Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Antonio Julià, Francisco Javier López-Longo, José J. Pérez Venegas, Silvia Bonàs-Guarch, Àlex Olivé, José Luís Andreu, Mª. Ángeles Aguirre-Zamorano, Paloma Vela, Joan M. Nolla, José Luís Marenco de la Fuente, Antonio Zea, José María Pego-Reigosa, Mercedes Freire, Elvira Díez, Esther Rodríguez-Almaraz, Patricia Carreira, Ricardo Blanco, Víctor Martínez Taboada, María López-Lasanta, Mireia López Corbeto, Josep M. Mercader, David Torrents, Devin Absher, Sara Marsal, Antonio Fernández-Nebro

ABSTRACT

BACKGROUND: Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci associated with SLE risk. To date, however, established loci account for less than 30% of the disease heritability and additional risk variants have yet to be identified. Here we performed a GWAS followed by a meta-analysis to identify new genome-wide significant loci for SLE. METHODS: We genotyped a cohort of 907 patients with SLE (cases) and 1524 healthy controls from Spain and performed imputation using the 1000 Genomes reference data. We tested for association using logistic regression with correction for the principal components of variation. Meta-analysis of the association results was subsequently performed on 7,110,321 variants using genetic data from a large cohort of 4036 patients with SLE and 6959 controls of Northern European ancestry. Genetic association was also tested at the pathway level after removing the effect of known risk loci using PASCAL software. RESULTS: We identified five new loci associated with SLE at the genome-wide level of significance (p < 5 × 10- 8): GRB2, SMYD3, ST8SIA4, LAT2 and ARHGAP27. Pathway analysis revealed several biological processes significantly associated with SLE risk: B cell receptor signaling (p = 5.28 × 10- 6), CTLA4 co-stimulation during T cell activation (p = 3.06 × 10- 5), interleukin-4 signaling (p = 3.97 × 10- 5) and cell surface interactions at the vascular wall (p = 4.63 × 10- 5). CONCLUSIONS: Our results identify five novel loci for SLE susceptibility, and biologic pathways associated via multiple low-effect-size loci. More... »

PAGES

100

References to SciGraph publications

  • 2015-08. The support of human genetic evidence for approved drug indications in NATURE GENETICS
  • 2013-09. Transcriptome and genome sequencing uncovers functional variation in humans in NATURE
  • 2006-08. Principal components analysis corrects for stratification in genome-wide association studies in NATURE GENETICS
  • 2007-07. A new multipoint method for genome-wide association studies by imputation of genotypes in NATURE GENETICS
  • 2017-12. Human disease genomics: from variants to biology in GENOME BIOLOGY
  • 2018-12. Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes in NATURE COMMUNICATIONS
  • 2008-09. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus in NATURE GENETICS
  • 2016-12. New insights into the immunopathogenesis of systemic lupus erythematosus in NATURE REVIEWS RHEUMATOLOGY
  • 2015-12. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus in NATURE GENETICS
  • 2013-12. Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR in SCIENTIFIC REPORTS
  • 2003-02. LAB: A new membrane-associated adaptor molecule in B cell activation in NATURE IMMUNOLOGY
  • 2004-08. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells in NATURE CELL BIOLOGY
  • 2015-02. Gene expression analysis identifies global gene dosage sensitivity in cancer in NATURE GENETICS
  • 2016-08. Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus in NATURE GENETICS
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2009-07. Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus in NATURE IMMUNOLOGY
  • 2008-02. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci in NATURE GENETICS
  • 2015-02. Epigenomics: Roadmap for regulation in NATURE
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2013-10. Systematic identification of trans eQTLs as putative drivers of known disease associations in NATURE GENETICS
  • 2009-11. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus in NATURE GENETICS
  • 2012-04. Unmasking the immune recognition of prostate cancer with CTLA4 blockade in NATURE REVIEWS CANCER
  • 2013-01. Improved whole-chromosome phasing for disease and population genetic studies in NATURE METHODS
  • 2013-08. Validating therapeutic targets through human genetics in NATURE REVIEWS DRUG DISCOVERY
  • 2014-02. Genetics of rheumatoid arthritis contributes to biology and drug discovery in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13075-018-1604-1

    DOI

    http://dx.doi.org/10.1186/s13075-018-1604-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104295539

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29848360


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