Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSAndreas Lundt, Christina Henseler, Carola Wormuth, Julien Soos, Robin Seidel, Ralf Müller, Muhammad Imran Arshaad, Karl Broich, Jürgen Hescheler, Agapios Sachinidis, Dan Ehninger, Anna Papazoglou, Marco Weiergräber
ABSTRACTOBJECTIVES: Voltage-gated Ca2+ channels (VGCCs) are of central relevance in regulating Ca2+ influx into living cells. The low-voltage activated (LVA) Cav3 T-type Ca2+ channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Cav3.2 T-type Ca2+ channels seem to be of special importance as qPCR revealed a steady increase in Cav3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Cav3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Cav3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Cav3.2+/+, Cav3.2+/- and Cav3.2-/- mice from both genders which are of value for researchers who want to evaluate how Cav3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies. DATA DESCRIPTION: Information presented here includes ABR data from age-matched female and male Cav3.2+/+, Cav3.2+/- and Cav3.2-/- mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis. More... »
PAGES157
http://scigraph.springernature.com/pub.10.1186/s13104-019-4169-4
DOIhttp://dx.doi.org/10.1186/s13104-019-4169-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112897343
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30894204
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Lundt",
"givenName": "Andreas",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Henseler",
"givenName": "Christina",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Wormuth",
"givenName": "Carola",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Soos",
"givenName": "Julien",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Seidel",
"givenName": "Robin",
"type": "Person"
},
{
"affiliation": {
"name": [
"Cognitive Neurophysiology, Department of Psychiatry and Psychotherapy, University Hospital Cologne, University of Cologne, Faculty of Medicine, Kerpener Str. 62, 50937, Cologne, Germany"
],
"type": "Organization"
},
"familyName": "M\u00fcller",
"givenName": "Ralf",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Arshaad",
"givenName": "Muhammad Imran",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Broich",
"givenName": "Karl",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Cologne",
"id": "https://www.grid.ac/institutes/grid.6190.e",
"name": [
"Institute of Neurophysiology, University of Cologne, Faculty of Medicine, Robert-Koch-Str. 39, 50931, Cologne, Germany"
],
"type": "Organization"
},
"familyName": "Hescheler",
"givenName": "J\u00fcrgen",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Cologne",
"id": "https://www.grid.ac/institutes/grid.6190.e",
"name": [
"Institute of Neurophysiology, University of Cologne, Faculty of Medicine, Robert-Koch-Str. 39, 50931, Cologne, Germany"
],
"type": "Organization"
},
"familyName": "Sachinidis",
"givenName": "Agapios",
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Center for Neurodegenerative Diseases",
"id": "https://www.grid.ac/institutes/grid.424247.3",
"name": [
"Molecular and Cellular Cognition, German Center for Neurodegenerative Diseases (Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen, DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Ehninger",
"givenName": "Dan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Papazoglou",
"givenName": "Anna",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal Institute for Drugs and Medical Devices",
"id": "https://www.grid.ac/institutes/grid.414802.b",
"name": [
"Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Weiergr\u00e4ber",
"givenName": "Marco",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1126/science.1089268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062448531"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "OBJECTIVES: Voltage-gated Ca2+ channels (VGCCs) are of central relevance in regulating Ca2+ influx into living cells. The low-voltage activated (LVA) Cav3 T-type Ca2+ channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Cav3.2 T-type Ca2+ channels seem to be of special importance as qPCR revealed a steady increase in Cav3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Cav3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Cav3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Cav3.2+/+, Cav3.2+/- and Cav3.2-/- mice from both genders which are of value for researchers who want to evaluate how Cav3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies.\nDATA DESCRIPTION: Information presented here includes ABR data from age-matched female and male Cav3.2+/+, Cav3.2+/- and Cav3.2-/- mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis.",
"genre": "research_article",
"id": "sg:pub.10.1186/s13104-019-4169-4",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1039457",
"issn": [
"1756-0500"
],
"name": "BMC Research Notes",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "12"
}
],
"name": "Gender specific click and tone burst evoked ABR datasets from mice lacking the Cav3.2 T-type voltage-gated calcium channel",
"pagination": "157",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"45e9872573f4602fe0321e3a946f4d4b8b4f0e478db83917213cbfe214d6fddc"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30894204"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101462768"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13104-019-4169-4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112897343"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13104-019-4169-4",
"https://app.dimensions.ai/details/publication/pub.1112897343"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:53",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130805_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs13104-019-4169-4"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4169-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4169-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4169-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4169-4'
This table displays all metadata directly associated to this object as RDF triples.
151 TRIPLES
21 PREDICATES
30 URIs
21 LITERALS
9 BLANK NODES