Personalized approach in brain protection by hypothermia: individual changes in non-pathological and ischemia-related glutamate transport in brain nerve terminals View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Artem Pastukhov, Natalia Krisanova, Vitalii Maksymenko, Tatiana Borisova

ABSTRACT

BACKGROUND: Both deep and profound hypothermia are effectively applied in cardiac surgery of the aortic arch, when the reduction of cerebral circulation facilitates operations, and for the prevention of ischemic stroke consequences. Neurochemical discrimination of the effects of deep and profound hypothermia (27 and 17 °C, respectively) on non-pathological and pathological ischemia-related mechanisms of presynaptic glutamate transport with its potential contribution to predictive, preventive and personalized medicine (PPPM) was performed. METHODS: Experiments were conducted using nerve terminals isolated from rat cortex (synaptosomes). Glutamate transport in synaptosomes was analyzed using radiolabel l-[14C]glutamate. Diameter of synaptosomes was assessed by dynamic light scattering. RESULTS: Synaptosomal transporter-mediated uptake and tonic release of l-[14C]glutamate (oppositely directed processes, dynamic balance of which determines the physiological extracellular level of the neurotransmitter) decreased in a different range in deep/profound hypothermia. As a result, hypothermia-induced changes in extracellular l-[14C]glutamate are not evident (in one half of animals it increased, and in other it decreased). A progressive decrease from deep to profound hypothermia was shown for pathological mechanisms of presynaptic glutamate transport, that is, transporter-mediated l-[14C]glutamate release (*) stimulated by depolarization of the plasma membrane and (**) during dissipation of the proton gradient of synaptic vesicles by the protonophore FCCP. CONCLUSIONS: Therefore, the direction of hypothermia-induced changes in extracellular glutamate is unpredictable in "healthy" nerve terminals and depends on hypothermia sensitivity of uptake vs. tonic release. In affected nerve terminals (e.g., in brain regions suffering from a reduction of blood circulation during cardiac surgery, and core and penumbra zones of the insult), pathological transporter-mediated glutamate release from nerve terminals decreases with progressive significance from deep to profound hypothermia, thereby underlying its potent neuroprotective action. So, alterations in extracellular glutamate during hypothermia can be unique for each patient. An extent of a decrease in pathological glutamate transporter reversal depends on the size of damaged brain zone in each incident. Therefore, test parameters and clinical criteria of neuromonitoring for the evaluation of individual hypothermia-induced effects should be developed and delivered in practice in PPPM. More... »

PAGES

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13167-016-0075-1

DOI

http://dx.doi.org/10.1186/s13167-016-0075-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041693682

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27999623


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "The Department of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str, 01601, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pastukhov", 
        "givenName": "Artem", 
        "id": "sg:person.0642624225.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642624225.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "The Department of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str, 01601, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krisanova", 
        "givenName": "Natalia", 
        "id": "sg:person.0105352300.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105352300.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Technical University of Ukraine Kiev Polytechnic Institute", 
          "id": "https://www.grid.ac/institutes/grid.440544.5", 
          "name": [
            "Amosov Institute of Cardiovascular Surgery of the Academy of Medical Sciences of Ukraine, 6 N. Amosov Str, 03110, Kyiv, Ukraine", 
            "Faculty of Biomedical Engineering, National Technical University of Ukraine \u201cKPI\u201d, 16/2 Yangel Str, 56, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maksymenko", 
        "givenName": "Vitalii", 
        "id": "sg:person.010347072165.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347072165.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "The Department of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str, 01601, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borisova", 
        "givenName": "Tatiana", 
        "id": "sg:person.01230104173.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230104173.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.asr.2005.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000487602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.asr.2005.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000487602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10571-010-9532-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000770754", 
          "https://doi.org/10.1007/s10571-010-9532-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10571-010-9532-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000770754", 
          "https://doi.org/10.1007/s10571-010-9532-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.talanta.2014.12.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001113521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(00)00109-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003316994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.15.8733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003373976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-010-5756-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003400488", 
          "https://doi.org/10.1007/s00415-010-5756-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00839.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004697973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00839.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004697973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00839.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004697973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.26.041002.131412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008089791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.asr.2003.09.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008653419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-5728(01)00340-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011007891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2010.00873.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011081214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1878-5085-5-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014259711", 
          "https://doi.org/10.1186/1878-5085-5-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-0082(00)00067-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018189315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018530536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018530536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(03)00085-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018908959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(03)00085-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018908959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2008.10.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019432786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2003.01972.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022948485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-200110000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023092272", 
          "https://doi.org/10.1097/00004647-200110000-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-200110000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023092272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/989487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024749733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/295906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025748300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:nere.0000018847.98742.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026216448", 
          "https://doi.org/10.1023/b:nere.0000018847.98742.60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/174313209x444099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027780059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1331.2008.02321.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029880255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3325/cmj.2014.55.250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029913541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(74)31050-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030573040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.20.7.904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031942643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.45.31891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035620971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-2736(01)00301-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036936346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199607000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037935474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199607000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037935474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(86)90432-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038306758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.01166.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039492812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.asr.2008.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039581479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hs0102.100878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040904886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/iub.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042471821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/revneuro-2015-0044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044379208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-7759-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044993041", 
          "https://doi.org/10.1007/978-1-4614-7759-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-7759-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044993041", 
          "https://doi.org/10.1007/978-1-4614-7759-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-0186(03)00026-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045083078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000019910.90280.f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045807038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12951-016-0176-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047973410", 
          "https://doi.org/10.1186/s12951-016-0176-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/revneuro-2015-0023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049042502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10571-015-0321-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049742429", 
          "https://doi.org/10.1007/s10571-015-0321-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awm083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051464436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2010.00872.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051886203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002210050461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053250140", 
          "https://doi.org/10.1007/s002210050461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psychres.2005.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053258844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00207454.2012.751534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053471936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.1999.16.285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059299869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.27.5.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063341980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/2104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070914409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074849330", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3978/j.issn.2225-319x.2013.03.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078776437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1996.271.3.c863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082973122"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Both deep and profound hypothermia are effectively applied in cardiac surgery of the aortic arch, when the reduction of cerebral circulation facilitates operations, and for the prevention of ischemic stroke consequences. Neurochemical discrimination of the effects of deep and profound hypothermia (27 and 17 \u00b0C, respectively) on non-pathological and pathological ischemia-related mechanisms of presynaptic glutamate transport with its potential contribution to predictive, preventive and personalized medicine (PPPM) was performed.\nMETHODS: Experiments were conducted using nerve terminals isolated from rat cortex (synaptosomes). Glutamate transport in synaptosomes was analyzed using radiolabel l-[14C]glutamate. Diameter of synaptosomes was assessed by dynamic light scattering.\nRESULTS: Synaptosomal transporter-mediated uptake and tonic release of l-[14C]glutamate (oppositely directed processes, dynamic balance of which determines the physiological extracellular level of the neurotransmitter) decreased in a different range in deep/profound hypothermia. As a result, hypothermia-induced changes in extracellular l-[14C]glutamate are not evident (in one half of animals it increased, and in other it decreased). A progressive decrease from deep to profound hypothermia was shown for pathological mechanisms of presynaptic glutamate transport, that is, transporter-mediated l-[14C]glutamate release (*) stimulated by depolarization of the plasma membrane and (**) during dissipation of the proton gradient of synaptic vesicles by the protonophore FCCP.\nCONCLUSIONS: Therefore, the direction of hypothermia-induced changes in extracellular glutamate is unpredictable in \"healthy\" nerve terminals and depends on hypothermia sensitivity of uptake vs. tonic release. In affected nerve terminals (e.g., in brain regions suffering from a reduction of blood circulation during cardiac surgery, and core and penumbra zones of the insult), pathological transporter-mediated glutamate release from nerve terminals decreases with progressive significance from deep to profound hypothermia, thereby underlying its potent neuroprotective action. So, alterations in extracellular glutamate during hypothermia can be unique for each patient. An extent of a decrease in pathological glutamate transporter reversal depends on the size of damaged brain zone in each incident. Therefore, test parameters and clinical criteria of neuromonitoring for the evaluation of individual hypothermia-induced effects should be developed and delivered in practice in PPPM.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13167-016-0075-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042290", 
        "issn": [
          "1878-5077", 
          "1878-5085"
        ], 
        "name": "EPMA Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Personalized approach in brain protection by hypothermia: individual changes in non-pathological and ischemia-related glutamate transport in brain nerve terminals", 
    "pagination": "26", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c69c8349db5c305a152aee8d670fd936fabf84d0d2931eec3a2d1cc31d4e8f13"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27999623"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101517307"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13167-016-0075-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041693682"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13167-016-0075-1", 
      "https://app.dimensions.ai/details/publication/pub.1041693682"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70032_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13167-016-0075-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13167-016-0075-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13167-016-0075-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13167-016-0075-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13167-016-0075-1'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13167-016-0075-1 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nbe94cbfded1f437f8c28814638fa5923
4 schema:citation sg:pub.10.1007/978-1-4614-7759-4
5 sg:pub.10.1007/s002210050461
6 sg:pub.10.1007/s00415-010-5756-4
7 sg:pub.10.1007/s10571-010-9532-x
8 sg:pub.10.1007/s10571-015-0321-4
9 sg:pub.10.1023/b:nere.0000018847.98742.60
10 sg:pub.10.1097/00004647-200110000-00001
11 sg:pub.10.1186/1878-5085-5-2
12 sg:pub.10.1186/s12951-016-0176-y
13 https://app.dimensions.ai/details/publication/pub.1074849330
14 https://doi.org/10.1002/iub.98
15 https://doi.org/10.1016/0003-2697(86)90432-x
16 https://doi.org/10.1016/0076-6879(74)31050-6
17 https://doi.org/10.1016/j.asr.2003.09.039
18 https://doi.org/10.1016/j.asr.2005.10.007
19 https://doi.org/10.1016/j.asr.2008.04.012
20 https://doi.org/10.1016/j.athoracsur.2008.10.025
21 https://doi.org/10.1016/j.psychres.2005.08.023
22 https://doi.org/10.1016/j.talanta.2014.12.031
23 https://doi.org/10.1016/s0005-2736(01)00301-7
24 https://doi.org/10.1016/s0165-5728(01)00340-x
25 https://doi.org/10.1016/s0197-0186(03)00026-3
26 https://doi.org/10.1016/s0197-4580(03)00085-x
27 https://doi.org/10.1016/s0301-0082(00)00067-8
28 https://doi.org/10.1016/s0306-4522(00)00109-3
29 https://doi.org/10.1038/sj.jcbfm.9600039
30 https://doi.org/10.1046/j.1471-4159.2003.01972.x
31 https://doi.org/10.1073/pnas.96.15.8733
32 https://doi.org/10.1074/jbc.274.45.31891
33 https://doi.org/10.1089/neu.1999.16.285
34 https://doi.org/10.1093/brain/awm083
35 https://doi.org/10.1097/00000542-199607000-00022
36 https://doi.org/10.1097/00004647-200110000-00001
37 https://doi.org/10.1111/j.1468-1331.2008.02321.x
38 https://doi.org/10.1111/j.1476-5381.2010.00872.x
39 https://doi.org/10.1111/j.1476-5381.2010.00873.x
40 https://doi.org/10.1111/j.1747-4949.2012.00839.x
41 https://doi.org/10.1146/annurev.neuro.26.041002.131412
42 https://doi.org/10.1152/ajpcell.1996.271.3.c863
43 https://doi.org/10.1152/jn.01166.2003
44 https://doi.org/10.1155/2012/295906
45 https://doi.org/10.1155/2012/989487
46 https://doi.org/10.1161/01.str.0000019910.90280.f1
47 https://doi.org/10.1161/01.str.20.7.904
48 https://doi.org/10.1161/01.str.27.5.913
49 https://doi.org/10.1161/hs0102.100878
50 https://doi.org/10.1179/174313209x444099
51 https://doi.org/10.1515/revneuro-2015-0023
52 https://doi.org/10.1515/revneuro-2015-0044
53 https://doi.org/10.2741/2104
54 https://doi.org/10.3109/00207454.2012.751534
55 https://doi.org/10.3325/cmj.2014.55.250
56 https://doi.org/10.3978/j.issn.2225-319x.2013.03.01
57 schema:datePublished 2016-12
58 schema:datePublishedReg 2016-12-01
59 schema:description BACKGROUND: Both deep and profound hypothermia are effectively applied in cardiac surgery of the aortic arch, when the reduction of cerebral circulation facilitates operations, and for the prevention of ischemic stroke consequences. Neurochemical discrimination of the effects of deep and profound hypothermia (27 and 17 °C, respectively) on non-pathological and pathological ischemia-related mechanisms of presynaptic glutamate transport with its potential contribution to predictive, preventive and personalized medicine (PPPM) was performed. METHODS: Experiments were conducted using nerve terminals isolated from rat cortex (synaptosomes). Glutamate transport in synaptosomes was analyzed using radiolabel l-[14C]glutamate. Diameter of synaptosomes was assessed by dynamic light scattering. RESULTS: Synaptosomal transporter-mediated uptake and tonic release of l-[14C]glutamate (oppositely directed processes, dynamic balance of which determines the physiological extracellular level of the neurotransmitter) decreased in a different range in deep/profound hypothermia. As a result, hypothermia-induced changes in extracellular l-[14C]glutamate are not evident (in one half of animals it increased, and in other it decreased). A progressive decrease from deep to profound hypothermia was shown for pathological mechanisms of presynaptic glutamate transport, that is, transporter-mediated l-[14C]glutamate release (*) stimulated by depolarization of the plasma membrane and (**) during dissipation of the proton gradient of synaptic vesicles by the protonophore FCCP. CONCLUSIONS: Therefore, the direction of hypothermia-induced changes in extracellular glutamate is unpredictable in "healthy" nerve terminals and depends on hypothermia sensitivity of uptake vs. tonic release. In affected nerve terminals (e.g., in brain regions suffering from a reduction of blood circulation during cardiac surgery, and core and penumbra zones of the insult), pathological transporter-mediated glutamate release from nerve terminals decreases with progressive significance from deep to profound hypothermia, thereby underlying its potent neuroprotective action. So, alterations in extracellular glutamate during hypothermia can be unique for each patient. An extent of a decrease in pathological glutamate transporter reversal depends on the size of damaged brain zone in each incident. Therefore, test parameters and clinical criteria of neuromonitoring for the evaluation of individual hypothermia-induced effects should be developed and delivered in practice in PPPM.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N93476f991a1a4f49b2c882f53830f108
64 N9e633b6c58c14c4884ce97d72691b726
65 sg:journal.1042290
66 schema:name Personalized approach in brain protection by hypothermia: individual changes in non-pathological and ischemia-related glutamate transport in brain nerve terminals
67 schema:pagination 26
68 schema:productId N2142ed925db84b50b066de067a63c2be
69 N32a97ddbd21444c58ae7a37d35bf9231
70 N943cf5d8b414492297a8ae0b8e1ea3a6
71 Ndd25f3a4d3214ef48c1526e5bb5e2fd4
72 Nf93be2ac89df468aa182fddde97a50ef
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041693682
74 https://doi.org/10.1186/s13167-016-0075-1
75 schema:sdDatePublished 2019-04-11T12:37
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N8b95973ea7bd43fa8fc002f4797c2010
78 schema:url https://link.springer.com/10.1186%2Fs13167-016-0075-1
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N2142ed925db84b50b066de067a63c2be schema:name doi
83 schema:value 10.1186/s13167-016-0075-1
84 rdf:type schema:PropertyValue
85 N309bc32a1ac84da18107fe07ee244ce4 rdf:first sg:person.010347072165.10
86 rdf:rest Nef99e60e2a6f4b53b1d5fd6ef533f835
87 N32a97ddbd21444c58ae7a37d35bf9231 schema:name nlm_unique_id
88 schema:value 101517307
89 rdf:type schema:PropertyValue
90 N78c0c0acdab34f3fa6e136ffd7ba24e3 rdf:first sg:person.0105352300.44
91 rdf:rest N309bc32a1ac84da18107fe07ee244ce4
92 N8b95973ea7bd43fa8fc002f4797c2010 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N93476f991a1a4f49b2c882f53830f108 schema:issueNumber 1
95 rdf:type schema:PublicationIssue
96 N943cf5d8b414492297a8ae0b8e1ea3a6 schema:name readcube_id
97 schema:value c69c8349db5c305a152aee8d670fd936fabf84d0d2931eec3a2d1cc31d4e8f13
98 rdf:type schema:PropertyValue
99 N9e633b6c58c14c4884ce97d72691b726 schema:volumeNumber 7
100 rdf:type schema:PublicationVolume
101 Nbe94cbfded1f437f8c28814638fa5923 rdf:first sg:person.0642624225.43
102 rdf:rest N78c0c0acdab34f3fa6e136ffd7ba24e3
103 Ndd25f3a4d3214ef48c1526e5bb5e2fd4 schema:name dimensions_id
104 schema:value pub.1041693682
105 rdf:type schema:PropertyValue
106 Nef99e60e2a6f4b53b1d5fd6ef533f835 rdf:first sg:person.01230104173.60
107 rdf:rest rdf:nil
108 Nf93be2ac89df468aa182fddde97a50ef schema:name pubmed_id
109 schema:value 27999623
110 rdf:type schema:PropertyValue
111 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical and Health Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
115 schema:name Neurosciences
116 rdf:type schema:DefinedTerm
117 sg:journal.1042290 schema:issn 1878-5077
118 1878-5085
119 schema:name EPMA Journal
120 rdf:type schema:Periodical
121 sg:person.010347072165.10 schema:affiliation https://www.grid.ac/institutes/grid.440544.5
122 schema:familyName Maksymenko
123 schema:givenName Vitalii
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347072165.10
125 rdf:type schema:Person
126 sg:person.0105352300.44 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
127 schema:familyName Krisanova
128 schema:givenName Natalia
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105352300.44
130 rdf:type schema:Person
131 sg:person.01230104173.60 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
132 schema:familyName Borisova
133 schema:givenName Tatiana
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230104173.60
135 rdf:type schema:Person
136 sg:person.0642624225.43 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
137 schema:familyName Pastukhov
138 schema:givenName Artem
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642624225.43
140 rdf:type schema:Person
141 sg:pub.10.1007/978-1-4614-7759-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044993041
142 https://doi.org/10.1007/978-1-4614-7759-4
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/s002210050461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053250140
145 https://doi.org/10.1007/s002210050461
146 rdf:type schema:CreativeWork
147 sg:pub.10.1007/s00415-010-5756-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003400488
148 https://doi.org/10.1007/s00415-010-5756-4
149 rdf:type schema:CreativeWork
150 sg:pub.10.1007/s10571-010-9532-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000770754
151 https://doi.org/10.1007/s10571-010-9532-x
152 rdf:type schema:CreativeWork
153 sg:pub.10.1007/s10571-015-0321-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049742429
154 https://doi.org/10.1007/s10571-015-0321-4
155 rdf:type schema:CreativeWork
156 sg:pub.10.1023/b:nere.0000018847.98742.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026216448
157 https://doi.org/10.1023/b:nere.0000018847.98742.60
158 rdf:type schema:CreativeWork
159 sg:pub.10.1097/00004647-200110000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023092272
160 https://doi.org/10.1097/00004647-200110000-00001
161 rdf:type schema:CreativeWork
162 sg:pub.10.1186/1878-5085-5-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014259711
163 https://doi.org/10.1186/1878-5085-5-2
164 rdf:type schema:CreativeWork
165 sg:pub.10.1186/s12951-016-0176-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047973410
166 https://doi.org/10.1186/s12951-016-0176-y
167 rdf:type schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1074849330 schema:CreativeWork
169 https://doi.org/10.1002/iub.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042471821
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/0003-2697(86)90432-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038306758
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/0076-6879(74)31050-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030573040
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.asr.2003.09.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008653419
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.asr.2005.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000487602
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.asr.2008.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039581479
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.athoracsur.2008.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019432786
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.psychres.2005.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053258844
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.talanta.2014.12.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001113521
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/s0005-2736(01)00301-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036936346
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/s0165-5728(01)00340-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011007891
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/s0197-0186(03)00026-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045083078
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0197-4580(03)00085-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018908959
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0301-0082(00)00067-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018189315
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0306-4522(00)00109-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003316994
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1038/sj.jcbfm.9600039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018530536
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1046/j.1471-4159.2003.01972.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022948485
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1073/pnas.96.15.8733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003373976
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1074/jbc.274.45.31891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035620971
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1089/neu.1999.16.285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059299869
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1093/brain/awm083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051464436
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1097/00000542-199607000-00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037935474
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/00004647-200110000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023092272
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/j.1468-1331.2008.02321.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029880255
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1476-5381.2010.00872.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051886203
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1476-5381.2010.00873.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011081214
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1747-4949.2012.00839.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004697973
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1146/annurev.neuro.26.041002.131412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008089791
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1152/ajpcell.1996.271.3.c863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082973122
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1152/jn.01166.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039492812
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1155/2012/295906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025748300
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1155/2012/989487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024749733
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1161/01.str.0000019910.90280.f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045807038
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1161/01.str.20.7.904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031942643
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1161/01.str.27.5.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341980
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1161/hs0102.100878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040904886
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1179/174313209x444099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027780059
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1515/revneuro-2015-0023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049042502
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1515/revneuro-2015-0044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044379208
246 rdf:type schema:CreativeWork
247 https://doi.org/10.2741/2104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914409
248 rdf:type schema:CreativeWork
249 https://doi.org/10.3109/00207454.2012.751534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053471936
250 rdf:type schema:CreativeWork
251 https://doi.org/10.3325/cmj.2014.55.250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029913541
252 rdf:type schema:CreativeWork
253 https://doi.org/10.3978/j.issn.2225-319x.2013.03.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078776437
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.419966.5 schema:alternateName Palladin Institute of Biochemistry
256 schema:name The Department of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str, 01601, Kyiv, Ukraine
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.440544.5 schema:alternateName National Technical University of Ukraine Kiev Polytechnic Institute
259 schema:name Amosov Institute of Cardiovascular Surgery of the Academy of Medical Sciences of Ukraine, 6 N. Amosov Str, 03110, Kyiv, Ukraine
260 Faculty of Biomedical Engineering, National Technical University of Ukraine “KPI”, 16/2 Yangel Str, 56, Kyiv, Ukraine
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...