Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Bart Kolendowski, Haider Hassan, Milica Krstic, Majdina Isovic, Gobi Thillainadesan, Ann F. Chambers, Alan B. Tuck, Joseph Torchia

ABSTRACT

BACKGROUND: The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER binds to gene-specific enhancer regions in response to β-estradiol (E2) which undergo transcription producing noncoding enhancer RNA (eRNA). While eRNAs are important for transcriptional activation of neighboring genes, the mechanism remains poorly understood. RESULTS: Using ChIP-Seq we generate a global profile of thymine DNA glycosylase (TDG), an ER coactivator that plays an essential role in DNA demethylation, in response to E2 in the MCF7 breast cancer cell line. Remarkably, we found that in response to E2 TDG localized to enhancers which also recruit ERα, RNA Pol II and other coregulators and which are marked by histone modifications indicative of active enhancers. Importantly, depletion of TDG inhibits E2-mediated transcription of eRNAs and transcription of ER-target genes. Functionally, we find that TDG both sensitizes MCF7 cells to tamoxifen-mediated cytostasis and increases migration and invasion of MCF7 cells. CONCLUSIONS: Taken together we find that TDG plays a central role in mediating transcription at a subset of enhancers and governs how MCF7 cells respond to both estrogenic and anti-estrogenic compounds and may be an effective therapeutic target. More... »

PAGES

5

References to SciGraph publications

  • 1989-07. Modulation of human breast cancer cell adhesion by estrogens and antiestrogens in CLINICAL & EXPERIMENTAL METASTASIS
  • 2013-03. DNA methylation: roles in mammalian development in NATURE REVIEWS GENETICS
  • 2012-09. AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation in NATURE CHEMICAL BIOLOGY
  • 1983-07. Human breast carcinoma (MCF-7) serially transplanted into nude mice in THE JAPANESE JOURNAL OF SURGERY
  • 2014-12. Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma in BMC CANCER
  • 2012-08. Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase in GENOME BIOLOGY
  • 2013-01. DNA Methylation and Its Basic Function in NEUROPSYCHOPHARMACOLOGY
  • 2011-02. Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability in NATURE
  • 2013-06. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation in NATURE
  • 2008-03. Cyclical DNA methylation of a transcriptionally active promoter in NATURE
  • 2014-12. Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing in NATURE BIOTECHNOLOGY
  • 2008-12. Anti-oestrogens but not oestrogen deprivation promote cellular invasion in intercellular adhesion-deficient breast cancer cells in BREAST CANCER RESEARCH
  • 2007-07. Quantitative analysis of chromosome conformation capture assays (3C-qPCR) in NATURE PROTOCOLS
  • 2015-10. Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes in NATURE GENETICS
  • 2006. Methylation Dynamics in the Early Mammalian Embryo: Implications of Genome Reprogramming Defects for Development in DNA METHYLATION: DEVELOPMENT, GENETIC DISEASE AND CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13072-018-0176-2

    DOI

    http://dx.doi.org/10.1186/s13072-018-0176-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100687804

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29378668


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Movement", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin Immunoprecipitation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Synergism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enhancer Elements, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Estradiol", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MCF-7 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Polymerase II", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Estrogen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tamoxifen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thymine DNA Glycosylase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Whole Genome Sequencing", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Biochemistry, Western University, London, ON, Canada", 
                "Department of Oncology, Western University, London, ON, Canada", 
                "The London Regional Cancer Program and the Lawson Health Research Institute, Western University, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kolendowski", 
            "givenName": "Bart", 
            "id": "sg:person.014544114617.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014544114617.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Biochemistry, Western University, London, ON, Canada", 
                "Department of Oncology, Western University, London, ON, Canada", 
                "The London Regional Cancer Program and the Lawson Health Research Institute, Western University, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hassan", 
            "givenName": "Haider", 
            "id": "sg:person.013746534217.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013746534217.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Pathology, Western University, London, ON, Canada", 
                "The London Regional Cancer Program and the Lawson Health Research Institute, Western University, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krstic", 
            "givenName": "Milica", 
            "id": "sg:person.012554463335.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012554463335.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Oncology, Western University, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Isovic", 
            "givenName": "Majdina", 
            "id": "sg:person.0703123471.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703123471.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Biochemistry, Western University, London, ON, Canada", 
                "Department of Oncology, Western University, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thillainadesan", 
            "givenName": "Gobi", 
            "id": "sg:person.01360414371.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360414371.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "The London Regional Cancer Program and the Lawson Health Research Institute, Western University, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chambers", 
            "givenName": "Ann F.", 
            "id": "sg:person.0770367544.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770367544.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Oncology, Western University, London, ON, Canada", 
                "Department of Pathology, Western University, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tuck", 
            "givenName": "Alan B.", 
            "id": "sg:person.01330112664.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330112664.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "London Health Sciences Centre", 
              "id": "https://www.grid.ac/institutes/grid.412745.1", 
              "name": [
                "Department of Biochemistry, Western University, London, ON, Canada", 
                "Department of Oncology, Western University, London, ON, Canada", 
                "The London Regional Cancer Program and the Lawson Health Research Institute, Western University, London, ON, Canada", 
                "Cancer Research Laboratories, London Regional Cancer Program, N6A 4L6, London, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Torchia", 
            "givenName": "Joseph", 
            "id": "sg:person.01074731465.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074731465.73"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/nar/gkw257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002966090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15592294.2015.1062204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003897186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00453-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004612098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-0301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004873618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/10.8.2709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005140541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/vir.0.80426-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008503228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2012.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012205596", 
              "https://doi.org/10.1038/npp.2012.112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2012-13-8-r69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014113021", 
              "https://doi.org/10.1186/gb-2012-13-8-r69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016511715", 
              "https://doi.org/10.1038/nrg3354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.139469.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016544057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0099603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016679433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00934-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016765730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1210597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017751509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018622449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02469523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019890653", 
              "https://doi.org/10.1007/bf02469523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021083422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2007.243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021403754", 
              "https://doi.org/10.1038/nprot.2007.243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2014.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021735450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-31181-5_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022654536", 
              "https://doi.org/10.1007/3-540-31181-5_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01753661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023380085", 
              "https://doi.org/10.1007/bf01753661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01753661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023380085", 
              "https://doi.org/10.1007/bf01753661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026881115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0510310103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026928995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027731411", 
              "https://doi.org/10.1186/bcr2206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029643016", 
              "https://doi.org/10.1038/nature06544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030719910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(99)01971-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031330354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c111.284620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031871396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032380101", 
              "https://doi.org/10.1038/nbt.3073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2012.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035722258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036300730", 
              "https://doi.org/10.1038/nature09672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.06.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037445404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/iti0114111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038399782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038455631", 
              "https://doi.org/10.1186/1471-2407-14-172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039182708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.03.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040615414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m113.538835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043810597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1324151111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044350073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044900532", 
              "https://doi.org/10.1038/ng.3385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.122382.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046312726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1016071107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047051560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.08.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047811182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2013.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047835286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m304286200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048460213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049159634", 
              "https://doi.org/10.1038/nature12210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049278019", 
              "https://doi.org/10.1038/nchembio.1042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049823294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15592294.2015.1091145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058407232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1947601911404223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064081076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1568026615666150413154841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069195175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.26597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072302693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078811666", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082569807", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2017.05.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085566774"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "BACKGROUND: The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER binds to gene-specific enhancer regions in response to \u03b2-estradiol (E2) which undergo transcription producing noncoding enhancer RNA (eRNA). While eRNAs are important for transcriptional activation of neighboring genes, the mechanism remains poorly understood.\nRESULTS: Using ChIP-Seq we generate a global profile of thymine DNA glycosylase (TDG), an ER coactivator that plays an essential role in DNA demethylation, in response to E2 in the MCF7 breast cancer cell line. Remarkably, we found that in response to E2 TDG localized to enhancers which also recruit ER\u03b1, RNA Pol II and other coregulators and which are marked by histone modifications indicative of active enhancers. Importantly, depletion of TDG inhibits E2-mediated transcription of eRNAs and transcription of ER-target genes. Functionally, we find that TDG both sensitizes MCF7 cells to tamoxifen-mediated cytostasis and increases migration and invasion of MCF7 cells.\nCONCLUSIONS: Taken together we find that TDG plays a central role in mediating transcription at a subset of enhancers and governs how MCF7 cells respond to both estrogenic and anti-estrogenic compounds and may be an effective therapeutic target.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13072-018-0176-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1039921", 
            "issn": [
              "1756-8935"
            ], 
            "name": "Epigenetics & Chromatin", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization", 
        "pagination": "5", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3515798f99cdfe85ab6a4bb69f210cf442feb89be989555056d2ca2d25ed8f6e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29378668"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101471619"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13072-018-0176-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100687804"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13072-018-0176-2", 
          "https://app.dimensions.ai/details/publication/pub.1100687804"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T18:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000562.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186/s13072-018-0176-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13072-018-0176-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13072-018-0176-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13072-018-0176-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13072-018-0176-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    370 TRIPLES      21 PREDICATES      100 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13072-018-0176-2 schema:about N0cb16b0fc60c41f19c2fa840a0a0daf7
    2 N100649c5e12f49a9bd7c47f40f5020a8
    3 N2849a75136ff4fd8b868dae5bb97f17b
    4 N2aad6c3b811b420595a51c8ca06360f9
    5 N49b8bb8fcc0943ffbeb5e23be6a71536
    6 N51a7c6092ffe41fc9d7f5bb7e2451a2b
    7 N5520ad556ffc4ba2b59b851f52a8178b
    8 N57aa0f725c1248d69c0dad42410b84f7
    9 N67fdc55aa00a4f5bab4b5ad97c0e3ea4
    10 N78e2c51a124e44f3ba8e28bf81f7676a
    11 N961f795f30bc457f844effc4109ed882
    12 Nbcd39493c0304433a07c4e5affdc3ca8
    13 Ne5d664728bfb441e822d446ee5a7fea5
    14 Ne9b5b71a0c0b4a059e998db0175d1f67
    15 Nee33ba4947664a17a5d1e2014544a647
    16 Nefd14cd655d747aaa3564b0bdb04addd
    17 Nf4fcf145baaf4c38b5622f0e4351222f
    18 Nffb2898949be4f639e36e52bdcc48fcd
    19 anzsrc-for:11
    20 anzsrc-for:1112
    21 schema:author Nc5982510821c4be58fcb7383c8ff0aee
    22 schema:citation sg:pub.10.1007/3-540-31181-5_2
    23 sg:pub.10.1007/bf01753661
    24 sg:pub.10.1007/bf02469523
    25 sg:pub.10.1038/nature06544
    26 sg:pub.10.1038/nature09672
    27 sg:pub.10.1038/nature12210
    28 sg:pub.10.1038/nbt.3073
    29 sg:pub.10.1038/nchembio.1042
    30 sg:pub.10.1038/ng.3385
    31 sg:pub.10.1038/npp.2012.112
    32 sg:pub.10.1038/nprot.2007.243
    33 sg:pub.10.1038/nrg3354
    34 sg:pub.10.1186/1471-2407-14-172
    35 sg:pub.10.1186/bcr2206
    36 sg:pub.10.1186/gb-2012-13-8-r69
    37 https://app.dimensions.ai/details/publication/pub.1078811666
    38 https://app.dimensions.ai/details/publication/pub.1082569807
    39 https://doi.org/10.1016/j.bbrc.2012.08.007
    40 https://doi.org/10.1016/j.cell.2008.01.018
    41 https://doi.org/10.1016/j.cell.2011.06.020
    42 https://doi.org/10.1016/j.cell.2013.04.001
    43 https://doi.org/10.1016/j.cell.2013.04.002
    44 https://doi.org/10.1016/j.cell.2013.06.018
    45 https://doi.org/10.1016/j.cell.2014.05.010
    46 https://doi.org/10.1016/j.celrep.2015.08.066
    47 https://doi.org/10.1016/j.celrep.2017.05.007
    48 https://doi.org/10.1016/j.dnarep.2013.04.003
    49 https://doi.org/10.1016/j.molcel.2012.03.027
    50 https://doi.org/10.1016/j.molcel.2012.05.011
    51 https://doi.org/10.1016/j.molonc.2014.05.013
    52 https://doi.org/10.1016/s0092-8674(03)00934-6
    53 https://doi.org/10.1016/s0168-9525(99)01971-x
    54 https://doi.org/10.1016/s1097-2765(02)00453-7
    55 https://doi.org/10.1073/iti0114111
    56 https://doi.org/10.1073/pnas.0510310103
    57 https://doi.org/10.1073/pnas.1016071107
    58 https://doi.org/10.1073/pnas.1324151111
    59 https://doi.org/10.1074/jbc.c111.284620
    60 https://doi.org/10.1074/jbc.m113.538835
    61 https://doi.org/10.1074/jbc.m304286200
    62 https://doi.org/10.1080/15592294.2015.1062204
    63 https://doi.org/10.1080/15592294.2015.1091145
    64 https://doi.org/10.1093/nar/10.8.2709
    65 https://doi.org/10.1093/nar/gkw257
    66 https://doi.org/10.1099/vir.0.80426-0
    67 https://doi.org/10.1101/gr.122382.111
    68 https://doi.org/10.1101/gr.139469.112
    69 https://doi.org/10.1126/science.1210597
    70 https://doi.org/10.1158/0008-5472.can-08-0301
    71 https://doi.org/10.1177/1947601911404223
    72 https://doi.org/10.1371/journal.pone.0099603
    73 https://doi.org/10.2174/1568026615666150413154841
    74 https://doi.org/10.4161/epi.26597
    75 schema:datePublished 2018-12
    76 schema:datePublishedReg 2018-12-01
    77 schema:description BACKGROUND: The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER binds to gene-specific enhancer regions in response to β-estradiol (E2) which undergo transcription producing noncoding enhancer RNA (eRNA). While eRNAs are important for transcriptional activation of neighboring genes, the mechanism remains poorly understood. RESULTS: Using ChIP-Seq we generate a global profile of thymine DNA glycosylase (TDG), an ER coactivator that plays an essential role in DNA demethylation, in response to E2 in the MCF7 breast cancer cell line. Remarkably, we found that in response to E2 TDG localized to enhancers which also recruit ERα, RNA Pol II and other coregulators and which are marked by histone modifications indicative of active enhancers. Importantly, depletion of TDG inhibits E2-mediated transcription of eRNAs and transcription of ER-target genes. Functionally, we find that TDG both sensitizes MCF7 cells to tamoxifen-mediated cytostasis and increases migration and invasion of MCF7 cells. CONCLUSIONS: Taken together we find that TDG plays a central role in mediating transcription at a subset of enhancers and governs how MCF7 cells respond to both estrogenic and anti-estrogenic compounds and may be an effective therapeutic target.
    78 schema:genre research_article
    79 schema:inLanguage en
    80 schema:isAccessibleForFree true
    81 schema:isPartOf N0ee6d2de18e046a1b125c31fec74840c
    82 Ne66848beffff4bd482fc700fecb0beee
    83 sg:journal.1039921
    84 schema:name Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization
    85 schema:pagination 5
    86 schema:productId N5615d1a060254b8ea5635b84e39356a8
    87 N73fbce7b4e8340b1a11f3bbe57649805
    88 N7d2f72115d3f4287b6fbb61cf4869d52
    89 Neea057961b5a4ea58d77a579937cdc9b
    90 Nf45a25c5293645d9947391b57a1ace66
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100687804
    92 https://doi.org/10.1186/s13072-018-0176-2
    93 schema:sdDatePublished 2019-04-10T18:28
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher Ndafa7ccc8e614872ad7d4fc5dc059f1d
    96 schema:url http://link.springer.com/10.1186/s13072-018-0176-2
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N05af123765844400adf48de11d41634f rdf:first sg:person.0770367544.78
    101 rdf:rest Nccbb1e25043949f296402a3d251ad3a8
    102 N0cb16b0fc60c41f19c2fa840a0a0daf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Receptors, Estrogen
    104 rdf:type schema:DefinedTerm
    105 N0ee6d2de18e046a1b125c31fec74840c schema:volumeNumber 11
    106 rdf:type schema:PublicationVolume
    107 N100649c5e12f49a9bd7c47f40f5020a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name MCF-7 Cells
    109 rdf:type schema:DefinedTerm
    110 N2849a75136ff4fd8b868dae5bb97f17b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Breast Neoplasms
    112 rdf:type schema:DefinedTerm
    113 N2aad6c3b811b420595a51c8ca06360f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Humans
    115 rdf:type schema:DefinedTerm
    116 N49b8bb8fcc0943ffbeb5e23be6a71536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Sequence Analysis, RNA
    118 rdf:type schema:DefinedTerm
    119 N51a7c6092ffe41fc9d7f5bb7e2451a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Chromatin Immunoprecipitation
    121 rdf:type schema:DefinedTerm
    122 N5520ad556ffc4ba2b59b851f52a8178b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Drug Synergism
    124 rdf:type schema:DefinedTerm
    125 N5615d1a060254b8ea5635b84e39356a8 schema:name readcube_id
    126 schema:value 3515798f99cdfe85ab6a4bb69f210cf442feb89be989555056d2ca2d25ed8f6e
    127 rdf:type schema:PropertyValue
    128 N57aa0f725c1248d69c0dad42410b84f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Cell Movement
    130 rdf:type schema:DefinedTerm
    131 N5b7f3a2e68d04884a9287c834f2cdc99 rdf:first sg:person.013746534217.93
    132 rdf:rest Na4d30e2cedc74f52ad3d3d54150a95a6
    133 N67fdc55aa00a4f5bab4b5ad97c0e3ea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Cell Proliferation
    135 rdf:type schema:DefinedTerm
    136 N73fbce7b4e8340b1a11f3bbe57649805 schema:name nlm_unique_id
    137 schema:value 101471619
    138 rdf:type schema:PropertyValue
    139 N78e2c51a124e44f3ba8e28bf81f7676a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Cell Survival
    141 rdf:type schema:DefinedTerm
    142 N7d2f72115d3f4287b6fbb61cf4869d52 schema:name pubmed_id
    143 schema:value 29378668
    144 rdf:type schema:PropertyValue
    145 N961f795f30bc457f844effc4109ed882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Whole Genome Sequencing
    147 rdf:type schema:DefinedTerm
    148 Na4d30e2cedc74f52ad3d3d54150a95a6 rdf:first sg:person.012554463335.53
    149 rdf:rest Ncc4ea79d6af94335856f5084401afdbd
    150 Nbc0165017d2e4adfa2ac817ef6af2b14 rdf:first sg:person.01360414371.03
    151 rdf:rest N05af123765844400adf48de11d41634f
    152 Nbcd39493c0304433a07c4e5affdc3ca8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Enhancer Elements, Genetic
    154 rdf:type schema:DefinedTerm
    155 Nc5982510821c4be58fcb7383c8ff0aee rdf:first sg:person.014544114617.53
    156 rdf:rest N5b7f3a2e68d04884a9287c834f2cdc99
    157 Nc9396d0206c74ff5a2b29b96cef5dda6 rdf:first sg:person.01074731465.73
    158 rdf:rest rdf:nil
    159 Ncc4ea79d6af94335856f5084401afdbd rdf:first sg:person.0703123471.08
    160 rdf:rest Nbc0165017d2e4adfa2ac817ef6af2b14
    161 Nccbb1e25043949f296402a3d251ad3a8 rdf:first sg:person.01330112664.67
    162 rdf:rest Nc9396d0206c74ff5a2b29b96cef5dda6
    163 Ndafa7ccc8e614872ad7d4fc5dc059f1d schema:name Springer Nature - SN SciGraph project
    164 rdf:type schema:Organization
    165 Ne5d664728bfb441e822d446ee5a7fea5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Tamoxifen
    167 rdf:type schema:DefinedTerm
    168 Ne66848beffff4bd482fc700fecb0beee schema:issueNumber 1
    169 rdf:type schema:PublicationIssue
    170 Ne9b5b71a0c0b4a059e998db0175d1f67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Female
    172 rdf:type schema:DefinedTerm
    173 Nee33ba4947664a17a5d1e2014544a647 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Thymine DNA Glycosylase
    175 rdf:type schema:DefinedTerm
    176 Neea057961b5a4ea58d77a579937cdc9b schema:name doi
    177 schema:value 10.1186/s13072-018-0176-2
    178 rdf:type schema:PropertyValue
    179 Nefd14cd655d747aaa3564b0bdb04addd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Estradiol
    181 rdf:type schema:DefinedTerm
    182 Nf45a25c5293645d9947391b57a1ace66 schema:name dimensions_id
    183 schema:value pub.1100687804
    184 rdf:type schema:PropertyValue
    185 Nf4fcf145baaf4c38b5622f0e4351222f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name RNA Polymerase II
    187 rdf:type schema:DefinedTerm
    188 Nffb2898949be4f639e36e52bdcc48fcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name DNA Methylation
    190 rdf:type schema:DefinedTerm
    191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Medical and Health Sciences
    193 rdf:type schema:DefinedTerm
    194 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    195 schema:name Oncology and Carcinogenesis
    196 rdf:type schema:DefinedTerm
    197 sg:journal.1039921 schema:issn 1756-8935
    198 schema:name Epigenetics & Chromatin
    199 rdf:type schema:Periodical
    200 sg:person.01074731465.73 schema:affiliation https://www.grid.ac/institutes/grid.412745.1
    201 schema:familyName Torchia
    202 schema:givenName Joseph
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074731465.73
    204 rdf:type schema:Person
    205 sg:person.012554463335.53 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    206 schema:familyName Krstic
    207 schema:givenName Milica
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012554463335.53
    209 rdf:type schema:Person
    210 sg:person.01330112664.67 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    211 schema:familyName Tuck
    212 schema:givenName Alan B.
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330112664.67
    214 rdf:type schema:Person
    215 sg:person.01360414371.03 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    216 schema:familyName Thillainadesan
    217 schema:givenName Gobi
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360414371.03
    219 rdf:type schema:Person
    220 sg:person.013746534217.93 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    221 schema:familyName Hassan
    222 schema:givenName Haider
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013746534217.93
    224 rdf:type schema:Person
    225 sg:person.014544114617.53 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    226 schema:familyName Kolendowski
    227 schema:givenName Bart
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014544114617.53
    229 rdf:type schema:Person
    230 sg:person.0703123471.08 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    231 schema:familyName Isovic
    232 schema:givenName Majdina
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703123471.08
    234 rdf:type schema:Person
    235 sg:person.0770367544.78 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    236 schema:familyName Chambers
    237 schema:givenName Ann F.
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770367544.78
    239 rdf:type schema:Person
    240 sg:pub.10.1007/3-540-31181-5_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022654536
    241 https://doi.org/10.1007/3-540-31181-5_2
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/bf01753661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023380085
    244 https://doi.org/10.1007/bf01753661
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/bf02469523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019890653
    247 https://doi.org/10.1007/bf02469523
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/nature06544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029643016
    250 https://doi.org/10.1038/nature06544
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nature09672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036300730
    253 https://doi.org/10.1038/nature09672
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nature12210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049159634
    256 https://doi.org/10.1038/nature12210
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nbt.3073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032380101
    259 https://doi.org/10.1038/nbt.3073
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nchembio.1042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049278019
    262 https://doi.org/10.1038/nchembio.1042
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/ng.3385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044900532
    265 https://doi.org/10.1038/ng.3385
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/npp.2012.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012205596
    268 https://doi.org/10.1038/npp.2012.112
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nprot.2007.243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021403754
    271 https://doi.org/10.1038/nprot.2007.243
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nrg3354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016511715
    274 https://doi.org/10.1038/nrg3354
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1186/1471-2407-14-172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038455631
    277 https://doi.org/10.1186/1471-2407-14-172
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1186/bcr2206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027731411
    280 https://doi.org/10.1186/bcr2206
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1186/gb-2012-13-8-r69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014113021
    283 https://doi.org/10.1186/gb-2012-13-8-r69
    284 rdf:type schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1078811666 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1082569807 schema:CreativeWork
    287 https://doi.org/10.1016/j.bbrc.2012.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035722258
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.cell.2008.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030719910
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.cell.2011.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018622449
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.cell.2013.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026881115
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.cell.2013.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021083422
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.cell.2013.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037445404
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.cell.2014.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039182708
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.celrep.2015.08.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047811182
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.celrep.2017.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085566774
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.dnarep.2013.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047835286
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.molcel.2012.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040615414
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.molcel.2012.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049823294
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.molonc.2014.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021735450
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0092-8674(03)00934-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016765730
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s0168-9525(99)01971-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031330354
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s1097-2765(02)00453-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004612098
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/iti0114111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038399782
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.0510310103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026928995
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1073/pnas.1016071107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047051560
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1073/pnas.1324151111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044350073
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1074/jbc.c111.284620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031871396
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1074/jbc.m113.538835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043810597
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1074/jbc.m304286200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048460213
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1080/15592294.2015.1062204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003897186
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1080/15592294.2015.1091145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058407232
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/nar/10.8.2709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005140541
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1093/nar/gkw257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002966090
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1099/vir.0.80426-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008503228
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1101/gr.122382.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046312726
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1101/gr.139469.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016544057
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1126/science.1210597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017751509
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1158/0008-5472.can-08-0301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004873618
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1177/1947601911404223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064081076
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1371/journal.pone.0099603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016679433
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.2174/1568026615666150413154841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069195175
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.4161/epi.26597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302693
    358 rdf:type schema:CreativeWork
    359 https://www.grid.ac/institutes/grid.39381.30 schema:alternateName Western University
    360 schema:name Department of Biochemistry, Western University, London, ON, Canada
    361 Department of Oncology, Western University, London, ON, Canada
    362 Department of Pathology, Western University, London, ON, Canada
    363 The London Regional Cancer Program and the Lawson Health Research Institute, Western University, London, ON, Canada
    364 rdf:type schema:Organization
    365 https://www.grid.ac/institutes/grid.412745.1 schema:alternateName London Health Sciences Centre
    366 schema:name Cancer Research Laboratories, London Regional Cancer Program, N6A 4L6, London, ON, Canada
    367 Department of Biochemistry, Western University, London, ON, Canada
    368 Department of Oncology, Western University, London, ON, Canada
    369 The London Regional Cancer Program and the Lawson Health Research Institute, Western University, London, ON, Canada
    370 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...