DNA replication dynamics of vole genome and its epigenetic regulation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Kathrin S. Heinz, Alexander Rapp, Corella S. Casas-Delucchi, Anne Lehmkuhl, Ismael Romero-Fernández, Antonio Sánchez, Oliver H. Krämer, J. Alberto Marchal, M. Cristina Cardoso

ABSTRACT

BACKGROUND: The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of these heterochromatin blocks have been studied, but little is known about their DNA replication dynamics and epigenetic composition. RESULTS: Here, we show prominent epigenetic marks of the heterochromatic blocks in the giant sex chromosomes of female Microtus cabrerae cells. While the X chromosomes are hypoacetylated and cytosine hypomethylated, they are either enriched for macroH2A and H3K27me3 typical for facultative heterochromatin or for H3K9me3 and HP1 beta typical for constitutive heterochromatin. Using pulse-chase replication labeling and time-lapse microscopy, we found that the heterochromatic block enriched for macroH2A/H3K27me3 of the X chromosome is replicated during mid-S-phase, prior to the heterochromatic block enriched for H3K9me3/HP1 beta, which is replicated during late S-phase. To test whether histone acetylation level regulates its replication dynamics, we induced either global hyperacetylation by pharmacological inhibition or by targeting a histone acetyltransferase to the heterochromatic region of the X chromosomes. Our data reveal that histone acetylation level affects DNA replication dynamics of the sex chromosomes' heterochromatin and leads to a global reduction in replication fork rate genome wide. CONCLUSIONS: In conclusion, we mapped major epigenetic modifications controlling the structure of the sex chromosome-associated heterochromatin and demonstrated the occurrence of differences in the molecular mechanisms controlling the replication timing of the heterochromatic blocks at the sex chromosomes in female Microtus cabrerae cells. Furthermore, we highlighted a conserved role of histone acetylation level on replication dynamics across mammalian species. More... »

PAGES

18

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13072-019-0262-0

DOI

http://dx.doi.org/10.1186/s13072-019-0262-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112759290

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30871586


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Technical University of Darmstadt", 
          "id": "https://www.grid.ac/institutes/grid.6546.1", 
          "name": [
            "Cell Biology and Epigenetics, Department of Biology, Technische Universit\u00e4t Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heinz", 
        "givenName": "Kathrin S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University of Darmstadt", 
          "id": "https://www.grid.ac/institutes/grid.6546.1", 
          "name": [
            "Cell Biology and Epigenetics, Department of Biology, Technische Universit\u00e4t Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rapp", 
        "givenName": "Alexander", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Cell Biology and Epigenetics, Department of Biology, Technische Universit\u00e4t Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany", 
            "Chromosome Replication Laboratory, The Francis Crick Institute, NW1 1AT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casas-Delucchi", 
        "givenName": "Corella S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University of Darmstadt", 
          "id": "https://www.grid.ac/institutes/grid.6546.1", 
          "name": [
            "Cell Biology and Epigenetics, Department of Biology, Technische Universit\u00e4t Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehmkuhl", 
        "givenName": "Anne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ja\u00e9n", 
          "id": "https://www.grid.ac/institutes/grid.21507.31", 
          "name": [
            "Department of Experimental Biology, University of Ja\u00e9n, Ja\u00e9n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero-Fern\u00e1ndez", 
        "givenName": "Ismael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ja\u00e9n", 
          "id": "https://www.grid.ac/institutes/grid.21507.31", 
          "name": [
            "Department of Experimental Biology, University of Ja\u00e9n, Ja\u00e9n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00e1nchez", 
        "givenName": "Antonio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center of the Johannes Gutenberg University Mainz", 
          "id": "https://www.grid.ac/institutes/grid.410607.4", 
          "name": [
            "Institute of Toxicology, Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz, Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00e4mer", 
        "givenName": "Oliver H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ja\u00e9n", 
          "id": "https://www.grid.ac/institutes/grid.21507.31", 
          "name": [
            "Department of Experimental Biology, University of Ja\u00e9n, Ja\u00e9n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchal", 
        "givenName": "J. Alberto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University of Darmstadt", 
          "id": "https://www.grid.ac/institutes/grid.6546.1", 
          "name": [
            "Cell Biology and Epigenetics, Department of Biology, Technische Universit\u00e4t Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardoso", 
        "givenName": "M. Cristina", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncomms11207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000609872", 
          "https://doi.org/10.1038/ncomms11207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003676239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-016-1878-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004187364", 
          "https://doi.org/10.1007/s00204-016-1878-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-016-1878-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004187364", 
          "https://doi.org/10.1007/s00204-016-1878-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005996496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fon.09.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006149341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000074347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006951537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.2008.951251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007219288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.2008.951251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007219288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007304424", 
          "https://doi.org/10.1038/35040083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007304424", 
          "https://doi.org/10.1038/35040083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007304424", 
          "https://doi.org/10.1038/35040083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1876110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011052364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-009-9201-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013399427", 
          "https://doi.org/10.1007/s00335-009-9201-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-009-9201-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013399427", 
          "https://doi.org/10.1007/s00335-009-9201-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-009-9201-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013399427", 
          "https://doi.org/10.1007/s00335-009-9201-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013557985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013659166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00542-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013711059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000133115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015540570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1206-1313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777909", 
          "https://doi.org/10.1038/ncb1206-1313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1206-1313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777909", 
          "https://doi.org/10.1038/ncb1206-1313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00159-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021905780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-005-5077-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022734472", 
          "https://doi.org/10.1007/s10577-005-5077-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-005-5077-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022734472", 
          "https://doi.org/10.1007/s10577-005-5077-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022937373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-014-0502-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023199836", 
          "https://doi.org/10.1007/s00412-014-0502-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2010-11-11-r110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023581356", 
          "https://doi.org/10.1186/gb-2010-11-11-r110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-012-0389-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025665523", 
          "https://doi.org/10.1007/s00412-012-0389-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1996.0360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027452841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(86)90583-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028419187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029757346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms1218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031041127", 
          "https://doi.org/10.1038/ncomms1218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031754872", 
          "https://doi.org/10.1038/nsmb.1665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031842651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-8935-6-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032233933", 
          "https://doi.org/10.1186/1756-8935-6-27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.33.23027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033640182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01948012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035618578", 
          "https://doi.org/10.1007/bf01948012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01948012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035618578", 
          "https://doi.org/10.1007/bf01948012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1365-2540.2001.00959.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038223357", 
          "https://doi.org/10.1046/j.1365-2540.2001.00959.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a010132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038991629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2005.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039798142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2005.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039798142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040623877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041029041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1084274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042001662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1084274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042001662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00644-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044127325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/190372a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048297848", 
          "https://doi.org/10.1038/190372a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.149.2.271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048639934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.16.9130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049376340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00702-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049625235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw1197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059932123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2532961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069978365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/nucl.2.5.17861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072306164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077682045", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077739285", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082427089", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkx281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084602573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-03096-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101086616", 
          "https://doi.org/10.1038/s41467-018-03096-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-03096-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101086616", 
          "https://doi.org/10.1038/s41467-018-03096-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-03096-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101086616", 
          "https://doi.org/10.1038/s41467-018-03096-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of these heterochromatin blocks have been studied, but little is known about their DNA replication dynamics and epigenetic composition.\nRESULTS: Here, we show prominent epigenetic marks of the heterochromatic blocks in the giant sex chromosomes of female Microtus cabrerae cells. While the X chromosomes are hypoacetylated and cytosine hypomethylated, they are either enriched for macroH2A and H3K27me3 typical for facultative heterochromatin or for H3K9me3 and HP1 beta typical for constitutive heterochromatin. Using pulse-chase replication labeling and time-lapse microscopy, we found that the heterochromatic block enriched for macroH2A/H3K27me3 of the X chromosome is replicated during mid-S-phase, prior to the heterochromatic block enriched for H3K9me3/HP1 beta, which is replicated during late S-phase. To test whether histone acetylation level regulates its replication dynamics, we induced either global hyperacetylation by pharmacological inhibition or by targeting a histone acetyltransferase to the heterochromatic region of the X chromosomes. Our data reveal that histone acetylation level affects DNA replication dynamics of the sex chromosomes' heterochromatin and leads to a global reduction in replication fork rate genome wide.\nCONCLUSIONS: In conclusion, we mapped major epigenetic modifications controlling the structure of the sex chromosome-associated heterochromatin and demonstrated the occurrence of differences in the molecular mechanisms controlling the replication timing of the heterochromatic blocks at the sex chromosomes in female Microtus cabrerae cells. Furthermore, we highlighted a conserved role of histone acetylation level on replication dynamics across mammalian species.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13072-019-0262-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7884527", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1039921", 
        "issn": [
          "1756-8935"
        ], 
        "name": "Epigenetics & Chromatin", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "DNA replication dynamics of vole genome and its epigenetic regulation", 
    "pagination": "18", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1978fd44ef69a25035bbb5d532e40aeb6e66eed342721dff9f32bf3e488860a2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30871586"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101471619"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13072-019-0262-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112759290"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13072-019-0262-0", 
      "https://app.dimensions.ai/details/publication/pub.1112759290"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78968_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13072-019-0262-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13072-019-0262-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13072-019-0262-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13072-019-0262-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13072-019-0262-0'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      78 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13072-019-0262-0 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N78b79f364d5c4baea35e80062e5055e0
4 schema:citation sg:pub.10.1007/bf01948012
5 sg:pub.10.1007/s00204-016-1878-5
6 sg:pub.10.1007/s00335-009-9201-x
7 sg:pub.10.1007/s00412-012-0389-2
8 sg:pub.10.1007/s00412-014-0502-9
9 sg:pub.10.1007/s10577-005-5077-0
10 sg:pub.10.1038/190372a0
11 sg:pub.10.1038/35040083
12 sg:pub.10.1038/ncb1206-1313
13 sg:pub.10.1038/ncomms11207
14 sg:pub.10.1038/ncomms1218
15 sg:pub.10.1038/nsmb.1665
16 sg:pub.10.1038/s41467-018-03096-0
17 sg:pub.10.1046/j.1365-2540.2001.00959.x
18 sg:pub.10.1186/1756-8935-6-27
19 sg:pub.10.1186/gb-2010-11-11-r110
20 https://app.dimensions.ai/details/publication/pub.1077682045
21 https://app.dimensions.ai/details/publication/pub.1077739285
22 https://app.dimensions.ai/details/publication/pub.1082427089
23 https://doi.org/10.1006/excr.1996.0360
24 https://doi.org/10.1016/0014-4827(86)90583-5
25 https://doi.org/10.1016/j.cell.2007.02.005
26 https://doi.org/10.1016/j.cell.2009.01.017
27 https://doi.org/10.1016/j.molcel.2009.12.012
28 https://doi.org/10.1016/j.tibs.2005.06.007
29 https://doi.org/10.1016/s0092-8674(01)00542-6
30 https://doi.org/10.1016/s0092-8674(02)00644-x
31 https://doi.org/10.1016/s1097-2765(02)00702-5
32 https://doi.org/10.1073/pnas.96.16.9130
33 https://doi.org/10.1074/jbc.274.33.23027
34 https://doi.org/10.1083/jcb.149.2.271
35 https://doi.org/10.1093/hmg/ddh016
36 https://doi.org/10.1093/nar/gki665
37 https://doi.org/10.1093/nar/gkr723
38 https://doi.org/10.1093/nar/gks784
39 https://doi.org/10.1093/nar/gkw1197
40 https://doi.org/10.1093/nar/gkx281
41 https://doi.org/10.1101/cshperspect.a010132
42 https://doi.org/10.1101/gad.1876110
43 https://doi.org/10.1126/science.1084274
44 https://doi.org/10.1128/mcb.00159-10
45 https://doi.org/10.1158/0008-5472.can-09-3028
46 https://doi.org/10.1159/000074347
47 https://doi.org/10.1159/000133115
48 https://doi.org/10.1242/jcs.00635
49 https://doi.org/10.1369/jhc.2008.951251
50 https://doi.org/10.2217/fon.09.36
51 https://doi.org/10.2307/2532961
52 https://doi.org/10.4161/nucl.2.5.17861
53 schema:datePublished 2019-12
54 schema:datePublishedReg 2019-12-01
55 schema:description BACKGROUND: The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of these heterochromatin blocks have been studied, but little is known about their DNA replication dynamics and epigenetic composition. RESULTS: Here, we show prominent epigenetic marks of the heterochromatic blocks in the giant sex chromosomes of female Microtus cabrerae cells. While the X chromosomes are hypoacetylated and cytosine hypomethylated, they are either enriched for macroH2A and H3K27me3 typical for facultative heterochromatin or for H3K9me3 and HP1 beta typical for constitutive heterochromatin. Using pulse-chase replication labeling and time-lapse microscopy, we found that the heterochromatic block enriched for macroH2A/H3K27me3 of the X chromosome is replicated during mid-S-phase, prior to the heterochromatic block enriched for H3K9me3/HP1 beta, which is replicated during late S-phase. To test whether histone acetylation level regulates its replication dynamics, we induced either global hyperacetylation by pharmacological inhibition or by targeting a histone acetyltransferase to the heterochromatic region of the X chromosomes. Our data reveal that histone acetylation level affects DNA replication dynamics of the sex chromosomes' heterochromatin and leads to a global reduction in replication fork rate genome wide. CONCLUSIONS: In conclusion, we mapped major epigenetic modifications controlling the structure of the sex chromosome-associated heterochromatin and demonstrated the occurrence of differences in the molecular mechanisms controlling the replication timing of the heterochromatic blocks at the sex chromosomes in female Microtus cabrerae cells. Furthermore, we highlighted a conserved role of histone acetylation level on replication dynamics across mammalian species.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf Na680d01cdabb4e74b048a48882166c7e
60 Ne0f17cc5d7ce43a1951329c508f1483f
61 sg:journal.1039921
62 schema:name DNA replication dynamics of vole genome and its epigenetic regulation
63 schema:pagination 18
64 schema:productId N0feec4424de7420aa0dd7c6ded06cafc
65 N77060f5b940e46c4bea64e1fb2eaa116
66 Nab113911353b4975b9e9f163aab8d272
67 Nbad7181f0d334b04a80e87d51ca6303f
68 Ncfd2c82f475b44e382e980324c708c8d
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112759290
70 https://doi.org/10.1186/s13072-019-0262-0
71 schema:sdDatePublished 2019-04-11T13:20
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N127c18d07ce54778bfec00e783aa6cff
74 schema:url https://link.springer.com/10.1186%2Fs13072-019-0262-0
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N016b337bd89d4a28823983eefa3e771d schema:affiliation https://www.grid.ac/institutes/grid.21507.31
79 schema:familyName Marchal
80 schema:givenName J. Alberto
81 rdf:type schema:Person
82 N0feec4424de7420aa0dd7c6ded06cafc schema:name readcube_id
83 schema:value 1978fd44ef69a25035bbb5d532e40aeb6e66eed342721dff9f32bf3e488860a2
84 rdf:type schema:PropertyValue
85 N101bfcbf4f6f478ca96ae8575e5f7ca9 schema:affiliation https://www.grid.ac/institutes/grid.21507.31
86 schema:familyName Sánchez
87 schema:givenName Antonio
88 rdf:type schema:Person
89 N127c18d07ce54778bfec00e783aa6cff schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N1614d58c794f417e960c2ad51ae4f970 rdf:first N1d7259f2431245b78f9140f6d5c489f8
92 rdf:rest N64eba71d918c463fb64af00b53e081d0
93 N1d7259f2431245b78f9140f6d5c489f8 schema:affiliation https://www.grid.ac/institutes/grid.6546.1
94 schema:familyName Rapp
95 schema:givenName Alexander
96 rdf:type schema:Person
97 N279caad817c84350969f5baf9a743c4b schema:affiliation https://www.grid.ac/institutes/grid.410607.4
98 schema:familyName Krämer
99 schema:givenName Oliver H.
100 rdf:type schema:Person
101 N36ab3bc2fa3b486e918e38e7d618788b rdf:first N016b337bd89d4a28823983eefa3e771d
102 rdf:rest Ncfa2010286d54b728e09dc39302308b0
103 N4b705c477c194a3b8337592fef8c921c schema:affiliation https://www.grid.ac/institutes/grid.6546.1
104 schema:familyName Cardoso
105 schema:givenName M. Cristina
106 rdf:type schema:Person
107 N56c6d381e0154eb0bf646a1dff1ee114 schema:affiliation https://www.grid.ac/institutes/grid.6546.1
108 schema:familyName Heinz
109 schema:givenName Kathrin S.
110 rdf:type schema:Person
111 N64eba71d918c463fb64af00b53e081d0 rdf:first Nfdad38c0004b47e88891d135cd3491f6
112 rdf:rest Nb502c659eaf5442d8fbe007eecd6267f
113 N6c35a4a826964c66936a1b695f6d7846 rdf:first N279caad817c84350969f5baf9a743c4b
114 rdf:rest N36ab3bc2fa3b486e918e38e7d618788b
115 N77060f5b940e46c4bea64e1fb2eaa116 schema:name doi
116 schema:value 10.1186/s13072-019-0262-0
117 rdf:type schema:PropertyValue
118 N78b79f364d5c4baea35e80062e5055e0 rdf:first N56c6d381e0154eb0bf646a1dff1ee114
119 rdf:rest N1614d58c794f417e960c2ad51ae4f970
120 N8fb9a3dc7bc24e05844977c44372f392 schema:affiliation https://www.grid.ac/institutes/grid.21507.31
121 schema:familyName Romero-Fernández
122 schema:givenName Ismael
123 rdf:type schema:Person
124 N9d1759f5b68c43c283f2d3846ff5757a schema:affiliation https://www.grid.ac/institutes/grid.6546.1
125 schema:familyName Lehmkuhl
126 schema:givenName Anne
127 rdf:type schema:Person
128 Na680d01cdabb4e74b048a48882166c7e schema:issueNumber 1
129 rdf:type schema:PublicationIssue
130 Nab113911353b4975b9e9f163aab8d272 schema:name pubmed_id
131 schema:value 30871586
132 rdf:type schema:PropertyValue
133 Nb502c659eaf5442d8fbe007eecd6267f rdf:first N9d1759f5b68c43c283f2d3846ff5757a
134 rdf:rest Nb9e6f16b39e74d53bc4193e2dca61ad1
135 Nb9e6f16b39e74d53bc4193e2dca61ad1 rdf:first N8fb9a3dc7bc24e05844977c44372f392
136 rdf:rest Ndea6254b3855441b832aa8bf5e05dc79
137 Nbad7181f0d334b04a80e87d51ca6303f schema:name dimensions_id
138 schema:value pub.1112759290
139 rdf:type schema:PropertyValue
140 Ncfa2010286d54b728e09dc39302308b0 rdf:first N4b705c477c194a3b8337592fef8c921c
141 rdf:rest rdf:nil
142 Ncfd2c82f475b44e382e980324c708c8d schema:name nlm_unique_id
143 schema:value 101471619
144 rdf:type schema:PropertyValue
145 Ndea6254b3855441b832aa8bf5e05dc79 rdf:first N101bfcbf4f6f478ca96ae8575e5f7ca9
146 rdf:rest N6c35a4a826964c66936a1b695f6d7846
147 Ne0f17cc5d7ce43a1951329c508f1483f schema:volumeNumber 12
148 rdf:type schema:PublicationVolume
149 Nfdad38c0004b47e88891d135cd3491f6 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
150 schema:familyName Casas-Delucchi
151 schema:givenName Corella S.
152 rdf:type schema:Person
153 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biological Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
157 schema:name Genetics
158 rdf:type schema:DefinedTerm
159 sg:grant.7884527 http://pending.schema.org/fundedItem sg:pub.10.1186/s13072-019-0262-0
160 rdf:type schema:MonetaryGrant
161 sg:journal.1039921 schema:issn 1756-8935
162 schema:name Epigenetics & Chromatin
163 rdf:type schema:Periodical
164 sg:pub.10.1007/bf01948012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035618578
165 https://doi.org/10.1007/bf01948012
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/s00204-016-1878-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004187364
168 https://doi.org/10.1007/s00204-016-1878-5
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s00335-009-9201-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013399427
171 https://doi.org/10.1007/s00335-009-9201-x
172 rdf:type schema:CreativeWork
173 sg:pub.10.1007/s00412-012-0389-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025665523
174 https://doi.org/10.1007/s00412-012-0389-2
175 rdf:type schema:CreativeWork
176 sg:pub.10.1007/s00412-014-0502-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023199836
177 https://doi.org/10.1007/s00412-014-0502-9
178 rdf:type schema:CreativeWork
179 sg:pub.10.1007/s10577-005-5077-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022734472
180 https://doi.org/10.1007/s10577-005-5077-0
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/190372a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048297848
183 https://doi.org/10.1038/190372a0
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/35040083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007304424
186 https://doi.org/10.1038/35040083
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/ncb1206-1313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777909
189 https://doi.org/10.1038/ncb1206-1313
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/ncomms11207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000609872
192 https://doi.org/10.1038/ncomms11207
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/ncomms1218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031041127
195 https://doi.org/10.1038/ncomms1218
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/nsmb.1665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031754872
198 https://doi.org/10.1038/nsmb.1665
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/s41467-018-03096-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101086616
201 https://doi.org/10.1038/s41467-018-03096-0
202 rdf:type schema:CreativeWork
203 sg:pub.10.1046/j.1365-2540.2001.00959.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038223357
204 https://doi.org/10.1046/j.1365-2540.2001.00959.x
205 rdf:type schema:CreativeWork
206 sg:pub.10.1186/1756-8935-6-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032233933
207 https://doi.org/10.1186/1756-8935-6-27
208 rdf:type schema:CreativeWork
209 sg:pub.10.1186/gb-2010-11-11-r110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023581356
210 https://doi.org/10.1186/gb-2010-11-11-r110
211 rdf:type schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1077682045 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1077739285 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082427089 schema:CreativeWork
215 https://doi.org/10.1006/excr.1996.0360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027452841
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0014-4827(86)90583-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028419187
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.cell.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022937373
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.cell.2009.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040623877
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.molcel.2009.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013557985
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.tibs.2005.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039798142
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0092-8674(01)00542-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013711059
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0092-8674(02)00644-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044127325
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s1097-2765(02)00702-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049625235
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1073/pnas.96.16.9130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049376340
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1074/jbc.274.33.23027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033640182
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1083/jcb.149.2.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048639934
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/hmg/ddh016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003676239
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1093/nar/gki665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013659166
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1093/nar/gkr723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031842651
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/nar/gks784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029757346
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/nar/gkw1197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059932123
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1093/nar/gkx281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084602573
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1101/cshperspect.a010132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038991629
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1101/gad.1876110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011052364
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1126/science.1084274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042001662
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1128/mcb.00159-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021905780
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1158/0008-5472.can-09-3028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041029041
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1159/000074347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006951537
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1159/000133115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015540570
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1242/jcs.00635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005996496
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1369/jhc.2008.951251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007219288
268 rdf:type schema:CreativeWork
269 https://doi.org/10.2217/fon.09.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006149341
270 rdf:type schema:CreativeWork
271 https://doi.org/10.2307/2532961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069978365
272 rdf:type schema:CreativeWork
273 https://doi.org/10.4161/nucl.2.5.17861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306164
274 rdf:type schema:CreativeWork
275 https://www.grid.ac/institutes/grid.21507.31 schema:alternateName University of Jaén
276 schema:name Department of Experimental Biology, University of Jaén, Jaén, Spain
277 rdf:type schema:Organization
278 https://www.grid.ac/institutes/grid.410607.4 schema:alternateName University Medical Center of the Johannes Gutenberg University Mainz
279 schema:name Institute of Toxicology, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
282 schema:name Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany
283 Chromosome Replication Laboratory, The Francis Crick Institute, NW1 1AT, London, UK
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.6546.1 schema:alternateName Technical University of Darmstadt
286 schema:name Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...