Epigenetic origin of adaptive phenotypic variants in the human blood fluke Schistosoma mansoni View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07-04

AUTHORS

Sara Fneich, André Théron, Céline Cosseau, Anne Rognon, Benoit Aliaga, Jérôme Buard, David Duval, Nathalie Arancibia, Jérôme Boissier, David Roquis, Guillaume Mitta, Christoph Grunau

ABSTRACT

BackgroundAdaptive evolution is not possible without the generation of phenotypic variants. The origin of these variations has been a central topic in evolutionary biology. Up to now, it was commonly accepted that standing genetic variation is the only cause of phenotypic variants. However, epigenetic information is emerging as a complementary source of heritable phenotypic variation that contributes to evolution. The relative importance of genetics and epigenetics in generating heritable phenotypic variation is nevertheless a matter of debate.ResultsWe used a host–parasite system to address this question. The human blood fluke Schistosoma mansoni can adapt rapidly to new intermediate snail hosts. The interaction between parasite and mollusk is characterized by a compatibility polymorphism illustrating the evolutionary dynamics in this system. The principal molecular marker for compatibility (infection success) is the expression pattern of a group of polymorphic mucins (SmPoMuc) in the parasite. We show here that chromatin structure changes as the SmPoMuc promoters are the cause for SmPoMuc transcription polymorphism leading to phenotypic novelty and increase in infection success, i.e., fitness.ConclusionWe establish that epigenetic changes can be the major if not only cause of adaptive phenotypic variants in Schistosoma mansoni, suggesting that epimutations can provide material for adaptive evolution in the absence of genetic variation in other systems. In addition, our results indicate that epidrugs can be used to control parasite development but also parasite evolution. More... »

PAGES

27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13072-016-0076-2

DOI

http://dx.doi.org/10.1186/s13072-016-0076-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019325795

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27379173


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59 infection success
60 information
61 interaction
62 intermediate snail host
63 mansoni
64 markers
65 materials
66 matter
67 matter of debate
68 molecular markers
69 mollusks
70 mucin
71 novelty
72 only cause
73 origin
74 parasites
75 patterns
76 phenotypic novelty
77 phenotypic variants
78 phenotypic variation
79 polymorphism
80 promoter
81 questions
82 relative importance
83 results
84 snail host
85 source
86 structure
87 success
88 system
89 topic
90 variants
91 variation
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