Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-08-03

AUTHORS

Minh Duc Do, Thao Phuong Mai, Anh Duy Do, Quang Dinh Nguyen, Nghia Hieu Le, Linh Gia Hoang Le, Vu Anh Hoang, Anh Ngoc Le, Hung Quoc Le, Pascal Richette, Matthieu Resche-Rigon, Thomas Bardin

ABSTRACT

ObjectiveThe aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese.MethodsAll patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Patients with severe (SCARs) and mild (MCARs) CARs and controls were compared for differences in features prospectively collected, and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated.ResultsOn comparing 32 patients with SCARs and 395 tolerant controls, we identified eight strong risk factors: increased age (OR 15.1 [95% CI 5.8–40.1], P < 0.0001), female sex (OR 333 [40–43,453], P < 0.0001), allopurinol for asymptomatic hyperuricemia (OR 955 [120–125,847], P < 0.0001), allopurinol starting dose > 150 mg (OR 316 [101–122], P < 0.0001), diuretics intake (OR 304 [35–40,018], P < 0.0001), eGFR < 60 ml/min/1.73 m2 (OR 100 [32–353], P < 0.0001), history of allopurinol-induced skin reaction (OR 78 [6–10,808], P = 0.004), and HLA-B*58:01 carriage (OR 147 [45–746], P < 0.0001). HLA-B*58:01 allele frequency in controls was 7.3%. For MCARs (n = 74), risk factors were eGFR < 60 ml/min/1.73 m2 (OR 4.9 [1.61–14.6], P = 0.006), history of allopurinol-induced skin reaction (OR 27 [2–3777], P = 0.01), and asymptomatic hyperuricemia (OR 27 [2–3777], P = 0.01).ConclusionThis study confirmed 8 risk factors, including HLA-B*58:01, for SCARs and identified 3 risk factors for MCARs in Kinh Vietnamese. HLA-B*58:01 genotyping could guide the indication for allopurinol in Kinh Vietnamese patients with gout. More... »

PAGES

182

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13075-020-02273-1

DOI

http://dx.doi.org/10.1186/s13075-020-02273-1

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https://app.dimensions.ai/details/publication/pub.1129842559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32746911


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55 factors
56 features
57 female sex
58 frequency
59 genotyping
60 gout
61 history
62 hyperuricemia
63 indications
64 interval
65 kit
66 m2
67 odds ratio
68 patients
69 presence
70 ratio
71 reaction
72 results
73 risk factors
74 scar
75 sex
76 skin reactions
77 starting dose
78 strong risk factor
79 study
80 tolerant control
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