Oxidative stress and adipokine levels were significantly correlated in diabetic patients with hyperglycemic crises View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Juan Li, Xingping Shen

ABSTRACT

Background: To investigate the relationship between blood adipokine level and oxidative stress in diabetic patients with hyperglycemic crises before and after treatment. Methods: We measured superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), and levels of 8-iso-prostaglandin F2α (8-iso-PGF2α), adiponectin, leptin, and resistin in 63 diabetic patients with hyperglycemic crises. Results: Prior to treatment, patients with hyperglycemic crises had significantly lower serum SOD activity, TAC, and adiponectin and leptin levels, and higher serum levels of MDA, 8-iso-PGF2α, and resistin compared with the healthy control individuals (all at P < 0.05). After treatment, SOD, TAC, adiponectin, and leptin levels increased significantly, while MDA, 8-iso-PGF2α, and resistin levels decreased significantly (all at P < 0.05) in the patients. Conclusions: Diabetic patients with hyperglycemic crises have increased oxidative stress, which is associated with serum adipokine abnormalities; improved oxidative stress after treatment suggests that oxidative stress may serve as target and/or indicator for the treatment of hyperglycemic crises. More... »

PAGES

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13098-019-0410-5

DOI

http://dx.doi.org/10.1186/s13098-019-0410-5

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https://app.dimensions.ai/details/publication/pub.1111954606

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30774721


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