Distinct epigenetic features of differentiation-regulated replication origins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Owen K. Smith, RyanGuk Kim, Haiqing Fu, Melvenia M. Martin, Chii Mei Lin, Koichi Utani, Ya Zhang, Anna B. Marks, Marc Lalande, Stormy Chamberlain, Maxwell W. Libbrecht, Eric E. Bouhassira, Michael C. Ryan, William S. Noble, Mirit I. Aladjem

ABSTRACT

BACKGROUND: Eukaryotic genome duplication starts at discrete sequences (replication origins) that coordinate cell cycle progression, ensure genomic stability and modulate gene expression. Origins share some sequence features, but their activity also responds to changes in transcription and cellular differentiation status. RESULTS: To identify chromatin states and histone modifications that locally mark replication origins, we profiled origin distributions in eight human cell lines representing embryonic and differentiated cell types. Consistent with a role of chromatin structure in determining origin activity, we found that cancer and non-cancer cells of similar lineages exhibited highly similar replication origin distributions. Surprisingly, our study revealed that DNase hypersensitivity, which often correlates with early replication at large-scale chromatin domains, did not emerge as a strong local determinant of origin activity. Instead, we found that two distinct sets of chromatin modifications exhibited strong local associations with two discrete groups of replication origins. The first origin group consisted of about 40,000 regions that actively initiated replication in all cell types and preferentially colocalized with unmethylated CpGs and with the euchromatin markers, H3K4me3 and H3K9Ac. The second group included origins that were consistently active in cells of a single type or lineage and preferentially colocalized with the heterochromatin marker, H3K9me3. Shared origins replicated throughout the S-phase of the cell cycle, whereas cell-type-specific origins preferentially replicated during late S-phase. CONCLUSIONS: These observations are in line with the hypothesis that differentiation-associated changes in chromatin and gene expression affect the activation of specific replication origins. More... »

PAGES

18

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13072-016-0067-3

DOI

http://dx.doi.org/10.1186/s13072-016-0067-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008514271

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27168766


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Owen K.", 
        "id": "sg:person.0672467477.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672467477.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "In Silico Solutions, 22033, Falls Church, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "RyanGuk", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Haiqing", 
        "id": "sg:person.010760706017.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010760706017.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin", 
        "givenName": "Melvenia M.", 
        "id": "sg:person.01026552054.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026552054.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Chii Mei", 
        "id": "sg:person.07662472537.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07662472537.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Utani", 
        "givenName": "Koichi", 
        "id": "sg:person.01242436633.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242436633.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Ya", 
        "id": "sg:person.01257227054.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257227054.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marks", 
        "givenName": "Anna B.", 
        "id": "sg:person.01305506277.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305506277.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Connecticut Health Center", 
          "id": "https://www.grid.ac/institutes/grid.208078.5", 
          "name": [
            "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 06032, Farmington, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lalande", 
        "givenName": "Marc", 
        "id": "sg:person.0601620146.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601620146.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Connecticut Health Center", 
          "id": "https://www.grid.ac/institutes/grid.208078.5", 
          "name": [
            "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 06032, Farmington, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chamberlain", 
        "givenName": "Stormy", 
        "id": "sg:person.01033371440.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033371440.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Computer Science and Engineering, University of Washington, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Libbrecht", 
        "givenName": "Maxwell W.", 
        "id": "sg:person.01327317342.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327317342.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Cell Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouhassira", 
        "givenName": "Eric E.", 
        "id": "sg:person.0713750405.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713750405.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "In Silico Solutions, 22033, Falls Church, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ryan", 
        "givenName": "Michael C.", 
        "id": "sg:person.012555442607.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012555442607.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Computer Science and Engineering, University of Washington, 98195, Seattle, WA, USA", 
            "Department of Genome Sciences, University of Washington, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noble", 
        "givenName": "William S.", 
        "id": "sg:person.01334532172.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334532172.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aladjem", 
        "givenName": "Mirit I.", 
        "id": "sg:person.0577534542.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577534542.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1091/mbc.e09-08-0707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001808325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-90-481-3471-7_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003520291", 
          "https://doi.org/10.1007/978-90-481-3471-7_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-90-481-3471-7_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003520291", 
          "https://doi.org/10.1007/978-90-481-3471-7_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.155218.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007348247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2006.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007436957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.06496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008588191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0602400103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009060164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009335235", 
          "https://doi.org/10.1038/nrg2143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.052308.103205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009427734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80294-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009510527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2013.03.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011256700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2014.05.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011615194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gm252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013158948", 
          "https://doi.org/10.1186/gm252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm4002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013555301", 
          "https://doi.org/10.1038/nrm4002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.8.5685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013654305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.219626.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014471937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.compbiolchem.2014.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015042682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms7746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018203239", 
          "https://doi.org/10.1038/ncomms7746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2007.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018570608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msb.134859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018801428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msb.134859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018801428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2006.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021482698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.187989.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021899515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-009-9105-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024641014", 
          "https://doi.org/10.1007/s10577-009-9105-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-009-9105-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024641014", 
          "https://doi.org/10.1007/s10577-009-9105-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.7.2958-2967.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddu006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028020327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.192799.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028603130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12864-015-1345-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029089338", 
          "https://doi.org/10.1186/s12864-015-1345-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12864-015-1345-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029089338", 
          "https://doi.org/10.1186/s12864-015-1345-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.05587-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029331744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-013-0448-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031432616", 
          "https://doi.org/10.1007/s00412-013-0448-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033219210", 
          "https://doi.org/10.1038/nature12243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1004319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033283831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ilar.53.3-4.232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033291556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2011.12.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033899588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.099655.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034553890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1004282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035368940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035484107", 
          "https://doi.org/10.1038/nsmb.2339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0805208105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035577825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035775870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1004487107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035870892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.10370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038377320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0060245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038654851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.094060.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038779049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2012.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039019521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040154675", 
          "https://doi.org/10.1038/nbt1202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040154675", 
          "https://doi.org/10.1038/nbt1202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.184341.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040187241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms8051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040436854", 
          "https://doi.org/10.1038/ncomms8051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041238764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.183848.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041784702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.124644.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042008136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1084203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042483658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0953-8984/27/6/064102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043051275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1024910307162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044761681", 
          "https://doi.org/10.1023/a:1024910307162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044841979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045134099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0052990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047412823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.8.2426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047930839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddl187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051069329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471143030.cb2220s65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051258036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201407004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052567298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0912402107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053165778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.270.5237.815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062551553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5298.343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5379.1005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062562057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1214/11-aoas466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064392153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.11.4.19097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072296587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/epi.26870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072302707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/epi.6.6.16179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072303170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075005865", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.176.9.5446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077224526"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Eukaryotic genome duplication starts at discrete sequences (replication origins) that coordinate cell cycle progression, ensure genomic stability and modulate gene expression. Origins share some sequence features, but their activity also responds to changes in transcription and cellular differentiation status.\nRESULTS: To identify chromatin states and histone modifications that locally mark replication origins, we profiled origin distributions in eight human cell lines representing embryonic and differentiated cell types. Consistent with a role of chromatin structure in determining origin activity, we found that cancer and non-cancer cells of similar lineages exhibited highly similar replication origin distributions. Surprisingly, our study revealed that DNase hypersensitivity, which often correlates with early replication at large-scale chromatin domains, did not emerge as a strong local determinant of origin activity. Instead, we found that two distinct sets of chromatin modifications exhibited strong local associations with two discrete groups of replication origins. The first origin group consisted of about 40,000 regions that actively initiated replication in all cell types and preferentially colocalized with unmethylated CpGs and with the euchromatin markers, H3K4me3 and H3K9Ac. The second group included origins that were consistently active in cells of a single type or lineage and preferentially colocalized with the heterochromatin marker, H3K9me3. Shared origins replicated throughout the S-phase of the cell cycle, whereas cell-type-specific origins preferentially replicated during late S-phase.\nCONCLUSIONS: These observations are in line with the hypothesis that differentiation-associated changes in chromatin and gene expression affect the activation of specific replication origins.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13072-016-0067-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705247", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2528352", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723674", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1039921", 
        "issn": [
          "1756-8935"
        ], 
        "name": "Epigenetics & Chromatin", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Distinct epigenetic features of differentiation-regulated replication origins", 
    "pagination": "18", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "28904d85a00db193ef7f7ebd4bd391c8f132b4ed56410cea3c02a52fa62f0a07"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27168766"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101471619"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13072-016-0067-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008514271"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13072-016-0067-3", 
      "https://app.dimensions.ai/details/publication/pub.1008514271"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13072-016-0067-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13072-016-0067-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13072-016-0067-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13072-016-0067-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13072-016-0067-3'


 

This table displays all metadata directly associated to this object as RDF triples.

401 TRIPLES      21 PREDICATES      97 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13072-016-0067-3 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nbc6b82f3574149d2a34dce542124bab7
4 schema:citation sg:pub.10.1007/978-90-481-3471-7_5
5 sg:pub.10.1007/s00412-013-0448-3
6 sg:pub.10.1007/s10577-009-9105-3
7 sg:pub.10.1023/a:1024910307162
8 sg:pub.10.1038/nature12243
9 sg:pub.10.1038/nbt1202
10 sg:pub.10.1038/ncomms7746
11 sg:pub.10.1038/ncomms8051
12 sg:pub.10.1038/nrg2143
13 sg:pub.10.1038/nrm4002
14 sg:pub.10.1038/nsmb.2339
15 sg:pub.10.1186/gm252
16 sg:pub.10.1186/s12864-015-1345-3
17 https://app.dimensions.ai/details/publication/pub.1075005865
18 https://doi.org/10.1002/0471143030.cb2220s65
19 https://doi.org/10.1002/bies.10370
20 https://doi.org/10.1002/msb.134859
21 https://doi.org/10.1016/j.ceb.2006.04.001
22 https://doi.org/10.1016/j.compbiolchem.2014.08.020
23 https://doi.org/10.1016/j.cub.2011.12.028
24 https://doi.org/10.1016/j.devcel.2012.09.003
25 https://doi.org/10.1016/j.jmb.2013.03.040
26 https://doi.org/10.1016/j.jmb.2014.05.027
27 https://doi.org/10.1016/j.tcb.2007.04.002
28 https://doi.org/10.1016/j.yexcr.2006.09.020
29 https://doi.org/10.1016/s1097-2765(00)80294-4
30 https://doi.org/10.1038/sj.emboj.7600077
31 https://doi.org/10.1073/pnas.0602400103
32 https://doi.org/10.1073/pnas.0805208105
33 https://doi.org/10.1073/pnas.0912402107
34 https://doi.org/10.1073/pnas.1004487107
35 https://doi.org/10.1083/jcb.201407004
36 https://doi.org/10.1088/0953-8984/27/6/064102
37 https://doi.org/10.1091/mbc.e09-08-0707
38 https://doi.org/10.1093/bioinformatics/btp340
39 https://doi.org/10.1093/emboj/17.8.2426
40 https://doi.org/10.1093/hmg/ddl187
41 https://doi.org/10.1093/hmg/ddu006
42 https://doi.org/10.1093/ilar.53.3-4.232
43 https://doi.org/10.1101/gad.1084203
44 https://doi.org/10.1101/gad.219626.113
45 https://doi.org/10.1101/gr.094060.109
46 https://doi.org/10.1101/gr.099655.109
47 https://doi.org/10.1101/gr.124644.111
48 https://doi.org/10.1101/gr.155218.113
49 https://doi.org/10.1101/gr.183848.114
50 https://doi.org/10.1101/gr.184341.114
51 https://doi.org/10.1101/gr.187989.114
52 https://doi.org/10.1101/gr.192799.115
53 https://doi.org/10.1126/science.270.5237.815
54 https://doi.org/10.1126/science.275.5298.343
55 https://doi.org/10.1126/science.281.5379.1005
56 https://doi.org/10.1128/mcb.05587-11
57 https://doi.org/10.1128/mcb.19.8.5685
58 https://doi.org/10.1128/mcb.24.7.2958-2967.2004
59 https://doi.org/10.1146/annurev.biochem.052308.103205
60 https://doi.org/10.1214/11-aoas466
61 https://doi.org/10.1371/journal.pbio.0060245
62 https://doi.org/10.1371/journal.pgen.1000446
63 https://doi.org/10.1371/journal.pgen.1003542
64 https://doi.org/10.1371/journal.pgen.1004282
65 https://doi.org/10.1371/journal.pgen.1004319
66 https://doi.org/10.1371/journal.pone.0052990
67 https://doi.org/10.4049/jimmunol.176.9.5446
68 https://doi.org/10.4161/cc.11.4.19097
69 https://doi.org/10.4161/epi.26870
70 https://doi.org/10.4161/epi.6.6.16179
71 https://doi.org/10.7554/elife.06496
72 schema:datePublished 2016-12
73 schema:datePublishedReg 2016-12-01
74 schema:description BACKGROUND: Eukaryotic genome duplication starts at discrete sequences (replication origins) that coordinate cell cycle progression, ensure genomic stability and modulate gene expression. Origins share some sequence features, but their activity also responds to changes in transcription and cellular differentiation status. RESULTS: To identify chromatin states and histone modifications that locally mark replication origins, we profiled origin distributions in eight human cell lines representing embryonic and differentiated cell types. Consistent with a role of chromatin structure in determining origin activity, we found that cancer and non-cancer cells of similar lineages exhibited highly similar replication origin distributions. Surprisingly, our study revealed that DNase hypersensitivity, which often correlates with early replication at large-scale chromatin domains, did not emerge as a strong local determinant of origin activity. Instead, we found that two distinct sets of chromatin modifications exhibited strong local associations with two discrete groups of replication origins. The first origin group consisted of about 40,000 regions that actively initiated replication in all cell types and preferentially colocalized with unmethylated CpGs and with the euchromatin markers, H3K4me3 and H3K9Ac. The second group included origins that were consistently active in cells of a single type or lineage and preferentially colocalized with the heterochromatin marker, H3K9me3. Shared origins replicated throughout the S-phase of the cell cycle, whereas cell-type-specific origins preferentially replicated during late S-phase. CONCLUSIONS: These observations are in line with the hypothesis that differentiation-associated changes in chromatin and gene expression affect the activation of specific replication origins.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N5e3b650ef2b543389cf5e138387d165c
79 Ne7c53ca6ba234a92b240606947c6e76b
80 sg:journal.1039921
81 schema:name Distinct epigenetic features of differentiation-regulated replication origins
82 schema:pagination 18
83 schema:productId N4934defc54f4402c906a9826434f971c
84 N9de5f74b03564fd1a3fa2db83a4c454d
85 Nb5b8665666dc4e9fa5c902719eac61c5
86 Nde126527c3fa4570b77dd683f17febe8
87 Ndf41cd04671c4e8fb23282649838f582
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008514271
89 https://doi.org/10.1186/s13072-016-0067-3
90 schema:sdDatePublished 2019-04-10T23:23
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Nadeefed44ea34ec7980b3944533a3762
93 schema:url http://link.springer.com/10.1186%2Fs13072-016-0067-3
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N129d50ae7a694357af6b4ee1437ac310 rdf:first sg:person.07662472537.25
98 rdf:rest Ncf31c552c7b1402b879398a76e2f8fc5
99 N2281a13ef3c84cc88f9b7ea9d5c445af rdf:first sg:person.010760706017.34
100 rdf:rest N9a7efd2b2dbb4c7685a3f4b85a28215d
101 N311853b1d01a497e8b7415fb4297a673 rdf:first sg:person.012555442607.69
102 rdf:rest Nd9a9eb67a7de4e148b4102522412cefd
103 N3c5dc8e2ce574a7096f9354e38d68aa5 rdf:first sg:person.0577534542.31
104 rdf:rest rdf:nil
105 N4934defc54f4402c906a9826434f971c schema:name nlm_unique_id
106 schema:value 101471619
107 rdf:type schema:PropertyValue
108 N4dd4845970c147eb888a8387fd65e7eb rdf:first sg:person.01033371440.86
109 rdf:rest Ne691feaaa3f149bb80627f7c9946de49
110 N5e3b650ef2b543389cf5e138387d165c schema:issueNumber 1
111 rdf:type schema:PublicationIssue
112 N632dc2fc251343158d5cd9b37f99fa85 schema:name In Silico Solutions, 22033, Falls Church, VA, USA
113 rdf:type schema:Organization
114 N659eb1621c734ee1a45d2e11d3992583 schema:affiliation Na83e43a22de64c9b91afad2e36de765c
115 schema:familyName Kim
116 schema:givenName RyanGuk
117 rdf:type schema:Person
118 N6d7c2459adbf4f988b533fabc07b2856 rdf:first N659eb1621c734ee1a45d2e11d3992583
119 rdf:rest N2281a13ef3c84cc88f9b7ea9d5c445af
120 N85f2367266ca4509acc631a6232c8872 rdf:first sg:person.0713750405.12
121 rdf:rest N311853b1d01a497e8b7415fb4297a673
122 N9a7efd2b2dbb4c7685a3f4b85a28215d rdf:first sg:person.01026552054.57
123 rdf:rest N129d50ae7a694357af6b4ee1437ac310
124 N9de5f74b03564fd1a3fa2db83a4c454d schema:name dimensions_id
125 schema:value pub.1008514271
126 rdf:type schema:PropertyValue
127 Na0c338243b6e40eaace5454f909630d3 rdf:first sg:person.0601620146.33
128 rdf:rest N4dd4845970c147eb888a8387fd65e7eb
129 Na83e43a22de64c9b91afad2e36de765c schema:name In Silico Solutions, 22033, Falls Church, VA, USA
130 rdf:type schema:Organization
131 Nadeefed44ea34ec7980b3944533a3762 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 Nb4be95ab4f044900b2bd4615726c4f62 rdf:first sg:person.01257227054.71
134 rdf:rest Nbf9dcf957962452c9a709680df123eba
135 Nb5b8665666dc4e9fa5c902719eac61c5 schema:name readcube_id
136 schema:value 28904d85a00db193ef7f7ebd4bd391c8f132b4ed56410cea3c02a52fa62f0a07
137 rdf:type schema:PropertyValue
138 Nbc6b82f3574149d2a34dce542124bab7 rdf:first sg:person.0672467477.82
139 rdf:rest N6d7c2459adbf4f988b533fabc07b2856
140 Nbf9dcf957962452c9a709680df123eba rdf:first sg:person.01305506277.09
141 rdf:rest Na0c338243b6e40eaace5454f909630d3
142 Ncf31c552c7b1402b879398a76e2f8fc5 rdf:first sg:person.01242436633.19
143 rdf:rest Nb4be95ab4f044900b2bd4615726c4f62
144 Nd9a9eb67a7de4e148b4102522412cefd rdf:first sg:person.01334532172.13
145 rdf:rest N3c5dc8e2ce574a7096f9354e38d68aa5
146 Nde126527c3fa4570b77dd683f17febe8 schema:name pubmed_id
147 schema:value 27168766
148 rdf:type schema:PropertyValue
149 Ndf41cd04671c4e8fb23282649838f582 schema:name doi
150 schema:value 10.1186/s13072-016-0067-3
151 rdf:type schema:PropertyValue
152 Ne691feaaa3f149bb80627f7c9946de49 rdf:first sg:person.01327317342.73
153 rdf:rest N85f2367266ca4509acc631a6232c8872
154 Ne7c53ca6ba234a92b240606947c6e76b schema:volumeNumber 9
155 rdf:type schema:PublicationVolume
156 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
157 schema:name Biological Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
160 schema:name Genetics
161 rdf:type schema:DefinedTerm
162 sg:grant.2528352 http://pending.schema.org/fundedItem sg:pub.10.1186/s13072-016-0067-3
163 rdf:type schema:MonetaryGrant
164 sg:grant.2705247 http://pending.schema.org/fundedItem sg:pub.10.1186/s13072-016-0067-3
165 rdf:type schema:MonetaryGrant
166 sg:grant.2723674 http://pending.schema.org/fundedItem sg:pub.10.1186/s13072-016-0067-3
167 rdf:type schema:MonetaryGrant
168 sg:journal.1039921 schema:issn 1756-8935
169 schema:name Epigenetics & Chromatin
170 rdf:type schema:Periodical
171 sg:person.01026552054.57 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
172 schema:familyName Martin
173 schema:givenName Melvenia M.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026552054.57
175 rdf:type schema:Person
176 sg:person.01033371440.86 schema:affiliation https://www.grid.ac/institutes/grid.208078.5
177 schema:familyName Chamberlain
178 schema:givenName Stormy
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033371440.86
180 rdf:type schema:Person
181 sg:person.010760706017.34 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
182 schema:familyName Fu
183 schema:givenName Haiqing
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010760706017.34
185 rdf:type schema:Person
186 sg:person.01242436633.19 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
187 schema:familyName Utani
188 schema:givenName Koichi
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242436633.19
190 rdf:type schema:Person
191 sg:person.012555442607.69 schema:affiliation N632dc2fc251343158d5cd9b37f99fa85
192 schema:familyName Ryan
193 schema:givenName Michael C.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012555442607.69
195 rdf:type schema:Person
196 sg:person.01257227054.71 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
197 schema:familyName Zhang
198 schema:givenName Ya
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257227054.71
200 rdf:type schema:Person
201 sg:person.01305506277.09 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
202 schema:familyName Marks
203 schema:givenName Anna B.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305506277.09
205 rdf:type schema:Person
206 sg:person.01327317342.73 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
207 schema:familyName Libbrecht
208 schema:givenName Maxwell W.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327317342.73
210 rdf:type schema:Person
211 sg:person.01334532172.13 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
212 schema:familyName Noble
213 schema:givenName William S.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334532172.13
215 rdf:type schema:Person
216 sg:person.0577534542.31 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
217 schema:familyName Aladjem
218 schema:givenName Mirit I.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577534542.31
220 rdf:type schema:Person
221 sg:person.0601620146.33 schema:affiliation https://www.grid.ac/institutes/grid.208078.5
222 schema:familyName Lalande
223 schema:givenName Marc
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601620146.33
225 rdf:type schema:Person
226 sg:person.0672467477.82 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
227 schema:familyName Smith
228 schema:givenName Owen K.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672467477.82
230 rdf:type schema:Person
231 sg:person.0713750405.12 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
232 schema:familyName Bouhassira
233 schema:givenName Eric E.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713750405.12
235 rdf:type schema:Person
236 sg:person.07662472537.25 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
237 schema:familyName Lin
238 schema:givenName Chii Mei
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07662472537.25
240 rdf:type schema:Person
241 sg:pub.10.1007/978-90-481-3471-7_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003520291
242 https://doi.org/10.1007/978-90-481-3471-7_5
243 rdf:type schema:CreativeWork
244 sg:pub.10.1007/s00412-013-0448-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031432616
245 https://doi.org/10.1007/s00412-013-0448-3
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s10577-009-9105-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024641014
248 https://doi.org/10.1007/s10577-009-9105-3
249 rdf:type schema:CreativeWork
250 sg:pub.10.1023/a:1024910307162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044761681
251 https://doi.org/10.1023/a:1024910307162
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nature12243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033219210
254 https://doi.org/10.1038/nature12243
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nbt1202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040154675
257 https://doi.org/10.1038/nbt1202
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/ncomms7746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018203239
260 https://doi.org/10.1038/ncomms7746
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/ncomms8051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040436854
263 https://doi.org/10.1038/ncomms8051
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nrg2143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009335235
266 https://doi.org/10.1038/nrg2143
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nrm4002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013555301
269 https://doi.org/10.1038/nrm4002
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nsmb.2339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035484107
272 https://doi.org/10.1038/nsmb.2339
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/gm252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013158948
275 https://doi.org/10.1186/gm252
276 rdf:type schema:CreativeWork
277 sg:pub.10.1186/s12864-015-1345-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029089338
278 https://doi.org/10.1186/s12864-015-1345-3
279 rdf:type schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1075005865 schema:CreativeWork
281 https://doi.org/10.1002/0471143030.cb2220s65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051258036
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1002/bies.10370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038377320
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1002/msb.134859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018801428
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.ceb.2006.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021482698
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.compbiolchem.2014.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015042682
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.cub.2011.12.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033899588
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.devcel.2012.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039019521
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.jmb.2013.03.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011256700
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.jmb.2014.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011615194
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.tcb.2007.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018570608
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.yexcr.2006.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007436957
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s1097-2765(00)80294-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009510527
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1038/sj.emboj.7600077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045134099
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.0602400103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009060164
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.0805208105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035577825
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1073/pnas.0912402107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053165778
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1073/pnas.1004487107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035870892
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1083/jcb.201407004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052567298
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1088/0953-8984/27/6/064102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043051275
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1091/mbc.e09-08-0707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001808325
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/bioinformatics/btp340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041238764
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/emboj/17.8.2426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047930839
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/hmg/ddl187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051069329
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/hmg/ddu006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028020327
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/ilar.53.3-4.232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033291556
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1101/gad.1084203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042483658
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1101/gad.219626.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014471937
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1101/gr.094060.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038779049
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1101/gr.099655.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553890
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1101/gr.124644.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042008136
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1101/gr.155218.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007348247
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1101/gr.183848.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041784702
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1101/gr.184341.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040187241
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1101/gr.187989.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021899515
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1101/gr.192799.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028603130
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.270.5237.815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551553
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1126/science.275.5298.343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555516
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1126/science.281.5379.1005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562057
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1128/mcb.05587-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029331744
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1128/mcb.19.8.5685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013654305
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1128/mcb.24.7.2958-2967.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706743
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1146/annurev.biochem.052308.103205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009427734
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1214/11-aoas466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064392153
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1371/journal.pbio.0060245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038654851
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1371/journal.pgen.1000446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035775870
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1371/journal.pgen.1003542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044841979
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1371/journal.pgen.1004282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035368940
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1371/journal.pgen.1004319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033283831
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1371/journal.pone.0052990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047412823
378 rdf:type schema:CreativeWork
379 https://doi.org/10.4049/jimmunol.176.9.5446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077224526
380 rdf:type schema:CreativeWork
381 https://doi.org/10.4161/cc.11.4.19097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296587
382 rdf:type schema:CreativeWork
383 https://doi.org/10.4161/epi.26870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302707
384 rdf:type schema:CreativeWork
385 https://doi.org/10.4161/epi.6.6.16179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072303170
386 rdf:type schema:CreativeWork
387 https://doi.org/10.7554/elife.06496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008588191
388 rdf:type schema:CreativeWork
389 https://www.grid.ac/institutes/grid.208078.5 schema:alternateName University of Connecticut Health Center
390 schema:name Department of Genetics and Developmental Biology, University of Connecticut Health Center, 06032, Farmington, CT, USA
391 rdf:type schema:Organization
392 https://www.grid.ac/institutes/grid.251993.5 schema:alternateName Albert Einstein College of Medicine
393 schema:name Department of Cell Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
396 schema:name Department of Computer Science and Engineering, University of Washington, 98195, Seattle, WA, USA
397 Department of Genome Sciences, University of Washington, 98195, Seattle, WA, USA
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
400 schema:name DNA Replication Group, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA
401 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...