Spatio-temporal analysis of the genetic diversity and complexity of Plasmodium falciparum infections in Kedougou, southeastern Senegal View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Makhtar Niang, Laty G. Thiam, Cheikh Loucoubar, Abdourahmane Sow, Bacary D. Sadio, Mawlouth Diallo, Amadou A. Sall, Aissatou Toure-Balde

ABSTRACT

BACKGROUND: Genetic analyses of the malaria parasite population and its temporal and spatial dynamics could provide an assessment of the effectiveness of disease control strategies. The genetic diversity of Plasmodium falciparum has been poorly documented in Senegal, and limited data are available from the Kedougou Region. This study examines the spatial and temporal variation of the genetic diversity and complexity of P. falciparum infections in acute febrile patients in Kedougou, southeastern Senegal. A total of 263 sera from patients presenting with acute febrile illness and attending Kedougou health facilities between July 2009 and July 2013 were obtained from a collection established as part of arbovirus surveillance in Kedougou. Samples identified as P. falciparum by nested PCR were characterized for their genetic diversity and complexity using msp-1 and msp-2 polymorphic markers. RESULTS: Samples containing only P. falciparum accounted for 60.83% (160/263) of the examined samples. All three msp-1 allelic families (K1, MAD20 and RO33) and two msp-2 allelic families (FC27 and 3D7) were detected in all villages investigated over the 5-year collection period. The average genotype per allelic family was comparable between villages. Frequencies of msp-1 and msp-2 allelic types showed no correlation with age (Fisher's exact test, P = 0.59) or gender (Fisher's exact test, P = 0.973), and were similarly distributed throughout the 5-year sampling period (Fisher's exact test, P = 0.412) and across villages (Fisher's exact test, P = 0.866). Mean multiplicity of infection (MOI) for both msp-1 and msp-2 was highest in Kedougou village (2.25 and 2.21, respectively) and among younger patients aged ≤ 15 years (2.12 and 2.00, respectively). The mean MOI was highest in 2009 and decreased progressively onward. CONCLUSION: Characterization of the genetic diversity and complexity of P. falciparum infections in Kedougou revealed no spatio-temporal variation in the genetic diversity of P. falciparum isolates. However, mean MOI varied with time of sera collection and decreased over the course of the study (July 2009 to July 2013). This suggests a slow progressive decrease of malaria transmission intensity in Kedougou Region despite the limited impact of preventive and control measures implemented by the National Malaria Control Programme on malaria morbidity and mortality. More... »

PAGES

33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13071-017-1976-0

DOI

http://dx.doi.org/10.1186/s13071-017-1976-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008431618

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28103905


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Protozoan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaria, Falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Merozoite Surface Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protozoan Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Senegal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spatio-Temporal Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Institut Pasteur Dakar, Immunology Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niang", 
        "givenName": "Makhtar", 
        "id": "sg:person.015210622144.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015210622144.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cheikh Anta Diop University", 
          "id": "https://www.grid.ac/institutes/grid.8191.1", 
          "name": [
            "Institut Pasteur Dakar, Immunology Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal", 
            "Department of Animal Biology, Cheikh Anta Diop University of Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiam", 
        "givenName": "Laty G.", 
        "id": "sg:person.0613346131.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613346131.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Institut Pasteur Dakar, Biostatistics, Bioinformatics and Modeling Group, 36 Avenue Pasteur, BP 220, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loucoubar", 
        "givenName": "Cheikh", 
        "id": "sg:person.01264707676.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264707676.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Institut Pasteur Dakar, Arbovirus and Viral Hemorrhagic Fevers Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sow", 
        "givenName": "Abdourahmane", 
        "id": "sg:person.01337143361.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337143361.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Institut Pasteur Dakar, Arbovirus and Viral Hemorrhagic Fevers Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sadio", 
        "givenName": "Bacary D.", 
        "id": "sg:person.016145262213.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016145262213.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Institut Pasteur Dakar, Medical Entomology Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diallo", 
        "givenName": "Mawlouth", 
        "id": "sg:person.0712007366.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712007366.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Institut Pasteur Dakar, Arbovirus and Viral Hemorrhagic Fevers Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sall", 
        "givenName": "Amadou A.", 
        "id": "sg:person.0575401220.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575401220.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Institut Pasteur Dakar, Immunology Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toure-Balde", 
        "givenName": "Aissatou", 
        "id": "sg:person.0757756450.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757756450.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00436-003-0854-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000439439", 
          "https://doi.org/10.1007/s00436-003-0854-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01813.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001003367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01813.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001003367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-12-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001361713", 
          "https://doi.org/10.1186/1475-2875-12-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-015-0843-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004734152", 
          "https://doi.org/10.1186/s12936-015-0843-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-3156.2003.00968.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009576125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-015-0808-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011571041", 
          "https://doi.org/10.1186/s12936-015-0808-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-9-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015318796", 
          "https://doi.org/10.1186/1475-2875-9-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-3305-4-233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017092543", 
          "https://doi.org/10.1186/1756-3305-4-233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(96)90446-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019888264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/136485908x252340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020337882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-8-135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021465976", 
          "https://doi.org/10.1186/1475-2875-8-135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.69.12.7783-7792.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022572317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0040093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029396300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(99)90323-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031388099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(99)90323-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031388099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61596-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036594093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(14)70712-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037818763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-016-1100-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040428946", 
          "https://doi.org/10.1186/s12936-016-1100-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-3156.2002.00881.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043228142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-016-1208-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043270993", 
          "https://doi.org/10.1186/s12936-016-1208-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-015-0745-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043948492", 
          "https://doi.org/10.1186/s12936-015-0745-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-015-0745-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043948492", 
          "https://doi.org/10.1186/s12936-015-0745-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-2-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044004045", 
          "https://doi.org/10.1186/1475-2875-2-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(11)70194-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045839569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1505691112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050203041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2001.tb03891.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050645398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-7-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050756754", 
          "https://doi.org/10.1186/1475-2875-7-17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(99)90120-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051572248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1995-7645(13)60102-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053120379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-271-6:103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075088139", 
          "https://doi.org/10.1385/1-59259-271-6:103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-271-6:189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075088149", 
          "https://doi.org/10.1385/1-59259-271-6:189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2006.75.146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077268421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2007.77.444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077479414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1996.54.632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082909437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1997.56.141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083063889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1998.59.726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083356524"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Genetic analyses of the malaria parasite population and its temporal and spatial dynamics could provide an assessment of the effectiveness of disease control strategies. The genetic diversity of Plasmodium falciparum has been poorly documented in Senegal, and limited data are available from the Kedougou Region. This study examines the spatial and temporal variation of the genetic diversity and complexity of P. falciparum infections in acute febrile patients in Kedougou, southeastern Senegal. A total of 263 sera from patients presenting with acute febrile illness and attending Kedougou health facilities between July 2009 and July 2013 were obtained from a collection established as part of arbovirus surveillance in Kedougou. Samples identified as P. falciparum by nested PCR were characterized for their genetic diversity and complexity using msp-1 and msp-2 polymorphic markers.\nRESULTS: Samples containing only P. falciparum accounted for 60.83% (160/263) of the examined samples. All three msp-1 allelic families (K1, MAD20 and RO33) and two msp-2 allelic families (FC27 and 3D7) were detected in all villages investigated over the 5-year collection period. The average genotype per allelic family was comparable between villages. Frequencies of msp-1 and msp-2 allelic types showed no correlation with age (Fisher's exact test, P\u2009=\u20090.59) or gender (Fisher's exact test, P\u2009=\u20090.973), and were similarly distributed throughout the 5-year sampling period (Fisher's exact test, P\u2009=\u20090.412) and across villages (Fisher's exact test, P\u2009=\u20090.866). Mean multiplicity of infection (MOI) for both msp-1 and msp-2 was highest in Kedougou village (2.25 and 2.21, respectively) and among younger patients aged\u2009\u2264\u200915\u00a0years (2.12 and 2.00, respectively). The mean MOI was highest in 2009 and decreased progressively onward.\nCONCLUSION: Characterization of the genetic diversity and complexity of P. falciparum infections in Kedougou revealed no spatio-temporal variation in the genetic diversity of P. falciparum isolates. However, mean MOI varied with time of sera collection and decreased over the course of the study (July 2009 to July 2013). This suggests a slow progressive decrease of malaria transmission intensity in Kedougou Region despite the limited impact of preventive and control measures implemented by the National Malaria Control Programme on malaria morbidity and mortality.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13071-017-1976-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1039458", 
        "issn": [
          "1756-3305"
        ], 
        "name": "Filaria Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Spatio-temporal analysis of the genetic diversity and complexity of Plasmodium falciparum infections in Kedougou, southeastern Senegal", 
    "pagination": "33", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "282af49ea89ea3cb978e08c6d08dca9853fb0a53fa76900e127a02becfb04d11"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28103905"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101462774"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13071-017-1976-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008431618"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13071-017-1976-0", 
      "https://app.dimensions.ai/details/publication/pub.1008431618"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89814_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13071-017-1976-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13071-017-1976-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13071-017-1976-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13071-017-1976-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13071-017-1976-0'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      75 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13071-017-1976-0 schema:about N014ba343e3ca4e64867504387e4e64df
2 N0bd33cc3fec84a1f98d26a7299be74e9
3 N0fc4449f80b64ba9bd64c55f4963a44c
4 N13f85f3d97e74fb19eba45fcdcea7220
5 N2702f79823604bd98f9ce7057b072a33
6 N43f873cb5a7648fba40a2285832c90d3
7 N5b84a432a3284e3ba2be30a888117591
8 N5d29c5104c9e4ccdab88cb3d6383b4e7
9 N72b67c14c9a74c67b641acff70124897
10 Ncdd2898174554fbeb249546af80d1146
11 Nf278c16a7f114034851ed4d9cf4706ba
12 Nfdd6901c229741e9b8a8f90be7d94322
13 anzsrc-for:11
14 anzsrc-for:1117
15 schema:author Ndb712377f1f64d7d9c20470c8306bea7
16 schema:citation sg:pub.10.1007/s00436-003-0854-1
17 sg:pub.10.1186/1475-2875-12-22
18 sg:pub.10.1186/1475-2875-2-12
19 sg:pub.10.1186/1475-2875-7-17
20 sg:pub.10.1186/1475-2875-8-135
21 sg:pub.10.1186/1475-2875-9-1
22 sg:pub.10.1186/1756-3305-4-233
23 sg:pub.10.1186/s12936-015-0745-9
24 sg:pub.10.1186/s12936-015-0808-y
25 sg:pub.10.1186/s12936-015-0843-8
26 sg:pub.10.1186/s12936-016-1100-5
27 sg:pub.10.1186/s12936-016-1208-7
28 sg:pub.10.1385/1-59259-271-6:103
29 sg:pub.10.1385/1-59259-271-6:189
30 https://doi.org/10.1016/s0035-9203(96)90446-0
31 https://doi.org/10.1016/s0035-9203(99)90120-7
32 https://doi.org/10.1016/s0035-9203(99)90323-1
33 https://doi.org/10.1016/s0140-6736(08)61596-2
34 https://doi.org/10.1016/s1473-3099(11)70194-3
35 https://doi.org/10.1016/s1473-3099(14)70712-1
36 https://doi.org/10.1016/s1995-7645(13)60102-9
37 https://doi.org/10.1046/j.1365-3156.2002.00881.x
38 https://doi.org/10.1046/j.1365-3156.2003.00968.x
39 https://doi.org/10.1073/pnas.1505691112
40 https://doi.org/10.1111/j.1365-3156.2007.01813.x
41 https://doi.org/10.1111/j.1749-6632.2001.tb03891.x
42 https://doi.org/10.1128/iai.69.12.7783-7792.2001
43 https://doi.org/10.1179/136485908x252340
44 https://doi.org/10.1371/journal.pmed.0040093
45 https://doi.org/10.4269/ajtmh.1996.54.632
46 https://doi.org/10.4269/ajtmh.1997.56.141
47 https://doi.org/10.4269/ajtmh.1998.59.726
48 https://doi.org/10.4269/ajtmh.2006.75.146
49 https://doi.org/10.4269/ajtmh.2007.77.444
50 schema:datePublished 2017-12
51 schema:datePublishedReg 2017-12-01
52 schema:description BACKGROUND: Genetic analyses of the malaria parasite population and its temporal and spatial dynamics could provide an assessment of the effectiveness of disease control strategies. The genetic diversity of Plasmodium falciparum has been poorly documented in Senegal, and limited data are available from the Kedougou Region. This study examines the spatial and temporal variation of the genetic diversity and complexity of P. falciparum infections in acute febrile patients in Kedougou, southeastern Senegal. A total of 263 sera from patients presenting with acute febrile illness and attending Kedougou health facilities between July 2009 and July 2013 were obtained from a collection established as part of arbovirus surveillance in Kedougou. Samples identified as P. falciparum by nested PCR were characterized for their genetic diversity and complexity using msp-1 and msp-2 polymorphic markers. RESULTS: Samples containing only P. falciparum accounted for 60.83% (160/263) of the examined samples. All three msp-1 allelic families (K1, MAD20 and RO33) and two msp-2 allelic families (FC27 and 3D7) were detected in all villages investigated over the 5-year collection period. The average genotype per allelic family was comparable between villages. Frequencies of msp-1 and msp-2 allelic types showed no correlation with age (Fisher's exact test, P = 0.59) or gender (Fisher's exact test, P = 0.973), and were similarly distributed throughout the 5-year sampling period (Fisher's exact test, P = 0.412) and across villages (Fisher's exact test, P = 0.866). Mean multiplicity of infection (MOI) for both msp-1 and msp-2 was highest in Kedougou village (2.25 and 2.21, respectively) and among younger patients aged ≤ 15 years (2.12 and 2.00, respectively). The mean MOI was highest in 2009 and decreased progressively onward. CONCLUSION: Characterization of the genetic diversity and complexity of P. falciparum infections in Kedougou revealed no spatio-temporal variation in the genetic diversity of P. falciparum isolates. However, mean MOI varied with time of sera collection and decreased over the course of the study (July 2009 to July 2013). This suggests a slow progressive decrease of malaria transmission intensity in Kedougou Region despite the limited impact of preventive and control measures implemented by the National Malaria Control Programme on malaria morbidity and mortality.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N9515460e4f6a4731bdf02b8a3ddbc8cc
57 Nb444e13c76e54ebca139ed7b55c8fe89
58 sg:journal.1039458
59 schema:name Spatio-temporal analysis of the genetic diversity and complexity of Plasmodium falciparum infections in Kedougou, southeastern Senegal
60 schema:pagination 33
61 schema:productId N5e7a983fef0c4a6f860e135b36363be0
62 N8cae1b5748a2449282fb8a25d6f632df
63 Na61d1782474f43eeb2cb30482d740c19
64 Nd4922481f1f14ff58cd631277264630b
65 Ne16d2634bdb74d479e57b6664f48459e
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008431618
67 https://doi.org/10.1186/s13071-017-1976-0
68 schema:sdDatePublished 2019-04-11T09:59
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N0d854b63196a4e1ab371e9fb657538b4
71 schema:url https://link.springer.com/10.1186%2Fs13071-017-1976-0
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N014ba343e3ca4e64867504387e4e64df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Alleles
77 rdf:type schema:DefinedTerm
78 N0bd33cc3fec84a1f98d26a7299be74e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Antigens, Protozoan
80 rdf:type schema:DefinedTerm
81 N0d854b63196a4e1ab371e9fb657538b4 schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N0fc4449f80b64ba9bd64c55f4963a44c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Plasmodium falciparum
85 rdf:type schema:DefinedTerm
86 N13f85f3d97e74fb19eba45fcdcea7220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Genetic Variation
88 rdf:type schema:DefinedTerm
89 N2702f79823604bd98f9ce7057b072a33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Polymerase Chain Reaction
91 rdf:type schema:DefinedTerm
92 N43f873cb5a7648fba40a2285832c90d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Sequence Analysis, DNA
94 rdf:type schema:DefinedTerm
95 N490f705e34334182bd08012ac0e30be4 rdf:first sg:person.01264707676.10
96 rdf:rest N7e64e74472064a01a1c8b775a3d03893
97 N5b84a432a3284e3ba2be30a888117591 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N5d29c5104c9e4ccdab88cb3d6383b4e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Senegal
102 rdf:type schema:DefinedTerm
103 N5da81c1a3e24408eb0d99520a99b7770 rdf:first sg:person.0712007366.13
104 rdf:rest Na9896b154196495b8014ec3e09c0753a
105 N5e7a983fef0c4a6f860e135b36363be0 schema:name nlm_unique_id
106 schema:value 101462774
107 rdf:type schema:PropertyValue
108 N63004923a59d4576a244d79b8be46026 rdf:first sg:person.0613346131.38
109 rdf:rest N490f705e34334182bd08012ac0e30be4
110 N72b67c14c9a74c67b641acff70124897 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Merozoite Surface Protein 1
112 rdf:type schema:DefinedTerm
113 N74878b67bd28400881fbf7c4eb4ee9ca rdf:first sg:person.0757756450.54
114 rdf:rest rdf:nil
115 N7e64e74472064a01a1c8b775a3d03893 rdf:first sg:person.01337143361.31
116 rdf:rest Nfd7386f2eac04e919069a4f4b37b113c
117 N8cae1b5748a2449282fb8a25d6f632df schema:name dimensions_id
118 schema:value pub.1008431618
119 rdf:type schema:PropertyValue
120 N9515460e4f6a4731bdf02b8a3ddbc8cc schema:volumeNumber 10
121 rdf:type schema:PublicationVolume
122 Na61d1782474f43eeb2cb30482d740c19 schema:name doi
123 schema:value 10.1186/s13071-017-1976-0
124 rdf:type schema:PropertyValue
125 Na9896b154196495b8014ec3e09c0753a rdf:first sg:person.0575401220.81
126 rdf:rest N74878b67bd28400881fbf7c4eb4ee9ca
127 Nb444e13c76e54ebca139ed7b55c8fe89 schema:issueNumber 1
128 rdf:type schema:PublicationIssue
129 Ncdd2898174554fbeb249546af80d1146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Malaria, Falciparum
131 rdf:type schema:DefinedTerm
132 Nd4922481f1f14ff58cd631277264630b schema:name readcube_id
133 schema:value 282af49ea89ea3cb978e08c6d08dca9853fb0a53fa76900e127a02becfb04d11
134 rdf:type schema:PropertyValue
135 Ndb712377f1f64d7d9c20470c8306bea7 rdf:first sg:person.015210622144.63
136 rdf:rest N63004923a59d4576a244d79b8be46026
137 Ne16d2634bdb74d479e57b6664f48459e schema:name pubmed_id
138 schema:value 28103905
139 rdf:type schema:PropertyValue
140 Nf278c16a7f114034851ed4d9cf4706ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Spatio-Temporal Analysis
142 rdf:type schema:DefinedTerm
143 Nfd7386f2eac04e919069a4f4b37b113c rdf:first sg:person.016145262213.56
144 rdf:rest N5da81c1a3e24408eb0d99520a99b7770
145 Nfdd6901c229741e9b8a8f90be7d94322 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Protozoan Proteins
147 rdf:type schema:DefinedTerm
148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
149 schema:name Medical and Health Sciences
150 rdf:type schema:DefinedTerm
151 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
152 schema:name Public Health and Health Services
153 rdf:type schema:DefinedTerm
154 sg:journal.1039458 schema:issn 1756-3305
155 schema:name Filaria Journal
156 rdf:type schema:Periodical
157 sg:person.01264707676.10 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
158 schema:familyName Loucoubar
159 schema:givenName Cheikh
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264707676.10
161 rdf:type schema:Person
162 sg:person.01337143361.31 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
163 schema:familyName Sow
164 schema:givenName Abdourahmane
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337143361.31
166 rdf:type schema:Person
167 sg:person.015210622144.63 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
168 schema:familyName Niang
169 schema:givenName Makhtar
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015210622144.63
171 rdf:type schema:Person
172 sg:person.016145262213.56 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
173 schema:familyName Sadio
174 schema:givenName Bacary D.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016145262213.56
176 rdf:type schema:Person
177 sg:person.0575401220.81 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
178 schema:familyName Sall
179 schema:givenName Amadou A.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575401220.81
181 rdf:type schema:Person
182 sg:person.0613346131.38 schema:affiliation https://www.grid.ac/institutes/grid.8191.1
183 schema:familyName Thiam
184 schema:givenName Laty G.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613346131.38
186 rdf:type schema:Person
187 sg:person.0712007366.13 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
188 schema:familyName Diallo
189 schema:givenName Mawlouth
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712007366.13
191 rdf:type schema:Person
192 sg:person.0757756450.54 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
193 schema:familyName Toure-Balde
194 schema:givenName Aissatou
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757756450.54
196 rdf:type schema:Person
197 sg:pub.10.1007/s00436-003-0854-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000439439
198 https://doi.org/10.1007/s00436-003-0854-1
199 rdf:type schema:CreativeWork
200 sg:pub.10.1186/1475-2875-12-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001361713
201 https://doi.org/10.1186/1475-2875-12-22
202 rdf:type schema:CreativeWork
203 sg:pub.10.1186/1475-2875-2-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044004045
204 https://doi.org/10.1186/1475-2875-2-12
205 rdf:type schema:CreativeWork
206 sg:pub.10.1186/1475-2875-7-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050756754
207 https://doi.org/10.1186/1475-2875-7-17
208 rdf:type schema:CreativeWork
209 sg:pub.10.1186/1475-2875-8-135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021465976
210 https://doi.org/10.1186/1475-2875-8-135
211 rdf:type schema:CreativeWork
212 sg:pub.10.1186/1475-2875-9-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015318796
213 https://doi.org/10.1186/1475-2875-9-1
214 rdf:type schema:CreativeWork
215 sg:pub.10.1186/1756-3305-4-233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017092543
216 https://doi.org/10.1186/1756-3305-4-233
217 rdf:type schema:CreativeWork
218 sg:pub.10.1186/s12936-015-0745-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043948492
219 https://doi.org/10.1186/s12936-015-0745-9
220 rdf:type schema:CreativeWork
221 sg:pub.10.1186/s12936-015-0808-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1011571041
222 https://doi.org/10.1186/s12936-015-0808-y
223 rdf:type schema:CreativeWork
224 sg:pub.10.1186/s12936-015-0843-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004734152
225 https://doi.org/10.1186/s12936-015-0843-8
226 rdf:type schema:CreativeWork
227 sg:pub.10.1186/s12936-016-1100-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040428946
228 https://doi.org/10.1186/s12936-016-1100-5
229 rdf:type schema:CreativeWork
230 sg:pub.10.1186/s12936-016-1208-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043270993
231 https://doi.org/10.1186/s12936-016-1208-7
232 rdf:type schema:CreativeWork
233 sg:pub.10.1385/1-59259-271-6:103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075088139
234 https://doi.org/10.1385/1-59259-271-6:103
235 rdf:type schema:CreativeWork
236 sg:pub.10.1385/1-59259-271-6:189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075088149
237 https://doi.org/10.1385/1-59259-271-6:189
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0035-9203(96)90446-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019888264
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0035-9203(99)90120-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051572248
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0035-9203(99)90323-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031388099
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0140-6736(08)61596-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036594093
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s1473-3099(11)70194-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045839569
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s1473-3099(14)70712-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037818763
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s1995-7645(13)60102-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053120379
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1046/j.1365-3156.2002.00881.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043228142
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1046/j.1365-3156.2003.00968.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009576125
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1073/pnas.1505691112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050203041
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1365-3156.2007.01813.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001003367
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1749-6632.2001.tb03891.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050645398
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1128/iai.69.12.7783-7792.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022572317
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1179/136485908x252340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020337882
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1371/journal.pmed.0040093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029396300
268 rdf:type schema:CreativeWork
269 https://doi.org/10.4269/ajtmh.1996.54.632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082909437
270 rdf:type schema:CreativeWork
271 https://doi.org/10.4269/ajtmh.1997.56.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083063889
272 rdf:type schema:CreativeWork
273 https://doi.org/10.4269/ajtmh.1998.59.726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083356524
274 rdf:type schema:CreativeWork
275 https://doi.org/10.4269/ajtmh.2006.75.146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077268421
276 rdf:type schema:CreativeWork
277 https://doi.org/10.4269/ajtmh.2007.77.444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077479414
278 rdf:type schema:CreativeWork
279 https://www.grid.ac/institutes/grid.418508.0 schema:alternateName Institut Pasteur de Dakar
280 schema:name Institut Pasteur Dakar, Arbovirus and Viral Hemorrhagic Fevers Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal
281 Institut Pasteur Dakar, Biostatistics, Bioinformatics and Modeling Group, 36 Avenue Pasteur, BP 220, Dakar, Senegal
282 Institut Pasteur Dakar, Immunology Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal
283 Institut Pasteur Dakar, Medical Entomology Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.8191.1 schema:alternateName Cheikh Anta Diop University
286 schema:name Department of Animal Biology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
287 Institut Pasteur Dakar, Immunology Unit, 36 Avenue Pasteur, BP 220, Dakar, Senegal
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...