Evaluation of diagnostic performance of rK28 ELISA using urine for diagnosis of visceral leishmaniasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Prakash Ghosh, Khondaker R. H. Bhaskar, Faria Hossain, Md Anik Ashfaq Khan, Aarthy C. Vallur, Malcolm S. Duthie, Shinjiro Hamano, Md Abdus Salam, M. Mamun Huda, Md Gulam Musawwir Khan, Rhea N. Coler, Steven G. Reed, Dinesh Mondal

ABSTRACT

BACKGROUND: Recombinant fusion proteins are now commonly used to detect circulating antibodies for the serodiagnosis of visceral leishmaniasis (VL) in Asia, Africa and the Americas. Although simple, these tests still require blood collection and their use in remote settings can be limited due to the need of collection devices, serum fractionation instrument and generation of biohazardous waste. The development of an accurate and non-invasive diagnostic algorithm for VL, such as could be achieved with urine, is desirable. METHODS: We enrolled 87 VL patients and 81 non-VL individuals, including 33 healthy endemic controls, 16 healthy non-endemic controls, 16 disease controls and 16 tuberculosis (TB) patients. We compared the efficacy of recombinant antigens rK28, rK39 and rKRP42 for the diagnosis of VL when either serum or urine were used to develop antibody-detection ELISA. RESULTS: As expected, each of the antigens readily detected antibodies in the serum of VL patients. rK28 ELISA showed the highest sensitivity (98.9 %), followed by rK39 and rKRP42 ELISA (97.7 and 94.4 %, respectively); overall specificity was > 96 %. When urine was used as the test analyte, only a marginal drop in sensitivity was observed, with rK28 ELISA again demonstrating the greatest sensitivity (95.4 %), followed by rK39 and rKRP42 ELISA, respectively. Again, the overall specificity was > 96 %. CONCLUSIONS: Our data indicate the potential for using urine in the diagnosis of VL. Detection of antibodies against rK28 demonstrated the greatest sensitivity. Together, our results indicate that rK28-based antibody detection tests using urine could provide a completely non-invasive tool amenable for diagnosis of VL in remote locations. More... »

PAGES

383

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13071-016-1667-2

DOI

http://dx.doi.org/10.1186/s13071-016-1667-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005790927

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27377266


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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