Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

José García-Solano, María C. Turpin, Daniel Torres-Moreno, Francisco Huertas-López, Anne Tuomisto, Markus J. Mäkinen, Ana Conesa, Pablo Conesa-Zamora

ABSTRACT

BACKGROUND: Altered methylation patterns are driving forces in colorectal carcinogenesis. The serrated adenocarcinoma (SAC) and sporadic colorectal carcinoma showing histological and molecular features of microsatellite instability (hmMSI-H) are two endpoints of the so-called serrated pathological route sharing some characteristics but displaying a totally different immune response and clinical outcome. However, there are no studies comparing the methylome of these two subtypes of colorectal carcinomas. The methylation status of 450,000 CpG sites using the Infinium Human Methylation 450 BeadChip array was investigated in 48 colorectal specimens, including 39 SACs and 9 matched hmMSI-H. RESULTS: Microarray data comparing SAC and hmMSI-H showed an enrichment in functions related to morphogenesis, neurogenesis, cytoskeleton, metabolism, vesicle transport and immune response and also significant differential methylation of 1540 genes, including CD14 and HLA-DOA which were more methylated in hmMSI-H than in SAC and subsequently validated at the CpG, mRNA and protein level using pyrosequencing, quantitative polymerase chain reaction (qPCR) and immunohistochemistry. CONCLUSIONS: These results demonstrate particular epigenetic regulation patterns in SAC which may help to define key molecules responsible for the characteristic weak immune response of SAC and identify potential targets for treating SAC, which lacks molecular targeted therapy. More... »

PAGES

141

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13148-018-0571-3

DOI

http://dx.doi.org/10.1186/s13148-018-0571-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109798841

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30413173


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto Murciano de Investigaci\u00f3n Biosanitaria", 
          "id": "https://www.grid.ac/institutes/grid.452553.0", 
          "name": [
            "Department of Pathology, Santa Luc\u00eda General University Hospital (HGUSL), C/Mezquita s/n, 30202, Cartagena, Spain", 
            "Facultad de Ciencias de la Salud, Catholic University of Murcia (UCAM), Murcia, Spain", 
            "Instituto Murciano de Investigaciones Biosanitarias (IMIB), Murcia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Solano", 
        "givenName": "Jos\u00e9", 
        "id": "sg:person.01370571073.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370571073.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Carretera Pozuelo-Majadahonda km. 1.800 28223 Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turpin", 
        "givenName": "Mar\u00eda C.", 
        "id": "sg:person.01252376726.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252376726.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Santa Luc\u00eda General University Hospital (HGUSL), C/Mezquita s/n, 30202, Cartagena, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torres-Moreno", 
        "givenName": "Daniel", 
        "id": "sg:person.01303223230.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303223230.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida", 
          "id": "https://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Microbiology and Cell Sciences Department, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huertas-L\u00f3pez", 
        "givenName": "Francisco", 
        "id": "sg:person.010354543030.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010354543030.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oulu University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412326.0", 
          "name": [
            "Cancer and Translational Medicine Research Institute, Department of Pathology, and Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuomisto", 
        "givenName": "Anne", 
        "id": "sg:person.01005332143.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005332143.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oulu University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412326.0", 
          "name": [
            "Cancer and Translational Medicine Research Institute, Department of Pathology, and Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e4kinen", 
        "givenName": "Markus J.", 
        "id": "sg:person.0776032133.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776032133.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida", 
          "id": "https://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Microbiology and Cell Sciences Department, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA", 
            "Genomics of Gene Expression Laboratory, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain", 
            "Genetics Institute, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conesa", 
        "givenName": "Ana", 
        "id": "sg:person.0670774700.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670774700.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Murciano de Investigaci\u00f3n Biosanitaria", 
          "id": "https://www.grid.ac/institutes/grid.452553.0", 
          "name": [
            "Facultad de Ciencias de la Salud, Catholic University of Murcia (UCAM), Murcia, Spain", 
            "Instituto Murciano de Investigaciones Biosanitarias (IMIB), Murcia, Spain", 
            "Department of Clinical Chemistry, Santa Luc\u00eda General University Hospital (HGUSL), C/Mezquita s/n, 30202, Cartagena, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conesa-Zamora", 
        "givenName": "Pablo", 
        "id": "sg:person.0631147714.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631147714.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(87)90552-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000838677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2009.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004700411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.27454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005507866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2010.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010102811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014080321", 
          "https://doi.org/10.1038/nrc1165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014080321", 
          "https://doi.org/10.1038/nrc1165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000213313.36306.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015554142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000213313.36306.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015554142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2006.02548.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015892356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181bb6bdc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017042899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181bb6bdc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017042899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181bb6bdc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017042899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181bb6bdc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017042899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018860683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1850", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018934726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1850", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018934726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2011.03821.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019382355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2016.00560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020848368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.27674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021289068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00327-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025828788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00438-010-0522-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025932972", 
          "https://doi.org/10.1007/s00438-010-0522-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00438-010-0522-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025932972", 
          "https://doi.org/10.1007/s00438-010-0522-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.05.080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029569408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033764390", 
          "https://doi.org/10.1038/sj.onc.1209778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033764390", 
          "https://doi.org/10.1038/sj.onc.1209778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1440-1711.2005.01370.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033797339", 
          "https://doi.org/10.1111/j.1440-1711.2005.01370.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1711.2005.01370.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033797339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0021800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034510199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034923242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0141817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037554602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ajt.13509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038353557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039993829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2011.04043.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040254498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13148-015-0128-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040579369", 
          "https://doi.org/10.1186/s13148-015-0128-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044135237", 
          "https://doi.org/10.1038/75556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044135237", 
          "https://doi.org/10.1038/75556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-13-3198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045121239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-13-3198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045121239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-14-293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048954126", 
          "https://doi.org/10.1186/1471-2164-14-293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-3051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050762714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2012.07.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052388845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078408584", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10238-017-0455-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083743717", 
          "https://doi.org/10.1007/s10238-017-0455-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10238-017-0455-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083743717", 
          "https://doi.org/10.1007/s10238-017-0455-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000010019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101275933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000010019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101275933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000010019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101275933"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Altered methylation patterns are driving forces in colorectal carcinogenesis. The serrated adenocarcinoma (SAC) and sporadic colorectal carcinoma showing histological and molecular features of microsatellite instability (hmMSI-H) are two endpoints of the so-called serrated pathological route sharing some characteristics but displaying a totally different immune response and clinical outcome. However, there are no studies comparing the methylome of these two subtypes of colorectal carcinomas. The methylation status of 450,000 CpG sites using the Infinium Human Methylation 450 BeadChip array was investigated in 48 colorectal specimens, including 39 SACs and 9 matched hmMSI-H.\nRESULTS: Microarray data comparing SAC and hmMSI-H showed an enrichment in functions related to morphogenesis, neurogenesis, cytoskeleton, metabolism, vesicle transport and immune response and also significant differential methylation of 1540 genes, including CD14 and HLA-DOA which were more methylated in hmMSI-H than in SAC and subsequently validated at the CpG, mRNA and protein level using pyrosequencing, quantitative polymerase chain reaction (qPCR) and immunohistochemistry.\nCONCLUSIONS: These results demonstrate particular epigenetic regulation patterns in SAC which may help to define key molecules responsible for the characteristic weak immune response of SAC and identify potential targets for treating SAC, which lacks molecular targeted therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13148-018-0571-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042271", 
        "issn": [
          "1868-7075", 
          "1868-7083"
        ], 
        "name": "Clinical Epigenetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers", 
    "pagination": "141", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b5a88130a30dbf0830d8186c1518450e4cc8b198ed7462b3df729170db193bfe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30413173"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101516977"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13148-018-0571-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1109798841"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13148-018-0571-3", 
      "https://app.dimensions.ai/details/publication/pub.1109798841"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53977_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13148-018-0571-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13148-018-0571-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13148-018-0571-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13148-018-0571-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13148-018-0571-3'


 

This table displays all metadata directly associated to this object as RDF triples.

243 TRIPLES      21 PREDICATES      63 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13148-018-0571-3 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N7a85e5d1631145c3acb87f40b4924c01
4 schema:citation sg:pub.10.1007/s00438-010-0522-y
5 sg:pub.10.1007/s10238-017-0455-4
6 sg:pub.10.1038/75556
7 sg:pub.10.1038/nrc1165
8 sg:pub.10.1038/sj.onc.1209778
9 sg:pub.10.1111/j.1440-1711.2005.01370.x
10 sg:pub.10.1186/1471-2164-14-293
11 sg:pub.10.1186/s13148-015-0128-7
12 https://app.dimensions.ai/details/publication/pub.1078408584
13 https://doi.org/10.1002/ijc.27454
14 https://doi.org/10.1002/ijc.27674
15 https://doi.org/10.1002/path.1850
16 https://doi.org/10.1016/j.ejca.2009.04.011
17 https://doi.org/10.1016/j.humpath.2010.04.002
18 https://doi.org/10.1016/j.humpath.2012.07.020
19 https://doi.org/10.1016/s0140-6736(87)90552-6
20 https://doi.org/10.1053/j.gastro.2008.05.080
21 https://doi.org/10.1093/bioinformatics/bts680
22 https://doi.org/10.1093/nar/gkn318
23 https://doi.org/10.1097/01.pas.0000213313.36306.85
24 https://doi.org/10.1097/md.0000000000010019
25 https://doi.org/10.1097/pap.0b013e3181bb6bdc
26 https://doi.org/10.1111/ajt.13509
27 https://doi.org/10.1111/his.12055
28 https://doi.org/10.1111/j.1365-2559.2006.02548.x
29 https://doi.org/10.1111/j.1365-2559.2011.03821.x
30 https://doi.org/10.1111/j.1365-2559.2011.04043.x
31 https://doi.org/10.1111/j.1440-1711.2005.01370.x
32 https://doi.org/10.1128/mcb.00327-10
33 https://doi.org/10.1158/0008-5472.can-13-3198
34 https://doi.org/10.1158/0008-5472.can-14-3051
35 https://doi.org/10.1371/journal.pone.0021800
36 https://doi.org/10.1371/journal.pone.0141817
37 https://doi.org/10.3389/fimmu.2016.00560
38 schema:datePublished 2018-12
39 schema:datePublishedReg 2018-12-01
40 schema:description BACKGROUND: Altered methylation patterns are driving forces in colorectal carcinogenesis. The serrated adenocarcinoma (SAC) and sporadic colorectal carcinoma showing histological and molecular features of microsatellite instability (hmMSI-H) are two endpoints of the so-called serrated pathological route sharing some characteristics but displaying a totally different immune response and clinical outcome. However, there are no studies comparing the methylome of these two subtypes of colorectal carcinomas. The methylation status of 450,000 CpG sites using the Infinium Human Methylation 450 BeadChip array was investigated in 48 colorectal specimens, including 39 SACs and 9 matched hmMSI-H. RESULTS: Microarray data comparing SAC and hmMSI-H showed an enrichment in functions related to morphogenesis, neurogenesis, cytoskeleton, metabolism, vesicle transport and immune response and also significant differential methylation of 1540 genes, including CD14 and HLA-DOA which were more methylated in hmMSI-H than in SAC and subsequently validated at the CpG, mRNA and protein level using pyrosequencing, quantitative polymerase chain reaction (qPCR) and immunohistochemistry. CONCLUSIONS: These results demonstrate particular epigenetic regulation patterns in SAC which may help to define key molecules responsible for the characteristic weak immune response of SAC and identify potential targets for treating SAC, which lacks molecular targeted therapy.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N0c2205a6fe644f52a6a1e2a136087c20
45 N7873704921ac4e03bd05f4a403236962
46 sg:journal.1042271
47 schema:name Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers
48 schema:pagination 141
49 schema:productId N2fffcd0b081c4c0fb6f111b786d28133
50 N7d7fe9a4e85d464db075a6f892e18a43
51 N8ae32f6b54e643869b8a0147865a9f17
52 Na0557264711141a7add59c38e2facd26
53 Nc40b227a71254f42be7bde3a0b49646c
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109798841
55 https://doi.org/10.1186/s13148-018-0571-3
56 schema:sdDatePublished 2019-04-11T12:10
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N33fa73e2b3694af08b597b47678d1a59
59 schema:url https://link.springer.com/10.1186%2Fs13148-018-0571-3
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0b6f589571a9452a98bd4f9173473e1c rdf:first sg:person.0631147714.07
64 rdf:rest rdf:nil
65 N0c2205a6fe644f52a6a1e2a136087c20 schema:volumeNumber 10
66 rdf:type schema:PublicationVolume
67 N14825a1a8b32402b9609789941962be7 rdf:first sg:person.0776032133.81
68 rdf:rest N6040b653f0c2432b811817acf1f223ca
69 N2347d1324919456d80dc5985572c9d63 rdf:first sg:person.010354543030.46
70 rdf:rest Ncf09a17ef8c2479caa49d6cd13476778
71 N2fffcd0b081c4c0fb6f111b786d28133 schema:name pubmed_id
72 schema:value 30413173
73 rdf:type schema:PropertyValue
74 N33fa73e2b3694af08b597b47678d1a59 schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 N6040b653f0c2432b811817acf1f223ca rdf:first sg:person.0670774700.83
77 rdf:rest N0b6f589571a9452a98bd4f9173473e1c
78 N7873704921ac4e03bd05f4a403236962 schema:issueNumber 1
79 rdf:type schema:PublicationIssue
80 N7a85e5d1631145c3acb87f40b4924c01 rdf:first sg:person.01370571073.22
81 rdf:rest Ne229b9f3e6fc4825a51a003bdfb12fe3
82 N7d7fe9a4e85d464db075a6f892e18a43 schema:name doi
83 schema:value 10.1186/s13148-018-0571-3
84 rdf:type schema:PropertyValue
85 N8ae32f6b54e643869b8a0147865a9f17 schema:name dimensions_id
86 schema:value pub.1109798841
87 rdf:type schema:PropertyValue
88 N8f3fe50513154b1d857d5bbc7ecdfc37 rdf:first sg:person.01303223230.07
89 rdf:rest N2347d1324919456d80dc5985572c9d63
90 Na0557264711141a7add59c38e2facd26 schema:name nlm_unique_id
91 schema:value 101516977
92 rdf:type schema:PropertyValue
93 Nb30879a586584e7fa787113b4008fcc8 schema:name Department of Pathology, Santa Lucía General University Hospital (HGUSL), C/Mezquita s/n, 30202, Cartagena, Spain
94 rdf:type schema:Organization
95 Nc40b227a71254f42be7bde3a0b49646c schema:name readcube_id
96 schema:value b5a88130a30dbf0830d8186c1518450e4cc8b198ed7462b3df729170db193bfe
97 rdf:type schema:PropertyValue
98 Ncf09a17ef8c2479caa49d6cd13476778 rdf:first sg:person.01005332143.50
99 rdf:rest N14825a1a8b32402b9609789941962be7
100 Ne229b9f3e6fc4825a51a003bdfb12fe3 rdf:first sg:person.01252376726.33
101 rdf:rest N8f3fe50513154b1d857d5bbc7ecdfc37
102 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
103 schema:name Medical and Health Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
106 schema:name Immunology
107 rdf:type schema:DefinedTerm
108 sg:journal.1042271 schema:issn 1868-7075
109 1868-7083
110 schema:name Clinical Epigenetics
111 rdf:type schema:Periodical
112 sg:person.01005332143.50 schema:affiliation https://www.grid.ac/institutes/grid.412326.0
113 schema:familyName Tuomisto
114 schema:givenName Anne
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005332143.50
116 rdf:type schema:Person
117 sg:person.010354543030.46 schema:affiliation https://www.grid.ac/institutes/grid.15276.37
118 schema:familyName Huertas-López
119 schema:givenName Francisco
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010354543030.46
121 rdf:type schema:Person
122 sg:person.01252376726.33 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
123 schema:familyName Turpin
124 schema:givenName María C.
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252376726.33
126 rdf:type schema:Person
127 sg:person.01303223230.07 schema:affiliation Nb30879a586584e7fa787113b4008fcc8
128 schema:familyName Torres-Moreno
129 schema:givenName Daniel
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303223230.07
131 rdf:type schema:Person
132 sg:person.01370571073.22 schema:affiliation https://www.grid.ac/institutes/grid.452553.0
133 schema:familyName García-Solano
134 schema:givenName José
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370571073.22
136 rdf:type schema:Person
137 sg:person.0631147714.07 schema:affiliation https://www.grid.ac/institutes/grid.452553.0
138 schema:familyName Conesa-Zamora
139 schema:givenName Pablo
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631147714.07
141 rdf:type schema:Person
142 sg:person.0670774700.83 schema:affiliation https://www.grid.ac/institutes/grid.15276.37
143 schema:familyName Conesa
144 schema:givenName Ana
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670774700.83
146 rdf:type schema:Person
147 sg:person.0776032133.81 schema:affiliation https://www.grid.ac/institutes/grid.412326.0
148 schema:familyName Mäkinen
149 schema:givenName Markus J.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776032133.81
151 rdf:type schema:Person
152 sg:pub.10.1007/s00438-010-0522-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1025932972
153 https://doi.org/10.1007/s00438-010-0522-y
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s10238-017-0455-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083743717
156 https://doi.org/10.1007/s10238-017-0455-4
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/75556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044135237
159 https://doi.org/10.1038/75556
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/nrc1165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014080321
162 https://doi.org/10.1038/nrc1165
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/sj.onc.1209778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033764390
165 https://doi.org/10.1038/sj.onc.1209778
166 rdf:type schema:CreativeWork
167 sg:pub.10.1111/j.1440-1711.2005.01370.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033797339
168 https://doi.org/10.1111/j.1440-1711.2005.01370.x
169 rdf:type schema:CreativeWork
170 sg:pub.10.1186/1471-2164-14-293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048954126
171 https://doi.org/10.1186/1471-2164-14-293
172 rdf:type schema:CreativeWork
173 sg:pub.10.1186/s13148-015-0128-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040579369
174 https://doi.org/10.1186/s13148-015-0128-7
175 rdf:type schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1078408584 schema:CreativeWork
177 https://doi.org/10.1002/ijc.27454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005507866
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/ijc.27674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021289068
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1002/path.1850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018934726
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.ejca.2009.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004700411
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.humpath.2010.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010102811
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.humpath.2012.07.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052388845
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/s0140-6736(87)90552-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000838677
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1053/j.gastro.2008.05.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029569408
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1093/bioinformatics/bts680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034923242
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1093/nar/gkn318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039993829
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1097/01.pas.0000213313.36306.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015554142
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1097/md.0000000000010019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101275933
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1097/pap.0b013e3181bb6bdc schema:sameAs https://app.dimensions.ai/details/publication/pub.1017042899
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1111/ajt.13509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038353557
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1111/his.12055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018860683
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1111/j.1365-2559.2006.02548.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015892356
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/j.1365-2559.2011.03821.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019382355
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1111/j.1365-2559.2011.04043.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040254498
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/j.1440-1711.2005.01370.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033797339
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1128/mcb.00327-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025828788
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1158/0008-5472.can-13-3198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045121239
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1158/0008-5472.can-14-3051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050762714
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1371/journal.pone.0021800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034510199
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1371/journal.pone.0141817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037554602
224 rdf:type schema:CreativeWork
225 https://doi.org/10.3389/fimmu.2016.00560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020848368
226 rdf:type schema:CreativeWork
227 https://www.grid.ac/institutes/grid.15276.37 schema:alternateName University of Florida
228 schema:name Genetics Institute, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA
229 Genomics of Gene Expression Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain
230 Microbiology and Cell Sciences Department, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA
231 rdf:type schema:Organization
232 https://www.grid.ac/institutes/grid.412326.0 schema:alternateName Oulu University Hospital
233 schema:name Cancer and Translational Medicine Research Institute, Department of Pathology, and Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.449795.2 schema:alternateName Universidad Francisco de Vitoria
236 schema:name Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Carretera Pozuelo-Majadahonda km. 1.800 28223 Pozuelo de Alarcón, Madrid, Spain
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.452553.0 schema:alternateName Instituto Murciano de Investigación Biosanitaria
239 schema:name Department of Clinical Chemistry, Santa Lucía General University Hospital (HGUSL), C/Mezquita s/n, 30202, Cartagena, Spain
240 Department of Pathology, Santa Lucía General University Hospital (HGUSL), C/Mezquita s/n, 30202, Cartagena, Spain
241 Facultad de Ciencias de la Salud, Catholic University of Murcia (UCAM), Murcia, Spain
242 Instituto Murciano de Investigaciones Biosanitarias (IMIB), Murcia, Spain
243 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...