Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03-11

AUTHORS

Yoshinao Muro, Yuji Hosono, Kazumitsu Sugiura, Yasushi Ogawa, Tsuneyo Mimori, Masashi Akiyama

ABSTRACT

IntroductionAnti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients, previous large studies of Japanese patients with scleroderma reported that anti-PM/Scl are not found in Japanese patients at all. The PM/Scl autoantigen complex comprises 11–16 different polypeptides; ELISA with PM1-α peptide, which is a major epitope of the PM/Scl complex, has frequently been used for the detection of these antibodies in recent studies. However, no ELISA kit is commercially available in Japan.MethodsIn this study, we developed an immunoassay for measuring antibodies against recombinant PM/Scl-100 and PM/Scl-75 polypeptides, which are the two major targets of the complex, and we investigated their presence in 600 Japanese patients with various systemic autoimmune conditions. Immunoprecipitation analysis using the recombinants in addition to traditional radiolabeled cell extracts were also applied to ELISA-positive sera.ResultsIn ELISA, 11 patients were positive for anti-PM/Scl-100 antibodies and 7 of these 11 patients were also positive for anti-PM/Scl-75 antibodies. Immunoprecipitation analysis using the recombinants in addition to traditional radiolabeled cell extracts confirmed that 9 out of these 11 patients immunoprecipitated the typical sets of PM/Scl proteins. In total, 4/16 (25%) undifferentiated connective tissue disease (UCTD) patients, 3/126 (2.4%) dermatomyositis patients, 1/223 (0.4%) SSc patients, 1/88 (1.1%) Sjögren’s syndrome patients, 0/123 patients with systemic lupus erythematosus, 0/17 patients with overlap syndrome and 0/7 patients with PM were judged to be positive for anti-PM/Scl antibodies.ConclusionsThis is the first report of Japanese autoimmune patients with anti-PM/Scl antibodies. In Japanese patients, anti-PM/Scl antibodies are only very rarely found, and they are not always specific for dermatomyositis (DM) or SSc; they are also present in various autoimmune conditions with the highest prevalence being in UCTD. All anti-PM/Scl-positive DM cases are complicated with interstitial lung disease and/or cancer, while no life-threatening involvement was found in other anti-PM/Scl-positive cases. Further studies on larger cohorts are necessary to define the clinical significance of anti-PM/Scl antibodies in autoimmune diseases. More... »

PAGES

57

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13075-015-0573-x

DOI

http://dx.doi.org/10.1186/s13075-015-0573-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037422430

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25885224


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymyositis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Scleroderma, Systemic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
            "Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muro", 
        "givenName": "Yoshinao", 
        "id": "sg:person.015476662654.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015476662654.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hosono", 
        "givenName": "Yuji", 
        "id": "sg:person.01347062420.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347062420.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiura", 
        "givenName": "Kazumitsu", 
        "id": "sg:person.0617007352.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617007352.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogawa", 
        "givenName": "Yasushi", 
        "id": "sg:person.01242625762.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242625762.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mimori", 
        "givenName": "Tsuneyo", 
        "id": "sg:person.01026121614.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026121614.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiyama", 
        "givenName": "Masashi", 
        "id": "sg:person.013324706103.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013324706103.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/ar1729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031400161", 
          "https://doi.org/10.1186/ar1729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-011-1751-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016089557", 
          "https://doi.org/10.1007/s10067-011-1751-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar3495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001755554", 
          "https://doi.org/10.1186/ar3495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar4207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035605129", 
          "https://doi.org/10.1186/ar4207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023184203", 
          "https://doi.org/10.1186/ar389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-009-0155-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017199593", 
          "https://doi.org/10.1007/s10165-009-0155-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043190712", 
          "https://doi.org/10.1186/ar2276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030139507", 
          "https://doi.org/10.1186/ar2614"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-03-11", 
    "datePublishedReg": "2015-03-11", 
    "description": "IntroductionAnti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients, previous large studies of Japanese patients with scleroderma reported that anti-PM/Scl are not found in Japanese patients at all. The PM/Scl autoantigen complex comprises 11\u201316 different polypeptides; ELISA with PM1-\u03b1 peptide, which is a major epitope of the PM/Scl complex, has frequently been used for the detection of these antibodies in recent studies. However, no ELISA kit is commercially available in Japan.MethodsIn this study, we developed an immunoassay for measuring antibodies against recombinant PM/Scl-100 and PM/Scl-75 polypeptides, which are the two major targets of the complex, and we investigated their presence in 600 Japanese patients with various systemic autoimmune conditions. Immunoprecipitation analysis using the recombinants in addition to traditional radiolabeled cell extracts were also applied to ELISA-positive sera.ResultsIn ELISA, 11 patients were positive for anti-PM/Scl-100 antibodies and 7 of these 11 patients were also positive for anti-PM/Scl-75 antibodies. Immunoprecipitation analysis using the recombinants in addition to traditional radiolabeled cell extracts confirmed that 9 out of these 11 patients immunoprecipitated the typical sets of PM/Scl proteins. In total, 4/16 (25%) undifferentiated connective tissue disease (UCTD) patients, 3/126 (2.4%) dermatomyositis patients, 1/223 (0.4%) SSc patients, 1/88 (1.1%) Sj\u00f6gren\u2019s syndrome patients, 0/123 patients with systemic lupus erythematosus, 0/17 patients with overlap syndrome and 0/7 patients with PM were judged to be positive for anti-PM/Scl antibodies.ConclusionsThis is the first report of Japanese autoimmune patients with anti-PM/Scl antibodies. In Japanese patients, anti-PM/Scl antibodies are only very rarely found, and they are not always specific for dermatomyositis (DM) or SSc; they are also present in various autoimmune conditions with the highest prevalence being in UCTD. All anti-PM/Scl-positive DM cases are complicated with interstitial lung disease and/or cancer, while no life-threatening involvement was found in other anti-PM/Scl-positive cases. Further studies on larger cohorts are necessary to define the clinical significance of anti-PM/Scl antibodies in autoimmune diseases.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13075-015-0573-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6112002", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6149980", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6074170", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297499", 
        "issn": [
          "1478-6354", 
          "1478-6362"
        ], 
        "name": "Arthritis Research & Therapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "anti-PM/Scl antibodies", 
      "anti-PM/Scl", 
      "Scl antibodies", 
      "systemic autoimmune conditions", 
      "Japanese patients", 
      "autoimmune conditions", 
      "PM/Scl", 
      "SSc patients", 
      "autoimmune diseases", 
      "syndrome patients", 
      "PM/Scl complex", 
      "PM/Scl antibodies", 
      "connective tissue disease patients", 
      "life-threatening involvement", 
      "systemic autoimmune disease", 
      "systemic lupus erythematosus", 
      "interstitial lung disease", 
      "Sj\u00f6gren's syndrome patients", 
      "previous large studies", 
      "ELISA-positive sera", 
      "dermatomyositis patients", 
      "overlap syndrome", 
      "lupus erythematosus", 
      "disease patients", 
      "autoimmune patients", 
      "lung disease", 
      "high prevalence", 
      "clinical significance", 
      "large cohort", 
      "polymyositis", 
      "patients", 
      "DM cases", 
      "SCL reactivity", 
      "ELISA kit", 
      "larger study", 
      "major epitopes", 
      "immunoprecipitation analysis", 
      "scleroderma", 
      "antibodies", 
      "disease", 
      "dermatomyositis", 
      "Further studies", 
      "major target", 
      "syndrome", 
      "ELISA", 
      "Recent studies", 
      "Scl complex", 
      "first report", 
      "cell extracts", 
      "SCL protein", 
      "erythematosus", 
      "myositis", 
      "cohort", 
      "cancer", 
      "prevalence", 
      "MethodsIn", 
      "UCTD", 
      "study", 
      "ConclusionsThis", 
      "serum", 
      "SCL", 
      "extract", 
      "epitopes", 
      "total", 
      "cases", 
      "immunoassay", 
      "SSC", 
      "involvement", 
      "report", 
      "kit", 
      "peptides", 
      "polypeptide", 
      "recombinants", 
      "target", 
      "addition", 
      "protein", 
      "significance", 
      "analysis", 
      "presence", 
      "reactivity", 
      "conditions", 
      "different polypeptides", 
      "detection", 
      "Japan", 
      "complexes", 
      "set", 
      "typical set"
    ], 
    "name": "Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma", 
    "pagination": "57", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037422430"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13075-015-0573-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25885224"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13075-015-0573-x", 
      "https://app.dimensions.ai/details/publication/pub.1037422430"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_660.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13075-015-0573-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0573-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0573-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0573-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13075-015-0573-x'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      22 PREDICATES      130 URIs      114 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13075-015-0573-x schema:about N0a1133d5cff4469696ad20e18c1c4f3d
2 N3124fce264ef421da24c28b5bda6f889
3 N40dda67a45da46169edc2de13466293b
4 N596f343610c943e8b5918750e47c139f
5 N64d06aea3d2f4a689a785767962544c8
6 N808f8ec8ef9f4d18a85f60765f840eec
7 N8c51819f8c084d7692e8527d2a5264d8
8 N9cbfcee25897464dae68de450e33f81d
9 Ne8a024c03f1d4b789fad45dca644fa9e
10 anzsrc-for:11
11 anzsrc-for:1107
12 schema:author Ncd8d5bfcd7714d7f8859fb4e2e91a305
13 schema:citation sg:pub.10.1007/s10067-011-1751-0
14 sg:pub.10.1007/s10165-009-0155-3
15 sg:pub.10.1186/ar1729
16 sg:pub.10.1186/ar2276
17 sg:pub.10.1186/ar2614
18 sg:pub.10.1186/ar3495
19 sg:pub.10.1186/ar389
20 sg:pub.10.1186/ar4207
21 schema:datePublished 2015-03-11
22 schema:datePublishedReg 2015-03-11
23 schema:description IntroductionAnti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients, previous large studies of Japanese patients with scleroderma reported that anti-PM/Scl are not found in Japanese patients at all. The PM/Scl autoantigen complex comprises 11–16 different polypeptides; ELISA with PM1-α peptide, which is a major epitope of the PM/Scl complex, has frequently been used for the detection of these antibodies in recent studies. However, no ELISA kit is commercially available in Japan.MethodsIn this study, we developed an immunoassay for measuring antibodies against recombinant PM/Scl-100 and PM/Scl-75 polypeptides, which are the two major targets of the complex, and we investigated their presence in 600 Japanese patients with various systemic autoimmune conditions. Immunoprecipitation analysis using the recombinants in addition to traditional radiolabeled cell extracts were also applied to ELISA-positive sera.ResultsIn ELISA, 11 patients were positive for anti-PM/Scl-100 antibodies and 7 of these 11 patients were also positive for anti-PM/Scl-75 antibodies. Immunoprecipitation analysis using the recombinants in addition to traditional radiolabeled cell extracts confirmed that 9 out of these 11 patients immunoprecipitated the typical sets of PM/Scl proteins. In total, 4/16 (25%) undifferentiated connective tissue disease (UCTD) patients, 3/126 (2.4%) dermatomyositis patients, 1/223 (0.4%) SSc patients, 1/88 (1.1%) Sjögren’s syndrome patients, 0/123 patients with systemic lupus erythematosus, 0/17 patients with overlap syndrome and 0/7 patients with PM were judged to be positive for anti-PM/Scl antibodies.ConclusionsThis is the first report of Japanese autoimmune patients with anti-PM/Scl antibodies. In Japanese patients, anti-PM/Scl antibodies are only very rarely found, and they are not always specific for dermatomyositis (DM) or SSc; they are also present in various autoimmune conditions with the highest prevalence being in UCTD. All anti-PM/Scl-positive DM cases are complicated with interstitial lung disease and/or cancer, while no life-threatening involvement was found in other anti-PM/Scl-positive cases. Further studies on larger cohorts are necessary to define the clinical significance of anti-PM/Scl antibodies in autoimmune diseases.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree true
27 schema:isPartOf N919c4925938149fdaa0d2c314010ed1f
28 Nd682d60c36bb4d218ed5ee41b3892894
29 sg:journal.1297499
30 schema:keywords ConclusionsThis
31 DM cases
32 ELISA
33 ELISA kit
34 ELISA-positive sera
35 Further studies
36 Japan
37 Japanese patients
38 MethodsIn
39 PM/Scl
40 PM/Scl antibodies
41 PM/Scl complex
42 Recent studies
43 SCL
44 SCL protein
45 SCL reactivity
46 SSC
47 SSc patients
48 Scl antibodies
49 Scl complex
50 Sjögren's syndrome patients
51 UCTD
52 addition
53 analysis
54 anti-PM/Scl
55 anti-PM/Scl antibodies
56 antibodies
57 autoimmune conditions
58 autoimmune diseases
59 autoimmune patients
60 cancer
61 cases
62 cell extracts
63 clinical significance
64 cohort
65 complexes
66 conditions
67 connective tissue disease patients
68 dermatomyositis
69 dermatomyositis patients
70 detection
71 different polypeptides
72 disease
73 disease patients
74 epitopes
75 erythematosus
76 extract
77 first report
78 high prevalence
79 immunoassay
80 immunoprecipitation analysis
81 interstitial lung disease
82 involvement
83 kit
84 large cohort
85 larger study
86 life-threatening involvement
87 lung disease
88 lupus erythematosus
89 major epitopes
90 major target
91 myositis
92 overlap syndrome
93 patients
94 peptides
95 polymyositis
96 polypeptide
97 presence
98 prevalence
99 previous large studies
100 protein
101 reactivity
102 recombinants
103 report
104 scleroderma
105 serum
106 set
107 significance
108 study
109 syndrome
110 syndrome patients
111 systemic autoimmune conditions
112 systemic autoimmune disease
113 systemic lupus erythematosus
114 target
115 total
116 typical set
117 schema:name Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma
118 schema:pagination 57
119 schema:productId N254390cee17a484097b3546fabe12d51
120 Nacd54ef35b6948bd926b56ca3832b7d6
121 Ncd2daffc690d494887580143b44f3a73
122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037422430
123 https://doi.org/10.1186/s13075-015-0573-x
124 schema:sdDatePublished 2022-05-20T07:30
125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
126 schema:sdPublisher Nab437d7d22264a8eb2ca9be8433f4460
127 schema:url https://doi.org/10.1186/s13075-015-0573-x
128 sgo:license sg:explorer/license/
129 sgo:sdDataset articles
130 rdf:type schema:ScholarlyArticle
131 N0a1133d5cff4469696ad20e18c1c4f3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Japan
133 rdf:type schema:DefinedTerm
134 N254390cee17a484097b3546fabe12d51 schema:name pubmed_id
135 schema:value 25885224
136 rdf:type schema:PropertyValue
137 N3124fce264ef421da24c28b5bda6f889 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Female
139 rdf:type schema:DefinedTerm
140 N40dda67a45da46169edc2de13466293b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Enzyme-Linked Immunosorbent Assay
142 rdf:type schema:DefinedTerm
143 N4427470af0ad4c2fbb0fdcef592ccfb1 rdf:first sg:person.01026121614.49
144 rdf:rest N4b6daa7794714ce4b0a45a617d7a5893
145 N4b6daa7794714ce4b0a45a617d7a5893 rdf:first sg:person.013324706103.19
146 rdf:rest rdf:nil
147 N55cdb113d59f4301af7df898bcdb6f5f rdf:first sg:person.01242625762.93
148 rdf:rest N4427470af0ad4c2fbb0fdcef592ccfb1
149 N596f343610c943e8b5918750e47c139f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Autoimmune Diseases
151 rdf:type schema:DefinedTerm
152 N64d06aea3d2f4a689a785767962544c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Humans
154 rdf:type schema:DefinedTerm
155 N808f8ec8ef9f4d18a85f60765f840eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Polymyositis
157 rdf:type schema:DefinedTerm
158 N8c51819f8c084d7692e8527d2a5264d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Male
160 rdf:type schema:DefinedTerm
161 N8dfeef872c93425bba0d22d6bd9b44c9 rdf:first sg:person.01347062420.06
162 rdf:rest N90023aef46da4a9d853aaa7e0980c5fa
163 N90023aef46da4a9d853aaa7e0980c5fa rdf:first sg:person.0617007352.91
164 rdf:rest N55cdb113d59f4301af7df898bcdb6f5f
165 N919c4925938149fdaa0d2c314010ed1f schema:volumeNumber 17
166 rdf:type schema:PublicationVolume
167 N9cbfcee25897464dae68de450e33f81d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Autoantibodies
169 rdf:type schema:DefinedTerm
170 Nab437d7d22264a8eb2ca9be8433f4460 schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 Nacd54ef35b6948bd926b56ca3832b7d6 schema:name doi
173 schema:value 10.1186/s13075-015-0573-x
174 rdf:type schema:PropertyValue
175 Ncd2daffc690d494887580143b44f3a73 schema:name dimensions_id
176 schema:value pub.1037422430
177 rdf:type schema:PropertyValue
178 Ncd8d5bfcd7714d7f8859fb4e2e91a305 rdf:first sg:person.015476662654.11
179 rdf:rest N8dfeef872c93425bba0d22d6bd9b44c9
180 Nd682d60c36bb4d218ed5ee41b3892894 schema:issueNumber 1
181 rdf:type schema:PublicationIssue
182 Ne8a024c03f1d4b789fad45dca644fa9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Scleroderma, Systemic
184 rdf:type schema:DefinedTerm
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
189 schema:name Immunology
190 rdf:type schema:DefinedTerm
191 sg:grant.6074170 http://pending.schema.org/fundedItem sg:pub.10.1186/s13075-015-0573-x
192 rdf:type schema:MonetaryGrant
193 sg:grant.6112002 http://pending.schema.org/fundedItem sg:pub.10.1186/s13075-015-0573-x
194 rdf:type schema:MonetaryGrant
195 sg:grant.6149980 http://pending.schema.org/fundedItem sg:pub.10.1186/s13075-015-0573-x
196 rdf:type schema:MonetaryGrant
197 sg:journal.1297499 schema:issn 1478-6354
198 1478-6362
199 schema:name Arthritis Research & Therapy
200 schema:publisher Springer Nature
201 rdf:type schema:Periodical
202 sg:person.01026121614.49 schema:affiliation grid-institutes:grid.258799.8
203 schema:familyName Mimori
204 schema:givenName Tsuneyo
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026121614.49
206 rdf:type schema:Person
207 sg:person.01242625762.93 schema:affiliation grid-institutes:grid.27476.30
208 schema:familyName Ogawa
209 schema:givenName Yasushi
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242625762.93
211 rdf:type schema:Person
212 sg:person.013324706103.19 schema:affiliation grid-institutes:grid.27476.30
213 schema:familyName Akiyama
214 schema:givenName Masashi
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013324706103.19
216 rdf:type schema:Person
217 sg:person.01347062420.06 schema:affiliation grid-institutes:grid.258799.8
218 schema:familyName Hosono
219 schema:givenName Yuji
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347062420.06
221 rdf:type schema:Person
222 sg:person.015476662654.11 schema:affiliation grid-institutes:grid.27476.30
223 schema:familyName Muro
224 schema:givenName Yoshinao
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015476662654.11
226 rdf:type schema:Person
227 sg:person.0617007352.91 schema:affiliation grid-institutes:grid.27476.30
228 schema:familyName Sugiura
229 schema:givenName Kazumitsu
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617007352.91
231 rdf:type schema:Person
232 sg:pub.10.1007/s10067-011-1751-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016089557
233 https://doi.org/10.1007/s10067-011-1751-0
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s10165-009-0155-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017199593
236 https://doi.org/10.1007/s10165-009-0155-3
237 rdf:type schema:CreativeWork
238 sg:pub.10.1186/ar1729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031400161
239 https://doi.org/10.1186/ar1729
240 rdf:type schema:CreativeWork
241 sg:pub.10.1186/ar2276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043190712
242 https://doi.org/10.1186/ar2276
243 rdf:type schema:CreativeWork
244 sg:pub.10.1186/ar2614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030139507
245 https://doi.org/10.1186/ar2614
246 rdf:type schema:CreativeWork
247 sg:pub.10.1186/ar3495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001755554
248 https://doi.org/10.1186/ar3495
249 rdf:type schema:CreativeWork
250 sg:pub.10.1186/ar389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023184203
251 https://doi.org/10.1186/ar389
252 rdf:type schema:CreativeWork
253 sg:pub.10.1186/ar4207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035605129
254 https://doi.org/10.1186/ar4207
255 rdf:type schema:CreativeWork
256 grid-institutes:grid.258799.8 schema:alternateName Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Sakyo-ku, 606-8507, Kyoto, Japan
257 schema:name Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Sakyo-ku, 606-8507, Kyoto, Japan
258 rdf:type schema:Organization
259 grid-institutes:grid.27476.30 schema:alternateName Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
260 Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
261 schema:name Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
262 Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...