Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan View Full Text


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Article Info

DATE

2021-02-01

AUTHORS

Yutaro Soejima, Yohei Kirino, Mitsuhiro Takeno, Michiko Kurosawa, Masaki Takeuchi, Ryusuke Yoshimi, Yumiko Sugiyama, Shigeru Ohno, Yukiko Asami, Akiko Sekiguchi, Toshihisa Igarashi, Shohei Nagaoka, Yoshiaki Ishigatsubo, Hideaki Nakajima, Nobuhisa Mizuki

ABSTRACT

BackgroundWe hypothesized that Behçet’s disease (BD) consists of several clinical subtypes with different severity, resulting in heterogeneity of the disease. Here, we conducted a study to identify clinical clusters of BD.MethodsA total of 657 patients registered in the Yokohama City University (YCU) regional BD registry between 1990 and 2018, as well as 6754 patients who were initially registered in the Japanese Ministry of Health, Labour and Welfare (MHLW) database between 2003 and 2014, were investigated. The YCU registry data regarding the clinical manifestations of BD, human leukocyte antigen (HLA) status, treatments, and hospitalizations were analyzed first, followed by similar analyses of the MHLW for validation. A hierarchical cluster analysis was independently performed in both patient groups.ResultsA hierarchical cluster analysis determined five independent clinical clusters in the YCU cohort. Individual counterparts of the YCU clusters were confirmed in the MHLW registry. Recent phenotypical evolutions of BD in Japan, such as increased gastrointestinal (GI) involvement, reduced complete type according to the Japan Criteria, and reduced HLA-B51 positivity were associated with chronologically changing proportions of the clinical clusters.ConclusionsIn this study, we identified independent clinical clusters among BD patients in Japan and found that the proportion of each cluster varied over time. We propose five independent clusters namely “mucocutaneous”, “mucocutaneous with arthritis”, “neuro”, “GI”, and “eye.” More... »

PAGES

49

References to SciGraph publications

  • 2019-02-11. Phenotypes in Behçet’s syndrome in INTERNAL AND EMERGENCY MEDICINE
  • 2016-10-03. Continuous evolution of clinical phenotype in 578 Japanese patients with Behçet’s disease: a retrospective observational study in ARTHRITIS RESEARCH & THERAPY
  • 2018-01-03. Behçet syndrome: a contemporary view in NATURE REVIEWS RHEUMATOLOGY
  • 2013-08-10. Gastrointestinal manifestations of Behçet’s disease in Japan: a study of 43 patients in RHEUMATOLOGY INTERNATIONAL
  • 2012-06-07. Behçet Syndrome: Is It One Condition? in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2007-02-20. HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Behçet's disease in MODERN RHEUMATOLOGY
  • 2013-01-06. Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1 in NATURE GENETICS
  • 2019-06-04. Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet’s disease in ARTHRITIS RESEARCH & THERAPY
  • 2014-11-12. Overview in BEHÇET'S DISEASE
  • 2017-01-03. Identification of genetic susceptibility loci for intestinal Behçet’s disease in SCIENTIFIC REPORTS
  • 2010-07-11. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease in NATURE GENETICS
  • 2010-07-11. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci in NATURE GENETICS
  • 2016-04-13. Factors associated with exacerbation of newly diagnosed mild ulcerative colitis based on a nationwide registry in Japan in JOURNAL OF GASTROENTEROLOGY
  • Journal

    TITLE

    Arthritis Research & Therapy

    ISSUE

    1

    VOLUME

    23

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13075-020-02406-6

    DOI

    http://dx.doi.org/10.1186/s13075-020-02406-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1135025823

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33522943


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    330 schema:name Department of Rheumatology, Yokohama Minami Kyosai Hospital, 1-21-1 Mutsuura Higashi, 236-0037, Yokohama, Japan
    331 rdf:type schema:Organization
    332 grid-institutes:grid.460144.3 schema:alternateName Department of Rheumatology, Yamato City Hospital, Fukaminishi, 242-8602, Yamato, Japan
    333 schema:name Department of Rheumatology, Yamato City Hospital, Fukaminishi, 242-8602, Yamato, Japan
    334 rdf:type schema:Organization
     




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