Regulatory T cells and control of the germinal centre response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10

AUTHORS

Ine Vanderleyden, Michelle A Linterman, Kenneth GC Smith

ABSTRACT

Germinal centres (GCs) are specialised lymphoid microenvironments that form in secondary B-cell follicles upon exposure to T-dependent antigens. In the GC, clonal expansion, selection and differentiation of GC B cells result in the production of high-affinity plasma cells and memory B cells that provide protection against subsequent infection. The GC is carefully regulated to fulfil its critical role in defence against infection and to ensure that immunological tolerance is not broken in the process. The GC response can be controlled by a number of mechanisms, one of which is by forkhead box p3 expressing regulatory T (Treg) cells, a suppressive population of CD4+ T cells. A specialised subset of Treg cells - follicular regulatory T (Tfr) cells - form after immunisation and are able to access the GC, where they control the size and output of the response. Our knowledge of Treg cell control of the GC is expanding. In this review we will discuss recent advances in the field, with a particular emphasis on the differentiation and function of Tfr cells in the GC. More... »

PAGES

471

References to SciGraph publications

  • 2009-06. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation in NATURE IMMUNOLOGY
  • 2014-01. Priming of T follicular helper cells by dendritic cells in IMMUNOLOGY AND CELL BIOLOGY
  • 2012-03. Selection of regulatory T cells in the thymus in NATURE REVIEWS IMMUNOLOGY
  • 2010-09. Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance in NATURE
  • 2013-02. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood in NATURE IMMUNOLOGY
  • 2014-03. Homeostatic control of regulatory T cell diversity in NATURE REVIEWS IMMUNOLOGY
  • 2014-12. FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability in NATURE COMMUNICATIONS
  • 2011-08. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions in NATURE MEDICINE
  • 2013-04. Regulatory T cells: recommendations to simplify the nomenclature in NATURE IMMUNOLOGY
  • 2014-06-29. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease in NATURE IMMUNOLOGY
  • 2003-04. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells in NATURE IMMUNOLOGY
  • 2007-09. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells in NATURE IMMUNOLOGY
  • 2007-11. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells in NATURE
  • 2013-04-24. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility in NATURE
  • 2011-04. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells in NATURE IMMUNOLOGY
  • 2014-03. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development in NATURE
  • 2009-08. EBI2 mediates B cell segregation between the outer and centre follicle in NATURE
  • 2010-06. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells in NATURE IMMUNOLOGY
  • 2011-08. Foxp3+ follicular regulatory T cells control the germinal center response in NATURE MEDICINE
  • 2010-03. The regulation of IL-10 production by immune cells in NATURE REVIEWS IMMUNOLOGY
  • 2005-05. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity in NATURE
  • 2009-12. Dysregulation of germinal centres in autoimmune disease in NATURE REVIEWS IMMUNOLOGY
  • 2009-01. The who, how and where of antigen presentation to B cells in NATURE REVIEWS IMMUNOLOGY
  • 2006-04. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires in NATURE IMMUNOLOGY
  • 2014-05. Clonal selection in the germinal centre by regulated proliferation and hypermutation in NATURE
  • 2009-03. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13075-014-0471-7

    DOI

    http://dx.doi.org/10.1186/s13075-014-0471-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033648211

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25606598


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