Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Lin Chen, Donghui Zhang, Wenyue Zhang, Yuxiao Zhu, Min Hou, Bingya Yang, Zhipeng Xu, Minjun Ji, Guanling Wu

ABSTRACT

BACKGROUND: The involvement of CD8+T cells in schistosomiasis is being increasingly appreciated, but the underlying mechanism is not well defined. RESULTS: In this study, we showed that the absence of Batf3 alleviated liver damage in Batf3 -/- mice infected with S. japonicum. We found alleviated liver granulomatous inflammation in Batf3 -/- mice with schistosomiasis japonica could not be attributed to the difference in schistosome egg or worm burden. The stronger Tc1 cell responses observed in Batf3 -/- mice suggested that the deletion of Batf3 resulted in more activation of CD8+T cells unexpectedly during the natural infection of schistosomes. We detected a small amount of CD8α+ DCs in the spleen of Batf3 -/- mice at 9w post-infection. This small amount of newly generated CD8α+ DCs might contribute to enhanced activation of CD8+T cells via cross-presentation and activation which then attenuate hepatic pathological damage found in Batf3 -/- mice. CONCLUSIONS: Our study provides evidence that Batf3 is associated with the immunoregulation of the liver granuloma formation, which may confer a new options for schistosomiasis treatment. More... »

PAGES

306

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13071-017-2250-1

    DOI

    http://dx.doi.org/10.1186/s13071-017-2250-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1086156468

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28646891


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