BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Raunak Shrestha, Noushin Nabavi, Yen-Yi Lin, Fan Mo, Shawn Anderson, Stanislav Volik, Hans H. Adomat, Dong Lin, Hui Xue, Xin Dong, Robert Shukin, Robert H. Bell, Brian McConeghy, Anne Haegert, Sonal Brahmbhatt, Estelle Li, Htoo Zarni Oo, Antonio Hurtado-Coll, Ladan Fazli, Joshua Zhou, Yarrow McConnell, Andrea McCart, Andrew Lowy, Gregg B. Morin, Tianhui Chen, Mads Daugaard, S. Cenk Sahinalp, Faraz Hach, Stephane Le Bihan, Martin E. Gleave, Yuzhuo Wang, Andrew Churg, Colin C. Collins

ABSTRACT

BACKGROUND: Malignant peritoneal mesothelioma (PeM) is a rare and fatal cancer that originates from the peritoneal lining of the abdomen. Standard treatment of PeM is limited to cytoreductive surgery and/or chemotherapy, and no effective targeted therapies for PeM exist. Some immune checkpoint inhibitor studies of mesothelioma have found positivity to be associated with a worse prognosis. METHODS: To search for novel therapeutic targets for PeM, we performed a comprehensive integrative multi-omics analysis of the genome, transcriptome, and proteome of 19 treatment-naïve PeM, and in particular, we examined BAP1 mutation and copy number status and its relationship to immune checkpoint inhibitor activation. RESULTS: We found that PeM could be divided into tumors with an inflammatory tumor microenvironment and those without and that this distinction correlated with haploinsufficiency of BAP1. To further investigate the role of BAP1, we used our recently developed cancer driver gene prioritization algorithm, HIT'nDRIVE, and observed that PeM with BAP1 haploinsufficiency form a distinct molecular subtype characterized by distinct gene expression patterns of chromatin remodeling, DNA repair pathways, and immune checkpoint receptor activation. We demonstrate that this subtype is correlated with an inflammatory tumor microenvironment and thus is a candidate for immune checkpoint blockade therapies. CONCLUSIONS: Our findings reveal BAP1 to be a potential, easily trackable prognostic and predictive biomarker for PeM immunotherapy that refines PeM disease classification. BAP1 stratification may improve drug response rates in ongoing phases I and II clinical trials exploring the use of immune checkpoint blockade therapies in PeM in which BAP1 status is not considered. This integrated molecular characterization provides a comprehensive foundation for improved management of a subset of PeM patients. More... »

PAGES

8

References to SciGraph publications

  • 2010-10. Differential expression analysis for sequence count data in GENOME BIOLOGY
  • 2017-06. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation in NATURE
  • 2016-12. Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research in SCIENTIFIC REPORTS
  • 2015-12. BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2017-02. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X in MODERN PATHOLOGY
  • 2018-12. CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial in TRIALS
  • 2016-01. The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma in MODERN PATHOLOGY
  • 2016-04. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations in NATURE GENETICS
  • 2011-07. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma in NATURE GENETICS
  • 2011-04. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers in GENOME BIOLOGY
  • 2013-12. Inferring tumour purity and stromal and immune cell admixture from expression data in NATURE COMMUNICATIONS
  • 2015-05. Robust enumeration of cell subsets from tissue expression profiles in NATURE METHODS
  • 2009-08. Pleural and peritoneal mesotheliomas in SEER: age effects and temporal trends, 1973–2005 in CANCER CAUSES & CONTROL
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13073-019-0620-3

    DOI

    http://dx.doi.org/10.1186/s13073-019-0620-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112219991

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30777124


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