Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Vesela Encheva, Clémence Foltz, Ambrosius P. Snijders, Eva-Maria Frickel

ABSTRACT

OBJECTIVE: The intracellular parasite Toxoplasma gondii can invade any nucleated cell residing inside a parasitophorous vacuole (PV). Upon infection, the cytokine interferon gamma (IFNγ) is produced and elicits host defence mechanisms able to recognise the PV and destroy the parasite. Hereby, Guanylate binding proteins, ubiquitin and the E3 ubiquitin ligases Tripartite Motif Containing 21 (TRIM21) and TNF receptor associated factor 6 are targeted to the murine PV leading to its destruction. This study is the side product of research aiming to identify ubiquitinated substrates in a TRIM21-dependent fashion in murine cells infected with Toxoplasma. RESULTS: We infected IFNγ-stimulated murine embryonic fibroblasts (MEFs) from either C57BL/6×129 wild-type (WT) mice or C57BL/6 TRIM21-/- mice with Toxoplasma. Using mass spectrometry, we analysed proteins in both cell backgrounds presenting with the di-glycine remnant of ubiquitination. In addition, we compared peptide levels between WT and TRIM21-/- cells. In line with earlier reports, Gbp1 was expressed to higher levels in the C57BL/6×129 WT MEFs compared to the C57BL/6-only background TRIM21-/- MEFs. Protein expression differences in these different murine backgrounds thus precluded identification of TRIM21-dependent ubiquitinated substrates. Nevertheless, we identified and confirmed Gbp1 and Gbp2 as being ubiquitinated in a Toxoplasma-infection independent manner. More... »

PAGES

166

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13104-018-3267-z

DOI

http://dx.doi.org/10.1186/s13104-018-3267-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101356823

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29510761


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toxoplasmosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitination", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Mass Spectrometry and Proteomics Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Encheva", 
        "givenName": "Vesela", 
        "id": "sg:person.0711254207.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711254207.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Host-Toxoplasma Interaction Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foltz", 
        "givenName": "Cl\u00e9mence", 
        "id": "sg:person.01116613701.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116613701.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Mass Spectrometry and Proteomics Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Snijders", 
        "givenName": "Ambrosius P.", 
        "id": "sg:person.01341405243.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341405243.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Host-Toxoplasma Interaction Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frickel", 
        "givenName": "Eva-Maria", 
        "id": "sg:person.01266246531.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266246531.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007816708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2012.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019426318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2010.00992.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022618702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1515966112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025662278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.01157-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027267327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027597437", 
          "https://doi.org/10.1038/nbt.2839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16412-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030211666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.1.5271.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031708123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1006027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032073292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(84)90016-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034265942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0804121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036144757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0024434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039030606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.9.4717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041872390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.251967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043299302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046526437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.183954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047308281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.11.7729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048058697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.o112.027094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049624550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.04.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050551967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.04.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050551967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00347-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052505852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083258432", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-05487-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090546650", 
          "https://doi.org/10.1038/s41598-017-05487-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature24467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092185083", 
          "https://doi.org/10.1038/nature24467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature24467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092185083", 
          "https://doi.org/10.1038/nature24467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature24467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092185083", 
          "https://doi.org/10.1038/nature24467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2017.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092185178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.01979-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099597679"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "OBJECTIVE: The intracellular parasite Toxoplasma gondii can invade any nucleated cell residing inside a parasitophorous vacuole (PV). Upon infection, the cytokine interferon gamma (IFN\u03b3) is produced and elicits host defence mechanisms able to recognise the PV and destroy the parasite. Hereby, Guanylate binding proteins, ubiquitin and the E3 ubiquitin ligases Tripartite Motif Containing 21 (TRIM21) and TNF receptor associated factor 6 are targeted to the murine PV leading to its destruction. This study is the side product of research aiming to identify ubiquitinated substrates in a TRIM21-dependent fashion in murine cells infected with Toxoplasma.\nRESULTS: We infected IFN\u03b3-stimulated murine embryonic fibroblasts (MEFs) from either C57BL/6\u00d7129 wild-type (WT) mice or C57BL/6 TRIM21-/- mice with Toxoplasma. Using mass spectrometry, we analysed proteins in both cell backgrounds presenting with the di-glycine remnant of ubiquitination. In addition, we compared peptide levels between WT and TRIM21-/- cells. In line with earlier reports, Gbp1 was expressed to higher levels in the C57BL/6\u00d7129 WT MEFs compared to the C57BL/6-only background TRIM21-/- MEFs. Protein expression differences in these different murine backgrounds thus precluded identification of TRIM21-dependent ubiquitinated substrates. Nevertheless, we identified and confirmed Gbp1 and Gbp2 as being ubiquitinated in a Toxoplasma-infection independent manner.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13104-018-3267-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3643158", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2786897", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6798171", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6798224", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1039457", 
        "issn": [
          "1756-0500"
        ], 
        "name": "BMC Research Notes", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection", 
    "pagination": "166", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2c4165237b4cd436d530d8c29903fba480eb9e6f04dcc50f9976343d97eaa833"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29510761"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101462768"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13104-018-3267-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101356823"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13104-018-3267-z", 
      "https://app.dimensions.ai/details/publication/pub.1101356823"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60354_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13104-018-3267-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13104-018-3267-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13104-018-3267-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13104-018-3267-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13104-018-3267-z'


 

This table displays all metadata directly associated to this object as RDF triples.

207 TRIPLES      21 PREDICATES      62 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13104-018-3267-z schema:about N14342660d34e4fed86eb2892591f3bbd
2 N262ce67d444649b6aa40a8c4429fbc4f
3 N3e7a8157166448b6876edccc6746e59a
4 N607ba26df1544d14af2f443a092e2dfb
5 Nab68d4da393d40c9841715687bdef33d
6 Nbfa855107cbc45b48abeec5fbf09e375
7 Nc5472d196ef24002a2bf8bf03a67a486
8 Nef71f2252c624510b806c509243e45ce
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author Nc0f14e90157e4837a4197c8b236dcb9b
12 schema:citation sg:pub.10.1038/nature24467
13 sg:pub.10.1038/nbt.2839
14 sg:pub.10.1038/s41598-017-05487-7
15 https://app.dimensions.ai/details/publication/pub.1083258432
16 https://doi.org/10.1016/0042-6822(84)90016-3
17 https://doi.org/10.1016/j.celrep.2015.09.005
18 https://doi.org/10.1016/j.celrep.2016.04.047
19 https://doi.org/10.1016/j.chom.2017.09.007
20 https://doi.org/10.1016/j.immuni.2012.06.009
21 https://doi.org/10.1016/s0140-6736(04)16412-x
22 https://doi.org/10.1016/s1097-2765(01)00347-1
23 https://doi.org/10.1073/pnas.1515966112
24 https://doi.org/10.1074/jbc.m111.251967
25 https://doi.org/10.1074/mcp.o112.027094
26 https://doi.org/10.1111/j.1600-065x.2010.00992.x
27 https://doi.org/10.1128/mbio.01157-15
28 https://doi.org/10.1128/mbio.01979-17
29 https://doi.org/10.1128/mcb.11.9.4717
30 https://doi.org/10.1136/bmj.1.5271.83
31 https://doi.org/10.1242/jcs.183954
32 https://doi.org/10.1371/journal.pone.0024434
33 https://doi.org/10.1371/journal.ppat.1003320
34 https://doi.org/10.1371/journal.ppat.1006027
35 https://doi.org/10.4049/jimmunol.0804121
36 https://doi.org/10.4049/jimmunol.179.11.7729
37 schema:datePublished 2018-12
38 schema:datePublishedReg 2018-12-01
39 schema:description OBJECTIVE: The intracellular parasite Toxoplasma gondii can invade any nucleated cell residing inside a parasitophorous vacuole (PV). Upon infection, the cytokine interferon gamma (IFNγ) is produced and elicits host defence mechanisms able to recognise the PV and destroy the parasite. Hereby, Guanylate binding proteins, ubiquitin and the E3 ubiquitin ligases Tripartite Motif Containing 21 (TRIM21) and TNF receptor associated factor 6 are targeted to the murine PV leading to its destruction. This study is the side product of research aiming to identify ubiquitinated substrates in a TRIM21-dependent fashion in murine cells infected with Toxoplasma. RESULTS: We infected IFNγ-stimulated murine embryonic fibroblasts (MEFs) from either C57BL/6×129 wild-type (WT) mice or C57BL/6 TRIM21-/- mice with Toxoplasma. Using mass spectrometry, we analysed proteins in both cell backgrounds presenting with the di-glycine remnant of ubiquitination. In addition, we compared peptide levels between WT and TRIM21-/- cells. In line with earlier reports, Gbp1 was expressed to higher levels in the C57BL/6×129 WT MEFs compared to the C57BL/6-only background TRIM21-/- MEFs. Protein expression differences in these different murine backgrounds thus precluded identification of TRIM21-dependent ubiquitinated substrates. Nevertheless, we identified and confirmed Gbp1 and Gbp2 as being ubiquitinated in a Toxoplasma-infection independent manner.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N87c929a802ee42a589cdb27493e785ff
44 Ne4066ed02823420787aa48cfe8d11fc7
45 sg:journal.1039457
46 schema:name Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection
47 schema:pagination 166
48 schema:productId N0cb348b95ceb40858f6f1349772f0cd6
49 N1ea095a553a54a28aa16b1fef07dcec4
50 N4c185efc2d3947a6a46dc9936c0af639
51 N861f012fb01d421bb06e050f5bfca25a
52 Nac8aca74ad2a49b68aa587845872af23
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101356823
54 https://doi.org/10.1186/s13104-018-3267-z
55 schema:sdDatePublished 2019-04-11T11:03
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher Ndde9f0123adb4569a398c3781fbb5da2
58 schema:url https://link.springer.com/10.1186%2Fs13104-018-3267-z
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N0c51e390bcd04ea6938a66dccb50ada7 rdf:first sg:person.01341405243.01
63 rdf:rest N34b2369cbeea493288c454eab68b72a9
64 N0cb348b95ceb40858f6f1349772f0cd6 schema:name dimensions_id
65 schema:value pub.1101356823
66 rdf:type schema:PropertyValue
67 N14342660d34e4fed86eb2892591f3bbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Animals
69 rdf:type schema:DefinedTerm
70 N1ea095a553a54a28aa16b1fef07dcec4 schema:name pubmed_id
71 schema:value 29510761
72 rdf:type schema:PropertyValue
73 N262ce67d444649b6aa40a8c4429fbc4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name GTP-Binding Proteins
75 rdf:type schema:DefinedTerm
76 N31fc6a14af344ab09acf8793806901a0 rdf:first sg:person.01116613701.01
77 rdf:rest N0c51e390bcd04ea6938a66dccb50ada7
78 N34b2369cbeea493288c454eab68b72a9 rdf:first sg:person.01266246531.82
79 rdf:rest rdf:nil
80 N3e7a8157166448b6876edccc6746e59a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Fibroblasts
82 rdf:type schema:DefinedTerm
83 N4c185efc2d3947a6a46dc9936c0af639 schema:name doi
84 schema:value 10.1186/s13104-018-3267-z
85 rdf:type schema:PropertyValue
86 N607ba26df1544d14af2f443a092e2dfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Mice
88 rdf:type schema:DefinedTerm
89 N861f012fb01d421bb06e050f5bfca25a schema:name readcube_id
90 schema:value 2c4165237b4cd436d530d8c29903fba480eb9e6f04dcc50f9976343d97eaa833
91 rdf:type schema:PropertyValue
92 N87c929a802ee42a589cdb27493e785ff schema:volumeNumber 11
93 rdf:type schema:PublicationVolume
94 Nab68d4da393d40c9841715687bdef33d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Mice, Inbred C57BL
96 rdf:type schema:DefinedTerm
97 Nac8aca74ad2a49b68aa587845872af23 schema:name nlm_unique_id
98 schema:value 101462768
99 rdf:type schema:PropertyValue
100 Nbfa855107cbc45b48abeec5fbf09e375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Embryo, Mammalian
102 rdf:type schema:DefinedTerm
103 Nc0f14e90157e4837a4197c8b236dcb9b rdf:first sg:person.0711254207.57
104 rdf:rest N31fc6a14af344ab09acf8793806901a0
105 Nc5472d196ef24002a2bf8bf03a67a486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Toxoplasmosis
107 rdf:type schema:DefinedTerm
108 Ndde9f0123adb4569a398c3781fbb5da2 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 Ne4066ed02823420787aa48cfe8d11fc7 schema:issueNumber 1
111 rdf:type schema:PublicationIssue
112 Nef71f2252c624510b806c509243e45ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Ubiquitination
114 rdf:type schema:DefinedTerm
115 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
116 schema:name Biological Sciences
117 rdf:type schema:DefinedTerm
118 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
119 schema:name Biochemistry and Cell Biology
120 rdf:type schema:DefinedTerm
121 sg:grant.2786897 http://pending.schema.org/fundedItem sg:pub.10.1186/s13104-018-3267-z
122 rdf:type schema:MonetaryGrant
123 sg:grant.3643158 http://pending.schema.org/fundedItem sg:pub.10.1186/s13104-018-3267-z
124 rdf:type schema:MonetaryGrant
125 sg:grant.6798171 http://pending.schema.org/fundedItem sg:pub.10.1186/s13104-018-3267-z
126 rdf:type schema:MonetaryGrant
127 sg:grant.6798224 http://pending.schema.org/fundedItem sg:pub.10.1186/s13104-018-3267-z
128 rdf:type schema:MonetaryGrant
129 sg:journal.1039457 schema:issn 1756-0500
130 schema:name BMC Research Notes
131 rdf:type schema:Periodical
132 sg:person.01116613701.01 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
133 schema:familyName Foltz
134 schema:givenName Clémence
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116613701.01
136 rdf:type schema:Person
137 sg:person.01266246531.82 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
138 schema:familyName Frickel
139 schema:givenName Eva-Maria
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266246531.82
141 rdf:type schema:Person
142 sg:person.01341405243.01 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
143 schema:familyName Snijders
144 schema:givenName Ambrosius P.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341405243.01
146 rdf:type schema:Person
147 sg:person.0711254207.57 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
148 schema:familyName Encheva
149 schema:givenName Vesela
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711254207.57
151 rdf:type schema:Person
152 sg:pub.10.1038/nature24467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092185083
153 https://doi.org/10.1038/nature24467
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/nbt.2839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027597437
156 https://doi.org/10.1038/nbt.2839
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/s41598-017-05487-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090546650
159 https://doi.org/10.1038/s41598-017-05487-7
160 rdf:type schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1083258432 schema:CreativeWork
162 https://doi.org/10.1016/0042-6822(84)90016-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034265942
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.celrep.2015.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007816708
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.celrep.2016.04.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050551967
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.chom.2017.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092185178
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.immuni.2012.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019426318
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/s0140-6736(04)16412-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030211666
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/s1097-2765(01)00347-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052505852
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1073/pnas.1515966112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025662278
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1074/jbc.m111.251967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043299302
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1074/mcp.o112.027094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049624550
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1111/j.1600-065x.2010.00992.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022618702
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1128/mbio.01157-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027267327
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1128/mbio.01979-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099597679
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1128/mcb.11.9.4717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041872390
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1136/bmj.1.5271.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031708123
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1242/jcs.183954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047308281
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1371/journal.pone.0024434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039030606
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1371/journal.ppat.1003320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046526437
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1371/journal.ppat.1006027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032073292
199 rdf:type schema:CreativeWork
200 https://doi.org/10.4049/jimmunol.0804121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036144757
201 rdf:type schema:CreativeWork
202 https://doi.org/10.4049/jimmunol.179.11.7729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048058697
203 rdf:type schema:CreativeWork
204 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
205 schema:name Host-Toxoplasma Interaction Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK
206 Mass Spectrometry and Proteomics Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK
207 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...