Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep). View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jens Peter Hansen, Manan Pareek, Allan Hvolby, Anne Schmedes, Tomas Toft, Erik Dahl, Connie Thurøe Nielsen

ABSTRACT

OBJECTIVE: To examine whether vitamin D supplementation in patients with depression would result in a reduction in Hamilton D-17 depression score (primary outcome) at 3 and 6 months compared to controls and to explore the correlations between serum vitamin D and symptoms of depression, wellbeing, systolic blood pressure, and waist circumference. In this outpatient multicentre study conducted between 2010 and 2013, patients, 18-65 years old, diagnosed with mild to severe depression were randomly assigned to receive D supplementation 70 micrograms daily or placebo on top of standard treatment. Participants, care givers and those assessing the outcomes were blinded to group assignment. RESULTS: At baseline, 23 patients had a normal 25(OH)D level, 22 had insufficiency (< 25 nmol/L), and 17 had deficiency (25-50 nmol/L). No significant reduction in depression was seen after vitamin D supplementation compared to placebo at Hamilton (18.4-18.0; p = 0.73 at 12 weeks). Vitamin D supplementation did not provide a reduction in symptom score among patients with depression. Trial registration The trial was registered in the National Board of Health (EudraCT: 2011-002585-20) and in ClinicalTrials.Gov (NCT01390662). More... »

PAGES

203

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13104-019-4218-z

DOI

http://dx.doi.org/10.1186/s13104-019-4218-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113181865

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30944021


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