The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Yuriy Baglaenko, Nan-Hua Chang, Sindhu R. Johnson, Waleed Hafiz, Kieran Manion, Dario Ferri, Babak Noamani, Dennisse Bonilla, Sina Rusta-Sellehy, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman, Carolina Landolt-Marticorena, Joan Wither

ABSTRACT

BACKGROUND: Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs are also seen in healthy individuals, most of whom will not develop SARD. Here, we examined a unique cohort of asymptomatic ANA+ individuals to determine whether they share any of the cellular immunologic features seen in SARD. METHODS: Healthy ANA- controls and ANA+ (ANA ≥1:160 by immunofluorescence) participants with no SARD criteria, with at least one criterion (undifferentiated connective tissue disease (UCTD)), or meeting SARD classification criteria were recruited. Peripheral blood cellular immunological changes were assessed by flow cytometry and transcript levels of BAFF, interferon (IFN)-induced and plasma cell-expressed genes were quantified by NanoString. RESULTS: A number of the immunologic abnormalities seen in SARD, including changes in peripheral B (switched memory) and T (iNKT, T regulatory, activated memory T follicular helper) subsets and B cell activation, were also seen in asymptomatic ANA+ subjects and those with UCTD. The extent of these immunologic changes correlated with ANA titer or the number of different specific ANAs produced. Principal component analysis of the cellular data indicated that a significant proportion of asymptomatic ANA+ subjects and subjects with UCTD clustered with patients with early SARD, rather than ANA- healthy controls. CONCLUSIONS: ANA production is associated with altered T and B cell activation even in asymptomatic individuals. Some of the currently accepted cellular features of SARD may be associated with ANA production rather than the immunologic events that cause symptoms in SARD. More... »

PAGES

264

References to SciGraph publications

  • 2006-04. B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome in ARTHRITIS RESEARCH & THERAPY
  • 2017-12. Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis in ARTHRITIS RESEARCH & THERAPY
  • 2011-10. Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease in ARTHRITIS RESEARCH & THERAPY
  • 2018-06. Induction and transcriptional regulation of the co-inhibitory gene module in T cells in NATURE
  • 2011-02. Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden in ARTHRITIS RESEARCH & THERAPY
  • 1998-05. Undifferentiated connective tissue disease: Natural history and evolution into definite CTD assessed in 84 patients initially diagnosed as early UCTD in CLINICAL RHEUMATOLOGY
  • 1996-05. Follow-up of 151 patients with high-titer U1RNP antibodies in CLINICAL RHEUMATOLOGY
  • 2008-10. Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity in ARTHRITIS RESEARCH & THERAPY
  • 2015-12. Polychromatic flow cytometry in evaluating rheumatic disease patients in ARTHRITIS RESEARCH & THERAPY
  • 2011-10. Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus in ARTHRITIS RESEARCH & THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13075-018-1752-3

    DOI

    http://dx.doi.org/10.1186/s13075-018-1752-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110261692

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30486869


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada", 
                "Department of Immunology, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baglaenko", 
            "givenName": "Yuriy", 
            "id": "sg:person.01055262207.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055262207.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "Nan-Hua", 
            "id": "sg:person.01336656605.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336656605.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Division of Rheumatology, University Health Network, Toronto, ON, Canada", 
                "Department of Medicine, University of Toronto, Toronto, ON, Canada", 
                "Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada", 
                "Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnson", 
            "givenName": "Sindhu R.", 
            "id": "sg:person.015164001622.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015164001622.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "Division of Rheumatology, University Health Network, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hafiz", 
            "givenName": "Waleed", 
            "id": "sg:person.010710632147.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010710632147.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada", 
                "Department of Immunology, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manion", 
            "givenName": "Kieran", 
            "id": "sg:person.01251475551.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251475551.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada", 
                "Department of Immunology, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferri", 
            "givenName": "Dario", 
            "id": "sg:person.010642644233.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010642644233.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Noamani", 
            "givenName": "Babak", 
            "id": "sg:person.01025703421.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025703421.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonilla", 
            "givenName": "Dennisse", 
            "id": "sg:person.016231400151.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016231400151.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rusta-Sellehy", 
            "givenName": "Sina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lakeridge Health", 
              "id": "https://www.grid.ac/institutes/grid.468187.4", 
              "name": [
                "Lakeridge Health Services, Oshawa, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lisnevskaia", 
            "givenName": "Larissa", 
            "id": "sg:person.01262013456.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262013456.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Division of Rheumatology, Sick Children\u2019s Hospital, Toronto, ON, Canada", 
                "Department of Pediatrics, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Silverman", 
            "givenName": "Earl", 
            "id": "sg:person.012765747472.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012765747472.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Division of Rheumatology, University Health Network, Toronto, ON, Canada", 
                "Department of Medicine, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bookman", 
            "givenName": "Arthur", 
            "id": "sg:person.0711747421.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711747421.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Landolt-Marticorena", 
            "givenName": "Carolina", 
            "id": "sg:person.01120410117.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120410117.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada", 
                "Department of Immunology, University of Toronto, Toronto, ON, Canada", 
                "Division of Rheumatology, University Health Network, Toronto, ON, Canada", 
                "Department of Medicine, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wither", 
            "givenName": "Joan", 
            "id": "sg:person.0664472661.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664472661.90"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1006/clim.2001.5060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002435534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.165.10.5970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003764385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humimm.2013.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004464799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cei.12703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004687895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/acr.22304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004708133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/1744666x.2016.1109449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005498304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/03009742.2010.528021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006602131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2013-204424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007344405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/03009740801910361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007444012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.39214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009021514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar1912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009055466", 
              "https://doi.org/10.1186/ar1912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.38119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009324036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.23.021704.115843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010527724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2011-200463", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012436383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08916934.2012.748751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012906088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.38194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013938708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2012-202216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014951125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar3258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015008424", 
              "https://doi.org/10.1186/ar3258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.20999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017768567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rdc.2014.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018062672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.40004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018757416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.40004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018757416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.39706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019066195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08916930008995989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019829258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar2505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021259881", 
              "https://doi.org/10.1186/ar2505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.24038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021618156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clim.2013.02.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022495515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa021933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023642069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2014.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023911264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2004.031781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024102066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.23498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024287575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002281-199511000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025368028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002281-199511000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025368028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.25032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028845466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.25032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028845466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1529-0131(200103)44:3<647::aid-anr113>3.0.co;2-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030713720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031681078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780400928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032541017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2249.2002.02017.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032641258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaut.2015.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033508810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.10949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033980158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar3474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034958122", 
              "https://doi.org/10.1186/ar3474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/keq457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035709915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.20274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035781690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.autrev.2013.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036148842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2007.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037974061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0066134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038742327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clim.2011.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039020350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar3486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039201924", 
              "https://doi.org/10.1186/ar3486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.61.6.554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039471766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.176.4.2074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039636475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/08916930500050145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040913018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaut.2016.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041472205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2015-208140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044226548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.08.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044451020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01451046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044871307", 
              "https://doi.org/10.1007/bf01451046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01451046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044871307", 
              "https://doi.org/10.1007/bf01451046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxn056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045018170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13075-015-0561-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047281601", 
              "https://doi.org/10.1186/s13075-015-0561-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13075-015-0561-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047281601", 
              "https://doi.org/10.1186/s13075-015-0561-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.10445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050892769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02229703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051428577", 
              "https://doi.org/10.1007/bf02229703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02229703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051428577", 
              "https://doi.org/10.1007/bf02229703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.38734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052975040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3005191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062687775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/096120300678828073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064153843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/096120300678828073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064153843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/096120300678828073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064153843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203304lu477oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203304lu477oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203304lu477oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3899/jrheum.160327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071544155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-101-6-748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073689652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074543755", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.167.4.2361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074859915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074860648", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.167.7.3610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074883326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075311596", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076886942", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077003375", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.180.2.1276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077586931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078691841", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082969808", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13075-017-1243-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252262", 
              "https://doi.org/10.1186/s13075-017-1243-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13075-017-1243-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252262", 
              "https://doi.org/10.1186/s13075-017-1243-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.07.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091351169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.40424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100557559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.40488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101524264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0206-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104562421", 
              "https://doi.org/10.1038/s41586-018-0206-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0206-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104562421", 
              "https://doi.org/10.1038/s41586-018-0206-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0206-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104562421", 
              "https://doi.org/10.1038/s41586-018-0206-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2018.01360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104881441"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "BACKGROUND: Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs are also seen in healthy individuals, most of whom will not develop SARD. Here, we examined a unique cohort of asymptomatic ANA+ individuals to determine whether they share any of the cellular immunologic features seen in SARD.\nMETHODS: Healthy ANA- controls and ANA+ (ANA \u22651:160 by immunofluorescence) participants with no SARD criteria, with at least one criterion (undifferentiated connective tissue disease (UCTD)), or meeting SARD classification criteria were recruited. Peripheral blood cellular immunological changes were assessed by flow cytometry and transcript levels of BAFF, interferon (IFN)-induced and plasma cell-expressed genes were quantified by NanoString.\nRESULTS: A number of the immunologic abnormalities seen in SARD, including changes in peripheral B (switched memory) and T (iNKT, T regulatory, activated memory T follicular helper) subsets and B cell activation, were also seen in asymptomatic ANA+ subjects and those with UCTD. The extent of these immunologic changes correlated with ANA titer or the number of different specific ANAs produced. Principal component analysis of the cellular data indicated that a significant proportion\u00a0of asymptomatic ANA+ subjects and subjects with UCTD clustered\u00a0 with patients with early SARD, rather than ANA- healthy controls.\nCONCLUSIONS: ANA production is associated with altered T and B cell activation even in asymptomatic individuals. Some of the currently accepted cellular features of SARD may be associated with ANA production rather than the immunologic events that cause symptoms in SARD.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13075-018-1752-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1297499", 
            "issn": [
              "1478-6354", 
              "1478-6362"
            ], 
            "name": "Arthritis Research & Therapy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease", 
        "pagination": "264", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b99f207ac4d84c6a56e17cf564a36792a98b000a6b01fb953bf735281052477b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30486869"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101154438"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13075-018-1752-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110261692"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13075-018-1752-3", 
          "https://app.dimensions.ai/details/publication/pub.1110261692"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000282_0000000282/records_78272_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs13075-018-1752-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1752-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1752-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1752-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1752-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    413 TRIPLES      21 PREDICATES      108 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13075-018-1752-3 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author N4da1e7be5225465ba2d9d3920299275f
    4 schema:citation sg:pub.10.1007/bf01451046
    5 sg:pub.10.1007/bf02229703
    6 sg:pub.10.1038/s41586-018-0206-z
    7 sg:pub.10.1186/ar1912
    8 sg:pub.10.1186/ar2505
    9 sg:pub.10.1186/ar3258
    10 sg:pub.10.1186/ar3474
    11 sg:pub.10.1186/ar3486
    12 sg:pub.10.1186/s13075-015-0561-1
    13 sg:pub.10.1186/s13075-017-1243-y
    14 https://app.dimensions.ai/details/publication/pub.1074543755
    15 https://app.dimensions.ai/details/publication/pub.1074860648
    16 https://app.dimensions.ai/details/publication/pub.1075311596
    17 https://app.dimensions.ai/details/publication/pub.1076886942
    18 https://app.dimensions.ai/details/publication/pub.1077003375
    19 https://app.dimensions.ai/details/publication/pub.1078691841
    20 https://app.dimensions.ai/details/publication/pub.1082969808
    21 https://doi.org/10.1002/1529-0131(200103)44:3<647::aid-anr113>3.0.co;2-i
    22 https://doi.org/10.1002/acr.22304
    23 https://doi.org/10.1002/art.10445
    24 https://doi.org/10.1002/art.10949
    25 https://doi.org/10.1002/art.1780400928
    26 https://doi.org/10.1002/art.20274
    27 https://doi.org/10.1002/art.20999
    28 https://doi.org/10.1002/art.23498
    29 https://doi.org/10.1002/art.24038
    30 https://doi.org/10.1002/art.25032
    31 https://doi.org/10.1002/art.38119
    32 https://doi.org/10.1002/art.38194
    33 https://doi.org/10.1002/art.38734
    34 https://doi.org/10.1002/art.39214
    35 https://doi.org/10.1002/art.39706
    36 https://doi.org/10.1002/art.40004
    37 https://doi.org/10.1002/art.40424
    38 https://doi.org/10.1002/art.40488
    39 https://doi.org/10.1006/clim.2001.5060
    40 https://doi.org/10.1016/j.autrev.2013.02.003
    41 https://doi.org/10.1016/j.cell.2017.07.026
    42 https://doi.org/10.1016/j.clim.2011.08.005
    43 https://doi.org/10.1016/j.clim.2013.02.024
    44 https://doi.org/10.1016/j.coi.2007.04.008
    45 https://doi.org/10.1016/j.humimm.2013.08.003
    46 https://doi.org/10.1016/j.immuni.2009.07.005
    47 https://doi.org/10.1016/j.immuni.2013.08.031
    48 https://doi.org/10.1016/j.it.2014.06.002
    49 https://doi.org/10.1016/j.jaut.2015.01.009
    50 https://doi.org/10.1016/j.jaut.2016.06.001
    51 https://doi.org/10.1016/j.rdc.2014.07.004
    52 https://doi.org/10.1046/j.1365-2249.2002.02017.x
    53 https://doi.org/10.1056/nejmoa021933
    54 https://doi.org/10.1080/03009740801910361
    55 https://doi.org/10.1080/08916930500050145
    56 https://doi.org/10.1093/intimm/dxn056
    57 https://doi.org/10.1093/rheumatology/keq457
    58 https://doi.org/10.1097/00002281-199511000-00017
    59 https://doi.org/10.1111/cei.12703
    60 https://doi.org/10.1126/scitranslmed.3005191
    61 https://doi.org/10.1136/annrheumdis-2011-200463
    62 https://doi.org/10.1136/annrheumdis-2012-202216
    63 https://doi.org/10.1136/annrheumdis-2013-204424
    64 https://doi.org/10.1136/annrheumdis-2015-208140
    65 https://doi.org/10.1136/ard.2004.031781
    66 https://doi.org/10.1136/ard.61.6.554
    67 https://doi.org/10.1146/annurev.immunol.23.021704.115843
    68 https://doi.org/10.1191/096120300678828073
    69 https://doi.org/10.1191/0961203304lu477oa
    70 https://doi.org/10.1371/journal.pone.0066134
    71 https://doi.org/10.1586/1744666x.2016.1109449
    72 https://doi.org/10.3109/03009742.2010.528021
    73 https://doi.org/10.3109/08916930008995989
    74 https://doi.org/10.3109/08916934.2012.748751
    75 https://doi.org/10.3389/fimmu.2018.01360
    76 https://doi.org/10.3899/jrheum.160327
    77 https://doi.org/10.4049/jimmunol.165.10.5970
    78 https://doi.org/10.4049/jimmunol.167.4.2361
    79 https://doi.org/10.4049/jimmunol.167.7.3610
    80 https://doi.org/10.4049/jimmunol.176.4.2074
    81 https://doi.org/10.4049/jimmunol.180.2.1276
    82 https://doi.org/10.7326/0003-4819-101-6-748
    83 schema:datePublished 2018-12
    84 schema:datePublishedReg 2018-12-01
    85 schema:description BACKGROUND: Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs are also seen in healthy individuals, most of whom will not develop SARD. Here, we examined a unique cohort of asymptomatic ANA+ individuals to determine whether they share any of the cellular immunologic features seen in SARD. METHODS: Healthy ANA- controls and ANA+ (ANA ≥1:160 by immunofluorescence) participants with no SARD criteria, with at least one criterion (undifferentiated connective tissue disease (UCTD)), or meeting SARD classification criteria were recruited. Peripheral blood cellular immunological changes were assessed by flow cytometry and transcript levels of BAFF, interferon (IFN)-induced and plasma cell-expressed genes were quantified by NanoString. RESULTS: A number of the immunologic abnormalities seen in SARD, including changes in peripheral B (switched memory) and T (iNKT, T regulatory, activated memory T follicular helper) subsets and B cell activation, were also seen in asymptomatic ANA+ subjects and those with UCTD. The extent of these immunologic changes correlated with ANA titer or the number of different specific ANAs produced. Principal component analysis of the cellular data indicated that a significant proportion of asymptomatic ANA+ subjects and subjects with UCTD clustered  with patients with early SARD, rather than ANA- healthy controls. CONCLUSIONS: ANA production is associated with altered T and B cell activation even in asymptomatic individuals. Some of the currently accepted cellular features of SARD may be associated with ANA production rather than the immunologic events that cause symptoms in SARD.
    86 schema:genre research_article
    87 schema:inLanguage en
    88 schema:isAccessibleForFree true
    89 schema:isPartOf N351e7f55c8074c86ab7678483596b78b
    90 N3b24d131de644336b149f8758badb000
    91 sg:journal.1297499
    92 schema:name The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease
    93 schema:pagination 264
    94 schema:productId N2955fc2ac85444bfbcf996dcddca5326
    95 N5d80e7391d524b9b8fc562a351e47891
    96 N676a2d6da99e462ab2a24fd4722dbe7a
    97 N7b89798164614a07ab571a36322f1072
    98 Nf8559d3e8e1a45ffb9737221967b719f
    99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110261692
    100 https://doi.org/10.1186/s13075-018-1752-3
    101 schema:sdDatePublished 2019-04-11T08:19
    102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    103 schema:sdPublisher N4f1534935f654642ac8237758d5c052d
    104 schema:url https://link.springer.com/10.1186%2Fs13075-018-1752-3
    105 sgo:license sg:explorer/license/
    106 sgo:sdDataset articles
    107 rdf:type schema:ScholarlyArticle
    108 N00ecc2643e3a4ff0be22464fae51295a rdf:first sg:person.01025703421.34
    109 rdf:rest N0c8e7066fd0d4822bb9e7346129d1bb4
    110 N07001f30c87b4062be0a51b003f90172 rdf:first sg:person.01336656605.92
    111 rdf:rest N1b308cf716234a3490666b8500de3403
    112 N0c8e7066fd0d4822bb9e7346129d1bb4 rdf:first sg:person.016231400151.84
    113 rdf:rest N331cb740da074e4b8dc554ee608e0f58
    114 N1360373cfa41436dbb6fe6db96854891 rdf:first sg:person.012765747472.39
    115 rdf:rest Neaa4424c03c04a34a780c9d8a7c98bc0
    116 N1b308cf716234a3490666b8500de3403 rdf:first sg:person.015164001622.91
    117 rdf:rest N512b213a22ea4441bd0419bfe608bd0d
    118 N2955fc2ac85444bfbcf996dcddca5326 schema:name nlm_unique_id
    119 schema:value 101154438
    120 rdf:type schema:PropertyValue
    121 N331cb740da074e4b8dc554ee608e0f58 rdf:first N850e63cd068f4176a47a9425b3e3201c
    122 rdf:rest Nd8e25da8d34f4342b9f78c7598cdbe4e
    123 N351e7f55c8074c86ab7678483596b78b schema:issueNumber 1
    124 rdf:type schema:PublicationIssue
    125 N3b24d131de644336b149f8758badb000 schema:volumeNumber 20
    126 rdf:type schema:PublicationVolume
    127 N4da1e7be5225465ba2d9d3920299275f rdf:first sg:person.01055262207.23
    128 rdf:rest N07001f30c87b4062be0a51b003f90172
    129 N4f1534935f654642ac8237758d5c052d schema:name Springer Nature - SN SciGraph project
    130 rdf:type schema:Organization
    131 N512b213a22ea4441bd0419bfe608bd0d rdf:first sg:person.010710632147.14
    132 rdf:rest N966ddd049e3c4ff5a8da625c19b85f2e
    133 N5d80e7391d524b9b8fc562a351e47891 schema:name readcube_id
    134 schema:value b99f207ac4d84c6a56e17cf564a36792a98b000a6b01fb953bf735281052477b
    135 rdf:type schema:PropertyValue
    136 N676a2d6da99e462ab2a24fd4722dbe7a schema:name pubmed_id
    137 schema:value 30486869
    138 rdf:type schema:PropertyValue
    139 N7b89798164614a07ab571a36322f1072 schema:name doi
    140 schema:value 10.1186/s13075-018-1752-3
    141 rdf:type schema:PropertyValue
    142 N850e63cd068f4176a47a9425b3e3201c schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    143 schema:familyName Rusta-Sellehy
    144 schema:givenName Sina
    145 rdf:type schema:Person
    146 N966ddd049e3c4ff5a8da625c19b85f2e rdf:first sg:person.01251475551.31
    147 rdf:rest Nb785b67e609b40428291e668ca3be461
    148 Nb785b67e609b40428291e668ca3be461 rdf:first sg:person.010642644233.64
    149 rdf:rest N00ecc2643e3a4ff0be22464fae51295a
    150 Nba4a14df0d04418a856cdb7a4f3b5f7f rdf:first sg:person.0664472661.90
    151 rdf:rest rdf:nil
    152 Nd8e25da8d34f4342b9f78c7598cdbe4e rdf:first sg:person.01262013456.51
    153 rdf:rest N1360373cfa41436dbb6fe6db96854891
    154 Neaa4424c03c04a34a780c9d8a7c98bc0 rdf:first sg:person.0711747421.15
    155 rdf:rest Nfc82ce31a0634424907786450590d73e
    156 Nf8559d3e8e1a45ffb9737221967b719f schema:name dimensions_id
    157 schema:value pub.1110261692
    158 rdf:type schema:PropertyValue
    159 Nfc82ce31a0634424907786450590d73e rdf:first sg:person.01120410117.71
    160 rdf:rest Nba4a14df0d04418a856cdb7a4f3b5f7f
    161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Medical and Health Sciences
    163 rdf:type schema:DefinedTerm
    164 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Immunology
    166 rdf:type schema:DefinedTerm
    167 sg:journal.1297499 schema:issn 1478-6354
    168 1478-6362
    169 schema:name Arthritis Research & Therapy
    170 rdf:type schema:Periodical
    171 sg:person.01025703421.34 schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    172 schema:familyName Noamani
    173 schema:givenName Babak
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025703421.34
    175 rdf:type schema:Person
    176 sg:person.01055262207.23 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    177 schema:familyName Baglaenko
    178 schema:givenName Yuriy
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055262207.23
    180 rdf:type schema:Person
    181 sg:person.010642644233.64 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    182 schema:familyName Ferri
    183 schema:givenName Dario
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010642644233.64
    185 rdf:type schema:Person
    186 sg:person.010710632147.14 schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    187 schema:familyName Hafiz
    188 schema:givenName Waleed
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010710632147.14
    190 rdf:type schema:Person
    191 sg:person.01120410117.71 schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    192 schema:familyName Landolt-Marticorena
    193 schema:givenName Carolina
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120410117.71
    195 rdf:type schema:Person
    196 sg:person.01251475551.31 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    197 schema:familyName Manion
    198 schema:givenName Kieran
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251475551.31
    200 rdf:type schema:Person
    201 sg:person.01262013456.51 schema:affiliation https://www.grid.ac/institutes/grid.468187.4
    202 schema:familyName Lisnevskaia
    203 schema:givenName Larissa
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262013456.51
    205 rdf:type schema:Person
    206 sg:person.012765747472.39 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    207 schema:familyName Silverman
    208 schema:givenName Earl
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012765747472.39
    210 rdf:type schema:Person
    211 sg:person.01336656605.92 schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    212 schema:familyName Chang
    213 schema:givenName Nan-Hua
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336656605.92
    215 rdf:type schema:Person
    216 sg:person.015164001622.91 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    217 schema:familyName Johnson
    218 schema:givenName Sindhu R.
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015164001622.91
    220 rdf:type schema:Person
    221 sg:person.016231400151.84 schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    222 schema:familyName Bonilla
    223 schema:givenName Dennisse
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016231400151.84
    225 rdf:type schema:Person
    226 sg:person.0664472661.90 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    227 schema:familyName Wither
    228 schema:givenName Joan
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664472661.90
    230 rdf:type schema:Person
    231 sg:person.0711747421.15 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    232 schema:familyName Bookman
    233 schema:givenName Arthur
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711747421.15
    235 rdf:type schema:Person
    236 sg:pub.10.1007/bf01451046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044871307
    237 https://doi.org/10.1007/bf01451046
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/bf02229703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051428577
    240 https://doi.org/10.1007/bf02229703
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/s41586-018-0206-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1104562421
    243 https://doi.org/10.1038/s41586-018-0206-z
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1186/ar1912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055466
    246 https://doi.org/10.1186/ar1912
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1186/ar2505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021259881
    249 https://doi.org/10.1186/ar2505
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1186/ar3258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015008424
    252 https://doi.org/10.1186/ar3258
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/ar3474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034958122
    255 https://doi.org/10.1186/ar3474
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/ar3486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039201924
    258 https://doi.org/10.1186/ar3486
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1186/s13075-015-0561-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047281601
    261 https://doi.org/10.1186/s13075-015-0561-1
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/s13075-017-1243-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252262
    264 https://doi.org/10.1186/s13075-017-1243-y
    265 rdf:type schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1074543755 schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1074860648 schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1075311596 schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1076886942 schema:CreativeWork
    270 https://app.dimensions.ai/details/publication/pub.1077003375 schema:CreativeWork
    271 https://app.dimensions.ai/details/publication/pub.1078691841 schema:CreativeWork
    272 https://app.dimensions.ai/details/publication/pub.1082969808 schema:CreativeWork
    273 https://doi.org/10.1002/1529-0131(200103)44:3<647::aid-anr113>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1030713720
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/acr.22304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004708133
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1002/art.10445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050892769
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1002/art.10949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033980158
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1002/art.1780400928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032541017
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1002/art.20274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035781690
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1002/art.20999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017768567
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1002/art.23498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024287575
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1002/art.24038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021618156
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1002/art.25032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028845466
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1002/art.38119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009324036
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1002/art.38194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013938708
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1002/art.38734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052975040
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1002/art.39214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009021514
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1002/art.39706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019066195
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1002/art.40004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018757416
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1002/art.40424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100557559
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1002/art.40488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101524264
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1006/clim.2001.5060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002435534
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.autrev.2013.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036148842
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.cell.2017.07.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091351169
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.clim.2011.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039020350
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.clim.2013.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022495515
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.coi.2007.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037974061
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.humimm.2013.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004464799
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.immuni.2009.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031681078
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.immuni.2013.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044451020
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.it.2014.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023911264
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.jaut.2015.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033508810
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.jaut.2016.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041472205
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.rdc.2014.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018062672
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1046/j.1365-2249.2002.02017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032641258
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1056/nejmoa021933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023642069
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1080/03009740801910361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007444012
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1080/08916930500050145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040913018
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1093/intimm/dxn056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045018170
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1093/rheumatology/keq457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035709915
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1097/00002281-199511000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025368028
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1111/cei.12703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004687895
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1126/scitranslmed.3005191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687775
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1136/annrheumdis-2011-200463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012436383
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1136/annrheumdis-2012-202216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014951125
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1136/annrheumdis-2013-204424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007344405
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1136/annrheumdis-2015-208140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044226548
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1136/ard.2004.031781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024102066
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1136/ard.61.6.554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039471766
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1146/annurev.immunol.23.021704.115843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010527724
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1191/096120300678828073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064153843
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1191/0961203304lu477oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1064154497
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1371/journal.pone.0066134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038742327
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1586/1744666x.2016.1109449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005498304
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.3109/03009742.2010.528021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006602131
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.3109/08916930008995989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019829258
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.3109/08916934.2012.748751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012906088
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.3389/fimmu.2018.01360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104881441
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.3899/jrheum.160327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071544155
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.4049/jimmunol.165.10.5970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003764385
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.4049/jimmunol.167.4.2361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074859915
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.4049/jimmunol.167.7.3610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074883326
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.4049/jimmunol.176.4.2074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039636475
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.4049/jimmunol.180.2.1276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077586931
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.7326/0003-4819-101-6-748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073689652
    396 rdf:type schema:CreativeWork
    397 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
    398 schema:name Department of Immunology, University of Toronto, Toronto, ON, Canada
    399 Department of Medicine, University of Toronto, Toronto, ON, Canada
    400 Department of Pediatrics, University of Toronto, Toronto, ON, Canada
    401 Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada
    402 Division of Rheumatology, Sick Children’s Hospital, Toronto, ON, Canada
    403 Division of Rheumatology, University Health Network, Toronto, ON, Canada
    404 Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
    405 Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada
    406 rdf:type schema:Organization
    407 https://www.grid.ac/institutes/grid.231844.8 schema:alternateName University Health Network
    408 schema:name Division of Rheumatology, University Health Network, Toronto, ON, Canada
    409 Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, M5T 2S8, Toronto, ON, Canada
    410 rdf:type schema:Organization
    411 https://www.grid.ac/institutes/grid.468187.4 schema:alternateName Lakeridge Health
    412 schema:name Lakeridge Health Services, Oshawa, ON, Canada
    413 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...