Continuous evolution of clinical phenotype in 578 Japanese patients with Behçet’s disease: a retrospective observational study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-03

AUTHORS

Yohei Kirino, Haruko Ideguchi, Mitsuhiro Takeno, Akiko Suda, Kana Higashitani, Yosuke Kunishita, Kaoru Takase-Minegishi, Maasa Tamura, Toshiyuki Watanabe, Yukiko Asami, Takeaki Uehara, Ryusuke Yoshimi, Tetsu Yamazaki, Akiko Sekiguchi, Atsushi Ihata, Shigeru Ohno, Atsuhisa Ueda, Toshihisa Igarashi, Shohei Nagaoka, Yoshiaki Ishigatsubo, Hideaki Nakajima

ABSTRACT

BACKGROUND: It has been suggested that the phenotypes of Behçet's disease (BD) in Japan are changing. To ask whether the evolution of BD holds true in recent-onset cases in Japan, we performed a retrospective study. METHODS: We reviewed the records of 578 patients with BD who met the 1987 revised diagnostic criteria of the Behçet's disease research committee of Japan. The patients were divided into three groups based on the date of disease onset. We compared the demography, clinical features, and treatments among them with or without adjustment for the observation period. Patients having oral ulcers, genital ulcers, regional skin involvement, and uveitis are categorized as having complete-type BD, and the associated factors were determined by univariate and multivariate logistic regression analyses. RESULTS: Male patients had a higher propensity for uveitis and central nervous system (CNS) involvement, whereas female patients had higher rates of genital ulcers and arthritis. We found a significant trend in reduction of complete-type, genital ulcer, HLA-B51 carriers, and increment of gastrointestinal BD over time. Multiple regression analysis identified HLA-B51 positivity, earlier date of disease onset, and younger age of onset as independently associated with complete-type BD. Although treatments had been also chronologically changed, the causative relationship between therapeutic agents and phenotypical changes was not determined from the study. CONCLUSION: The present study revealed that phenotypical evolution was characterized by decreased incidence of the complete type and increment of gastrointestinal involvement in Japanese patients with BD during the last 30 years. More... »

PAGES

217

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13075-016-1115-x

DOI

http://dx.doi.org/10.1186/s13075-016-1115-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026087970

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27716399


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364 Department of Rheumatology, Chigasaki City Hospital, Chigasaki, Japan
365 Department of Rheumatology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan
366 Department of Rheumatology, Yamato City Hospital, Yamato, Japan
367 Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan
368 Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama, 236-0004 Japan
369 Y-CURD study group, Yokohama, Japan
370 Yokohama City University, Yokohama, Japan
371 Yokosuka Center for Rheumatic Diseases, Yokosuka City Hospital, Yokosuka, Japan
372 rdf:type schema:Organization
373 grid-institutes:grid.268441.d schema:alternateName Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama, 236-0004 Japan
374 schema:name Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama, 236-0004 Japan
375 rdf:type schema:Organization
 




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