Ontology type: schema:ScholarlyArticle
2019-12
AUTHORSRonghui Gu, Yuehu Wang, Shibiao Wu, Yeling Wang, Ping Li, Li Xu, Yue Zhou, Ze’e Chen, Edward J. Kennelly, Chunlin Long
ABSTRACTThe medicinal plant Tirpitzia sinensis has been used by the Zhuang ethnic people in mountainous areas of Southwest China to stop bleeding, invigorate blood circulation, and treat inflammation and wounds. In order to further explore its traditional medicinal uses, the phytochemical constituents of this species were examined. Three new compounds, the lignan tirpitzin (1), the flavonoid tirpitzoside (2), and the furan-glycoside tirpitziol (3), along with five known compounds were isolated from the aerial part of T. sinensis for the first time. The structures of these compounds were elucidated by 1D and 2D NMR, LC/MS, IR spectrometric methods and compared with published data. The results of an in silico pharmacophore-based analysis showed potential targets of the new compounds, including ERBB2, IRAK4, LCK, JAK2, MAPK14, and MMP-12. These targets suggested that 1–3 may be involved with wound-healing and/or inflammation, leading to an in vitro assay of nitric oxide (NO) inhibition assays with lipopolysaccharide-induced BV-2 cells. All three new compounds displayed moderate NO inhibitory activity with the IC50 values of 14.97 ± 0.87, 26.63 ± 1.32, and 17.09 ± 2.3 μM, respectively. More... »
PAGES47
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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13065-019-0568-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13065-019-0568-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13065-019-0568-9'
This table displays all metadata directly associated to this object as RDF triples.
279 TRIPLES
20 PREDICATES
76 URIs
17 LITERALS
5 BLANK NODES