Predictive value of persistent NS1 antigen positivity beyond 3rd day for dengue haemorrhagic fever in Sri Lankan children. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Mihira Manamperi, Bernard Deepal Wanniarachchi Jayamanne, Thilini Somaratne, Natasha Perera, LakKumar Fernando

ABSTRACT

OBJECTIVE: Dengue haemorrhagic fever (DHF) is a major public health concern responsible for significant morbidity in both adult and paediatric populations in Sri Lanka. This study examined if persistent non structural protein 1 (NS1) antigen positivity beyond day 3 was predictive of the occurrence of dengue haemorrhagic fever. The patients were followed up during their in-hospital stay and the severity of the illness was classified according to the WHO classification. The NS1 antigen test was repeated after day 3 of the onset of illness, at least 2 days after the initial test. RESULTS: One hundred and fifty-seven patients were enrolled. Persistent NS1 antigen test positivity after day 3 of the illness was not predictive of subsequent development of DHF. Out of multiple other demographic and illness related factors assessed, only having a secondary dengue infection was associated with a high risk of DHF (relative risk = 3.077, 95% CI 1.361, 6.954). Persistent NS1 positivity on day 3 may not be indicative of disease severity. However results need to be confirmed by a larger study with quantitative NS1 testing. More... »

PAGES

214

References to SciGraph publications

  • 2014-12. Dengue NS1 antigen as a marker of severe clinical disease in BMC INFECTIOUS DISEASES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13104-019-4250-z

    DOI

    http://dx.doi.org/10.1186/s13104-019-4250-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113300265

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30961645


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