Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-09-28

AUTHORS

Youqiong Ye, Xinwei Kuang, Zuozhong Xie, Long Liang, Zhao Zhang, Yongchang Zhang, Fangyu Ma, Qian Gao, Ruimin Chang, Heng-Huan Lee, Shuang Zhao, Juan Su, Hui Li, Jingbo Peng, Huifang Chen, Minzhu Yin, Cong Peng, Nong Yang, Jing Wang, Jing Liu, Hong Liu, Leng Han, Xiang Chen

ABSTRACT

BackgroundImmune checkpoint blockade (ICB) therapy has demonstrated considerable clinical benefit in several malignancies, but has shown favorable response in only a small proportion of cancer patients. Recent studies have shown that matrix metalloproteinases (MMPs) are highly associated with the microenvironment of tumors and immune cells. However, it is unknown whether MMPs are involved in immunotherapy.MethodsHere, we used integrative analysis to explore the expression landscape of the MMP family and its association with immune features across multiple cancer types. We used T cell cytotoxicity-mediated tumor killing assay to determine the co-cultured T cell activity of SB-3CT, an MMP2/9 inhibitor. We then used in vitro assays to examine the regulating roles of SB-3CT on PD-L1. We further characterized the efficacy of SB-3CT, in combination with anti-PD-1 and/or anti-CTLA4 treatment in mouse models with melanoma and lung cancer.ResultsOur computational analysis demonstrated a strong association between MMP2/9 and immune features. We demonstrated that inhibition of MMP2/9 by SB-3CT significantly reduced the tumor burden and improved survival time by promoting anti-tumor immunity. Mechanistically, we showed that SB-3CT treatment significantly diminished both mRNA and protein levels of PD-L1 in cancer cells. Pre-clinically, SB-3CT treatment enhanced the therapeutic efficacy of PD-1 or CTLA-4 blockade in the treatment of both primary and metastatic tumors.ConclusionsOur study unraveled novel molecular mechanisms regarding the regulation of tumor PD-L1 and provided a novel combination therapeutic strategy of SB-3CT and ICB therapy to enhance the efficacy of immunotherapy. More... »

PAGES

83

References to SciGraph publications

  • 2018-05-15. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion in NATURE COMMUNICATIONS
  • 2000-09-20. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis in NATURE CELL BIOLOGY
  • 2014-11-26. PD-1 blockade induces responses by inhibiting adaptive immune resistance in NATURE
  • 2014-11-21. Remodelling the extracellular matrix in development and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-09-26. The Cancer Genome Atlas Pan-Cancer analysis project in NATURE GENETICS
  • 2019-06-03. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression in NATURE IMMUNOLOGY
  • 2015-03-09. HISAT: a fast spliced aligner with low memory requirements in NATURE METHODS
  • 2016-03-24. Targeting metastasis in NATURE REVIEWS CANCER
  • 1999-05. Marimastat (BB2516): Current status of development in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2018-07-05. Small-Molecule Targets in Tumor Immunotherapy in NATURAL PRODUCTS AND BIOPROSPECTING
  • 2006-09. Comparing antibody and small-molecule therapies for cancer in NATURE REVIEWS CANCER
  • 2018-10-04. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis in CELL RESEARCH
  • 2013-01-16. GSVA: gene set variation analysis for microarray and RNA-Seq data in BMC BIOINFORMATICS
  • 2015-02-18. StringTie enables improved reconstruction of a transcriptome from RNA-seq reads in NATURE BIOTECHNOLOGY
  • 2020-01-16. Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis in NATURE COMMUNICATIONS
  • 2018-11-05. HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity in NATURE CHEMICAL BIOLOGY
  • 2016-12-20. Regulatory T cells in cancer immunotherapy in CELL RESEARCH
  • 2017-08-08. Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer in CLINICAL EPIGENETICS
  • 2017-08-16. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity in NATURE
  • 2011-08-11. What does matrix metalloproteinase-1 expression in patients with breast cancer really tell us? in BMC MEDICINE
  • 2012-04-18. Matrix metalloproteinases and epidermal wound repair in CELL AND TISSUE RESEARCH
  • Journal

    TITLE

    Genome Medicine

    ISSUE

    1

    VOLUME

    12

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13073-020-00780-z

    DOI

    http://dx.doi.org/10.1186/s13073-020-00780-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131252046

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32988398


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