Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Florian Weigold, Jeannine Günther, Moritz Pfeiffenberger, Otavio Cabral-Marques, Elise Siegert, Duska Dragun, Aurélie Philippe, Ann-Katrin Regensburger, Andreas Recke, Xinhua Yu, Frank Petersen, Rusan Catar, Robert Biesen, Falk Hiepe, Gerd R. Burmester, Harald Heidecke, Gabriela Riemekasten

ABSTRACT

BACKGROUND: The chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two receptors are present in patients with SSc and are associated with clinical findings. METHODS: Anti-CXCR3 and anti-CXCR4 ab levels were measured in 449 sera from 327 SSc patients and in 234 sera from healthy donors (HD) by enzyme-linked immunosorbent assay (ELISA). In SSc, ab levels were compared with clinical data in a cross-sectional and longitudinal setting. Protein expression of CXCR3 and CXCR4 on peripheral blood mononuclear cells (PBMCs) was analyzed in 17 SSc patients and 8 HD by flow cytometry. RESULTS: Anti-CXCR3 and anti-CXCR4 ab levels were different among SSc subgroups compared with HD and were highest in diffuse SSc patients. The ab levels strongly correlated with each other (r = 0.85). Patients with SSc-related interstitial lung disease (SSc-ILD) exhibited higher ab levels which negatively correlated with lung function parameters (e.g., r = -0.5 and r = -0.43 for predicted vital capacity, respectively). However, patients with deterioration of lung function showed lower anti-CXCR3/4 ab levels compared with those with stable disease. Frequencies and median fluorescence intensities (MFI) of CXCR3+ and CXCR4+ PBMCs were lower in SSc patients compared with HD and correlated with the severity of skin and lung fibrosis. They correlated with the severity of skin and lung fibrosis. CONCLUSIONS: Anti-CXCR3/4 abs and their corresponding receptors are linked with the severity of SSc-ILD. Antibody levels discriminate patients with stable or decreasing lung function and could be used for risk stratification. More... »

PAGES

52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13075-018-1545-8

DOI

http://dx.doi.org/10.1186/s13075-018-1545-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101697100

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29566745


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weigold", 
        "givenName": "Florian", 
        "id": "sg:person.014141770024.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014141770024.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Rheumatism Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.418217.9", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital, Berlin, Germany", 
            "Cell Autoimmunity Group, German Rheumatism Research Center (DRFZ), Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00fcnther", 
        "givenName": "Jeannine", 
        "id": "sg:person.0657502524.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657502524.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Rheumatism Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.418217.9", 
          "name": [
            "Cell Autoimmunity Group, German Rheumatism Research Center (DRFZ), Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfeiffenberger", 
        "givenName": "Moritz", 
        "id": "sg:person.01333542722.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333542722.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L\u00fcbeck", 
          "id": "https://www.grid.ac/institutes/grid.4562.5", 
          "name": [
            "Department of Rheumatology, University of L\u00fcbeck, L\u00fcbeck, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cabral-Marques", 
        "givenName": "Otavio", 
        "id": "sg:person.01114537047.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114537047.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Siegert", 
        "givenName": "Elise", 
        "id": "sg:person.0632047322.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632047322.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Berlin Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.484013.a", 
          "name": [
            "Department of Nephrology and Critical Care Medicine, Charit\u00e9 University Hospital, Campus Virchow, Berlin, Germany", 
            "Berlin Institute of Health, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dragun", 
        "givenName": "Duska", 
        "id": "sg:person.01235023511.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235023511.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Nephrology and Critical Care Medicine, Charit\u00e9 University Hospital, Campus Virchow, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Philippe", 
        "givenName": "Aur\u00e9lie", 
        "id": "sg:person.0724017526.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724017526.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L\u00fcbeck", 
          "id": "https://www.grid.ac/institutes/grid.4562.5", 
          "name": [
            "Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Regensburger", 
        "givenName": "Ann-Katrin", 
        "id": "sg:person.010655275624.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010655275624.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L\u00fcbeck", 
          "id": "https://www.grid.ac/institutes/grid.4562.5", 
          "name": [
            "Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Recke", 
        "givenName": "Andreas", 
        "id": "sg:person.0702063420.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702063420.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center Borstel - Leibniz-Center for Medicine and Biosciences", 
          "id": "https://www.grid.ac/institutes/grid.418187.3", 
          "name": [
            "Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Xinhua", 
        "id": "sg:person.01070372446.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070372446.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center Borstel - Leibniz-Center for Medicine and Biosciences", 
          "id": "https://www.grid.ac/institutes/grid.418187.3", 
          "name": [
            "Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petersen", 
        "givenName": "Frank", 
        "id": "sg:person.01225551775.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225551775.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Berlin Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.484013.a", 
          "name": [
            "Department of Nephrology and Critical Care Medicine, Charit\u00e9 University Hospital, Campus Virchow, Berlin, Germany", 
            "Berlin Institute of Health, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Catar", 
        "givenName": "Rusan", 
        "id": "sg:person.01135655303.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135655303.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Biesen", 
        "givenName": "Robert", 
        "id": "sg:person.01002257656.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002257656.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiepe", 
        "givenName": "Falk", 
        "id": "sg:person.01241710345.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241710345.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burmester", 
        "givenName": "Gerd R.", 
        "id": "sg:person.01056410623.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056410623.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CellTrend GmbH, Luckenwalde, Brandenburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heidecke", 
        "givenName": "Harald", 
        "id": "sg:person.0655704326.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655704326.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center Borstel - Leibniz-Center for Medicine and Biosciences", 
          "id": "https://www.grid.ac/institutes/grid.418187.3", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital, Berlin, Germany", 
            "Cell Autoimmunity Group, German Rheumatism Research Center (DRFZ), Berlin, Germany", 
            "Department of Rheumatology, University of L\u00fcbeck, L\u00fcbeck, Germany", 
            "Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riemekasten", 
        "givenName": "Gabriela", 
        "id": "sg:person.01125461745.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125461745.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2000.17715.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004483805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2015.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006041473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar4457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007844832", 
          "https://doi.org/10.1186/ar4457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2006.062901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010116371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2152/jmi.60.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012411065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.04813.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013438546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.04813.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013438546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.24136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017997874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-015-0513-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020831966", 
          "https://doi.org/10.1007/s00281-015-0513-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/ken179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021432168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0000000000000002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022828270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0000000000000002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022828270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2016.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028493320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.2002.02017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032641258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2010.135772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033541154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-006-0330-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037171978", 
          "https://doi.org/10.1007/s00428-006-0330-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-006-0330-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037171978", 
          "https://doi.org/10.1007/s00428-006-0330-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar4503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039806518", 
          "https://doi.org/10.1186/ar4503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00044911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040331917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1962.03050210027006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040436228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03008200903056150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047001746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2008.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047505687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-1536-4-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047668870", 
          "https://doi.org/10.1186/1755-1536-4-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201403-0442oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047736922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci16861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047887670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/icb.2010.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051948366", 
          "https://doi.org/10.1038/icb.2010.158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.22047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053273877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2009.114264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053414596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.5b01337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055099762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cb500577j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055226676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.150061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071543806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.150474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071543901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074543762", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078576669", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078791707", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079704019", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2017.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085387747", 
          "https://doi.org/10.1038/nrrheum.2017.71"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: The chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two receptors are present in patients with SSc and are associated with clinical findings.\nMETHODS: Anti-CXCR3 and anti-CXCR4 ab levels were measured in 449 sera from 327 SSc patients and in 234 sera from healthy donors (HD) by enzyme-linked immunosorbent assay (ELISA). In SSc, ab levels were compared with clinical data in a cross-sectional and longitudinal setting. Protein expression of CXCR3 and CXCR4 on peripheral blood mononuclear cells (PBMCs) was analyzed in 17 SSc patients and 8 HD by flow cytometry.\nRESULTS: Anti-CXCR3 and anti-CXCR4 ab levels were different among SSc subgroups compared with HD and were highest in diffuse SSc patients. The ab levels strongly correlated with each other (r = 0.85). Patients with SSc-related interstitial lung disease (SSc-ILD) exhibited higher ab levels which negatively correlated with lung function parameters (e.g., r = -0.5 and r = -0.43 for predicted vital capacity, respectively). However, patients with deterioration of lung function showed lower anti-CXCR3/4 ab levels compared with those with stable disease. Frequencies and median fluorescence intensities (MFI) of CXCR3+ and CXCR4+ PBMCs were lower in SSc patients compared with HD and correlated with the severity of skin and lung fibrosis. They correlated with the severity of skin and lung fibrosis.\nCONCLUSIONS: Anti-CXCR3/4 abs and their corresponding receptors are linked with the severity of SSc-ILD. Antibody levels discriminate patients with stable or decreasing lung function and could be used for risk stratification.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13075-018-1545-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297499", 
        "issn": [
          "1478-6354", 
          "1478-6362"
        ], 
        "name": "Arthritis Research & Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis", 
    "pagination": "52", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4f812ada4617903ebe944b00ca12106c71c27d10a6136812e2dc30e1ce65c538"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29566745"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101154438"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13075-018-1545-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101697100"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13075-018-1545-8", 
      "https://app.dimensions.ai/details/publication/pub.1101697100"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000364_0000000364/records_72836_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13075-018-1545-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1545-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1545-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1545-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13075-018-1545-8'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      63 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13075-018-1545-8 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Na9439c1c18a64792b23541524e1c2e70
4 schema:citation sg:pub.10.1007/s00281-015-0513-5
5 sg:pub.10.1007/s00428-006-0330-2
6 sg:pub.10.1038/icb.2010.158
7 sg:pub.10.1038/nrrheum.2017.71
8 sg:pub.10.1186/1755-1536-4-15
9 sg:pub.10.1186/ar4457
10 sg:pub.10.1186/ar4503
11 https://app.dimensions.ai/details/publication/pub.1074543762
12 https://app.dimensions.ai/details/publication/pub.1078576669
13 https://app.dimensions.ai/details/publication/pub.1078791707
14 https://app.dimensions.ai/details/publication/pub.1079704019
15 https://doi.org/10.1001/jama.1962.03050210027006
16 https://doi.org/10.1002/art.22047
17 https://doi.org/10.1002/art.24136
18 https://doi.org/10.1016/j.autrev.2016.03.005
19 https://doi.org/10.1016/j.biocel.2008.02.012
20 https://doi.org/10.1016/j.jaut.2015.07.001
21 https://doi.org/10.1021/acs.jmedchem.5b01337
22 https://doi.org/10.1021/cb500577j
23 https://doi.org/10.1034/j.1600-065x.2000.17715.x
24 https://doi.org/10.1046/j.1365-2249.2002.02017.x
25 https://doi.org/10.1093/rheumatology/ken179
26 https://doi.org/10.1097/moh.0000000000000002
27 https://doi.org/10.1111/j.1749-6632.2009.04813.x
28 https://doi.org/10.1136/ard.2006.062901
29 https://doi.org/10.1136/ard.2009.114264
30 https://doi.org/10.1136/ard.2010.135772
31 https://doi.org/10.1164/rccm.201403-0442oc
32 https://doi.org/10.1172/jci16861
33 https://doi.org/10.1183/09031936.00044911
34 https://doi.org/10.2152/jmi.60.127
35 https://doi.org/10.3109/03008200903056150
36 https://doi.org/10.3899/jrheum.150061
37 https://doi.org/10.3899/jrheum.150474
38 schema:datePublished 2018-12
39 schema:datePublishedReg 2018-12-01
40 schema:description BACKGROUND: The chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two receptors are present in patients with SSc and are associated with clinical findings. METHODS: Anti-CXCR3 and anti-CXCR4 ab levels were measured in 449 sera from 327 SSc patients and in 234 sera from healthy donors (HD) by enzyme-linked immunosorbent assay (ELISA). In SSc, ab levels were compared with clinical data in a cross-sectional and longitudinal setting. Protein expression of CXCR3 and CXCR4 on peripheral blood mononuclear cells (PBMCs) was analyzed in 17 SSc patients and 8 HD by flow cytometry. RESULTS: Anti-CXCR3 and anti-CXCR4 ab levels were different among SSc subgroups compared with HD and were highest in diffuse SSc patients. The ab levels strongly correlated with each other (r = 0.85). Patients with SSc-related interstitial lung disease (SSc-ILD) exhibited higher ab levels which negatively correlated with lung function parameters (e.g., r = -0.5 and r = -0.43 for predicted vital capacity, respectively). However, patients with deterioration of lung function showed lower anti-CXCR3/4 ab levels compared with those with stable disease. Frequencies and median fluorescence intensities (MFI) of CXCR3+ and CXCR4+ PBMCs were lower in SSc patients compared with HD and correlated with the severity of skin and lung fibrosis. They correlated with the severity of skin and lung fibrosis. CONCLUSIONS: Anti-CXCR3/4 abs and their corresponding receptors are linked with the severity of SSc-ILD. Antibody levels discriminate patients with stable or decreasing lung function and could be used for risk stratification.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N6298a6141cad40448b2e9e91ad0729c8
45 N7e1a7b308b5a492d983a91aaebe25d49
46 sg:journal.1297499
47 schema:name Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis
48 schema:pagination 52
49 schema:productId N2bb050a8256c442fbee3bea86f5a8bf9
50 N4381b85fa2654934af0bdfbf8df6c61b
51 N56f2dc5d403e4dd681ce498b3afc98d2
52 Nc4727c7597c245f4ab7231c2f7918a6a
53 Nfd2e3c6b1393408397a2f874cd9a1d36
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101697100
55 https://doi.org/10.1186/s13075-018-1545-8
56 schema:sdDatePublished 2019-04-11T12:52
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N2bf1b915eace4e6c9a76b64bf1b1b711
59 schema:url https://link.springer.com/10.1186%2Fs13075-018-1545-8
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0740f68145b242f29240296cb90984be rdf:first sg:person.0702063420.71
64 rdf:rest Nbab6907d346544219546b85842c6cb0c
65 N2bb050a8256c442fbee3bea86f5a8bf9 schema:name dimensions_id
66 schema:value pub.1101697100
67 rdf:type schema:PropertyValue
68 N2bf1b915eace4e6c9a76b64bf1b1b711 schema:name Springer Nature - SN SciGraph project
69 rdf:type schema:Organization
70 N4381b85fa2654934af0bdfbf8df6c61b schema:name doi
71 schema:value 10.1186/s13075-018-1545-8
72 rdf:type schema:PropertyValue
73 N45838d79886546eeb742240d171f107c rdf:first sg:person.0655704326.21
74 rdf:rest N5ee52a7d7ee44ef594ed5c455ff71f8e
75 N4e5e3754cfb24b9bb47fc8a8edc79577 rdf:first sg:person.01114537047.33
76 rdf:rest Nb51e0d69763d41fbbaf2fe2bc07b88f6
77 N511a096e602b4c3ebb703624e7f56633 rdf:first sg:person.01225551775.29
78 rdf:rest Na7b43a90f4734bada163c6c35289a647
79 N536ca49fc5204414afc451e5b72e2133 rdf:first sg:person.01002257656.02
80 rdf:rest Ndb8e9f60e7694323aee8cc67347a07f4
81 N56f2dc5d403e4dd681ce498b3afc98d2 schema:name pubmed_id
82 schema:value 29566745
83 rdf:type schema:PropertyValue
84 N5ee52a7d7ee44ef594ed5c455ff71f8e rdf:first sg:person.01125461745.45
85 rdf:rest rdf:nil
86 N6298a6141cad40448b2e9e91ad0729c8 schema:volumeNumber 20
87 rdf:type schema:PublicationVolume
88 N76bd942f0f64486a879c0a2d6e4ec454 rdf:first sg:person.01235023511.51
89 rdf:rest Na607a3007ab8459d97ec27cefaf13fca
90 N7e1a7b308b5a492d983a91aaebe25d49 schema:issueNumber 1
91 rdf:type schema:PublicationIssue
92 N84d6d0652cb946db9d945cee7f78ce22 schema:name CellTrend GmbH, Luckenwalde, Brandenburg, Germany
93 rdf:type schema:Organization
94 N87908c995f224fb48dd28279a23e78e1 rdf:first sg:person.010655275624.49
95 rdf:rest N0740f68145b242f29240296cb90984be
96 Na607a3007ab8459d97ec27cefaf13fca rdf:first sg:person.0724017526.48
97 rdf:rest N87908c995f224fb48dd28279a23e78e1
98 Na7b43a90f4734bada163c6c35289a647 rdf:first sg:person.01135655303.23
99 rdf:rest N536ca49fc5204414afc451e5b72e2133
100 Na9439c1c18a64792b23541524e1c2e70 rdf:first sg:person.014141770024.19
101 rdf:rest Ndb6e7b221519497398a891439c379a76
102 Nb51e0d69763d41fbbaf2fe2bc07b88f6 rdf:first sg:person.0632047322.93
103 rdf:rest N76bd942f0f64486a879c0a2d6e4ec454
104 Nbab6907d346544219546b85842c6cb0c rdf:first sg:person.01070372446.93
105 rdf:rest N511a096e602b4c3ebb703624e7f56633
106 Nc4727c7597c245f4ab7231c2f7918a6a schema:name readcube_id
107 schema:value 4f812ada4617903ebe944b00ca12106c71c27d10a6136812e2dc30e1ce65c538
108 rdf:type schema:PropertyValue
109 Ncf3e974ef2844d2aa56a24efbb914835 rdf:first sg:person.01056410623.19
110 rdf:rest N45838d79886546eeb742240d171f107c
111 Ndb6e7b221519497398a891439c379a76 rdf:first sg:person.0657502524.73
112 rdf:rest Ne3c9c6706c084205b9d9189381fd3b77
113 Ndb8e9f60e7694323aee8cc67347a07f4 rdf:first sg:person.01241710345.80
114 rdf:rest Ncf3e974ef2844d2aa56a24efbb914835
115 Ne3c9c6706c084205b9d9189381fd3b77 rdf:first sg:person.01333542722.30
116 rdf:rest N4e5e3754cfb24b9bb47fc8a8edc79577
117 Nfd2e3c6b1393408397a2f874cd9a1d36 schema:name nlm_unique_id
118 schema:value 101154438
119 rdf:type schema:PropertyValue
120 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
121 schema:name Medical and Health Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
124 schema:name Cardiorespiratory Medicine and Haematology
125 rdf:type schema:DefinedTerm
126 sg:journal.1297499 schema:issn 1478-6354
127 1478-6362
128 schema:name Arthritis Research & Therapy
129 rdf:type schema:Periodical
130 sg:person.01002257656.02 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
131 schema:familyName Biesen
132 schema:givenName Robert
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002257656.02
134 rdf:type schema:Person
135 sg:person.01056410623.19 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
136 schema:familyName Burmester
137 schema:givenName Gerd R.
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056410623.19
139 rdf:type schema:Person
140 sg:person.010655275624.49 schema:affiliation https://www.grid.ac/institutes/grid.4562.5
141 schema:familyName Regensburger
142 schema:givenName Ann-Katrin
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010655275624.49
144 rdf:type schema:Person
145 sg:person.01070372446.93 schema:affiliation https://www.grid.ac/institutes/grid.418187.3
146 schema:familyName Yu
147 schema:givenName Xinhua
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070372446.93
149 rdf:type schema:Person
150 sg:person.01114537047.33 schema:affiliation https://www.grid.ac/institutes/grid.4562.5
151 schema:familyName Cabral-Marques
152 schema:givenName Otavio
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114537047.33
154 rdf:type schema:Person
155 sg:person.01125461745.45 schema:affiliation https://www.grid.ac/institutes/grid.418187.3
156 schema:familyName Riemekasten
157 schema:givenName Gabriela
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125461745.45
159 rdf:type schema:Person
160 sg:person.01135655303.23 schema:affiliation https://www.grid.ac/institutes/grid.484013.a
161 schema:familyName Catar
162 schema:givenName Rusan
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135655303.23
164 rdf:type schema:Person
165 sg:person.01225551775.29 schema:affiliation https://www.grid.ac/institutes/grid.418187.3
166 schema:familyName Petersen
167 schema:givenName Frank
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225551775.29
169 rdf:type schema:Person
170 sg:person.01235023511.51 schema:affiliation https://www.grid.ac/institutes/grid.484013.a
171 schema:familyName Dragun
172 schema:givenName Duska
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235023511.51
174 rdf:type schema:Person
175 sg:person.01241710345.80 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
176 schema:familyName Hiepe
177 schema:givenName Falk
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241710345.80
179 rdf:type schema:Person
180 sg:person.01333542722.30 schema:affiliation https://www.grid.ac/institutes/grid.418217.9
181 schema:familyName Pfeiffenberger
182 schema:givenName Moritz
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333542722.30
184 rdf:type schema:Person
185 sg:person.014141770024.19 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
186 schema:familyName Weigold
187 schema:givenName Florian
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014141770024.19
189 rdf:type schema:Person
190 sg:person.0632047322.93 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
191 schema:familyName Siegert
192 schema:givenName Elise
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632047322.93
194 rdf:type schema:Person
195 sg:person.0655704326.21 schema:affiliation N84d6d0652cb946db9d945cee7f78ce22
196 schema:familyName Heidecke
197 schema:givenName Harald
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655704326.21
199 rdf:type schema:Person
200 sg:person.0657502524.73 schema:affiliation https://www.grid.ac/institutes/grid.418217.9
201 schema:familyName Günther
202 schema:givenName Jeannine
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657502524.73
204 rdf:type schema:Person
205 sg:person.0702063420.71 schema:affiliation https://www.grid.ac/institutes/grid.4562.5
206 schema:familyName Recke
207 schema:givenName Andreas
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702063420.71
209 rdf:type schema:Person
210 sg:person.0724017526.48 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
211 schema:familyName Philippe
212 schema:givenName Aurélie
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724017526.48
214 rdf:type schema:Person
215 sg:pub.10.1007/s00281-015-0513-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020831966
216 https://doi.org/10.1007/s00281-015-0513-5
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s00428-006-0330-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037171978
219 https://doi.org/10.1007/s00428-006-0330-2
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/icb.2010.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051948366
222 https://doi.org/10.1038/icb.2010.158
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nrrheum.2017.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085387747
225 https://doi.org/10.1038/nrrheum.2017.71
226 rdf:type schema:CreativeWork
227 sg:pub.10.1186/1755-1536-4-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047668870
228 https://doi.org/10.1186/1755-1536-4-15
229 rdf:type schema:CreativeWork
230 sg:pub.10.1186/ar4457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007844832
231 https://doi.org/10.1186/ar4457
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/ar4503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039806518
234 https://doi.org/10.1186/ar4503
235 rdf:type schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1074543762 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1078576669 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1078791707 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1079704019 schema:CreativeWork
240 https://doi.org/10.1001/jama.1962.03050210027006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040436228
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/art.22047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053273877
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/art.24136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017997874
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.autrev.2016.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028493320
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.biocel.2008.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047505687
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.jaut.2015.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006041473
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1021/acs.jmedchem.5b01337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055099762
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1021/cb500577j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055226676
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1034/j.1600-065x.2000.17715.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004483805
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1046/j.1365-2249.2002.02017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032641258
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/rheumatology/ken179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021432168
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/moh.0000000000000002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022828270
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1749-6632.2009.04813.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013438546
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1136/ard.2006.062901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010116371
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1136/ard.2009.114264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053414596
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1136/ard.2010.135772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033541154
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1164/rccm.201403-0442oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1047736922
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1172/jci16861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047887670
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1183/09031936.00044911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040331917
277 rdf:type schema:CreativeWork
278 https://doi.org/10.2152/jmi.60.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012411065
279 rdf:type schema:CreativeWork
280 https://doi.org/10.3109/03008200903056150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047001746
281 rdf:type schema:CreativeWork
282 https://doi.org/10.3899/jrheum.150061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071543806
283 rdf:type schema:CreativeWork
284 https://doi.org/10.3899/jrheum.150474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071543901
285 rdf:type schema:CreativeWork
286 https://www.grid.ac/institutes/grid.418187.3 schema:alternateName Research Center Borstel - Leibniz-Center for Medicine and Biosciences
287 schema:name Cell Autoimmunity Group, German Rheumatism Research Center (DRFZ), Berlin, Germany
288 Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany
289 Department of Rheumatology, University of Lübeck, Lübeck, Germany
290 Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.418217.9 schema:alternateName German Rheumatism Research Centre
293 schema:name Cell Autoimmunity Group, German Rheumatism Research Center (DRFZ), Berlin, Germany
294 Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.4562.5 schema:alternateName University of Lübeck
297 schema:name Department of Dermatology, University of Lübeck, Lübeck, Germany
298 Department of Rheumatology, University of Lübeck, Lübeck, Germany
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.484013.a schema:alternateName Berlin Institute of Health
301 schema:name Berlin Institute of Health, Berlin, Germany
302 Department of Nephrology and Critical Care Medicine, Charité University Hospital, Campus Virchow, Berlin, Germany
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
305 schema:name Department of Nephrology and Critical Care Medicine, Charité University Hospital, Campus Virchow, Berlin, Germany
306 Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...