Aspirin is associated with low oral pH levels and antacid helps to increase oral pH View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Dileepa Senajith Ediriweera, Nuwani Dilina, Vipula Saparamadu, Inoka Fernando, Buddhika Kurukulasuriya, Deepika Fernando, Janakie Kurera

ABSTRACT

OBJECTIVE: Aspirin is a commonly used medicine for primary and secondary prevention of cardiovascular diseases. It is an acidic medicine associated with gastric irritation and acid reflux, which in turn can lead to low oral pH levels. Therefore, it is important to understand the association between aspirin and oral pH levels in order to achieve an optimum oral health condition among patients who take aspirin on prescription. RESULTS: Out of 373 patients, 162 (44%) were males and 245 (66%) were on aspirin. 71% of aspirin taking patients and 29% of non-aspirin taking patients had oral pH less than 6.5 (P < 0.01). Aspirin showed a significant association with low oral pH levels (odds ratio = 1.91, 95% CI 1.23-2.99, P < 0.01). 78 patients were given antacids and followed up for 4 weeks, 63 of them (81%) showed an improvement in oral pH and the improvement was marked in the group who had oral pH between 5.5-6.0 compared to the group who had oral pH between 6.0-6.5 (P = 0.03). The results show that aspirin therapy is associated with low oral pH and administration of an antacid with aspirin helps to increase the oral pH level. More... »

PAGES

137

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13104-018-3247-3

DOI

http://dx.doi.org/10.1186/s13104-018-3247-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101116911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29458438


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