1088d36876 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name tau Proteins
215 rdf:type schema:DefinedTerm
216 Nba63ed46029e411bb2411700ab10df0b rdf:first sg:person.0744507042.08
217 rdf:rest N4db61e510ac245b381da554d817142b4
218 Nc30cf16b0db5406db5825474b6531f6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Humans
220 rdf:type schema:DefinedTerm
221 Ndcb998eb63c640cdba5d1bd33a23b7a6 rdf:first sg:person.01216652756.98
222 rdf:rest N66f5c85977c143b8b5027ee50447fcfc
223 Ne0031e76ce6a4ee3bfe844067cc0defb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Amyloid beta-Peptides
225 rdf:type schema:DefinedTerm
226 Ne9cd729c69b645258c047987a88b8ef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Cyclic GMP
228 rdf:type schema:DefinedTerm
229 Nedb7c497363e46aea27976c29f5a3ebe rdf:first sg:person.010304274057.47
230 rdf:rest rdf:nil
231 Nf13df27981164844a6d70b1000f284cc rdf:first sg:person.01276714621.58
232 rdf:rest Nba63ed46029e411bb2411700ab10df0b
233 Nf13f21756ab04036b14ed1bd896ea79c rdf:first sg:person.01216600201.31
234 rdf:rest N9b273cf7d47d4ab888529dc59e838f34
235 Nf4d1e72f29c24068a56bbfccf15a6fc1 rdf:first sg:person.012111666541.76
236 rdf:rest Nf13f21756ab04036b14ed1bd896ea79c
237 Nf77ec70dde8145978ec9f65b1abac39c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
238 schema:name Cognition
239 rdf:type schema:DefinedTerm
240 Nfface74045bb4a95b6ae2b846c2d5bb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
241 schema:name Cyclic AMP
242 rdf:type schema:DefinedTerm
243 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
244 schema:name Medical and Health Sciences
245 rdf:type schema:DefinedTerm
246 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
247 schema:name Clinical Sciences
248 rdf:type schema:DefinedTerm
249 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
250 schema:name Neurosciences
251 rdf:type schema:DefinedTerm
252 sg:journal.1041797 schema:issn 1758-9193
253 schema:name Alzheimer's Research & Therapy
254 schema:publisher Springer Nature
255 rdf:type schema:Periodical
256 sg:person.010304274057.47 schema:affiliation grid-institutes:grid.6582.9
257 schema:familyName von Arnim
258 schema:givenName Christine A. F.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010304274057.47
260 rdf:type schema:Person
261 sg:person.012111666541.76 schema:affiliation grid-institutes:grid.6582.9
262 schema:familyName Hesse
263 schema:givenName Raphael
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012111666541.76
265 rdf:type schema:Person
266 sg:person.01216600201.31 schema:affiliation grid-institutes:grid.6582.9
267 schema:familyName Lausser
268 schema:givenName Ludwig
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216600201.31
270 rdf:type schema:Person
271 sg:person.01216652756.98 schema:affiliation grid-institutes:grid.6582.9
272 schema:familyName Tumani
273 schema:givenName Hayrettin
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216652756.98
275 rdf:type schema:Person
276 sg:person.01276714621.58 schema:affiliation grid-institutes:grid.6582.9
277 schema:familyName Schmid
278 schema:givenName Florian
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276714621.58
280 rdf:type schema:Person
281 sg:person.013315234657.89 schema:affiliation grid-institutes:grid.6582.9
282 schema:familyName Kestler
283 schema:givenName Hans A.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013315234657.89
285 rdf:type schema:Person
286 sg:person.013504627541.69 schema:affiliation grid-institutes:grid.6582.9
287 schema:familyName Gummert
288 schema:givenName Pauline
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013504627541.69
290 rdf:type schema:Person
291 sg:person.0633152201.28 schema:affiliation grid-institutes:grid.6582.9
292 schema:familyName Schnack
293 schema:givenName Cathrin
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633152201.28
295 rdf:type schema:Person
296 sg:person.0645302612.27 schema:affiliation grid-institutes:grid.420061.1
297 schema:familyName Kroker
298 schema:givenName Katja S.
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645302612.27
300 rdf:type schema:Person
301 sg:person.0710516633.27 schema:affiliation grid-institutes:grid.6582.9
302 schema:familyName Otto
303 schema:givenName Markus
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710516633.27
305 rdf:type schema:Person
306 sg:person.0744507042.08 schema:affiliation grid-institutes:grid.6582.9
307 schema:familyName Wahler
308 schema:givenName Anke
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744507042.08
310 rdf:type schema:Person
311 sg:person.0761531212.31 schema:affiliation grid-institutes:grid.420061.1
312 schema:familyName Rosenbrock
313 schema:givenName Holger
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761531212.31
315 rdf:type schema:Person
316 sg:pub.10.1007/978-3-540-68964-5_24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008438462
317 https://doi.org/10.1007/978-3-540-68964-5_24
318 rdf:type schema:CreativeWork
319 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
320 https://doi.org/10.1007/bf00308809
321 rdf:type schema:CreativeWork
322 sg:pub.10.1007/bf00427396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044844455
323 https://doi.org/10.1007/bf00427396
324 rdf:type schema:CreativeWork
325 sg:pub.10.1007/bf01276464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042509970
326 https://doi.org/10.1007/bf01276464
327 rdf:type schema:CreativeWork
328 sg:pub.10.1007/s12035-010-8104-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004478522
329 https://doi.org/10.1007/s12035-010-8104-x
330 rdf:type schema:CreativeWork
331 sg:pub.10.1016/j.nurt.2010.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033194220
332 https://doi.org/10.1016/j.nurt.2010.03.006
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/361031a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042608618
335 https://doi.org/10.1038/361031a0
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/nrn2867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031073156
338 https://doi.org/10.1038/nrn2867
339 rdf:type schema:CreativeWork
340 grid-institutes:grid.420061.1 schema:alternateName Department of CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany
341 Department of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany
342 schema:name Department of CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany
343 Department of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany
344 rdf:type schema:Organization
345 grid-institutes:grid.6582.9 schema:alternateName Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany
346 Institute of Medical Systems Biology, Ulm University, Ulm, Germany
347 schema:name Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany
348 Institute of Medical Systems Biology, Ulm University, Ulm, Germany
349 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...