The impact of transposable element activity on therapeutically relevant human stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Gerald G. Schumann, Nina V. Fuchs, Pablo Tristán-Ramos, Attila Sebe, Zoltán Ivics, Sara R. Heras

ABSTRACT

Human stem cells harbor significant potential for basic and clinical translational research as well as regenerative medicine. Currently ~ 3000 adult and ~ 30 pluripotent stem cell-based, interventional clinical trials are ongoing worldwide, and numbers are increasing continuously. Although stem cells are promising cell sources to treat a wide range of human diseases, there are also concerns regarding potential risks associated with their clinical use, including genomic instability and tumorigenesis concerns. Thus, a deeper understanding of the factors and molecular mechanisms contributing to stem cell genome stability are a prerequisite to harnessing their therapeutic potential for degenerative diseases. Chemical and physical factors are known to influence the stability of stem cell genomes, together with random mutations and Copy Number Variants (CNVs) that accumulated in cultured human stem cells. Here we review the activity of endogenous transposable elements (TEs) in human multipotent and pluripotent stem cells, and the consequences of their mobility for genomic integrity and host gene expression. We describe transcriptional and post-transcriptional mechanisms antagonizing the spread of TEs in the human genome, and highlight those that are more prevalent in multipotent and pluripotent stem cells. Notably, TEs do not only represent a source of mutations/CNVs in genomes, but are also often harnessed as tools to engineer the stem cell genome; thus, we also describe and discuss the most widely applied transposon-based tools and highlight the most relevant areas of their biomedical applications in stem cells. Taken together, this review will contribute to the assessment of the risk that endogenous TE activity and the application of genetically engineered TEs constitute for the biosafety of stem cells to be used for substitutive and regenerative cell therapies. More... »

PAGES

9

References to SciGraph publications

  • 2001-02. Initial sequencing and analysis of the human genome in NATURE
  • 2004-11. Processing of primary microRNAs by the Microprocessor complex in NATURE
  • 2010-04. Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET in NATURE
  • 2013-10. The Microprocessor controls the activity of mammalian retrotransposons in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-12. Origin and evolution of SINEs in eukaryotic genomes in HEREDITY
  • 2014-10-05. Clonal dynamics of native haematopoiesis in NATURE
  • 2016-12. Roles for retrotransposon insertions in human disease in MOBILE DNA
  • 2013-09-26. Seamless genome editing in human pluripotent stem cells using custom endonuclease–based gene targeting and the piggyBac transposon in NATURE PROTOCOLS
  • 2016. Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery in TRANSPOSONS AND RETROTRANSPOSONS
  • 2015. piggyBac Transposon-Based Insertional Mutagenesis in Mouse Haploid Embryonic Stem Cells in CHROMOSOMAL MUTAGENESIS
  • 2011-04. PIWI-interacting small RNAs: the vanguard of genome defence in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-01. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies in NATURE PROTOCOLS
  • 2016-12. L1-associated genomic regions are deleted in somatic cells of the healthy human brain in NATURE NEUROSCIENCE
  • 2017-10. LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo in NATURE GENETICS
  • 2012-10. Epigenetic interplay between mouse endogenous retroviruses and host genes in GENOME BIOLOGY
  • 2009-09. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis in NATURE NEUROSCIENCE
  • 2013-10-23. TET enzymes, TDG and the dynamics of DNA demethylation in NATURE
  • 2018-03. Post-transcriptional regulation of LINE-1 retrotransposition by AID/APOBEC and ADAR deaminases in CHROMOSOME RESEARCH
  • 2016-02-19. Whole-genome mutational burden analysis of three pluripotency induction methods in NATURE COMMUNICATIONS
  • 2009-10. The impact of retrotransposons on human genome evolution in NATURE REVIEWS GENETICS
  • 2014-12. An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons in NATURE
  • 2017-03-28. Japanese man is first to receive 'reprogrammed' stem cells from another person in NATURE
  • 2016-03. Pluripotent stem cells progressing to the clinic in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-10. miR-128 represses L1 retrotransposition by binding directly to L1 RNA in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-10. Evidence for the persistence of an active endogenous retrovirus (ERVE) in humans in GENETICA
  • 2009-06. Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates in NATURE GENETICS
  • 2013-03. Endogenous retroviruses function as species-specific enhancer elements in the placenta in NATURE GENETICS
  • 2015-09. Hallmarks of pluripotency in NATURE
  • 2011-11. Somatic retrotransposition alters the genetic landscape of the human brain in NATURE
  • 2011-05. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation in NATURE
  • 2004-05. Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes in NATURE
  • 2011-09. Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development in CELL RESEARCH
  • 1988-03. Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man in NATURE
  • 2016. Retrotransposon Capture Sequencing (RC-Seq): A Targeted, High-Throughput Approach to Resolve Somatic L1 Retrotransposition in Humans in TRANSPOSONS AND RETROTRANSPOSONS
  • 2013-03. Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-04. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells in NATURE
  • 2015-10. Current status of pluripotent stem cells: moving the first therapies to the clinic in NATURE REVIEWS DRUG DISCOVERY
  • 2009-06. Transposon-mediated genome manipulation in vertebrates in NATURE METHODS
  • 2007-12. Evaluating the protein coding potential of exonized transposable element sequences in BIOLOGY DIRECT
  • 2007-08. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells in NATURE
  • 2018-12. L1 retrotransposition in the soma: a field jumping ahead in MOBILE DNA
  • 2016-12. TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells in GENOME BIOLOGY
  • 2018-12. Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells in EPIGENETICS & CHROMATIN
  • 2016-12. TET enzymes: double agents in the transposable element–host genome conflict in GENOME BIOLOGY
  • 2010-01. KAP1 controls endogenous retroviruses in embryonic stem cells in NATURE
  • 2014-12. PhiC31/PiggyBac modified stromal stem cells: effect of interferon γ and/or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on murine melanoma in MOLECULAR CANCER
  • 2017-06-09. Transposable elements in cancer in NATURE REVIEWS CANCER
  • 2007-02. Adaptation to culture of human embryonic stem cells and oncogenesis in vivo in NATURE BIOTECHNOLOGY
  • 2013-09. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-03. Somatic coding mutations in human induced pluripotent stem cells in NATURE
  • 2006-09. L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-06. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition in NATURE
  • 2005-10. Genomic alterations in cultured human embryonic stem cells in NATURE GENETICS
  • 2013-12. An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells in NATURE COMMUNICATIONS
  • 2014-07-23. The DNA methylation landscape of human early embryos in NATURE
  • 2014-05. Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2015-12. Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo in EPIGENETICS & CHROMATIN
  • 2000-04. Human LINE retrotransposons generate processed pseudogenes in NATURE GENETICS
  • 1997-05. Many human L1 elements are capable of retrotransposition in NATURE GENETICS
  • 1998-10. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation in NATURE GENETICS
  • 2016-01-08. Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells in NATURE COMMUNICATIONS
  • 2009-08. L1 retrotransposition in human neural progenitor cells in NATURE
  • 2011-12. Stem cells in clinical practice: applications and warnings in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2011-03. Copy number variation and selection during reprogramming to pluripotency in NATURE
  • 2007-12. Exonization of the LTR transposable elements in human genome in BMC GENOMICS
  • 2000-04. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro in NATURE BIOTECHNOLOGY
  • 2010-07. Transposable elements have rewired the core regulatory network of human embryonic stem cells in NATURE GENETICS
  • 2018-01. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators in NATURE
  • 2010-11. L1 retrotransposition in neurons is modulated by MeCP2 in NATURE
  • 2011-09. Dynamic interactions between transposable elements and their hosts in NATURE REVIEWS GENETICS
  • 2003-09. LINE-mediated retrotransposition of marked Alu sequences in NATURE GENETICS
  • 2011-04. The tumorigenicity of human embryonic and induced pluripotent stem cells in NATURE REVIEWS CANCER
  • 2004-09. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L in NATURE
  • 2011-05. Ex vivo gene transfer and correction for cell-based therapies in NATURE REVIEWS GENETICS
  • 2003-12. RNA truncation by premature polyadenylation attenuates human mobile element activity in NATURE GENETICS
  • 2016-12. Restricting retrotransposons: a review in MOBILE DNA
  • 2013-11. Differential L1 regulation in pluripotent stem cells of humans and apes in NATURE
  • 2002-05. Alu repeats and human genomic diversity in NATURE REVIEWS GENETICS
  • 2011-04. Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development in NATURE
  • 2016-12. Transposable elements in the mammalian embryo: pioneers surviving through stealth and service in GENOME BIOLOGY
  • 2011-12. The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements in NATURE
  • 2012. Analysis of LINE-1 Expression in Human Pluripotent Cells in HUMAN EMBRYONIC STEM CELLS HANDBOOK
  • 2011-03. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells in NATURE
  • Journal

    TITLE

    Mobile DNA

    ISSUE

    1

    VOLUME

    10

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13100-019-0151-x

    DOI

    http://dx.doi.org/10.1186/s13100-019-0151-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112673254

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30899334


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