INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Sung-Hwa Sohn, Bohyun Kim, Hee Jung Sul, Yoo Jin Kim, Hyeong Su Kim, Hongtae Kim, Jong Bok Seo, Youngho Koh, Dae Young Zang

ABSTRACT

OBJECTIVE: Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in gastric cancer. We showed that decreased levels of RUNX3 are significantly associated with c-MET (r = - 0.4216, P = 0.0130). In addition, c-MET expression is a candidate for targeted therapy in gastric cancer. Therefore, in the present study, the anti-cancer effects of the c-MET inhibitor on gastric cancer cells from positive or negative for c-MET amplification were evaluated. RESULTS: INC280 treatment inhibits growth of a c-MET-amplified MKN45 (RUNX3-positive) and SNU620 (RUNX3-negative) diffuse type cells. Then, INC280 showed the highest inhibition and apoptotic rates with the lowest IC50s in MKN45 cells but not in c-MET-reduced MKN28 (intestinal type) cells. We also showed that INC280 inhibits the WNT signaling pathway and SNAIL expression in MKN45 cells. The data indicate that INC280 could be used as therapeutic agents for the prevention or treatment of diffuse gastric cancer positive for c-MET amplification. More... »

PAGES

125

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13104-019-4163-x

DOI

http://dx.doi.org/10.1186/s13104-019-4163-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112761394

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30871613


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hallym University Sacred Heart Hospital", 
          "id": "https://www.grid.ac/institutes/grid.488421.3", 
          "name": [
            "Hallym Translational Research Institute, Hallym University Sacred Heart Hospital, 14066, Anyang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sohn", 
        "givenName": "Sung-Hwa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hallym University Sacred Heart Hospital", 
          "id": "https://www.grid.ac/institutes/grid.488421.3", 
          "name": [
            "Hallym Translational Research Institute, Hallym University Sacred Heart Hospital, 14066, Anyang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Bohyun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hallym University Sacred Heart Hospital", 
          "id": "https://www.grid.ac/institutes/grid.488421.3", 
          "name": [
            "Hallym Translational Research Institute, Hallym University Sacred Heart Hospital, 14066, Anyang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sul", 
        "givenName": "Hee Jung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hallym University Sacred Heart Hospital", 
          "id": "https://www.grid.ac/institutes/grid.488421.3", 
          "name": [
            "Hallym Translational Research Institute, Hallym University Sacred Heart Hospital, 14066, Anyang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yoo Jin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Hematology-Oncology, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, 14086, Anyang-si, Gyeonggi-do, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyeong Su", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ulsan National Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.42687.3f", 
          "name": [
            "School of Life Sciences, Ulsan National Institute of Science and Technology, 689-798, Ulsan, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hongtae", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Korea Basic Research Institute Seoul Center, 02855, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seo", 
        "givenName": "Jong Bok", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hallym University", 
          "id": "https://www.grid.ac/institutes/grid.256753.0", 
          "name": [
            "Department of Bio-medical Gerontology, Ilsong Institute of Life Sciences, Hallym University, 14066, Anyang, Gyeonggi-do, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koh", 
        "givenName": "Youngho", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hallym University Sacred Heart Hospital", 
          "id": "https://www.grid.ac/institutes/grid.488421.3", 
          "name": [
            "Hallym Translational Research Institute, Hallym University Sacred Heart Hospital, 14066, Anyang, Republic of Korea", 
            "Division of Hematology-Oncology, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, 14086, Anyang-si, Gyeonggi-do, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zang", 
        "givenName": "Dae Young", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000859355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4143/crt.2014.46.2.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001643120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002152379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002152379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002765826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-10-1080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004233662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e328364f2b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007526083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e328364f2b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007526083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.7517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008544199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2016.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011210397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-0500-7-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012684213", 
          "https://doi.org/10.1186/1756-0500-7-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2011.01.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017157353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.995802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027449778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114516002518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028594764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199812)23:4<307::aid-gcc5>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031426743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.35.4928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036678166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2014.01.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037772382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00690-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038516403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ott.s40241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042887325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(92)91548-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043687980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-2457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044411597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0508776103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050433384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051533186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078308578", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078853343", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079021326", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079216508", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010428317712617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090389173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010428317712617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090389173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.19398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090843901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.19398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092695130"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "OBJECTIVE: Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in gastric cancer. We showed that decreased levels of RUNX3 are significantly associated with c-MET (r\u2009=\u2009-\u20090.4216, P\u2009=\u20090.0130). In addition, c-MET expression is a candidate for targeted therapy in gastric cancer. Therefore, in the present study, the anti-cancer effects of the c-MET inhibitor on gastric cancer cells from positive or negative for c-MET amplification were evaluated.\nRESULTS: INC280 treatment inhibits growth of a c-MET-amplified MKN45 (RUNX3-positive) and SNU620 (RUNX3-negative) diffuse type cells. Then, INC280 showed the highest inhibition and apoptotic rates with the lowest IC50s in MKN45 cells but not in c-MET-reduced MKN28 (intestinal type) cells. We also showed that INC280 inhibits the WNT signaling pathway and SNAIL expression in MKN45 cells. The data indicate that INC280 could be used as therapeutic agents for the prevention or treatment of diffuse gastric cancer positive for c-MET amplification.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13104-019-4163-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1039457", 
        "issn": [
          "1756-0500"
        ], 
        "name": "BMC Research Notes", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "INC280 inhibits Wnt/\u03b2-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification", 
    "pagination": "125", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "49321b1f2223df4be393fc02028ed0255e030dc80e7e81907e689135088624cf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30871613"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101462768"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13104-019-4163-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112761394"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13104-019-4163-x", 
      "https://app.dimensions.ai/details/publication/pub.1112761394"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78950_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13104-019-4163-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4163-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4163-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4163-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13104-019-4163-x'


 

This table displays all metadata directly associated to this object as RDF triples.

205 TRIPLES      21 PREDICATES      56 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13104-019-4163-x schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nf7115dadb54341528b988c66dd11ac57
4 schema:citation sg:pub.10.1186/1756-0500-7-6
5 https://app.dimensions.ai/details/publication/pub.1078308578
6 https://app.dimensions.ai/details/publication/pub.1078853343
7 https://app.dimensions.ai/details/publication/pub.1079021326
8 https://app.dimensions.ai/details/publication/pub.1079216508
9 https://doi.org/10.1002/(sici)1098-2264(199812)23:4<307::aid-gcc5>3.0.co;2-#
10 https://doi.org/10.1002/stem.1183
11 https://doi.org/10.1006/bbrc.1997.7517
12 https://doi.org/10.1016/0006-291x(92)91548-5
13 https://doi.org/10.1016/j.clon.2016.01.009
14 https://doi.org/10.1016/j.ejca.2014.01.029
15 https://doi.org/10.1016/s0092-8674(02)00690-6
16 https://doi.org/10.1017/s0007114516002518
17 https://doi.org/10.1053/j.gastro.2011.01.043
18 https://doi.org/10.1073/pnas.0508776103
19 https://doi.org/10.1093/hmg/ddi373
20 https://doi.org/10.1097/cej.0b013e328364f2b6
21 https://doi.org/10.1101/gad.995802
22 https://doi.org/10.1158/0008-5472.can-06-0410
23 https://doi.org/10.1158/0008-5472.can-08-2457
24 https://doi.org/10.1158/1055-9965.epi-10-1080
25 https://doi.org/10.1158/1078-0432.ccr-11-1157
26 https://doi.org/10.1177/1010428317712617
27 https://doi.org/10.1200/jco.2011.35.4928
28 https://doi.org/10.18632/oncotarget.19398
29 https://doi.org/10.2147/ott.s40241
30 https://doi.org/10.4143/crt.2014.46.2.109
31 schema:datePublished 2019-12
32 schema:datePublishedReg 2019-12-01
33 schema:description OBJECTIVE: Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in gastric cancer. We showed that decreased levels of RUNX3 are significantly associated with c-MET (r = - 0.4216, P = 0.0130). In addition, c-MET expression is a candidate for targeted therapy in gastric cancer. Therefore, in the present study, the anti-cancer effects of the c-MET inhibitor on gastric cancer cells from positive or negative for c-MET amplification were evaluated. RESULTS: INC280 treatment inhibits growth of a c-MET-amplified MKN45 (RUNX3-positive) and SNU620 (RUNX3-negative) diffuse type cells. Then, INC280 showed the highest inhibition and apoptotic rates with the lowest IC50s in MKN45 cells but not in c-MET-reduced MKN28 (intestinal type) cells. We also showed that INC280 inhibits the WNT signaling pathway and SNAIL expression in MKN45 cells. The data indicate that INC280 could be used as therapeutic agents for the prevention or treatment of diffuse gastric cancer positive for c-MET amplification.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N7d2bddc66f194c35b7d9782256ec21ed
38 N8e9f700eda8b425196057557a392360b
39 sg:journal.1039457
40 schema:name INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification
41 schema:pagination 125
42 schema:productId N13b576792ea044e2b2d2688d37c85dec
43 N446312515f5d42ebbab9ed3af85d8d7c
44 N922dbbbfa85240f2a795fcc7d9ef2c8e
45 Ncbd9511095004da79d2f633da0d5651b
46 Ne4ee36cadde34cdb85035cc9ea280ebb
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112761394
48 https://doi.org/10.1186/s13104-019-4163-x
49 schema:sdDatePublished 2019-04-11T13:19
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Ne42e0001432d4526bd5c3dd0937572ee
52 schema:url https://link.springer.com/10.1186%2Fs13104-019-4163-x
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N0e7beaab1d44450b91f0afeed7a8ad12 schema:affiliation Ncc4523651c954aedb934cd4359f0c6f3
57 schema:familyName Seo
58 schema:givenName Jong Bok
59 rdf:type schema:Person
60 N13b576792ea044e2b2d2688d37c85dec schema:name dimensions_id
61 schema:value pub.1112761394
62 rdf:type schema:PropertyValue
63 N1b136ae35d5e4a7fa87904db2ba382f0 schema:affiliation https://www.grid.ac/institutes/grid.42687.3f
64 schema:familyName Kim
65 schema:givenName Hongtae
66 rdf:type schema:Person
67 N1b8f275a9b93430b85b3f4fec65b292e rdf:first N0e7beaab1d44450b91f0afeed7a8ad12
68 rdf:rest Nd7a3673898f2482c86af43fd39af254b
69 N2075aff5f0a24bb2bf924e463832ca97 schema:name Division of Hematology-Oncology, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, 14086, Anyang-si, Gyeonggi-do, Republic of Korea
70 rdf:type schema:Organization
71 N3efdb3905ad541b3990c6420fad926e1 schema:affiliation N2075aff5f0a24bb2bf924e463832ca97
72 schema:familyName Kim
73 schema:givenName Hyeong Su
74 rdf:type schema:Person
75 N446312515f5d42ebbab9ed3af85d8d7c schema:name readcube_id
76 schema:value 49321b1f2223df4be393fc02028ed0255e030dc80e7e81907e689135088624cf
77 rdf:type schema:PropertyValue
78 N45dd6c96d7f64ddda5d2081526aa53eb rdf:first Nb6fa8c11918649a986f651a9dbb45b53
79 rdf:rest rdf:nil
80 N54261dfb2c124540bb855913922a57b7 rdf:first N559402441773421ea4df95773484d405
81 rdf:rest N7fb93218ce0449fd9ef3f3a1ce99b2cc
82 N559402441773421ea4df95773484d405 schema:affiliation https://www.grid.ac/institutes/grid.488421.3
83 schema:familyName Sul
84 schema:givenName Hee Jung
85 rdf:type schema:Person
86 N5c2f17582eb44ad3af055804e015a5d4 schema:affiliation https://www.grid.ac/institutes/grid.488421.3
87 schema:familyName Sohn
88 schema:givenName Sung-Hwa
89 rdf:type schema:Person
90 N7d2bddc66f194c35b7d9782256ec21ed schema:volumeNumber 12
91 rdf:type schema:PublicationVolume
92 N7fb93218ce0449fd9ef3f3a1ce99b2cc rdf:first Nf30f5a64f57448358d903c5a1a902663
93 rdf:rest Nbd5ed8c08b7f474a8b194dde46e854e1
94 N8aa8bdd5860d4f3f922c86e122230e9b schema:affiliation https://www.grid.ac/institutes/grid.256753.0
95 schema:familyName Koh
96 schema:givenName Youngho
97 rdf:type schema:Person
98 N8e9f700eda8b425196057557a392360b schema:issueNumber 1
99 rdf:type schema:PublicationIssue
100 N922dbbbfa85240f2a795fcc7d9ef2c8e schema:name pubmed_id
101 schema:value 30871613
102 rdf:type schema:PropertyValue
103 N9ac519706d5745d6b034555ca4838f58 rdf:first N1b136ae35d5e4a7fa87904db2ba382f0
104 rdf:rest N1b8f275a9b93430b85b3f4fec65b292e
105 Nb6fa8c11918649a986f651a9dbb45b53 schema:affiliation https://www.grid.ac/institutes/grid.488421.3
106 schema:familyName Zang
107 schema:givenName Dae Young
108 rdf:type schema:Person
109 Nbd5ed8c08b7f474a8b194dde46e854e1 rdf:first N3efdb3905ad541b3990c6420fad926e1
110 rdf:rest N9ac519706d5745d6b034555ca4838f58
111 Nc2cbb581dbc440989d029dba6055bff5 rdf:first Nf2cf4a79940e4c6799656b3bce6b83c5
112 rdf:rest N54261dfb2c124540bb855913922a57b7
113 Ncbd9511095004da79d2f633da0d5651b schema:name nlm_unique_id
114 schema:value 101462768
115 rdf:type schema:PropertyValue
116 Ncc4523651c954aedb934cd4359f0c6f3 schema:name Korea Basic Research Institute Seoul Center, 02855, Seoul, Republic of Korea
117 rdf:type schema:Organization
118 Nd7a3673898f2482c86af43fd39af254b rdf:first N8aa8bdd5860d4f3f922c86e122230e9b
119 rdf:rest N45dd6c96d7f64ddda5d2081526aa53eb
120 Ne42e0001432d4526bd5c3dd0937572ee schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 Ne4ee36cadde34cdb85035cc9ea280ebb schema:name doi
123 schema:value 10.1186/s13104-019-4163-x
124 rdf:type schema:PropertyValue
125 Nf2cf4a79940e4c6799656b3bce6b83c5 schema:affiliation https://www.grid.ac/institutes/grid.488421.3
126 schema:familyName Kim
127 schema:givenName Bohyun
128 rdf:type schema:Person
129 Nf30f5a64f57448358d903c5a1a902663 schema:affiliation https://www.grid.ac/institutes/grid.488421.3
130 schema:familyName Kim
131 schema:givenName Yoo Jin
132 rdf:type schema:Person
133 Nf7115dadb54341528b988c66dd11ac57 rdf:first N5c2f17582eb44ad3af055804e015a5d4
134 rdf:rest Nc2cbb581dbc440989d029dba6055bff5
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
139 schema:name Oncology and Carcinogenesis
140 rdf:type schema:DefinedTerm
141 sg:journal.1039457 schema:issn 1756-0500
142 schema:name BMC Research Notes
143 rdf:type schema:Periodical
144 sg:pub.10.1186/1756-0500-7-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012684213
145 https://doi.org/10.1186/1756-0500-7-6
146 rdf:type schema:CreativeWork
147 https://app.dimensions.ai/details/publication/pub.1078308578 schema:CreativeWork
148 https://app.dimensions.ai/details/publication/pub.1078853343 schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1079021326 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1079216508 schema:CreativeWork
151 https://doi.org/10.1002/(sici)1098-2264(199812)23:4<307::aid-gcc5>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1031426743
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1002/stem.1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002765826
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1006/bbrc.1997.7517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008544199
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/0006-291x(92)91548-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043687980
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.clon.2016.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011210397
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.ejca.2014.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037772382
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/s0092-8674(02)00690-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038516403
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1017/s0007114516002518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028594764
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1053/j.gastro.2011.01.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017157353
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1073/pnas.0508776103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050433384
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1093/hmg/ddi373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002152379
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1097/cej.0b013e328364f2b6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007526083
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1101/gad.995802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027449778
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1158/0008-5472.can-06-0410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000859355
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1158/0008-5472.can-08-2457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044411597
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1158/1055-9965.epi-10-1080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004233662
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1158/1078-0432.ccr-11-1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051533186
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1177/1010428317712617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090389173
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1200/jco.2011.35.4928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036678166
188 rdf:type schema:CreativeWork
189 https://doi.org/10.18632/oncotarget.19398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090843901
190 https://app.dimensions.ai/details/publication/pub.1092695130
191 rdf:type schema:CreativeWork
192 https://doi.org/10.2147/ott.s40241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042887325
193 rdf:type schema:CreativeWork
194 https://doi.org/10.4143/crt.2014.46.2.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001643120
195 rdf:type schema:CreativeWork
196 https://www.grid.ac/institutes/grid.256753.0 schema:alternateName Hallym University
197 schema:name Department of Bio-medical Gerontology, Ilsong Institute of Life Sciences, Hallym University, 14066, Anyang, Gyeonggi-do, Republic of Korea
198 rdf:type schema:Organization
199 https://www.grid.ac/institutes/grid.42687.3f schema:alternateName Ulsan National Institute of Science and Technology
200 schema:name School of Life Sciences, Ulsan National Institute of Science and Technology, 689-798, Ulsan, Republic of Korea
201 rdf:type schema:Organization
202 https://www.grid.ac/institutes/grid.488421.3 schema:alternateName Hallym University Sacred Heart Hospital
203 schema:name Division of Hematology-Oncology, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, 14086, Anyang-si, Gyeonggi-do, Republic of Korea
204 Hallym Translational Research Institute, Hallym University Sacred Heart Hospital, 14066, Anyang, Republic of Korea
205 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...