Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Sumaiya A. Islam, Sarah J. Goodman, Julia L. MacIsaac, Jelena Obradović, Ronald G. Barr, W. Thomas Boyce, Michael S. Kobor

ABSTRACT

BACKGROUND: The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of tissue-specific DNA methylation (DNAm) variation in human populations. To date, characterizations of inter-individual DNAm variability and DNAm concordance across tissues have been largely performed in adult tissues and therefore are limited in their relevance to DNAm profiles from pediatric samples. Given that DNAm patterns in early life undergo rapid changes and have been linked to a wide range of health outcomes and environmental exposures, direct investigations of tissue-specific DNAm variation in pediatric samples may help inform the design and interpretation of DNAm analyses from early life cohorts. In this study, we present a systematic comparison of genome-wide DNAm patterns between matched pediatric buccal epithelial cells (BECs) and peripheral blood mononuclear cells (PBMCs), two of the most widely used peripheral tissues in human epigenetic studies. Specifically, we assessed DNAm variability, cross-tissue DNAm concordance and genetic determinants of DNAm across two independent early life cohorts encompassing different ages. RESULTS: BECs had greater inter-individual DNAm variability compared to PBMCs and highly the variable CpGs are more likely to be positively correlated between the matched tissues compared to less variable CpGs. These sites were enriched for CpGs under genetic influence, suggesting that a substantial proportion of DNAm covariation between tissues can be attributed to genetic variation. Finally, we demonstrated the relevance of our findings to human epigenetic studies by categorizing CpGs from published DNAm association studies of pediatric BECs and peripheral blood. CONCLUSIONS: Taken together, our results highlight a number of important considerations and practical implications in the design and interpretation of EWAS analyses performed in pediatric peripheral tissues. More... »

PAGES

1

References to SciGraph publications

  • 2017-05-30. Associating cellular epigenetic models with human phenotypes in NATURE REVIEWS GENETICS
  • 2012-07. Functions of DNA methylation: islands, start sites, gene bodies and beyond in NATURE REVIEWS GENETICS
  • 2017-12. Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region in EPIGENETICS & CHROMATIN
  • 2013-09. Transcriptome and genome sequencing uncovers functional variation in humans in NATURE
  • 2015-12. Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants in NATURE COMMUNICATIONS
  • 2015-12. A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood in CLINICAL EPIGENETICS
  • 2015-12. quantro: a data-driven approach to guide the choice of an appropriate normalization method in GENOME BIOLOGY
  • 2014-12. Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type in BMC GENOMICS
  • 2016-03-21. Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans in NATURE COMMUNICATIONS
  • 2011-12. Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies in EPIGENETICS & CHROMATIN
  • 2015. Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach in POPULATION EPIGENETICS
  • 2015-12. Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci in NATURE COMMUNICATIONS
  • 2017-12. Choice of surrogate tissue influences neonatal EWAS findings in BMC MEDICINE
  • 2013-01. Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions in NATURE NEUROSCIENCE
  • 2013-12. Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array in EPIGENETICS & CHROMATIN
  • 2014-02. Accounting for cellular heterogeneity is critical in epigenome-wide association studies in GENOME BIOLOGY
  • 2012-12. DNA methylation arrays as surrogate measures of cell mixture distribution in BMC BIOINFORMATICS
  • 2014-12. Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression in EPIGENETICS & CHROMATIN
  • 2015-12. Concordant and discordant DNA methylation signatures of aging in human blood and brain in EPIGENETICS & CHROMATIN
  • 2010-03. Principles and challenges of genome-wide DNA methylation analysis in NATURE REVIEWS GENETICS
  • 2011-08. Epigenome-wide association studies for common human diseases in NATURE REVIEWS GENETICS
  • 2016-12. Systematic identification of genetic influences on methylation across the human life course in GENOME BIOLOGY
  • 2018-01-17. A user's guide to the ambiguous word 'epigenetics' in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-12. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome in BMC MEDICINE
  • 2009-02. DNA methylation profiles in monozygotic and dizygotic twins in NATURE GENETICS
  • 2018-12. Quantitation of the cellular content of saliva and buccal swab samples in SCIENTIFIC REPORTS
  • 2012-02. Population-specificity of human DNA methylation in GENOME BIOLOGY
  • 2016-12. DNA methylation signature of human fetal alcohol spectrum disorder in EPIGENETICS & CHROMATIN
  • 2012-10. Analysing and interpreting DNA methylation data in NATURE REVIEWS GENETICS
  • 2007-05-24. Perceptions of epigenetics in NATURE
  • 2016-12. Tobacco smoking differently influences cell types of the innate and adaptive immune system—indications from CpG site methylation in CLINICAL EPIGENETICS
  • 2007-04. Environmental epigenomics and disease susceptibility in NATURE REVIEWS GENETICS
  • 2005-10. A network-based analysis of systemic inflammation in humans in NATURE
  • 2015-07. Discordance of DNA Methylation Variance Between two Accessible Human Tissues in SCIENTIFIC REPORTS
  • 2017-12. The emerging landscape of dynamic DNA methylation in early childhood in BMC GENOMICS
  • 2013-08. From promises to practical strategies in epigenetic epidemiology in NATURE REVIEWS GENETICS
  • 2016-09. Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood in SCIENTIFIC REPORTS
  • 2017-12. Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder in NATURE COMMUNICATIONS
  • 2013-12. Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array in EPIGENETICS & CHROMATIN
  • 2011-01. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines in GENOME BIOLOGY
  • 2015-02. Integrative analysis of 111 reference human epigenomes in NATURE
  • 2015-12. DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies in CLINICAL EPIGENETICS
  • 2017-12. Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome in GENOME BIOLOGY
  • 2016-12. Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms in GENOME BIOLOGY
  • 2012-01. Dissecting the regulatory architecture of gene expression QTLs in GENOME BIOLOGY
  • 2014-11. Illumina human exome genotyping array clustering and quality control in NATURE PROTOCOLS
  • 2013-08. Charting a dynamic DNA methylation landscape of the human genome in NATURE
  • 2013-10. Recommendations for the design and analysis of epigenome-wide association studies in NATURE METHODS
  • 2016-01. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci in NATURE NEUROSCIENCE
  • 2007-05. The Epigenetic Basis of Twin Discordance in Age-Related Diseases in PEDIATRIC RESEARCH
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    http://scigraph.springernature.com/pub.10.1186/s13072-018-0245-6

    DOI

    http://dx.doi.org/10.1186/s13072-018-0245-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111053934

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30602389


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