Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Zachariah Payne Sellers, Lukasz Bolkun, Janusz Kloczko, Marzena Liliana Wojtaszewska, Krzysztof Lewandowski, Marcin Moniuszko, Mariusz Z. Ratajczak, Gabriela Schneider

ABSTRACT

BACKGROUND: The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evidence implicates the imprinted genes from this locus, DLK1 and MEG3, in the development and progression of acute myeloid leukemia (AML). However, the contribution of this locus to the treatment response of patients and their survival is unknown. METHODS: DNA methylation of select CG dinucleotide-containing amplicons (CpG sites) within the DLK1-MEG3 locus and within differentially methylated regions of other imprinted loci was assessed in the mononuclear cells of 45 AML patients by combined bisulfite restriction analysis. Methylation results were compared with patient response to first-round induction therapy and overall survival. Multivariable analysis was employed to identify independent prognostic factors for patient overall survival in AML. RESULTS: Increased methylation at CpG sites within the MEG3 promotor region was observed in AML patients having longer overall survival. In addition, patients with shorter overall survival had increased expression of DLK1 and MEG3, and methylation at the MEG3-DMR CpG site inversely correlated with MEG3 expression. Multivariable analysis revealed that methylation at CG9, a non-imprinted CpG site within the MEG3 promotor region which contains a CCCTC-binding factor (CTCF)-binding DNA sequence, is an independent prognostic factor for the overall survival of AML patients. CONCLUSIONS: The results of our pilot study underscore the importance of the DLK1-MEG3 locus in AML development and progression. We identify CG9 methylation as an independent prognostic factor for AML patient survival, which suggests that distinct miRNA signatures from the DLK1-MEG3 locus could reflect varying degrees of cell stemness and present novel opportunities for personalized therapies in the future. These data provide a foundation for future studies into the role of higher-order chromatin structure at DLK1-MEG3 in AML. More... »

PAGES

50

References to SciGraph publications

  • 2017-08. Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation in LEUKEMIA
  • 2005-08. Dlk1 in normal and abnormal hematopoiesis in LEUKEMIA
  • 2009-11. Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4+ very small embryonic-like stem cells in LEUKEMIA
  • 2018-12. Analysis of the Paternally-Imprinted DLK1–MEG3 and IGF2–H19 Tandem Gene Loci in NT2 Embryonal Carcinoma Cells Identifies DLK1 as a Potential Therapeutic Target in STEM CELL REVIEWS AND REPORTS
  • 2004-04. Birth of parthenogenetic mice that can develop to adulthood in NATURE
  • 2010-05. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells in NATURE
  • 2015-06. Imprinted genes in myeloid lineage commitment in normal and malignant hematopoiesis in LEUKEMIA
  • 2008-02. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes in NATURE GENETICS
  • 2013-08. Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence in NATURE
  • 2017-12. Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways in LEUKEMIA
  • 2012-09. Specific small nucleolar RNA expression profiles in acute leukemia in LEUKEMIA
  • 2007-09. High-frequency generation of viable mice from engineered bi-maternal embryos in NATURE BIOTECHNOLOGY
  • 2005-06. Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation in ONCOGENE
  • 2018-12. H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia in CLINICAL EPIGENETICS
  • 2005-12. Allele-specific methylation of a functional CTCF binding site upstream of MEG3 in the human imprinted domain of 14q32 in CHROMOSOME RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13148-019-0643-z

    DOI

    http://dx.doi.org/10.1186/s13148-019-0643-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112771414

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30876483


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