Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Paolo Boscolo-Rizzo, Carlo Furlan, Valentina Lupato, Jerry Polesel, Elisabetta Fratta

ABSTRACT

In the last years, the explosion of high throughput sequencing technologies has enabled epigenome-wide analyses, allowing a more comprehensive overview of the oropharyngeal squamous cell carcinoma (OPSCC) epigenetic landscape. In this setting, the cellular pathways contributing to the neoplastic phenotype, including cell cycle regulation, cell signaling, DNA repair, and apoptosis have been demonstrated to be potential targets of epigenetic alterations in OPSCC. Of note, it has becoming increasingly clear that HPV infection and OPSCC lifestyle risk factors differently drive the epigenetic machinery in cancer cells. Epigenetic changes, including DNA methylation, histone modifications, and non-coding RNA expression, can be used as powerful and reliable tools for early diagnosis of OPSCC patients and improve prognostication. Since epigenetic changes are dynamic and reversible, epigenetic enzymes may also represent suitable targets for the development of more effective OPSCC therapeutic strategies. Thus, this review will focus on the main known epigenetic modifications that can occur in OPSCC and their exploitation as potential biomarkers and therapeutic targets. Furthermore, we will address epigenetic alterations to OPSCC risk factors, with a particular focus on HPV infection, tobacco exposure, and heavy alcohol consumption. More... »

PAGES

124

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13148-017-0424-5

DOI

http://dx.doi.org/10.1186/s13148-017-0424-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1093037482

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29209433


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713 https://www.grid.ac/institutes/grid.418321.d schema:alternateName Centro di Riferimento Oncologico
714 schema:name Division of Radiotherapy, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano, PN, Italy
715 Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano, PN, Italy
716 Unit of Cancer Epidemiology, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano, PN, Italy
717 rdf:type schema:Organization
 




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