Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Andrea R. Tan, Curtis D. VandenBerg, Mukundan Attur, Steven B. Abramson, Martin M Knight, J. Chloe Bulinski, Gerard A. Ateshian, James L Cook, Clark T. Hung

ABSTRACT

BACKGROUND: During osteoarthritis and following surgical procedures, the environment of the knee is rich in proinflammatory cytokines such as IL-1. Introduction of tissue-engineered cartilage constructs to a chemically harsh milieu may limit the functionality of the implanted tissue over long periods. A chemical preconditioning scheme (application of low doses of IL-1) was tested as a method to prepare developing engineered tissue to withstand exposure to a higher concentration of the cytokine, known to elicit proteolysis as well as rapid degeneration of cartilage. METHODS: Using an established juvenile bovine model system, engineered cartilage was preconditioned with low doses of IL-1α (0.1 ng/mL, 0.5 ng/mL, and 1.0 ng/mL) for 7 days before exposure to an insult dose (10 ng/mL). The time frame over which this protection is afforded was investigated by altering the amount of time between preconditioning and insult as well as the time following insult. To explore a potential mechanism for this protection, one set of constructs was preconditioned with CoCl2, a chemical inducer of hypoxia, before exposure to the IL-1α insult. Finally, we examined the translation of this preconditioning method to extend to clinically relevant adult, passaged chondrocytes from a preclinical canine model. RESULTS: Low doses of IL-1α (0.1 ng/mL and 0.5 ng/mL) protected against subsequent catabolic degradation by cytokine insult, preserving mechanical stiffness and biochemical composition. Regardless of amount of time between preconditioning scheme and insult, protection was afforded. In a similar manner, preconditioning with CoCl2 similarly allowed for mediation of catabolic damage by IL-1α. The effects of preconditioning on clinically relevant adult, passaged chondrocytes from a preclinical canine model followed the same trends with low-dose IL-1β offering variable protection against insult. CONCLUSIONS: Chemical preconditioning schemes have the ability to protect engineered cartilage constructs from IL-1-induced catabolic degradation, offering potential modalities for therapeutic treatments. More... »

PAGES

361

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13075-015-0876-y

DOI

http://dx.doi.org/10.1186/s13075-015-0876-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018457428

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26667364


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cartilage, Articular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cattle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chondrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Engineering", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Andrea R.", 
        "id": "sg:person.0630704141.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630704141.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Luke's-Roosevelt Hospital Center", 
          "id": "https://www.grid.ac/institutes/grid.240873.a", 
          "name": [
            "Department of Orthopedic Surgery, St. Luke\u2019s-Roosevelt Hospital Center, 1000 10th Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "VandenBerg", 
        "givenName": "Curtis D.", 
        "id": "sg:person.0766551114.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766551114.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "New York University Hospital for Joint Disease, 301 E. 17th Street, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Attur", 
        "givenName": "Mukundan", 
        "id": "sg:person.0603146777.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603146777.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "New York University Hospital for Joint Disease, 301 E. 17th Street, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abramson", 
        "givenName": "Steven B.", 
        "id": "sg:person.0660617545.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660617545.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Institute of Bioengineering and School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knight", 
        "givenName": "Martin M", 
        "id": "sg:person.01025552355.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025552355.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bulinski", 
        "givenName": "J. Chloe", 
        "id": "sg:person.01313460151.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313460151.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY, USA", 
            "Department of Mechanical Engineering, Columbia University, 500 W. 120th Street, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ateshian", 
        "givenName": "Gerard A.", 
        "id": "sg:person.01357277633.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357277633.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Missouri", 
          "id": "https://www.grid.ac/institutes/grid.134936.a", 
          "name": [
            "Comparative Orthopaedic Laboratory, University of Missouri, 1100 Virginia Avenue, Columbia, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "James L", 
        "id": "sg:person.01102753263.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102753263.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "Clark T.", 
        "id": "sg:person.01202600370.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202600370.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nri1865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000000694", 
          "https://doi.org/10.1038/nri1865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000000694", 
          "https://doi.org/10.1038/nri1865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joca.2010.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000770604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.20538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001204256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiomech.2008.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001759254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.197723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002060047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.197723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002060047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiomech.2008.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003166747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2009.05.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004282666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resp.2008.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005270459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.12.4853-4862.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006013037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m800181-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008045161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.62.7.635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008851968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00031.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010045398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0049-0172(91)90024-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010254283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0049-0172(91)90024-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010254283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00856.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010560481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e3282ba5693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011456963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e3282ba5693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011456963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.22334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012209381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joca.2007.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012540130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:abme.0000007789.99565.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016924597", 
          "https://doi.org/10.1023/b:abme.0000007789.99565.42"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-1104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017176200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiomech.2005.03.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018682887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-8425-0_20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021037550", 
          "https://doi.org/10.1007/978-1-4613-8425-0_20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12265-009-9161-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021884391", 
          "https://doi.org/10.1007/s12265-009-9161-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12265-009-9161-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021884391", 
          "https://doi.org/10.1007/s12265-009-9161-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2009.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022065830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2600543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022888420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2600543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022888420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024189688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025506710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/joca.1998.0111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028004291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiomech.2008.01.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030485772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/2046-3758.34.2000238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030608733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtcvs.2009.01.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031974353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtcvs.2007.07.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034979807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03008209209014233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035344386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-9861(03)00129-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035741771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-9861(03)00129-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035741771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9290(98)00105-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039602724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6061/clinics/2012(01)06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041993938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2010.159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042329000", 
          "https://doi.org/10.1038/nrrheum.2010.159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2010.159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042329000", 
          "https://doi.org/10.1038/nrrheum.2010.159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.22145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042495032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(67)90167-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043207538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(67)90167-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043207538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.74.5.1124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049137364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvm025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050937966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107632703768247304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059206239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.2005.11.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059313395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2007.0347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059314939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2009.0482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2009.0581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2011.0155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.teb.2008.0586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059316930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200110001-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200110001-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200110001-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200110001-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200110001-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200110001-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1115/1.1611512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062072939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0363546510361950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063821684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0363546510361950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063821684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.137.8.8754787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064281113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.22203/ecm.v021a16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069338923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/ajvr.2000.61.766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070762001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/ajvr.2000.61.766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070762001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/ajvr.2005.66.1187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070763207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/ajvr.2005.66.1187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070763207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074559684", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075075881", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076875968", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083239598", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: During osteoarthritis and following surgical procedures, the environment of the knee is rich in proinflammatory cytokines such as IL-1. Introduction of tissue-engineered cartilage constructs to a chemically harsh milieu may limit the functionality of the implanted tissue over long periods. A chemical preconditioning scheme (application of low doses of IL-1) was tested as a method to prepare developing engineered tissue to withstand exposure to a higher concentration of the cytokine, known to elicit proteolysis as well as rapid degeneration of cartilage.\nMETHODS: Using an established juvenile bovine model system, engineered cartilage was preconditioned with low doses of IL-1\u03b1 (0.1 ng/mL, 0.5 ng/mL, and 1.0 ng/mL) for 7 days before exposure to an insult dose (10 ng/mL). The time frame over which this protection is afforded was investigated by altering the amount of time between preconditioning and insult as well as the time following insult. To explore a potential mechanism for this protection, one set of constructs was preconditioned with CoCl2, a chemical inducer of hypoxia, before exposure to the IL-1\u03b1 insult. Finally, we examined the translation of this preconditioning method to extend to clinically relevant adult, passaged chondrocytes from a preclinical canine model.\nRESULTS: Low doses of IL-1\u03b1 (0.1 ng/mL and 0.5 ng/mL) protected against subsequent catabolic degradation by cytokine insult, preserving mechanical stiffness and biochemical composition. Regardless of amount of time between preconditioning scheme and insult, protection was afforded. In a similar manner, preconditioning with CoCl2 similarly allowed for mediation of catabolic damage by IL-1\u03b1. The effects of preconditioning on clinically relevant adult, passaged chondrocytes from a preclinical canine model followed the same trends with low-dose IL-1\u03b2 offering variable protection against insult.\nCONCLUSIONS: Chemical preconditioning schemes have the ability to protect engineered cartilage constructs from IL-1-induced catabolic degradation, offering potential modalities for therapeutic treatments.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13075-015-0876-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2465271", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2465362", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439661", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297499", 
        "issn": [
          "1478-6354", 
          "1478-6362"
        ], 
        "name": "Arthritis Research & Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult", 
    "pagination": "361", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "57f1a3635bdc1e35247f2a56fbd254e3e22a3679e1a8b42d47743aebbf105197"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26667364"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101154438"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13075-015-0876-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018457428"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13075-015-0876-y", 
      "https://app.dimensions.ai/details/publication/pub.1018457428"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13075-015-0876-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0876-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0876-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0876-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0876-y'


 

This table displays all metadata directly associated to this object as RDF triples.

363 TRIPLES      21 PREDICATES      98 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13075-015-0876-y schema:about N09a00c79163442ffa845993e4842af8f
2 N16fc7ae8a65d4016a72f7d466624e884
3 N1fcc701262fa430abc8538b2c47392f5
4 N5565a28ac3e543bba23a61af0c8a384b
5 N5e77a30abb634a7f85bfa3118a5298cd
6 N7148ca4ecf9642f4a28491736fa304d4
7 N7a680aa74ec3497da8d8122a38bde65b
8 Na0c1ba0755be4062affc1ce6164371f8
9 Nbffb87c1fc2147f3ae730aa3b334ffff
10 Ncb8a9e0272b643b6b56029792b52803c
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author Ncb4b7442ddb74e50bff7dab0db9f977c
14 schema:citation sg:pub.10.1007/978-1-4613-8425-0_20
15 sg:pub.10.1007/s12265-009-9161-2
16 sg:pub.10.1023/b:abme.0000007789.99565.42
17 sg:pub.10.1038/nri1865
18 sg:pub.10.1038/nrrheum.2010.159
19 https://app.dimensions.ai/details/publication/pub.1074559684
20 https://app.dimensions.ai/details/publication/pub.1075075881
21 https://app.dimensions.ai/details/publication/pub.1076875968
22 https://app.dimensions.ai/details/publication/pub.1083239598
23 https://doi.org/10.1002/art.10849
24 https://doi.org/10.1002/art.21215
25 https://doi.org/10.1002/art.22145
26 https://doi.org/10.1002/jor.20538
27 https://doi.org/10.1002/jor.22334
28 https://doi.org/10.1016/0009-8981(67)90167-2
29 https://doi.org/10.1016/0049-0172(91)90024-t
30 https://doi.org/10.1016/j.bpj.2009.05.047
31 https://doi.org/10.1016/j.jacc.2009.02.015
32 https://doi.org/10.1016/j.jbiomech.2005.03.031
33 https://doi.org/10.1016/j.jbiomech.2008.01.026
34 https://doi.org/10.1016/j.jbiomech.2008.06.015
35 https://doi.org/10.1016/j.jbiomech.2008.08.023
36 https://doi.org/10.1016/j.joca.2007.03.008
37 https://doi.org/10.1016/j.joca.2010.09.003
38 https://doi.org/10.1016/j.jtcvs.2007.07.071
39 https://doi.org/10.1016/j.jtcvs.2009.01.028
40 https://doi.org/10.1016/j.resp.2008.07.006
41 https://doi.org/10.1016/s0003-9861(03)00129-2
42 https://doi.org/10.1016/s0021-9290(98)00105-5
43 https://doi.org/10.1042/bj2600543
44 https://doi.org/10.1053/joca.1998.0111
45 https://doi.org/10.1074/mcp.m800181-mcp200
46 https://doi.org/10.1089/107632703768247304
47 https://doi.org/10.1089/ten.2005.11.192
48 https://doi.org/10.1089/ten.tea.2007.0347
49 https://doi.org/10.1089/ten.tea.2009.0482
50 https://doi.org/10.1089/ten.tea.2009.0581
51 https://doi.org/10.1089/ten.tea.2011.0155
52 https://doi.org/10.1089/ten.teb.2008.0586
53 https://doi.org/10.1093/cvr/cvm025
54 https://doi.org/10.1097/00003086-200110001-00011
55 https://doi.org/10.1097/00003086-200110001-00014
56 https://doi.org/10.1097/bor.0b013e3282ba5693
57 https://doi.org/10.1115/1.1611512
58 https://doi.org/10.1128/mcb.25.12.4853-4862.2005
59 https://doi.org/10.1136/ard.62.7.635
60 https://doi.org/10.1152/ajpheart.00031.2004
61 https://doi.org/10.1152/ajpheart.00856.2007
62 https://doi.org/10.1161/01.cir.74.5.1124
63 https://doi.org/10.1161/circresaha.109.197723
64 https://doi.org/10.1177/0363546510361950
65 https://doi.org/10.1210/endo.137.8.8754787
66 https://doi.org/10.1302/2046-3758.34.2000238
67 https://doi.org/10.1634/stemcells.2007-1104
68 https://doi.org/10.22203/ecm.v021a16
69 https://doi.org/10.2460/ajvr.2000.61.766
70 https://doi.org/10.2460/ajvr.2005.66.1187
71 https://doi.org/10.3109/03008209209014233
72 https://doi.org/10.6061/clinics/2012(01)06
73 schema:datePublished 2015-12
74 schema:datePublishedReg 2015-12-01
75 schema:description BACKGROUND: During osteoarthritis and following surgical procedures, the environment of the knee is rich in proinflammatory cytokines such as IL-1. Introduction of tissue-engineered cartilage constructs to a chemically harsh milieu may limit the functionality of the implanted tissue over long periods. A chemical preconditioning scheme (application of low doses of IL-1) was tested as a method to prepare developing engineered tissue to withstand exposure to a higher concentration of the cytokine, known to elicit proteolysis as well as rapid degeneration of cartilage. METHODS: Using an established juvenile bovine model system, engineered cartilage was preconditioned with low doses of IL-1α (0.1 ng/mL, 0.5 ng/mL, and 1.0 ng/mL) for 7 days before exposure to an insult dose (10 ng/mL). The time frame over which this protection is afforded was investigated by altering the amount of time between preconditioning and insult as well as the time following insult. To explore a potential mechanism for this protection, one set of constructs was preconditioned with CoCl2, a chemical inducer of hypoxia, before exposure to the IL-1α insult. Finally, we examined the translation of this preconditioning method to extend to clinically relevant adult, passaged chondrocytes from a preclinical canine model. RESULTS: Low doses of IL-1α (0.1 ng/mL and 0.5 ng/mL) protected against subsequent catabolic degradation by cytokine insult, preserving mechanical stiffness and biochemical composition. Regardless of amount of time between preconditioning scheme and insult, protection was afforded. In a similar manner, preconditioning with CoCl2 similarly allowed for mediation of catabolic damage by IL-1α. The effects of preconditioning on clinically relevant adult, passaged chondrocytes from a preclinical canine model followed the same trends with low-dose IL-1β offering variable protection against insult. CONCLUSIONS: Chemical preconditioning schemes have the ability to protect engineered cartilage constructs from IL-1-induced catabolic degradation, offering potential modalities for therapeutic treatments.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree true
79 schema:isPartOf N31d47f19f9b64b64ba1eb31a16fdfe32
80 N87a00243016a4371830b626994f56e29
81 sg:journal.1297499
82 schema:name Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult
83 schema:pagination 361
84 schema:productId N26d48329886a47fd8d70b629c22b553a
85 N4a0fc1d58438487396e1706c89ca5c1d
86 N5ea5d285a22f46ba8e75cd28d2dead05
87 Nb093ee6009d54bc2b7a1fbd7a5036d2d
88 Nd384844d6db74d13a4a0255a1b7c0497
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457428
90 https://doi.org/10.1186/s13075-015-0876-y
91 schema:sdDatePublished 2019-04-10T14:09
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nf926ee580f6648e8bbea9da6a5071069
94 schema:url http://link.springer.com/10.1186%2Fs13075-015-0876-y
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N09a00c79163442ffa845993e4842af8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Tissue Engineering
100 rdf:type schema:DefinedTerm
101 N16fc7ae8a65d4016a72f7d466624e884 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Dogs
103 rdf:type schema:DefinedTerm
104 N1fcc701262fa430abc8538b2c47392f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cattle
106 rdf:type schema:DefinedTerm
107 N26d48329886a47fd8d70b629c22b553a schema:name doi
108 schema:value 10.1186/s13075-015-0876-y
109 rdf:type schema:PropertyValue
110 N31d47f19f9b64b64ba1eb31a16fdfe32 schema:issueNumber 1
111 rdf:type schema:PublicationIssue
112 N45fbab26676c42d3a0d8c460ce65782d rdf:first sg:person.0603146777.64
113 rdf:rest Nb2e4186d9c1341ebabf032658deff30a
114 N4a0fc1d58438487396e1706c89ca5c1d schema:name nlm_unique_id
115 schema:value 101154438
116 rdf:type schema:PropertyValue
117 N5565a28ac3e543bba23a61af0c8a384b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Animals
119 rdf:type schema:DefinedTerm
120 N5e77a30abb634a7f85bfa3118a5298cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Disease Models, Animal
122 rdf:type schema:DefinedTerm
123 N5ea5d285a22f46ba8e75cd28d2dead05 schema:name readcube_id
124 schema:value 57f1a3635bdc1e35247f2a56fbd254e3e22a3679e1a8b42d47743aebbf105197
125 rdf:type schema:PropertyValue
126 N7148ca4ecf9642f4a28491736fa304d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cytokines
128 rdf:type schema:DefinedTerm
129 N7a680aa74ec3497da8d8122a38bde65b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Chondrocytes
131 rdf:type schema:DefinedTerm
132 N87a00243016a4371830b626994f56e29 schema:volumeNumber 17
133 rdf:type schema:PublicationVolume
134 N881e6ca18bc340d6beab0bce3f6eb84c rdf:first sg:person.01313460151.54
135 rdf:rest Nc48f4b2ab0af43c0834add076660382f
136 N9804e7db33044d409410c373db16509e rdf:first sg:person.01102753263.71
137 rdf:rest N9b9d0f7c2dbe4cd7a81bc0fe61a05548
138 N9b9d0f7c2dbe4cd7a81bc0fe61a05548 rdf:first sg:person.01202600370.83
139 rdf:rest rdf:nil
140 Na0c1ba0755be4062affc1ce6164371f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Interleukin-1alpha
142 rdf:type schema:DefinedTerm
143 Nb093ee6009d54bc2b7a1fbd7a5036d2d schema:name pubmed_id
144 schema:value 26667364
145 rdf:type schema:PropertyValue
146 Nb2e4186d9c1341ebabf032658deff30a rdf:first sg:person.0660617545.53
147 rdf:rest Nfec7782e9ca14013ad426bc3cbbea988
148 Nbffb87c1fc2147f3ae730aa3b334ffff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Cartilage, Articular
150 rdf:type schema:DefinedTerm
151 Nc48f4b2ab0af43c0834add076660382f rdf:first sg:person.01357277633.77
152 rdf:rest N9804e7db33044d409410c373db16509e
153 Ncb4b7442ddb74e50bff7dab0db9f977c rdf:first sg:person.0630704141.63
154 rdf:rest Nce7d83b0dbb848da92f69831e78fae03
155 Ncb8a9e0272b643b6b56029792b52803c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Cells, Cultured
157 rdf:type schema:DefinedTerm
158 Nce7d83b0dbb848da92f69831e78fae03 rdf:first sg:person.0766551114.03
159 rdf:rest N45fbab26676c42d3a0d8c460ce65782d
160 Nd384844d6db74d13a4a0255a1b7c0497 schema:name dimensions_id
161 schema:value pub.1018457428
162 rdf:type schema:PropertyValue
163 Nf926ee580f6648e8bbea9da6a5071069 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nfec7782e9ca14013ad426bc3cbbea988 rdf:first sg:person.01025552355.57
166 rdf:rest N881e6ca18bc340d6beab0bce3f6eb84c
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
171 schema:name Clinical Sciences
172 rdf:type schema:DefinedTerm
173 sg:grant.2439661 http://pending.schema.org/fundedItem sg:pub.10.1186/s13075-015-0876-y
174 rdf:type schema:MonetaryGrant
175 sg:grant.2465271 http://pending.schema.org/fundedItem sg:pub.10.1186/s13075-015-0876-y
176 rdf:type schema:MonetaryGrant
177 sg:grant.2465362 http://pending.schema.org/fundedItem sg:pub.10.1186/s13075-015-0876-y
178 rdf:type schema:MonetaryGrant
179 sg:journal.1297499 schema:issn 1478-6354
180 1478-6362
181 schema:name Arthritis Research & Therapy
182 rdf:type schema:Periodical
183 sg:person.01025552355.57 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
184 schema:familyName Knight
185 schema:givenName Martin M
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025552355.57
187 rdf:type schema:Person
188 sg:person.01102753263.71 schema:affiliation https://www.grid.ac/institutes/grid.134936.a
189 schema:familyName Cook
190 schema:givenName James L
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102753263.71
192 rdf:type schema:Person
193 sg:person.01202600370.83 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
194 schema:familyName Hung
195 schema:givenName Clark T.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202600370.83
197 rdf:type schema:Person
198 sg:person.01313460151.54 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
199 schema:familyName Bulinski
200 schema:givenName J. Chloe
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313460151.54
202 rdf:type schema:Person
203 sg:person.01357277633.77 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
204 schema:familyName Ateshian
205 schema:givenName Gerard A.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357277633.77
207 rdf:type schema:Person
208 sg:person.0603146777.64 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
209 schema:familyName Attur
210 schema:givenName Mukundan
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603146777.64
212 rdf:type schema:Person
213 sg:person.0630704141.63 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
214 schema:familyName Tan
215 schema:givenName Andrea R.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630704141.63
217 rdf:type schema:Person
218 sg:person.0660617545.53 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
219 schema:familyName Abramson
220 schema:givenName Steven B.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660617545.53
222 rdf:type schema:Person
223 sg:person.0766551114.03 schema:affiliation https://www.grid.ac/institutes/grid.240873.a
224 schema:familyName VandenBerg
225 schema:givenName Curtis D.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766551114.03
227 rdf:type schema:Person
228 sg:pub.10.1007/978-1-4613-8425-0_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021037550
229 https://doi.org/10.1007/978-1-4613-8425-0_20
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s12265-009-9161-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021884391
232 https://doi.org/10.1007/s12265-009-9161-2
233 rdf:type schema:CreativeWork
234 sg:pub.10.1023/b:abme.0000007789.99565.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016924597
235 https://doi.org/10.1023/b:abme.0000007789.99565.42
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nri1865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000000694
238 https://doi.org/10.1038/nri1865
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nrrheum.2010.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042329000
241 https://doi.org/10.1038/nrrheum.2010.159
242 rdf:type schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1074559684 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1075075881 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1076875968 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1083239598 schema:CreativeWork
247 https://doi.org/10.1002/art.10849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025506710
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/art.21215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024189688
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/art.22145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042495032
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/jor.20538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001204256
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/jor.22334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012209381
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0009-8981(67)90167-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043207538
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/0049-0172(91)90024-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1010254283
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.bpj.2009.05.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004282666
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.jacc.2009.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022065830
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.jbiomech.2005.03.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018682887
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.jbiomech.2008.01.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030485772
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.jbiomech.2008.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003166747
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.jbiomech.2008.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001759254
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.joca.2007.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012540130
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.joca.2010.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000770604
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.jtcvs.2007.07.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034979807
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.jtcvs.2009.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031974353
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.resp.2008.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005270459
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0003-9861(03)00129-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035741771
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0021-9290(98)00105-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039602724
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1042/bj2600543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022888420
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1053/joca.1998.0111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028004291
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/mcp.m800181-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008045161
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1089/107632703768247304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059206239
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1089/ten.2005.11.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059313395
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1089/ten.tea.2007.0347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059314939
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1089/ten.tea.2009.0482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315423
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1089/ten.tea.2009.0581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315456
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1089/ten.tea.2011.0155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315878
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1089/ten.teb.2008.0586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059316930
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/cvr/cvm025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050937966
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1097/00003086-200110001-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060168909
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1097/00003086-200110001-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060168912
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1097/bor.0b013e3282ba5693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011456963
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1115/1.1611512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062072939
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1128/mcb.25.12.4853-4862.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006013037
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1136/ard.62.7.635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008851968
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1152/ajpheart.00031.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010045398
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1152/ajpheart.00856.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010560481
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1161/01.cir.74.5.1124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049137364
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1161/circresaha.109.197723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002060047
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1177/0363546510361950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063821684
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1210/endo.137.8.8754787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064281113
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1302/2046-3758.34.2000238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030608733
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1634/stemcells.2007-1104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017176200
336 rdf:type schema:CreativeWork
337 https://doi.org/10.22203/ecm.v021a16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069338923
338 rdf:type schema:CreativeWork
339 https://doi.org/10.2460/ajvr.2000.61.766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070762001
340 rdf:type schema:CreativeWork
341 https://doi.org/10.2460/ajvr.2005.66.1187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070763207
342 rdf:type schema:CreativeWork
343 https://doi.org/10.3109/03008209209014233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035344386
344 rdf:type schema:CreativeWork
345 https://doi.org/10.6061/clinics/2012(01)06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041993938
346 rdf:type schema:CreativeWork
347 https://www.grid.ac/institutes/grid.134936.a schema:alternateName University of Missouri
348 schema:name Comparative Orthopaedic Laboratory, University of Missouri, 1100 Virginia Avenue, Columbia, MO, USA
349 rdf:type schema:Organization
350 https://www.grid.ac/institutes/grid.137628.9 schema:alternateName New York University
351 schema:name New York University Hospital for Joint Disease, 301 E. 17th Street, New York, NY, USA
352 rdf:type schema:Organization
353 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
354 schema:name Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY, USA
355 Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY, USA
356 Department of Mechanical Engineering, Columbia University, 500 W. 120th Street, New York, NY, USA
357 rdf:type schema:Organization
358 https://www.grid.ac/institutes/grid.240873.a schema:alternateName St. Luke's-Roosevelt Hospital Center
359 schema:name Department of Orthopedic Surgery, St. Luke’s-Roosevelt Hospital Center, 1000 10th Avenue, New York, NY, USA
360 rdf:type schema:Organization
361 https://www.grid.ac/institutes/grid.4868.2 schema:alternateName Queen Mary University of London
362 schema:name Institute of Bioengineering and School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, London, UK
363 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...