Negative studies are helpful to compute the specificity of diagnostic tests: measuring Trypanosoma cruzi seroprevalence in Guanajuato, Mexico View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10-28

AUTHORS

Nicolás Padilla-Raygoza, Rubí Gamboa-León, Maria Jesus Ramirez-Sierra, Eric Dumonteil, Pierre Buekens, Ma Laura Ruiz-Paloalto, Rosalina Diaz-Guerrero

ABSTRACT

BACKGROUND: Publishing negative seroprevalence studies not only helps to have more accurate seroprevalence estimates but also allows calculating the specificity of the diagnostic tests used. We performed a population-based Trypanosoma cruzi seroprevalence survey in a community in central Mexico. RESULTS: We surveyed 204 women and children and collected blood by finger prick. We performed rapid tests (Stat-Pak, Chembio, Inc., Medford, New York) and recombinant Chagas ELISA tests v3.0 (Wiener, Rosario, Argentina). All rapid tests and all ELISA tests were negative. CONCLUSION: The rapid test had 100 % of specificity compared to the ELISA. More... »

PAGES

614

Journal

TITLE

BMC Research Notes

ISSUE

1

VOLUME

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13104-015-1612-z

DOI

http://dx.doi.org/10.1186/s13104-015-1612-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024419743

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26510987


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